- Connect
- About
- Education
- Research
- Publications
(859) 218-1386 (lab)
Inflammation and Lipo
University of Virginia, Charlottesville, VA | B.A. | 1981 | Biology |
University of Kentucky, Lexington, KY | Ph.D. | 1999 | Molecular Biology |
|
Research in the Webb laboratory focuses on mechanisms of cardiovascular disease, including atherosclerosis and abdominal aortic aneurysms. It has been recognized for decades that high levels of HDL in the blood reduce an individual's risk for heart attack and stroke, yet it is not well understood why HDL (the "good cholesterol") is cardioprotective. The Webb laboratory studies what regulates HDL levels in the blood, how HDL functions to reduce cardiovascular risk, and how inflammation, obesity, and diabetes alter the ability of HDL to function. Research projects integrate biochemical, cellular, and physiological analyses of HDLs obtained from transgenic mouse models as well as human subjects. Another area of research in the Webb laboratory focuses on a family of lipolytic enzymes, the secretory phospholipase A2’s (sPLA2), and their role in physiological and pathophysiological processes. The underlying hypothesis of the studies is that lipid products generated by sPLA2’s serve as bioactive mediators that have pleiotropic effects on fat, vascular, and immune cells.
- Webb, NR "High-Density Lipoproteins and Serum Amyloid A (SAA)." Current atherosclerosis reports 23, 2 (2021): 7. [PubMed Link] | [ Full text ]
- Barnett, JV ; Beckman, JA ; Bonaca, MP ; Carnethon, MR ; Cassis, LA ; Creager, MA ; Daugherty, A.; Feinberg, MW ; Freiberg, MS ; Goodney, PP ; Greenland, P.; Leeuwenburgh, C.; Lemaire, SA ; McDermott, MM ; Sabatine, MS ; Shen, YH ; Wasserman, DH ; Webb, NR ; Wells, QS "American Heart Association Vascular Disease Strategically Focused Research Network." Arteriosclerosis, thrombosis, and vascular biology 40, 3 (2020): e47-e54. [PubMed Link] | [ Full text ]
- Shen, YH ; Lemaire, SA ; Webb, NR ; Cassis, LA ; Daugherty, A.; Lu, HS "Aortic Aneurysms and Dissections Series." Arteriosclerosis, thrombosis, and vascular biology 40, 3 (2020): e37-e46. [PubMed Link] | [ Full text ]
- Ji, A.; Wang, X.; Noffsinger, VP ; Jennings, D ; De Beer, MC ; Beer, FC ; Tannock, LR ; Webb, NR "Serum amyloid A is not incorporated into HDL during HDL biogenesis." Journal of lipid research 61, 3 (2020): 328-337. [PubMed Link] | [ Full text ]
- Shen, YH ; Lemaire, SA ; Webb, NR ; Cassis, LA ; Daugherty, A.; Lu, HS "Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections." Arteriosclerosis, thrombosis, and vascular biology 40, 4 (2020): e78-e86. [PubMed Link] | [ Full text ]
- Lee, JW ; Stone, ML ; Porrett, PM ; Thomas, SK ; Komar, CA ; Li, JH ; Delman, D ; Graham, K ; Gladney, WL ; Hua, X.; Black, TA ; Chien, AL ; Majmundar, KS ; Thompson, JC ; Yee, SS ; O'Hara, MH ; Aggarwal, C ; Xin, D.; Shaked, A.; Gao, M.; Liu, D.; Borad, MJ ; Ramanathan, RK ; Carpenter, EL ; Ji, A.; De Beer, MC ; Beer, FC ; Webb, NR ; Beatty, GL "Hepatocytes direct the formation of a pro-metastatic niche in the liver." Nature 567, 7747 (2019): 249-252. [PubMed Link] | [ Full text ]
- Thompson, JC ; Wilson, PG ; Shridas, P.; Ji, A.; Beer, M.; Beer, FC ; Webb, NR ; Tannock, LR "Serum amyloid A3 is pro-atherogenic." Atherosclerosis 268, (2018): 32-35. [PubMed Link] | [ Full text ]
- Tannock, LR ; De Beer, MC ; Ji, A.; Shridas, P.; Noffsinger, VP ; Hartigh, L.; Chait, A.; Beer, FC ; Webb, NR "Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein." Journal of lipid research 59, 2 (2018): 339-347. [PubMed Link] | [ Full text ]
- Shridas, P.; De Beer, MC ; Webb, NR "High-density lipoprotein inhibits serum amyloid A-mediated reactive oxygen species generation and NLRP3 inflammasome activation." The Journal of biological chemistry 293, 34 (2018): 13257-13269. [PubMed Link] | [ Full text ]
- Wilson, PG ; Thompson, JC ; Shridas, P.; McNamara, PJ ; De Beer, MC ; Beer, FC ; Webb, NR ; Tannock, LR "Serum Amyloid A Is an Exchangeable Apolipoprotein." Arteriosclerosis, thrombosis, and vascular biology 38, 8 (2018): 1890-1900. [PubMed Link] | [ Full text ]
- Shridas, P.; Noffsinger, VP ; Trumbauer, AC ; Webb, NR "The dual role of group V secretory phospholipase A<sub>2</sub> in pancreatic β-cells." Endocrine 58, 1 (2017): 47-58. [PubMed Link] | [ Full text ]
- Kim, MH ; De Beer, MC ; Wroblewski, JM ; Charnigo, RJ ; Ji, A.; Webb, NR ; Beer, FC ; Westhuyzen, DR "Impact of individual acute phase serum amyloid A isoforms on HDL metabolism in mice." Journal of lipid research 57, 6 (2016): 969-79. [PubMed Link] | [ Full text ]
- Rosenson, RS ; Brewer HB, Jr ; Ansell, BJ ; Barter, P.; Chapman, MJ ; Heinecke, JW ; Kontush, A.; Tall, AR ; Webb, NR "Dysfunctional HDL and atherosclerotic cardiovascular disease." Nature reviews. Cardiology 13, 1 (2016): 48-60. [PubMed Link] | [ Full text ]