Lisa A. Cassis, Ph.D. | Saha Cardiovascular Research Center

Lisa A. Cassis, Ph.D.

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lcassis@uky.edu

859-323-4933 ext 81400

Room 521b C.T. Wethington Building, 900 S Limestone St, Lexington, KY 40536-0200

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Position(s):

Vice President of Research

Professor of Pharmacology and Nutritional Sciences

Co-Director, Division of Nutritional Sciences

Graduate Faculty in Nutritional Sciences

Cardiovascular Research Center

MD/PhD Program Mentor

Affiliation(s):

Pharmacology & Nutritional Sciences

Cardiovascular Research Center

Other Affiliation(s):

MD/PhD Program Mentor

CVRC - Affiliated Faculty

Nutritional Sciences Graduate Faculty

Pharmacology and Nutritional Sciences Primary Faculty

Toxicology - Joint Faculty

Interests / Specialties:

Obesity

Diabetes & Cardiovascular

Bio / Education:

West Virginia University, Morgantown, WV: BS in Pharmacology, May 1980
West Virginia University, Morgantown, WV: Ph.D. in Pharmacology, May 1984
Univ. of Wurzburg, Wurzburg, W. Germany: Post-doc in Pharmacology, May 1985
Univ. Of Virginia, Charlottesville, VA: Post-doc in Pharmacology, May 1988

Positions and Honors
Positions and Employment
1980-1984 Pharmacist (part-time), Monongahela Hospital, Morgantown, WV
1984-1985 Alexander von Humboldt Postdoctoral Fellow; Department of Pharmacology, University of Wurzburg, Wurzburg, Germany
1985-1988 Postdoctoral Fellow; Dept. of Pharmacology, University of Virginia, Charlottesville, VA
1988-1994 Assistant Professor; College of Pharmacy, University of Kentucky, Lexington, KY
1994-2000 Associate Professor; College of Pharmacy, University of Kentucky, Lexington, KY
2000 Professor; College of Pharmacy, University of Kentucky, Lexington, KY
2003 Director and Chair, Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY
2012 Chair, Department of Molecular and Biomedical Pharmacology
Professional Memberships and Honors
1986 National Research Service Award Postdoctoral Fellowship
1991 IBM Supercomputer Competition, First Place, Near IR Imaging of Atherosclerosis Lesions of Living Arteries, Lisa Cassis and Robert Lodder
1992 Research Career Development Award, NIHLBI
1996-2003 National American Heart Association Grant Reviewer, Co-Chair
1997-2001 Pharmacology Study Section Member, NIH

2010 Associate Editor, Gender Medicine
2010 Leadership Council, Council of High Blood Pressure Research, American Heart Association
2010 College of CRS Reviewers, NIH
2011-2016 Standing member, Vascular Cell and Molecular Biology Study Section, NIH
2012 Women’s Mentor of the Year, Council on Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association
2012 Mentor of the year, Center for Clinical and Translational Sciences, University of Kentucky
2012 Council for High Blood Pressure Research Harriett Dustan Award for Excellence in Hypertension Research, American Heart Association

Research Description:

Research in my laboratory focuses on the renin-angiotensin system (RAS) in metabolic and cardiovascular diseases. Since our initial discovery in 1988 that adipocytes express a high level of mRNA abundance for angiotensinogen, the only known precursor to angiotensin II (AngII), my laboratory has been studying the regulation of and functional significance of an adipocyte RAS. These studies have been continuously funded by the NIH since 1988. In 1999, in collaboration with Dr. Alan Daugherty at the University of Kentucky, we made the initial observation that infusion of AngII to hyperlipidemic mice increases atherosclerosis and causes formation of abdominal aortic aneurysms (AAAs). In 2000, we published extensive characterization of AngII-induced AAAs in The Journal of Clinical Investigation, a paper that has been cited in excess of 500 times. Current research in my laboratory in this area focuses on mechanisms for sex differences in AAA formation. I am Project Director of a project within the University of Kentucky Superfund Basic Science Research Program focused on polychlorinated biphenyls (PCBs). Our research in this area focuses on PCB-induced diabetes, with an interest in the role of adipocyte aryl hydrocarbon receptors as mediators of inflammation and insulin resistance in adipocytes. I have extensive experience administering programs related to obesity and cardiovascular diseases as Director of a multidisciplinary graduate center focused on training nutritional scientists, Chair of a Department of Nutritional Sciences, Chair of the Department of Molecular and Biomedical Pharmacology, and Director of an NIH T32 on Nutrition and Oxidative Stress, and Director of the Phase II NIH Center of Biomedical Research Excellence on Obesity and Cardiovascular Diseases (COCVD).

Grants:

Ongoing Research Support
R01 HL073085-06 Cassis (PI) 07/01/09 – 06/30/18
Angiotensin: A Link Between Obesity and Hypertension
The proposed studies will determine the role of adipose-derived angiotensin peptides in obesity-hypertension.
Role: PI

P42 ES007380-09 Hennig (PI) 04/01/08 – 03/31/20
The Impact of Obesity on PCB Toxicity
The proposed studies will define the role of polychlorinated biphenyls (PCBs) on angiotensin II-induced vascular diseases.
Role: Co-Investigator, PI – Project 4

P20 BM103527-06 Cassis (Program Director) 09/08/08 – 06/30/18
Center of Research in Obesity and Cardiovascular Disease
The proposed research will develop a center for the study of obesity and cardiovascular disease, and consists of 5 junior investigators and mentors.
Role: Program Director

R01 HL107326-01A1 Cassis (PI)
04/01/12 - 03/31/16
Sex differences in angiotensin II-induced vascular diseases
The proposed research will investigate the relative role of sex hormones versus sex chromosomes as mediators of increased aneurysm susceptibility in male mice.

PubMed Publications:

Alsiraj, Y.; Thatcher, SE ; Blalock, E.; Saintilnord, WN ; Daugherty, A.; Lu, HS ; Luo, W.; Shen, YH ; Lemaire, SA ; Arnold, AP ; Cassis, LA "Monosomy X in Female Mice Influences the Regional Formation and Augments the Severity of Angiotensin II-Induced Aortopathies." Arteriosclerosis, thrombosis, and vascular biology 41, 1 (2021): 269-283. [PubMed Link] | [ Full text ]
Watts, SW ; Alexander, BT ; Baylis, C.; Brown, NJ ; Cassis, LA ; Denton, KM ; Joe, B ; Lerman, LO ; Oparil, S.; Reckelhoff, JF ; Sandberg, K.; Touyz, RM "Connecting Generations of Scientists in the Council on Hypertension Through Harriet Dustan." Hypertension (Dallas, Tex. : 1979) 77, 2 (2021): 296-307. [PubMed Link] | [ Full text ]
Wu, CH ; Wu, C.; Howatt, DA ; Moorleghen, JJ ; Cassis, LA ; Daugherty, A.; Lu, HS "Two Amino Acids Proximate to the Renin Cleavage Site of Human Angiotensinogen Do Not Affect Blood Pressure and Atherosclerosis in Mice-Brief Report." Arteriosclerosis, thrombosis, and vascular biology 40, 9 (2020): 2108-2113. [PubMed Link] | [ Full text ]
Li, Y.; Ren, P.; Dawson, A.; Vasquez, HG ; Ageedi, W ; Zhang, C.; Luo, W.; Chen, R.; Li, Y.; Kim, S.; Lu, HS ; Cassis, LA ; Coselli, JS ; Daugherty, A.; Shen, YH ; Lemaire, SA "Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue." Circulation 142, 14 (2020): 1374-1388. [PubMed Link] | [ Full text ]
Barnett, JV ; Beckman, JA ; Bonaca, MP ; Carnethon, MR ; Cassis, LA ; Creager, MA ; Daugherty, A.; Feinberg, MW ; Freiberg, MS ; Goodney, PP ; Greenland, P.; Leeuwenburgh, C.; Lemaire, SA ; McDermott, MM ; Sabatine, MS ; Shen, YH ; Wasserman, DH ; Webb, NR ; Wells, QS "American Heart Association Vascular Disease Strategically Focused Research Network." Arteriosclerosis, thrombosis, and vascular biology 40, 3 (2020): e47-e54. [PubMed Link] | [ Full text ]
Shen, YH ; Lemaire, SA ; Webb, NR ; Cassis, LA ; Daugherty, A.; Lu, HS "Aortic Aneurysms and Dissections Series." Arteriosclerosis, thrombosis, and vascular biology 40, 3 (2020): e37-e46. [PubMed Link] | [ Full text ]
Shen, YH ; Lemaire, SA ; Webb, NR ; Cassis, LA ; Daugherty, A.; Lu, HS "Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections." Arteriosclerosis, thrombosis, and vascular biology 40, 4 (2020): e78-e86. [PubMed Link] | [ Full text ]
Littrell, Meagan ; Stoeger, C ; Maier, H ; Fuchs, H ; de Angelis, Hrabě ; Cassis, LA ; Gerhardt, GA ; Grondin, R.; Gailus-Durner, V "Costs of Implementing Quality in Research Practice." Handbook of experimental pharmacology 257, (2020): 399-423. [PubMed Link] | [ Full text ]
Shoemaker, R.; Tannock, LR ; Su, W.; Gong, M.; Gurley, SB ; Thatcher, SE ; Yiannikouris, F.; Ensor, CM ; Cassis, LA "Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice." Biology of sex differences 10, 1 (2019): 45. [PubMed Link] | [ Full text ]
Stegbauer, J ; Thatcher, SE ; Yang, G.; Bottermann, K ; Rump, LC ; Daugherty, A.; Cassis, LA "Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice." Journal of vascular surgery 70, 5 (2019): 1658-1668.e1. [PubMed Link] | [ Full text ]
Shoemaker, R.; Alsiraj, Y.; Chen, J.; Cassis, LA "Pancreatic AT1aR Deficiency Decreases Insulin Secretion in Obese C57BL/6 Mice." American journal of hypertension 32, 6 (2019): 597-604. [PubMed Link] | [ Full text ]
Alsiraj, Y.; Chen, X.; Thatcher, SE ; Temel, RE ; Cai, L.; Blalock, E.; Katz, W ; Ali, HM ; Petriello, M ; Deng, P.; Morris, AJ ; Wang, X.; Lusis, AJ ; Arnold, AP ; Reue, K.; Thompson, K.; Tso, P.; Cassis, LA "XX sex chromosome complement promotes atherosclerosis in mice." Nature communications 10, 1 (2019): 2631. [PubMed Link] | [ Full text ]
Jackson, EN ; Thatcher, SE ; Larian, N.; English, V.; Soman, S.; Morris, AJ ; Weng, J.; Stromberg, A.; Swanson, HI ; Pearson, K.; Cassis, LA "Effects of Aryl Hydrocarbon Receptor Deficiency on PCB-77-Induced Impairment of Glucose Homeostasis during Weight Loss in Male and Female Obese Mice." Environmental health perspectives 127, 7 (2019): 77004. [PubMed Link] | [ Full text ]
Dalmasso, C ; , ; Ensor, CM ; Yiannikouris, FB ; Giani, JF ; Cassis, LA ; Loria, AS "Female Mice Exposed to Postnatal Neglect Display Angiotensin II-Dependent Obesity-Induced Hypertension." Journal of the American Heart Association 8, 23 (2019): e012309. [PubMed Link] | [ Full text ]
Larian, N.; Ensor, M.; Thatcher, SE ; English, V.; Morris, AJ ; Stromberg, A.; Cassis, LA "Pseudomonas aeruginosa-derived pyocyanin reduces adipocyte differentiation, body weight, and fat mass as mechanisms contributing to septic cachexia." Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 130, (2019): 219-230. [PubMed Link] | [ Full text ]
Alsiraj, Y.; Thatcher, SE ; Blalock, E.; Fleenor, B.; Daugherty, A.; Cassis, LA "Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II-Induced Aortic Pathology." Arteriosclerosis, thrombosis, and vascular biology 38, 1 (2018): 143-153. [PubMed Link] | [ Full text ]
Robinet, P.; Milewicz, DM ; Cassis, LA ; Leeper, NJ ; Lu, HS ; Smith, JD "Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies-Statement From ATVB Council." Arteriosclerosis, thrombosis, and vascular biology 38, 2 (2018): 292-303. [PubMed Link] | [ Full text ]
Arnold, AP ; Cassis, LA ; Eghbali, M.; Reue, K.; Sandberg, K. "Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases." Arteriosclerosis, thrombosis, and vascular biology 37, 5 (2017): 746-756. [PubMed Link] | [ Full text ]
Thatcher, SE ; Black, JE ; Tanaka, H.; Kohama, K.; Fultz, ME ; Cassis, LA ; Wright, GL "Matrix Metalloproteinases -14, -9 and -2 are Localized to the Podosome and Involved in Podosome Development in the A7r5 Smooth Muscle Cell." Journal of cardiobiology 5, 1 (2017): [PubMed Link] |
Alsiraj, Y.; Thatcher, SE ; Charnigo, R.; Chen, K.; Blalock, E.; Daugherty, A.; Cassis, LA "Female Mice With an XY Sex Chromosome Complement Develop Severe Angiotensin II-Induced Abdominal Aortic Aneurysms." Circulation 135, 4 (2017): 379-391. [PubMed Link] | [ Full text ]
Vasam, G.; Joshi, S.; Thatcher, SE ; Bartelmez, SH ; Cassis, LA ; Jarajapu, YP "Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes." Diabetes 66, 2 (2017): 505-518. [PubMed Link] | [ Full text ]
Kim, HW ; Blomkalns, AL ; Ogbi, M.; Thomas, M.; Gavrila, D.; Neltner, BS ; Cassis, LA ; Thompson, RW ; Weiss, RM ; Lindower, PD ; Blanco, VM ; McCormick, ML ; Daugherty, A.; Fu, X.; Hazen, SL ; Stansfield, BK ; Huo, Y.; Fulton, DJ ; Chatterjee, T.; Weintraub, NL "Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine." American journal of physiology. Heart and circulatory physiology 313, 6 (2017): H1168-H1179. [PubMed Link] | [ Full text ]
Wang, Y.; Thatcher, SE ; Cassis, LA "Blood Pressure Monitoring Using Radio Telemetry Method in Mice." Methods in molecular biology (Clifton, N.J.) 1614, (2017): 75-85. [PubMed Link] | [ Full text ]
Wang, Y.; Thatcher, SE ; Cassis, LA "Measuring Blood Pressure Using a Noninvasive Tail Cuff Method in Mice." Methods in molecular biology (Clifton, N.J.) 1614, (2017): 69-73. [PubMed Link] | [ Full text ]
Wang, Y.; Cassis, LA ; Thatcher, SE "Use of a Fluorescent Substrate to Measure ACE2 Activity in the Mouse Abdominal Aorta." Methods in molecular biology (Clifton, N.J.) 1614, (2017): 61-67. [PubMed Link] | [ Full text ]
Lu, H.; Cassis, LA ; Vander Kooi, CW ; Daugherty, A. "Corrigendum: Structure and functions of angiotensinogen." Hypertension research : official journal of the Japanese Society of Hypertension 39, 11 (2016): 827. [PubMed Link] |
Li, J.; Song, J.; Zaytseva, YY ; Liu, Y.; Rychahou, P.; Jiang, K.; Starr, ME ; Kim, JT ; Harris, JW ; Yiannikouris, FB ; Katz, WS ; Nilsson, PM ; Orho-Melander, M.; Chen, J.; Zhu, H.; Fahrenholz, T.; Higashi, RM ; Gao, T.; Morris, AJ ; Cassis, LA ; Fan, TW ; Weiss, HL ; Dobner, PR ; Melander, O.; Jia, J.; Evers, BM "An obligatory role for neurotensin in high-fat-diet-induced obesity." Nature 533, 7603 (2016): 411-5. [PubMed Link] | [ Full text ]
Pati, P.; Fulton, DJ ; Bagi, Z.; Chen, F.; Wang, Y.; Kitchens, J.; Cassis, LA ; Stepp, DW ; Rudic, RD "Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice." Hypertension (Dallas, Tex. : 1979) 67, 3 (2016): 661-8. [PubMed Link] | [ Full text ]
Chen, X.; Howatt, DA ; Balakrishnan, A.; Moorleghen, JJ ; Wu, C.; Cassis, LA ; Daugherty, A.; Lu, H. "Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis-Brief Report." Arteriosclerosis, thrombosis, and vascular biology 36, 6 (2016): 1085-9. [PubMed Link] | [ Full text ]
Lu, H.; Cassis, LA ; Kooi, CW ; Daugherty, A. "Structure and functions of angiotensinogen." Hypertension research : official journal of the Japanese Society of Hypertension 39, 7 (2016): 492-500. [PubMed Link] |
Lu, H.; Wu, C.; Howatt, DA ; Balakrishnan, A.; Moorleghen, JJ ; Chen, X.; Zhao, M.; Graham, MJ ; Mullick, AE ; Crooke, RM ; Feldman, DL ; Cassis, LA ; Vander Kooi, CW ; Daugherty, A. "Angiotensinogen Exerts Effects Independent of Angiotensin II." Arteriosclerosis, thrombosis, and vascular biology 36, 2 (2016): 256-65. [PubMed Link] | [ Full text ]
Wang, Y.; Shoemaker, R.; Powell, D.; Su, W.; Thatcher, SE ; Cassis, LA "Differential Effects of Mas Receptor Deficiency on Cardiac Function and Blood Pressure in Obese Male and Female Mice." American journal of physiology. Heart and circulatory physiology (2016): ajpheart.00498.2016. [PubMed Link] | [ Full text ]
Chen, X.; Rateri, DL ; Howatt, DA ; Balakrishnan, A.; Moorleghen, JJ ; Cassis, LA ; Daugherty, A. "TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions." PloS one 11, 4 (2016): e0153811. [PubMed Link] | [ Full text ]
Lu, H.; Howatt, DA ; Balakrishnan, A.; Moorleghen, JJ ; Rateri, DL ; Cassis, LA ; Daugherty, A. "Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice." Journal of visualized experiments : JoVE 103 (2015): [PubMed Link] | [ Full text ]
Poduri, A.; Rateri, DL ; Howatt, DA ; Balakrishnan, A.; Moorleghen, JJ ; Cassis, LA ; Daugherty, A. "Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II-Induced Medial Hyperplasia in the Ascending Aorta." Arteriosclerosis, thrombosis, and vascular biology 35, 9 (2015): 1995-2002. [PubMed Link] | [ Full text ]
Baker, NA ; Shoemaker, R.; English, V.; Larian, N.; Sunkara, M.; Morris, AJ ; Walker, M.; Yiannikouris, F.; Cassis, LA "Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCB-Induced Disruption of Glucose Homeostasis in Lean and Obese Mice." Environmental health perspectives 123, 10 (2015): 944-50. [PubMed Link] | [ Full text ]
Yiannikouris, F.; Wang, Y.; Shoemaker, R.; Larian, N.; Thompson, J.; English, VL ; Charnigo, R.; Su, W.; Gong, M.; Cassis, LA "Deficiency of angiotensinogen in hepatocytes markedly decreases blood pressure in lean and obese male mice." Hypertension (Dallas, Tex. : 1979) 66, 4 (2015): 836-42. [PubMed Link] | [ Full text ]
Zhang, X.; Thatcher, S.; Wu, C.; Daugherty, A.; Cassis, LA "Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms." Journal of vascular surgery 61, 3 (2015): 767-76. [PubMed Link] | [ Full text ]
Wang, Y.; Shoemaker, R.; Thatcher, SE ; Batifoulier-Yiannikouris, F.; English, VL ; Cassis, LA "Administration of 17β-estradiol to ovariectomized obese female mice reverses obesity-hypertension through an ACE2-dependent mechanism." American journal of physiology. Endocrinology and metabolism 308, 12 (2015): E1066-75. [PubMed Link] | [ Full text ]
Davis, FM ; Rateri, DL ; Balakrishnan, A.; Howatt, DA ; Strickland, DK ; Muratoglu, SC ; Haggerty, CM ; Fornwalt, BK ; Cassis, LA ; Daugherty, A. "Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms." Arteriosclerosis, thrombosis, and vascular biology 35, 1 (2015): 155-62. [PubMed Link] | [ Full text ]
Shoemaker, R.; Yiannikouris, F.; Thatcher, SE ; Cassis, LA "ACE2 Deficiency Reduces Beta-Cell Mass and Impairs Beta-Cell Proliferation in Obese C57BL/6 Mice." American journal of physiology. Endocrinology and metabolism (2015): ajpendo.00054.2015. [PubMed Link] | [ Full text ]
Liu, J.; Lu, H.; Howatt, DA ; Balakrishnan, A.; Moorleghen, JJ ; Sorci-Thomas, M.; Cassis, LA ; Daugherty, A. "Associations of ApoAI and ApoB-containing lipoproteins with AngII-induced abdominal aortic aneurysms in mice." Arteriosclerosis, thrombosis, and vascular biology 35, 8 (2015): 1826-34. [PubMed Link] | [ Full text ]
Wu, C.; Xu, Y.; Lu, H.; Howatt, DA ; Balakrishnan, A.; Moorleghen, JJ ; Vander Kooi, CW ; Cassis, LA ; Wang, JA ; Daugherty, A. "Cys18-Cys137 disulfide bond in mouse angiotensinogen does not affect AngII-dependent functions in vivo." Hypertension (Dallas, Tex. : 1979) 65, 4 (2015): 800-5. [PubMed Link] | [ Full text ]
Thatcher, SE ; Zhang, X.; Woody, S.; Wang, Y.; Alsiraj, Y.; Charnigo, R.; Daugherty, A.; Cassis, LA "Exogenous 17-β estradiol administration blunts progression of established angiotensin II-induced abdominal aortic aneurysms in female ovariectomized mice." Biology of sex differences 6, (2015): 12. [PubMed Link] | [ Full text ]
Rateri, DL ; Davis, FM ; Balakrishnan, A.; Howatt, DA ; Moorleghen, JJ ; O'Connor, WN ; Charnigo, R.; Cassis, LA ; Daugherty, A. "Angiotensin II induces region-specific medial disruption during evolution of ascending aortic aneurysms." The American journal of pathology 184, 9 (2014): 2586-95. [PubMed Link] | [ Full text ]
Thatcher, SE ; Zhang, X.; Howatt, DA ; Yiannikouris, F.; Gurley, SB ; Ennis, T.; Curci, JA ; Daugherty, A.; Cassis, LA "Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms." Arteriosclerosis, thrombosis, and vascular biology 34, 12 (2014): 2617-23. [PubMed Link] | [ Full text ]
Narayanaswami, V.; Somkuwar, SS ; Horton, DB ; Cassis, LA ; Dwoskin, LP "Angiotensin AT1 and AT2 receptor antagonists modulate nicotine-evoked ³H dopamine and ³H norepinephrine release." Biochemical pharmacology 86, 5 (2013): 656-65. [PubMed Link] | [ Full text ]
Chen, X.; Lu, H.; Zhao, M.; Tashiro, K.; Cassis, LA ; Daugherty, A. "Contributions of leukocyte angiotensin-converting enzyme to development of atherosclerosis." Arteriosclerosis, thrombosis, and vascular biology 33, 9 (2013): 2075-80. [PubMed Link] | [ Full text ]
Blomkalns, AL ; Gavrila, D.; Thomas, M.; Neltner, BS ; Blanco, VM ; Benjamin, SB ; McCormick, ML ; Stoll, LL ; Denning, GM ; Collins, SP ; Qin, Z.; Daugherty, A.; Cassis, LA ; Thompson, RW ; Weiss, RM ; Lindower, PD ; Pinney, SM ; Chatterjee, T.; Weintraub, NL "CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation." Journal of the American Heart Association 2, 2 (2013): e000065. [PubMed Link] | [ Full text ]
Hoyt, RE ; Speakman, RO ; Brown, DR ; Cassis, LA ; Silcox, DL ; Anigbogu, CN ; Randall, DC "Chronic angiotensin-II treatment potentiates HR slowing in Sprague-Dawley rat during acute behavioral stress." Autonomic neuroscience : basic & clinical 174, 1-2 (2013): 42-6. [PubMed Link] | [ Full text ]
Liu, S.; Xie, Z.; Daugherty, A.; Cassis, LA ; Pearson, KJ ; Gong, MC ; Guo, Z. "Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt." Arteriosclerosis, thrombosis, and vascular biology 33, 7 (2013): 1568-79. [PubMed Link] | [ Full text ]
Baker, NA ; Karounos, M.; English, V.; Fang, J.; Wei, Y.; Stromberg, A.; Sunkara, M.; Morris, AJ ; Swanson, HI ; Cassis, LA "Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice." Environmental health perspectives 121, 1 (2013): 105-10. [PubMed Link] | [ Full text ]
Lu, H.; Wu, C.; Howatt, DA ; Balakrishnan, A.; Charnigo RJ, Jr ; Cassis, LA ; Daugherty, A. "Differential effects of dietary sodium intake on blood pressure and atherosclerosis in hypercholesterolemic mice." The Journal of nutritional biochemistry 24, 1 (2013): 49-53. [PubMed Link] | [ Full text ]
Kramer, SP ; Powell, DK ; Haggerty, CM ; Binkley, CM ; Mattingly, AC ; Cassis, LA ; Epstein, FH ; Fornwalt, BK "Obesity reduces left ventricular strains, torsion, and synchrony in mouse models: a cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance study." Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 15, (2013): 109. [PubMed Link] | [ Full text ]
Baker, NA ; English, V.; Sunkara, M.; Morris, AJ ; Pearson, KJ ; Cassis, LA "Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes." The Journal of nutritional biochemistry 24, 12 (2013): 2168-74. [PubMed Link] | [ Full text ]
Narayanaswami, V.; Thompson, AC ; Cassis, LA ; Bardo, MT ; Dwoskin, LP "Diet-induced obesity: dopamine transporter function, impulsivity and motivation." International journal of obesity (2005) 37, 8 (2013): 1095-103. [PubMed Link] | [ Full text ]
King, VL ; English, VL ; Bharadwaj, K.; Cassis, LA "Angiotensin II Stimulates Sympathetic Neurotransmission to Adipose Tissue." Physiological reports 1, 2 (2013): [PubMed Link] | [ Full text ]
Chen, X.; Lu, H.; Rateri, DL ; Cassis, LA ; Daugherty, A. "Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms." Current opinion in pharmacology 13, 2 (2013): 180-5. [PubMed Link] | [ Full text ]
Daugherty, A.; Rateri, DL ; Howatt, DA ; Charnigo, R.; Cassis, LA "PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism." PloS one 8, 4 (2013): e61849. [PubMed Link] | [ Full text ]
Chen, X.; Rateri, DL ; Howatt, DA ; Balakrishnan, A.; Moorleghen, JJ ; Morris, AJ ; Charnigo, R.; Cassis, LA ; Daugherty, A. "Amlodipine reduces AngII-induced aortic aneurysms and atherosclerosis in hypercholesterolemic mice." PloS one 8, 11 (2013): e81743. [PubMed Link] | [ Full text ]
Putnam, K.; Batifoulier-Yiannikouris, F.; Bharadwaj, KG ; Lewis, E.; Karounos, M.; Daugherty, A.; Cassis, LA "Deficiency of angiotensin type 1a receptors in adipocytes reduces differentiation and promotes hypertrophy of adipocytes in lean mice." Endocrinology 153, 10 (2012): 4677-86. [PubMed Link] | [ Full text ]
Lu, H.; Rateri, DL ; Bruemmer, D.; Cassis, LA ; Daugherty, A. "Novel mechanisms of abdominal aortic aneurysms." Current atherosclerosis reports 14, 5 (2012): 402-12. [PubMed Link] | [ Full text ]
Lu, H.; Rateri, DL ; Bruemmer, D.; Cassis, LA ; Daugherty, A. "Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms." Clinical science (London, England : 1979) 123, 9 (2012): 531-43. [PubMed Link] | [ Full text ]
Zhang, X.; Thatcher, SE ; Rateri, DL ; Bruemmer, D.; Charnigo, R.; Daugherty, A.; Cassis, LA "Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms." Circulation research 110, 11 (2012): e73-85. [PubMed Link] | [ Full text ]
Putnam, K.; Shoemaker, R.; Yiannikouris, F.; Cassis, LA "The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome." American journal of physiology. Heart and circulatory physiology 302, 6 (2012): H1219-30. [PubMed Link] | [ Full text ]
Lu, H.; Balakrishnan, A.; Howatt, DA ; Wu, C.; Charnigo, R.; Liau, G.; Cassis, LA ; Daugherty, A. "Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis." British journal of pharmacology 165, 6 (2012): 2000-2008. [PubMed Link] | [ Full text ]
Gupte, M.; Thatcher, SE ; Boustany-Kari, CM ; Shoemaker, R.; Yiannikouris, F.; Zhang, X.; Karounos, M.; Cassis, LA "Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice." Arteriosclerosis, thrombosis, and vascular biology 32, 6 (2012): 1392-9. [PubMed Link] | [ Full text ]
Yiannikouris, F.; Karounos, M.; Charnigo, R.; English, VL ; Rateri, DL ; Daugherty, A.; Cassis, LA "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice." American journal of physiology. Regulatory, integrative and comparative physiology 302, 2 (2012): R244-51. [PubMed Link] | [ Full text ]
Wang, S.; Subramanian, V.; Lu, H.; Howatt, DA ; Moorleghen, JJ ; Charnigo, R.; Cassis, LA ; Daugherty, A. "Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms." Atherosclerosis 220, 2 (2012): 375-80. [PubMed Link] | [ Full text ]
Yiannikouris, F.; Gupte, M.; Putnam, K.; Thatcher, S.; Charnigo, R.; Rateri, DL ; Daugherty, A.; Cassis, LA "Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice." Hypertension (Dallas, Tex. : 1979) 60, 6 (2012): 1524-30. [PubMed Link] | [ Full text ]
Thatcher, SE ; Gupte, M.; Hatch, N.; Cassis, LA "Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice." International journal of hypertension 2012, (2012): 762094. [PubMed Link] | [ Full text ]
Rateri, DL ; Moorleghen, JJ ; Knight, V.; Balakrishnan, A.; Howatt, DA ; Cassis, LA ; Daugherty, A. "Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice." PloS one 7, 12 (2012): e51483. [PubMed Link] | [ Full text ]
Poduri, A.; Owens AP, 3rd ; Howatt, DA ; Moorleghen, JJ ; Balakrishnan, A.; Cassis, LA ; Daugherty, A. "Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms." PloS one 7, 10 (2012): e48462. [PubMed Link] | [ Full text ]
Xie, X.; Lu, H.; Moorleghen, JJ ; Howatt, DA ; Rateri, DL ; Cassis, LA ; Daugherty, A. "Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice." PloS one 7, 9 (2012): e46411. [PubMed Link] | [ Full text ]
Rateri, DL ; Howatt, DA ; Moorleghen, JJ ; Charnigo, R.; Cassis, LA ; Daugherty, A. "Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm." The American journal of pathology 179, 3 (2011): 1542-8. [PubMed Link] | [ Full text ]
Wu, C.; Lu, H.; Cassis, LA ; Daugherty, A. "Molecular and Pathophysiological Features of Angiotensinogen: A Mini Review." North American journal of medicine & science 4, 4 (2011): 183-190. [PubMed Link] |
Li, H.; Weatherford, ET ; Davis, DR ; Keen, HL ; Grobe, JL ; Daugherty, A.; Cassis, LA ; Allen, AM ; Sigmund, CD "Renal proximal tubule angiotensin AT1A receptors regulate blood pressure." American journal of physiology. Regulatory, integrative and comparative physiology 301, 4 (2011): R1067-77. [PubMed Link] | [ Full text ]
Arsenescu, V.; Arsenescu, R.; Parulkar, M.; Karounos, M.; Zhang, X.; Baker, N.; Cassis, LA "Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice." Toxicology and applied pharmacology 257, 1 (2011): 148-54. [PubMed Link] | [ Full text ]
Rateri, DL ; Moorleghen, JJ ; Balakrishnan, A.; Owens AP, 3rd ; Howatt, DA ; Subramanian, V.; Poduri, A.; Charnigo, R.; Cassis, LA ; Daugherty, A. "Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice." Circulation research 108, 5 (2011): 574-81. [PubMed Link] | [ Full text ]
Owens AP, 3rd ; Rateri, DL ; Howatt, DA ; Moore, KJ ; Tobias, PS ; Curtiss, LK ; Lu, H.; Cassis, LA ; Daugherty, A. "MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4." Arteriosclerosis, thrombosis, and vascular biology 31, 12 (2011): 2813-9. [PubMed Link] | [ Full text ]
Uchida, HA ; Poduri, A.; Subramanian, V.; Cassis, LA ; Daugherty, A. "Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms." Arteriosclerosis, thrombosis, and vascular biology 31, 12 (2011): 2845-52. [PubMed Link] | [ Full text ]
Daugherty, A.; Cassis, LA ; Lu, H. "Complex pathologies of angiotensin II-induced abdominal aortic aneurysms." Journal of Zhejiang University. Science. B 12, 8 (2011): 624-8. [PubMed Link] | [ Full text ]
Thatcher, SE ; Zhang, X.; Howatt, DA ; Lu, H.; Gurley, SB ; Daugherty, A.; Cassis, LA "Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice." Arteriosclerosis, thrombosis, and vascular biology 31, 4 (2011): 758-65. [PubMed Link] | [ Full text ]
Grobe, JL ; Grobe, CL ; Beltz, TG ; Westphal, SG ; Morgan, DA ; Xu, D.; Lange, WJ ; Li, H.; Sakai, K.; Thedens, DR ; Cassis, LA ; Rahmouni, K.; Mark, AL ; Johnson, AK ; Sigmund, CD "The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance." Cell metabolism 12, 5 (2010): 431-42. [PubMed Link] | [ Full text ]
Daugherty, A.; Poduri, A.; Chen, X.; Lu, H.; Cassis, LA "Genetic variants of the Renin Angiotensin system: effects on atherosclerosis in experimental models and humans." Current atherosclerosis reports 12, 3 (2010): 167-73. [PubMed Link] | [ Full text ]
Daugherty, A.; Rateri, DL ; Charo, IF ; Owens, AP ; Howatt, DA ; Cassis, LA "Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice." Clinical science (London, England : 1979) 118, 11 (2010): 681-9. [PubMed Link] | [ Full text ]
Police, SB ; Putnam, K.; Thatcher, S.; Batifoulier-Yiannikouris, F.; Daugherty, A.; Cassis, LA "Weight loss in obese C57BL/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms." American journal of physiology. Heart and circulatory physiology 298, 6 (2010): H1932-8. [PubMed Link] | [ Full text ]
Owens AP, 3rd ; Subramanian, V.; Moorleghen, JJ ; Guo, Z.; McNamara, CA ; Cassis, LA ; Daugherty, A. "Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3." Circulation research 106, 3 (2010): 611-9. [PubMed Link] | [ Full text ]
Uchida, HA ; Kristo, F.; Rateri, DL ; Lu, H.; Charnigo, R.; Cassis, LA ; Daugherty, A. "Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice." Atherosclerosis 211, 2 (2010): 399-403. [PubMed Link] | [ Full text ]
Arzuaga, X.; Ren, N.; Stromberg, A.; Black, EP ; Arsenescu, V.; Cassis, LA ; Majkova, Z.; Toborek, M.; Hennig, B. "Induction of gene pattern changes associated with dysfunctional lipid metabolism induced by dietary fat and exposure to a persistent organic pollutant." Toxicology letters 189, 2 (2009): 96-101. [PubMed Link] | [ Full text ]
Police, SB ; Thatcher, SE ; Charnigo, R.; Daugherty, A.; Cassis, LA "Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation." Arteriosclerosis, thrombosis, and vascular biology 29, 10 (2009): 1458-64. [PubMed Link] | [ Full text ]
Cassis, LA ; Gupte, M.; Thayer, S.; Zhang, X.; Charnigo, R.; Howatt, DA ; Rateri, DL ; Daugherty, A. "ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice." American journal of physiology. Heart and circulatory physiology 296, 5 (2009): H1660-5. [PubMed Link] | [ Full text ]
Police, SB ; Harris, JC ; Lodder, RA ; Cassis, LA "Effect of diets containing sucrose vs. D-tagatose in hypercholesterolemic mice." Obesity (Silver Spring, Md.) 17, 2 (2009): 269-75. [PubMed Link] | [ Full text ]
Gupte, M.; Boustany-Kari, CM ; Bharadwaj, K.; Police, S.; Thatcher, S.; Gong, MC ; English, VL ; Cassis, LA "ACE2 is expressed in mouse adipocytes and regulated by a high-fat diet." American journal of physiology. Regulatory, integrative and comparative physiology 295, 3 (2008): R781-8. [PubMed Link] | [ Full text ]
Lu, H.; Rateri, DL ; Feldman, DL ; Charnigo RJ, Jr ; Fukamizu, A.; Ishida, J.; Oesterling, EG ; Cassis, LA ; Daugherty, A. "Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice." The Journal of clinical investigation 118, 3 (2008): 984-93. [PubMed Link] | [ Full text ]
Arsenescu, V.; Arsenescu, RI ; King, V.; Swanson, H.; Cassis, LA "Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis." Environmental health perspectives 116, 6 (2008): 761-8. [PubMed Link] | [ Full text ]
Henriques, T.; Zhang, X.; Yiannikouris, FB ; Daugherty, A.; Cassis, LA "Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice." Arteriosclerosis, thrombosis, and vascular biology 28, 7 (2008): 1251-6. [PubMed Link] | [ Full text ]
Daugherty, A.; Lu, H.; Rateri, DL ; Cassis, LA "Augmentation of the renin-angiotensin system by hypercholesterolemia promotes vascular diseases." Future lipidology 3, 6 (2008): 625-636. [PubMed Link] |
Cassis, LA ; Police, SB ; Yiannikouris, F.; Thatcher, SE "Local adipose tissue renin-angiotensin system." Current hypertension reports 10, 2 (2008): 93-8. [PubMed Link] |
Lu, H.; Rateri, DL ; Cassis, LA ; Daugherty, A. "The role of the renin-angiotensin system in aortic aneurysmal diseases." Current hypertension reports 10, 2 (2008): 99-106. [PubMed Link] |
Daugherty, A.; Cassis, LA "Commentary. Angiotensin converting enzyme inhibitors and aortic rupture: population based case control study." Perspectives in vascular surgery and endovascular therapy 19, 3 (2007): 342-4. [PubMed Link] |
Nomiyama, T.; Perez-Tilve, D.; Ogawa, D.; Gizard, F.; Zhao, Y.; Heywood, EB ; Jones, KL ; Kawamori, R.; Cassis, LA ; Tschöp, MH ; Bruemmer, D. "Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice." The Journal of clinical investigation 117, 10 (2007): 2877-88. [PubMed Link] | [ Full text ]
Boustany-Kari, CM ; Gong, M.; Akers, WS ; Guo, Z.; Cassis, LA "Enhanced vascular contractility and diminished coronary artery flow in rats made hypertensive from diet-induced obesity." International journal of obesity (2005) 31, 11 (2007): 1652-9. [PubMed Link] | [ Full text ]
Lu, H.; Cassis, LA ; Daugherty, A. "Atherosclerosis and arterial blood pressure in mice." Current drug targets 8, 11 (2007): 1181-9. [PubMed Link] |
Lu, H.; Boustany-Kari, CM ; Daugherty, A.; Cassis, LA "Angiotensin II increases adipose angiotensinogen expression." American journal of physiology. Endocrinology and metabolism 292, 5 (2007): E1280-7. [PubMed Link] | [ Full text ]
Vongpatanasin, W.; Thomas, GD ; Schwartz, R.; Cassis, LA ; Osborne-Lawrence, S.; Hahner, L.; Gibson, LL ; Black, S.; Samols, D.; Shaul, PW "C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice." Circulation 115, 8 (2007): 1020-8. [PubMed Link] | [ Full text ]
Stairs, DJ ; Neugebauer, NM ; Wei, X.; Boustany, C.; Hojahmat, M.; Cassis, LA ; Crooks, PA ; Dwoskin, LP ; Bardo, MT "Effects of nornicotine enantiomers on intravenous S(-)-nicotine self-administration and cardiovascular function in rats." Psychopharmacology 190, 2 (2007): 145-55. [PubMed Link] | [ Full text ]
Cassis, LA ; Rateri, DL ; Lu, H.; Daugherty, A. "Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms." Arteriosclerosis, thrombosis, and vascular biology 27, 2 (2007): 380-6. [PubMed Link] | [ Full text ]
King, VL ; Cassis, LA ; Daugherty, A. "Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice." The American journal of pathology 171, 6 (2007): 2040-7. [PubMed Link] | [ Full text ]
Daugherty, A.; Rateri, DL ; Cassis, LA "Role of the renin-angiotensin system in the development of abdominal aortic aneurysms in animals and humans." Annals of the New York Academy of Sciences 1085, (2006): 82-91. [PubMed Link] | [ Full text ]
Brown, DR ; Cassis, LA ; Silcox, DL ; Brown, LV ; Randall, DC "Empirical and theoretical analysis of the extremely low frequency arterial blood pressure power spectrum in unanesthetized rat." American journal of physiology. Heart and circulatory physiology 291, 6 (2006): H2816-24. [PubMed Link] | [ Full text ]
Thomas, M.; Gavrila, D.; McCormick, ML ; Miller FJ, Jr ; Daugherty, A.; Cassis, LA ; Dellsperger, KC ; Weintraub, NL "Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice." Circulation 114, 5 (2006): 404-413. [PubMed Link] | [ Full text ]
Cassis, LA ; Urbas, A.; Lodder, RA "Hyperspectral integrated computational imaging." Analytical and bioanalytical chemistry 382, 4 (2005): 868-72. [PubMed Link] | [ Full text ]
Boustany, CM ; Brown, DR ; Randall, DC ; Cassis, LA "AT1-receptor antagonism reverses the blood pressure elevation associated with diet-induced obesity." American journal of physiology. Regulatory, integrative and comparative physiology 289, 1 (2005): R181-6. [PubMed Link] | [ Full text ]
Cassis, LA ; Helton, MJ ; Howatt, DA ; King, VL ; Daugherty, A. "Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms." British journal of pharmacology 144, 3 (2005): 443-8. [PubMed Link] | [ Full text ]
Gavrila, D.; Li, WG ; McCormick, ML ; Thomas, M.; Daugherty, A.; Cassis, LA ; Miller FJ, Jr ; Oberley, LW ; Dellsperger, KC ; Weintraub, NL "Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice." Arteriosclerosis, thrombosis, and vascular biology 25, 8 (2005): 1671-7. [PubMed Link] | [ Full text ]
Boustany, CM ; Bharadwaj, K.; Daugherty, A.; Brown, DR ; Randall, DC ; Cassis, LA "Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension." American journal of physiology. Regulatory, integrative and comparative physiology 287, 4 (2004): R943-9. [PubMed Link] | [ Full text ]
Daugherty, A.; Cassis, LA "Mouse models of abdominal aortic aneurysms." Arteriosclerosis, thrombosis, and vascular biology 24, 3 (2004): 429-34. [PubMed Link] | [ Full text ]
Akers, WS ; Cassis, LA "Presynaptic modulation of evoked NE release contributes to sympathetic activation after pressure overload." American journal of physiology. Heart and circulatory physiology 286, 6 (2004): H2151-8. [PubMed Link] | [ Full text ]
Cassis, LA ; English, VL ; Bharadwaj, K.; Boustany, CM "Differential effects of local versus systemic angiotensin II in the regulation of leptin release from adipocytes." Endocrinology 145, 1 (2004): 169-74. [PubMed Link] | [ Full text ]
Cassis, LA ; Huang, J.; Gong, MC ; Daugherty, A. "Role of metabolism and receptor responsiveness in the attenuated responses to Angiotensin II in mice compared to rats." Regulatory peptides 117, 2 (2004): 107-16. [PubMed Link] | [ Full text ]
Daugherty, A.; Rateri, DL ; Lu, H.; Inagami, T.; Cassis, LA "Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor." Circulation 110, 25 (2004): 3849-57. [PubMed Link] | [ Full text ]
Henriques, TA ; Huang, J.; D'Souza, SS ; Daugherty, A.; Cassis, LA "Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice." Endocrinology 145, 8 (2004): 3866-72. [PubMed Link] | [ Full text ]
Saraff, K.; Babamusta, F.; Cassis, LA ; Daugherty, A. "Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice." Arteriosclerosis, thrombosis, and vascular biology 23, 9 (2003): 1621-6. [PubMed Link] | [ Full text ]
Manning, MW ; Cassis, LA ; Daugherty, A. "Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms." Arteriosclerosis, thrombosis, and vascular biology 23, 3 (2003): 483-8. [PubMed Link] | [ Full text ]
Urbas, A.; Manning, MW ; Daugherty, A.; Cassis, LA ; Lodder, RA "Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse." Analytical chemistry 75, 14 (2003): 3650-5. [PubMed Link] | [ Full text ]
Daugherty, A.; Cassis, LA "Mechanisms of abdominal aortic aneurysm formation." Current atherosclerosis reports 4, 3 (2002): 222-7. [PubMed Link] |
Daugherty, A.; Manning, MW ; Cassis, LA "Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis." British journal of pharmacology 134, 4 (2001): 865-70. [PubMed Link] | [ Full text ]
Daugherty, A.; Manning, MW ; Cassis, LA "Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice." The Journal of clinical investigation 105, 11 (2000): 1605-12. [PubMed Link] | [ Full text ]
Akers, WS ; Cross, A.; Speth, R.; Dwoskin, LP ; Cassis, LA "Renin-angiotensin system and sympathetic nervous system in cardiac pressure-overload hypertrophy." American journal of physiology. Heart and circulatory physiology 279, 6 (2000): H2797-806. [PubMed Link] | [ Full text ]
Cassis, LA "Fat cell metabolism: insulin, fatty acids, and renin." Current hypertension reports 2, 2 (2000): 132-8. [PubMed Link] |
Akers, WS ; Cassis, LA "Presynaptic modulation of sympathetic neurotransmission in rat left ventricle slices: effect of pressure overload." Journal of neural transmission (Vienna, Austria : 1996) 107, 8-9 (2000): 885-902. [PubMed Link] | [ Full text ]
King, VL ; Dwoskin, LP ; Cassis, LA "Cold exposure regulates the norepinephrine uptake transporter in rat brown adipose tissue." The American journal of physiology 276, 1 (1999): R143-51. [PubMed Link] | [ Full text ]
Cassis, LA ; Marshall, DE ; Fettinger, MJ ; Rosenbluth, B.; Lodder, RA "Mechanisms contributing to angiotensin II regulation of body weight." American journal of physiology. Endocrinology and metabolism 274, 5 (1998): E867-E876. [PubMed Link] | [ Full text ]
Cassis, LA ; Marshall, DE ; Fettinger, MJ ; Rosenbluth, B.; Lodder, RA "Mechanisms contributing to angiotensin II regulation of body weight." The American journal of physiology 274, 5 (1998): E867-76. [PubMed Link] | [ Full text ]
Buice RG, Jr ; Cassis, LA ; Lodder, RA "Near-IR and IR imaging in lipid metabolism and obesity." Cellular and molecular biology (Noisy-le-Grand, France) 44, 1 (1998): 53-64. [PubMed Link] |
Dempsey, RJ ; Cassis, LA ; Davis, DG ; Lodder, RA "Near-infrared imaging and spectroscopy in stroke research: lipoprotein distribution and disease." Annals of the New York Academy of Sciences 820, (1997): 149-69. [PubMed Link] | [ Full text ]
Cassis, LA ; Fettinger, MJ ; Roe, AL ; Shenoy, UR ; Howard, G. "Characterization and regulation of angiotensin II receptors in rat adipose tissue. Angiotensin receptors in adipose tissue." Advances in experimental medicine and biology 396, (1996): 39-47. [PubMed Link] |
Cassis, LA "Angiotensin II in brown adipose tissue from young and adult Zucker obese and lean rats." The American journal of physiology 266, 3 Pt 1 (1994): E453-8. [PubMed Link] | [ Full text ]
Cassis, LA ; Dwoskin, LP "Acute and chronic losartan administration: effect on angiotensin II content and modulation of 3H norepinephrine release from rat interscapular brown adipose tissue." Journal of neural transmission. General section 98, 2 (1994): 159-64. [PubMed Link] |
Cassis, LA ; Lodder, RA "Near-IR imaging of atheromas in living arterial tissue." Analytical chemistry 65, 9 (1993): 1247-56. [PubMed Link] |
Soltis, EE ; Jewell, AL ; Dwoskin, LP ; Cassis, LA "Acute and chronic effects of losartan (DuP 753) on blood pressure and vascular reactivity in normotensive rats." Clinical and experimental hypertension (New York, N.Y. : 1993) 15, 1 (1993): 171-84. [PubMed Link] | [ Full text ]
Cassis, LA "Role of angiotensin II in brown adipose thermogenesis during cold acclimation." The American journal of physiology 265, 6 Pt 1 (1993): E860-5. [PubMed Link] | [ Full text ]
Cassis, LA ; Rippetoe, PE ; Soltis, EE ; Painter, DJ ; Fitz, R.; Gillespie, MN "Angiotensin II and monocrotaline-induced pulmonary hypertension: effect of losartan (DuP 753), a nonpeptide angiotensin type 1 receptor antagonist." The Journal of pharmacology and experimental therapeutics 262, 3 (1992): 1168-72. [PubMed Link] | [ Full text ]
Cassis, LA "Downregulation of the renin-angiotensin system in streptozotocin-diabetic rats." The American journal of physiology 262, 1 Pt 1 (1992): E105-9. [PubMed Link] | [ Full text ]
Dwoskin, LP ; Jewell, AL ; Cassis, LA "DuP 753, a nonpeptide angiotensin II-1 receptor antagonist, alters dopaminergic function in rat striatum." Naunyn-Schmiedeberg's archives of pharmacology 345, 2 (1992): 153-9. [PubMed Link] |
Soltis, EE ; Cassis, LA "Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness." Clinical and experimental hypertension. Part A, Theory and practice 13, 2 (1991): 277-96. [PubMed Link] |
Cassis, LA ; Dwoskin, LP "Presynaptic modulation of neurotransmitter release by endogenous angiotensin II in brown adipose tissue." Journal of neural transmission. Supplementum 34, (1991): 129-37. [PubMed Link] |
Saye, JA ; Cassis, LA ; Sturgill, TW ; Lynch, KR ; Peach, MJ "Angiotensinogen gene expression in 3T3-L1 cells." The American journal of physiology 256, 2 Pt 1 (1989): C448-51. [PubMed Link] | [ Full text ]
Cassis, LA ; Lynch, KR ; Peach, MJ "Localization of angiotensinogen messenger RNA in rat aorta." Circulation research 62, 6 (1988): 1259-62. [PubMed Link] | [ Full text ]
Cassis, LA ; Saye, J.; Peach, MJ "Location and regulation of rat angiotensinogen messenger RNA." Hypertension (Dallas, Tex. : 1979) 11, 6 Pt 2 (1988): 591-6. [PubMed Link] | [ Full text ]
Cassis, LA ; Stitzel, RE ; Head, RJ "Influence of cold-induced increases in sympathetic nerve activity on norepinephrine content in the vasculature of the spontaneously hypertensive rat." Blood vessels 25, 2 (1988): 82-8. [PubMed Link] |
Cassis, LA ; Stitzel, RE ; Head, RJ "Hypernoradrenergic innervation of the caudal artery of the spontaneously hypertensive rat: an influence upon neuroeffector mechanisms." The Journal of pharmacology and experimental therapeutics 234, 3 (1985): 792-803. [PubMed Link] | [ Full text ]
Goto, K.; Longhurst, PA ; Cassis, LA ; Head, RJ ; Taylor, DA ; Rice, PJ ; Fleming, WW "Surgical sympathectomy of the heart in rodents and its effect on sensitivity to agonists." The Journal of pharmacology and experimental therapeutics 234, 1 (1985): 280-7. [PubMed Link] | [ Full text ]
Head, RJ ; Cassis, LA ; Robinson, RL ; Westfall, DP ; Stitzel, RE "Altered catecholamine contents in vascular and nonvascular tissues in genetically hypertensive rats." Blood vessels 22, 4 (1985): 196-204. [PubMed Link] |
Head, RJ ; Cassis, LA ; Barone, S.; Stitzel, RE ; Lande, IS "Neuronal deamination of endogenous and exogenous noradrenaline in the mesenteric artery of the spontaneously hypertensive rat." The Journal of pharmacy and pharmacology 36, 6 (1984): 382-5. [PubMed Link] | [ Full text ]