Shuxia Wang, M.D., Ph.D. | Saha Cardiovascular Research Center

Shuxia Wang, M.D., Ph.D.

swang7@email.uky.edu
859-218-1367 (office)
859-218-1368 (lab)
859-257-3646 (fax)
583 C.T. Wethington Bldg, 900 S Limestone St, Lexington, KY 40536-0200

Position(s):

Professor

Graduate Faculty in Nutritional Sciences

Cardiovascular Research Center

Affiliation(s):

Pharmacology & Nutritional Sciences

Cardiovascular Research Center

Other Affiliation(s):

CVRC - Affiliated Faculty

Nutritional Sciences Graduate Faculty

Pharmacology and Nutritional Sciences Primary Faculty

Interests / Specialties:

Obesity associated complications

Diabetic nephropathy

Bio / Education:

Shanxi Medical University, MD
Peking Union Medical College, PhD
University of Alabama at Birmingham, Postdoc

Research Description:

One research focus of my lab is kidney diseases including obesity/diabetes associated renal complications, ischemia-reperfusion induced acute kidney disease and aging-related kidney dysfunction. Other research focus includes mechanisms of obesity-associated inflammation and insulin resistance.

Grants:

NIH Grants

Selected Publications:

Shuxia Wang, Sruti Shiva, Maria H. Poczatek, Victor Darley-Usmar, and Joanne E. Murphy-Ullrich (2002). Nitric oxide and cGMP-dependent protein kinase regulation of thrombospondin 1-dependent TGF-beta activation in response to high glucose exposure. J Biol Chem. 277(12), 9880-8.

Shuxia Wang, Xing Wu, Thomas M. Lincoln and Joanne E. Murphy-Ullrich (2003). Expression of constitutively active cGMP-dependent protein kinase prevents glucose-induced thrombospondin1 expression and TGF-beta activation. Diabetes. 52 (8), 2144-2150.

Shu Liu, Lihua Shi, and Shuxia Wang (2007). Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury. Am J Physiol Renal Physiol, 293 (5), F1727-35, PMID: 17881461

Dejan Nikolic, Shu Liu, Yanzhang Li, and Shuxia Wang (2011). Over-expression of constitutively active PKG-I protects female, but not male mice from diet-induced obesity. Obesity, 19 (4), 784-91, PMID: 20930715

Yanzhang Li, Xiaopeng Tong, Courtney Rumala, Kate Clemons, and Shuxia Wang (2011). Thrombospondin1 deficiency reduces obesity-associated inflammation and imporves insulin sensitivity in a diet-induced obese mouse model. PloS One, 6 (10): e26656. PMID:22160771.

Yanzhang Li, Xiaopeng Tong, Haisety Memeiti, Kate Clemons, and Shuxia Wang (2012). Overexpression of cGMP-dependent protein kinase I (PKG-I) attenuates ischemia reperfusion induced kidney injury. Am J of Physiol Renal Physiol, 302(5): F561-70. PMID: 22039525

Hasiyeti Maiamitiyiming, Yanzhnag Li, Wenpeng Cui, Xiaopeng Tong, Heather Norman, Xinyu Qi, and Shuxia Wang (2013). Increasing cGMP-dependent protein kinase I activity attenuates cisplatin induced acute kidney injury. Am J of Physiol-renal, 2013, July 3

Wenpeng Cui, Maimaitiyiming Hasiyeti, Xinyu Qi, Heather Norman, and Shuxia Wang (2013). Thrombospondin1 mediates renal dysfunction in a mouse model of high fat diet induced obesity. Am J of Physiol-renal, 2013, July 17.

Yanzhang Li, Xinyu qi, Xiaopeng Tong, and Shuxia Wang (2013). Thrombospondin1 stimulates TNF-alpha expression in macrophages though activation of TLR4 pathway. Cellular and Molecular Immunology, 2013, Aug. 19 (Epub ahead of print)

PubMed Publications:

Liu, Y.;Zhang, C.;Li, Z.;Wang, C.;Jia, J.;Gao, T.;Hildebrandt, G.;Zhou, D.;Bondada, S.;Ji, P.;St Clair, D.;Liu, J.;Zhan, C.;Geiger, H.;Wang, S.;Liang, Y. "Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice." Stem cell reports 8, 4 (2017): 991-1004. [PubMed Link] | [ Full text ]
Guo, B.;Zhang, W.;Xu, S.;Lou, J.;Wang, S.;Men, X. "GSK-3β mediates dexamethasone-induced pancreatic β cell apoptosis." Life sciences 144, (2016): 1-7. [PubMed Link] | [ Full text ]
Li, Y.;Turpin, C.P.;Wang, S. "Role of thrombospondin 1 in liver diseases." Hepatology research : the official journal of the Japan Society of Hepatology (2016): [PubMed Link] | [ Full text ]
Maimaitiyiming, H.;Zhou, Q.;Wang, S. "Thrombospondin 1 Deficiency Ameliorates the Development of Adriamycin-Induced Proteinuric Kidney Disease." PloS one 11, 5 (2016): e0156144. [PubMed Link] | [ Full text ]
Maimaitiyiming, H.;Norman, H.;Zhou, Q.;Wang, S. "CD47 deficiency protects mice from diet-induced obesity and improves whole body glucose tolerance and insulin sensitivity." Scientific reports 5, (2015): 8846. [PubMed Link] | [ Full text ]
Wang, S. "Role of upstream stimulatory factor 2 in diabetic nephropathy." Frontiers in biology 10, 3 (2015): 221-229. [PubMed Link] |
Cui, W.;Maimaitiyiming, H.;Zhou, Q.;Norman, H.;Zhou, C.;Wang, S. "Interaction of thrombospondin1 and CD36 contributes to obesity-associated podocytopathy." Biochimica et biophysica acta 1852, 7 (2015): 1323-33. [PubMed Link] | [ Full text ]
Maimaitiyiming, H.;Clemons, K.;Zhou, Q.;Norman, H.;Wang, S. "Thrombospondin1 deficiency attenuates obesity-associated microvascular complications in ApoE-/- mice." PloS one 10, 3 (2015): e0121403. [PubMed Link] | [ Full text ]
Cui, W.;Maimaitiyiming, H.;Qi, X.;Norman, H.;Zhou, Q.;Wang, X.;Fu, J.;Wang, S. "Increasing cGMP-dependent protein kinase activity attenuates unilateral ureteral obstruction-induced renal fibrosis." American journal of physiology. Renal physiology 306, 9 (2014): F996-1007. [PubMed Link] | [ Full text ]
Chen, J.;Shetty, S.;Zhang, P.;Gao, R.;Hu, Y.;Wang, S.;Li, Z.;Fu, J. "Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury." Toxicology and applied pharmacology 277, 2 (2014): 118-23. [PubMed Link] | [ Full text ]
Gao, R.;Chen, J.;Hu, Y.;Li, Z.;Wang, S.;Shetty, S.;Fu, J. "Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury." PloS one 9, 6 (2014): e98909. [PubMed Link] | [ Full text ]
Cui, W.;Maimaitiyiming, H.;Qi, X.;Norman, H.;Wang, S. "Thrombospondin 1 mediates renal dysfunction in a mouse model of high-fat diet-induced obesity." American journal of physiology. Renal physiology 305, 6 (2013): F871-80. [PubMed Link] | [ Full text ]
Maimaitiyiming, H.;Li, Y.;Cui, W.;Tong, X.;Norman, H.;Qi, X.;Wang, S. "Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function." American journal of physiology. Renal physiology 305, 6 (2013): F881-90. [PubMed Link] | [ Full text ]
Li, Y.;Qi, X.;Tong, X.;Wang, S. "Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway." Cellular & molecular immunology 10, 6 (2013): 506-12. [PubMed Link] | [ Full text ]
Li, Y.;Tong, X.;Maimaitiyiming, H.;Clemons, K.;Cao, J.M.;Wang, S. "Overexpression of cGMP-dependent protein kinase I (PKG-I) attenuates ischemia-reperfusion-induced kidney injury." American journal of physiology. Renal physiology 302, 5 (2012): F561-70. [PubMed Link] | [ Full text ]
Nikolic, D.M.;Li, Y.;Liu, S.;Wang, S. "Overexpression of constitutively active PKG-I protects female, but not male mice from diet-induced obesity." Obesity (Silver Spring, Md.) 19, 4 (2011): 784-91. [PubMed Link] | [ Full text ]
Li, Y.;Tong, X.;Rumala, C.;Clemons, K.;Wang, S. "Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model." PloS one 6, 10 (2011): e26656. [PubMed Link] | [ Full text ]
Visavadiya, N.P.;Li, Y.;Wang, S. "High glucose upregulates upstream stimulatory factor 2 in human renal proximal tubular cells through angiotensin II-dependent activation of CREB." Nephron. Experimental nephrology 117, 3 (2011): e62-70. [PubMed Link] | [ Full text ]
Wang, S.;Lincoln, T.M.;Murphy-Ullrich, J.E. "Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF- beta activity in vascular smooth muscle cells." American journal of physiology. Cell physiology 298, 5 (2010): C1188-97. [PubMed Link] | [ Full text ]
Li, Y.;Wang, S. "Glycated albumin activates NADPH oxidase in rat mesangial cells through up-regulation of p47phox." Biochemical and biophysical research communications 397, 1 (2010): 5-11. [PubMed Link] | [ Full text ]
Son, Y.O.;Hitron, J.A.;Wang, X.;Chang, Q.;Pan, J.;Zhang, Z.;Liu, J.;Wang, S.;Lee, J.C.;Shi, X. "Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells." Toxicology and applied pharmacology 245, 2 (2010): 226-35. [PubMed Link] | [ Full text ]
Li, Y.;Wang, S. "Glycated albumin upregulates upstream stimulatory factor 2 gene transcription in mesangial cells." American journal of physiology. Renal physiology 299, 1 (2010): F121-7. [PubMed Link] | [ Full text ]
Shi, L.;Nikolic, D.;Liu, S.;Lu, H.;Wang, S. "Activation of renal renin-angiotensin system in upstream stimulatory factor 2 transgenic mice." American journal of physiology. Renal physiology 296, 2 (2009): F257-65. [PubMed Link] | [ Full text ]
Wang, S.;Li, Y. "Expression of constitutively active cGMP-dependent protein kinase inhibits glucose-induced vascular smooth muscle cell proliferation." American journal of physiology. Heart and circulatory physiology 297, 6 (2009): H2075-83. [PubMed Link] | [ Full text ]
Shi, L.;Liu, S.;Nikolic, D.;Wang, S. "High glucose levels upregulate upstream stimulatory factor 2 gene transcription in mesangial cells." Journal of cellular biochemistry 103, 6 (2008): 1952-61. [PubMed Link] | [ Full text ]
Liu, S.;Shi, L.;Wang, S. "Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury." American journal of physiology. Renal physiology 293, 5 (2007): F1727-35. [PubMed Link] | [ Full text ]
Liu, S.;Ma, X.;Gong, M.;Shi, L.;Lincoln, T.;Wang, S. "Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species." Free radical biology & medicine 42, 6 (2007): 852-63. [PubMed Link] | [ Full text ]

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