Shuxia Wang, M.D., Ph.D. | Saha Cardiovascular Research Center

Shuxia Wang, M.D., Ph.D.

swang7@email.uky.edu

859-218-1367 (office)
859-218-1368 (lab)
859-257-3646 (fax)

583 C.T. Wethington Bldg, 900 S Limestone St, Lexington, KY 40536-0200

Position(s):

Professor

Graduate Faculty in Nutritional Sciences

Cardiovascular Research Center

Affiliation(s):

Pharmacology & Nutritional Sciences

Cardiovascular Research Center

Other Affiliation(s):

CVRC - Affiliated Faculty

Nutritional Sciences Graduate Faculty

Pharmacology and Nutritional Sciences Primary Faculty

Interests / Specialties:

Obesity associated complications

Diabetic nephropathy

Bio / Education:

Shanxi Medical University, MD
Peking Union Medical College, PhD
University of Alabama at Birmingham, Postdoc

Research Description:

One research focus of my lab is kidney diseases including obesity/diabetes associated renal complications, ischemia-reperfusion induced acute kidney disease and aging-related kidney dysfunction. Other research focus includes mechanisms of obesity-associated inflammation and insulin resistance.

Grants:

NIH Grants

Selected Publications:

Shuxia Wang, Sruti Shiva, Maria H. Poczatek, Victor Darley-Usmar, and Joanne E. Murphy-Ullrich (2002). Nitric oxide and cGMP-dependent protein kinase regulation of thrombospondin 1-dependent TGF-beta activation in response to high glucose exposure. J Biol Chem. 277(12), 9880-8.

Shuxia Wang, Xing Wu, Thomas M. Lincoln and Joanne E. Murphy-Ullrich (2003). Expression of constitutively active cGMP-dependent protein kinase prevents glucose-induced thrombospondin1 expression and TGF-beta activation. Diabetes. 52 (8), 2144-2150.

Shu Liu, Lihua Shi, and Shuxia Wang (2007). Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury. Am J Physiol Renal Physiol, 293 (5), F1727-35, PMID: 17881461

Dejan Nikolic, Shu Liu, Yanzhang Li, and Shuxia Wang (2011). Over-expression of constitutively active PKG-I protects female, but not male mice from diet-induced obesity. Obesity, 19 (4), 784-91, PMID: 20930715

Yanzhang Li, Xiaopeng Tong, Courtney Rumala, Kate Clemons, and Shuxia Wang (2011). Thrombospondin1 deficiency reduces obesity-associated inflammation and imporves insulin sensitivity in a diet-induced obese mouse model. PloS One, 6 (10): e26656. PMID:22160771.

Yanzhang Li, Xiaopeng Tong, Haisety Memeiti, Kate Clemons, and Shuxia Wang (2012). Overexpression of cGMP-dependent protein kinase I (PKG-I) attenuates ischemia reperfusion induced kidney injury. Am J of Physiol Renal Physiol, 302(5): F561-70. PMID: 22039525

Hasiyeti Maiamitiyiming, Yanzhnag Li, Wenpeng Cui, Xiaopeng Tong, Heather Norman, Xinyu Qi, and Shuxia Wang (2013). Increasing cGMP-dependent protein kinase I activity attenuates cisplatin induced acute kidney injury. Am J of Physiol-renal, 2013, July 3

Wenpeng Cui, Maimaitiyiming Hasiyeti, Xinyu Qi, Heather Norman, and Shuxia Wang (2013). Thrombospondin1 mediates renal dysfunction in a mouse model of high fat diet induced obesity. Am J of Physiol-renal, 2013, July 17.

Yanzhang Li, Xinyu qi, Xiaopeng Tong, and Shuxia Wang (2013). Thrombospondin1 stimulates TNF-alpha expression in macrophages though activation of TLR4 pathway. Cellular and Molecular Immunology, 2013, Aug. 19 (Epub ahead of print)

PubMed Publications:

Li, D.; Gwag, T ; Wang, S. "Absence of CD47 maintains brown fat thermogenic capacity and protects mice from aging-related obesity and metabolic disorder." Biochemical and biophysical research communications 575, (2021): 14-19. [PubMed Link] | [ Full text ]
Gwag, T ; Mooli, RG Reddy; Li, D.; Lee, S.; Lee, EY ; Wang, S. "Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease." JHEP reports : innovation in hepatology 3, 1 (2021): 100193. [PubMed Link] | [ Full text ]
Gwag, T ; Meng, Z.; Sui, Y.; Helsley, RN ; Park, SH ; Wang, S.; Greenberg, RN ; Zhou, C. "Erratum to: Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis J Hepatol (2019); 70 (5): 930-940 ." Journal of hepatology 74, 4 (2021): 1003-1004. [PubMed Link] | [ Full text ]
Wang, J.; Yu, Q.; Qiu, Z.; Dai, T.; Wang, S.; Yang, X.; Evers, BM ; Wu, Y. "The combined effect of epigenetic inhibitors for LSD1 and BRD4 alters prostate cancer growth and invasion." Aging 12, 1 (2020): 397-415. [PubMed Link] | [ Full text ]
Norman-Burgdolf, H ; Li, D.; Sullivan, P.; Wang, S. "CD47 differentially regulates white and brown fat function." Biology open 9, 12 (2020): [PubMed Link] | [ Full text ]
Gwag, T ; Meng, Z.; Sui, Y.; Helsley, RN ; Park, SH ; Wang, S.; Greenberg, RN ; Zhou, C. "Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis." Journal of hepatology 70, 5 (2019): 930-940. [PubMed Link] | [ Full text ]
Memetimin, H ; Li, D.; Tan, K.; Zhou, C.; Liang, Y.; Wu, Y.; Wang, S. "Myeloid-specific deletion of thrombospondin 1 protects against inflammation and insulin resistance in long-term diet-induced obese male mice." American journal of physiology. Endocrinology and metabolism 315, 6 (2018): E1194-E1203. [PubMed Link] | [ Full text ]
Li, Y.; Turpin, CP ; Wang, S. "Role of thrombospondin 1 in liver diseases." Hepatology research : the official journal of the Japan Society of Hepatology 47, 2 (2017): 186-193. [PubMed Link] | [ Full text ]
Liu, Y.; Zhang, C.; Li, Z.; Wang, C.; Jia, J.; Gao, T.; Hildebrandt, G.; Zhou, D.; Bondada, S.; Ji, P.; St Clair, D.; Liu, J.; Zhan, C.; Geiger, H.; Wang, S.; Liang, Y. "Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice." Stem cell reports 8, 4 (2017): 991-1004. [PubMed Link] | [ Full text ]
Guo, B.; Zhang, W.; Xu, S.; Lou, J.; Wang, S.; Men, X. "GSK-3β mediates dexamethasone-induced pancreatic β cell apoptosis." Life sciences 144, (2016): 1-7. [PubMed Link] | [ Full text ]
Maimaitiyiming, H.; Zhou, Q.; Wang, S. "Thrombospondin 1 Deficiency Ameliorates the Development of Adriamycin-Induced Proteinuric Kidney Disease." PloS one 11, 5 (2016): e0156144. [PubMed Link] | [ Full text ]
Maimaitiyiming, H.; Norman, H.; Zhou, Q.; Wang, S. "CD47 deficiency protects mice from diet-induced obesity and improves whole body glucose tolerance and insulin sensitivity." Scientific reports 5, (2015): 8846. [PubMed Link] | [ Full text ]
Wang, S. "Role of upstream stimulatory factor 2 in diabetic nephropathy." Frontiers in biology 10, 3 (2015): 221-229. [PubMed Link] |
Cui, W.; Maimaitiyiming, H.; Zhou, Q.; Norman, H.; Zhou, C.; Wang, S. "Interaction of thrombospondin1 and CD36 contributes to obesity-associated podocytopathy." Biochimica et biophysica acta 1852, 7 (2015): 1323-33. [PubMed Link] | [ Full text ]
Maimaitiyiming, H.; Clemons, K.; Zhou, Q.; Norman, H.; Wang, S. "Thrombospondin1 deficiency attenuates obesity-associated microvascular complications in ApoE-/- mice." PloS one 10, 3 (2015): e0121403. [PubMed Link] | [ Full text ]
Cui, W.; Maimaitiyiming, H.; Qi, X.; Norman, H.; Zhou, Q.; Wang, X.; Fu, J.; Wang, S. "Increasing cGMP-dependent protein kinase activity attenuates unilateral ureteral obstruction-induced renal fibrosis." American journal of physiology. Renal physiology 306, 9 (2014): F996-1007. [PubMed Link] | [ Full text ]
Chen, J.; Shetty, S.; Zhang, P.; Gao, R.; Hu, Y.; Wang, S.; Li, Z.; Fu, J. "Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury." Toxicology and applied pharmacology 277, 2 (2014): 118-23. [PubMed Link] | [ Full text ]
Gao, R.; Chen, J.; Hu, Y.; Li, Z.; Wang, S.; Shetty, S.; Fu, J. "Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury." PloS one 9, 6 (2014): e98909. [PubMed Link] | [ Full text ]
Cui, W.; Maimaitiyiming, H.; Qi, X.; Norman, H.; Wang, S. "Thrombospondin 1 mediates renal dysfunction in a mouse model of high-fat diet-induced obesity." American journal of physiology. Renal physiology 305, 6 (2013): F871-80. [PubMed Link] | [ Full text ]
Maimaitiyiming, H.; Li, Y.; Cui, W.; Tong, X.; Norman, H.; Qi, X.; Wang, S. "Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function." American journal of physiology. Renal physiology 305, 6 (2013): F881-90. [PubMed Link] | [ Full text ]
Li, Y.; Qi, X.; Tong, X.; Wang, S. "Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway." Cellular & molecular immunology 10, 6 (2013): 506-12. [PubMed Link] | [ Full text ]
Li, Y.; Tong, X.; Maimaitiyiming, H.; Clemons, K.; Cao, JM ; Wang, S. "Overexpression of cGMP-dependent protein kinase I (PKG-I) attenuates ischemia-reperfusion-induced kidney injury." American journal of physiology. Renal physiology 302, 5 (2012): F561-70. [PubMed Link] | [ Full text ]
Nikolic, DM ; Li, Y.; Liu, S.; Wang, S. "Overexpression of constitutively active PKG-I protects female, but not male mice from diet-induced obesity." Obesity (Silver Spring, Md.) 19, 4 (2011): 784-91. [PubMed Link] | [ Full text ]
Li, Y.; Tong, X.; Rumala, C.; Clemons, K.; Wang, S. "Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model." PloS one 6, 10 (2011): e26656. [PubMed Link] | [ Full text ]
Visavadiya, NP ; Li, Y.; Wang, S. "High glucose upregulates upstream stimulatory factor 2 in human renal proximal tubular cells through angiotensin II-dependent activation of CREB." Nephron. Experimental nephrology 117, 3 (2011): e62-70. [PubMed Link] | [ Full text ]
Wang, S.; Lincoln, TM ; Murphy-Ullrich, JE "Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF- beta activity in vascular smooth muscle cells." American journal of physiology. Cell physiology 298, 5 (2010): C1188-97. [PubMed Link] | [ Full text ]
Li, Y.; Wang, S. "Glycated albumin activates NADPH oxidase in rat mesangial cells through up-regulation of p47phox." Biochemical and biophysical research communications 397, 1 (2010): 5-11. [PubMed Link] | [ Full text ]
Son, YO ; Hitron, JA ; Wang, X.; Chang, Q.; Pan, J.; Zhang, Z.; Liu, J.; Wang, S.; Lee, JC ; Shi, X. "Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells." Toxicology and applied pharmacology 245, 2 (2010): 226-35. [PubMed Link] | [ Full text ]
Li, Y.; Wang, S. "Glycated albumin upregulates upstream stimulatory factor 2 gene transcription in mesangial cells." American journal of physiology. Renal physiology 299, 1 (2010): F121-7. [PubMed Link] | [ Full text ]
Shi, L.; Nikolic, D.; Liu, S.; Lu, H.; Wang, S. "Activation of renal renin-angiotensin system in upstream stimulatory factor 2 transgenic mice." American journal of physiology. Renal physiology 296, 2 (2009): F257-65. [PubMed Link] | [ Full text ]
Wang, S.; Li, Y. "Expression of constitutively active cGMP-dependent protein kinase inhibits glucose-induced vascular smooth muscle cell proliferation." American journal of physiology. Heart and circulatory physiology 297, 6 (2009): H2075-83. [PubMed Link] | [ Full text ]
Shi, L.; Liu, S.; Nikolic, D.; Wang, S. "High glucose levels upregulate upstream stimulatory factor 2 gene transcription in mesangial cells." Journal of cellular biochemistry 103, 6 (2008): 1952-61. [PubMed Link] | [ Full text ]
Liu, S.; Shi, L.; Wang, S. "Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury." American journal of physiology. Renal physiology 293, 5 (2007): F1727-35. [PubMed Link] | [ Full text ]
Liu, S.; Ma, X.; Gong, M.; Shi, L.; Lincoln, T.; Wang, S. "Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species." Free radical biology & medicine 42, 6 (2007): 852-63. [PubMed Link] | [ Full text ]

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