Kenneth S. Campbell, Ph.D.

BA (Hons) Physics, University of Oxford, United Kingdom, 1990-1993
PhD, Muscle Physiology, University of Birmingham, United Kingdom, 1993-1998
Postdoc, Muscle Physiology, University of Wisconsin-Madison, USA, 1998-2003

Research Description:

Our mission is to help patients who have heart failure by bridging the scientific gaps between molecular, cellular and organ-level function.

We use biophysical, biochemical, and computational techniques and we collaborate extensively with cardiothoracic surgeons and cardiologists. Many of our experiments use tissue samples isolated from patients undergoing heart transplants and other cardiac surgeries.

For more information, see http://www.campbellmusclelab.org

PubMed Publications:

Clark, JA ; Sewanan, LR ; Schwan, J ; Kluger, J ; Campbell, KS ; Campbell, SG "Fast-relaxing cardiomyocytes exert a dominant role in the relaxation behavior of heterogeneous myocardium." Archives of biochemistry and biophysics 697, (2021): 108711. [PubMed Link] | [ Full text ]
Vikhorev, PG ; Vikhoreva, NN ; Yeung, W ; Li, A.; Lal, S.; Dos Remedios, CG ; Blair, CA ; Guglin, M.; Campbell, KS ; Yacoub, MH ; de Tombe, P ; Marston, SB "Titin-Truncating Mutations Associated With Dilated Cardiomyopathy Alter Length-Dependent Activation And Its Modulation Via Phosphorylation." Cardiovascular research (2020): [PubMed Link] | [ Full text ]
Verma, N.; Liu, M.; Ly, H.; Loria, A.; Campbell, KS ; Bush, H.; Kern, PA ; Jose, PA ; Taegtmeyer, H.; Bers, DM ; Despa, S.; Goldstein, LB ; Murray, AJ ; Despa, F. "Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries." Kidney international 97, 1 (2020): 143-155. [PubMed Link] | [ Full text ]
Blum, KP ; Campbell, KS ; Horslen, BC ; Nardelli, P ; Housley, SN ; Cope, TC ; Ting, LH "Diverse and complex muscle spindle afferent firing properties emerge from multiscale muscle mechanics." eLife 9, (2020): [PubMed Link] | [ Full text ]
Awinda, PO ; Bishaw, Y ; Watanabe, M.; Guglin, MA ; Campbell, KS ; Tanner, BCW "Effects of mavacamten on Ca2+ sensitivity of contraction as sarcomere length varied in human myocardium." British journal of pharmacology 177, 24 (2020): 5609-5621. [PubMed Link] | [ Full text ]
Blair, CA ; Brundage, EA ; Thompson, KL ; Stromberg, A.; Guglin, M.; Biesiadecki, BJ ; Campbell, KS "Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles." JACC. Basic to translational science 5, 8 (2020): 786-798. [PubMed Link] | [ Full text ]
Sevrieva, IR ; Brandmeier, B ; Ponnam, S ; Gautel, M.; Irving, M ; Campbell, KS ; Sun, YB ; Kampourakis, T "Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I." The Journal of biological chemistry 295, 14 (2020): 4398-4410. [PubMed Link] | [ Full text ]
McDonald, KS ; Hanft, LM ; Robinett, JC ; Guglin, M.; Campbell, KS "Regulation of Myofilament Contractile Function in Human Donor and Failing Hearts." Frontiers in physiology 11, (2020): 468. [PubMed Link] | [ Full text ]
Campbell, KS ; Chrisman, BS ; Campbell, SG "Multiscale Modeling of Cardiovascular Function Predicts That the End-Systolic Pressure Volume Relationship Can Be Targeted via Multiple Therapeutic Strategies." Frontiers in physiology 11, (2020): 1043. [PubMed Link] | [ Full text ]
Campbell, KS ; Yengo, CM ; Lee, LC ; Kotter, J.; Sorrell, VL ; Guglin, M.; Wenk, JF "Closing the therapeutic loop." Archives of biochemistry and biophysics 663, (2019): 129-131. [PubMed Link] | [ Full text ]
Lakie, M.; Campbell, KS "Muscle thixotropy-where are we now?" Journal of applied physiology (Bethesda, Md. : 1985) 126, 6 (2019): 1790-1799. [PubMed Link] | [ Full text ]
Niederer, SA ; Campbell, KS ; Campbell, SG "A short history of the development of mathematical models of cardiac mechanics." Journal of molecular and cellular cardiology 127, (2019): 11-19. [PubMed Link] | [ Full text ]
Campbell, KS ; Beard, DA ; Qu, Z. "The Heart by Numbers." Biophysical journal 117, 12 (2019): E1-E3. [PubMed Link] | [ Full text ]
Vikhorev, PG ; Smoktunowicz, N.; Munster, AB ; Copeland, ON ; Kostin, S.; Montgiraud, C.; Messer, AE ; Toliat, MR ; Li, A.; Dos Remedios, CG ; Lal, S.; Blair, CA ; Campbell, KS ; Guglin, M.; Richter, M ; Knoll, R.; Marston, SB "Author Correction: Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes." Scientific reports 8, 1 (2018): 14485. [PubMed Link] | [ Full text ]
Papadaki, M ; Holewinski, RJ ; Previs, SB ; Martin, TG ; Stachowski, MJ ; Li, A.; Blair, CA ; Moravec, CS ; Van Eyk, JE ; Campbell, KS ; Warshaw, DM ; Kirk, JA "Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function." JCI insight 3, 20 (2018): [PubMed Link] | [ Full text ]
Wen, Y.; Murach, KA ; Vechetti IJ, Jr ; Fry, CS ; Vickery, C.; Peterson, CA ; McCarthy, JJ ; Campbell, KS "MyoVision: software for automated high-content analysis of skeletal muscle immunohistochemistry." Journal of applied physiology (Bethesda, Md. : 1985) 124, 1 (2018): 40-51. [PubMed Link] | [ Full text ]
Campbell, KS ; Janssen, PML ; Campbell, SG "Force-Dependent Recruitment from the Myosin Off State Contributes to Length-Dependent Activation." Biophysical journal 115, 3 (2018): 543-553. [PubMed Link] | [ Full text ]
Zhang, X.; Liu, ZQ ; Singh, D.; Powell, DK ; Chung, CS ; Campbell, KS ; Wenk, JF "Differential Effects of Isoproterenol on Regional Myocardial Mechanics in Rat using 3D cine DENSE Cardiovascular Magnetic Resonance." Journal of biomechanical engineering (2018): [PubMed Link] |
Zhang, X.; Liu, ZQ ; Campbell, KS ; Wenk, JF "Evaluation of a Novel Finite Element Model of Active Contraction in the Heart." Frontiers in physiology 9, (2018): 425. [PubMed Link] | [ Full text ]
Fanter, CE ; Campbell, KS ; Warren, DE "The effects of pH and Pi on tension and Ca2+ sensitivity of ventricular myofilaments from the anoxia-tolerant painted turtle." The Journal of experimental biology 220, Pt 22 (2017): 4234-4241. [PubMed Link] | [ Full text ]
Vikhorev, PG ; Smoktunowicz, N.; Munster, AB ; Copeland, O.; Kostin, S.; Montgiraud, C.; Messer, AE ; Toliat, MR ; Li, A.; Dos Remedios, CG ; Lal, S.; Blair, CA ; Campbell, KS ; Guglin, M.; Richter, M ; Knoll, R.; Marston, SB "Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes." Scientific reports 7, 1 (2017): 14829. [PubMed Link] | [ Full text ]
Swenson, AM ; Tang, W.; Blair, CA ; Fetrow, CM ; Unrath, WC ; Previs, MJ ; Campbell, KS ; Yengo, CM "Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle." The Journal of biological chemistry 292, 9 (2017): 3768-3778. [PubMed Link] | [ Full text ]
Campbell, KS "Super-relaxation helps muscles work more efficiently." The Journal of physiology 595, 4 (2017): 1007-1008. [PubMed Link] | [ Full text ]
Chung, CS ; Hoopes, CW ; Campbell, KS "Myocardial relaxation is accelerated by fast stretch, not reduced afterload." Journal of molecular and cellular cardiology 103, (2017): 65-73. [PubMed Link] | [ Full text ]
Zhang, X.; Liu, ZQ ; Singh, D.; Wehner, GJ ; Powell, DK ; Campbell, KS ; Fornwalt, BK ; Wenk, JF "Regional quantification of myocardial mechanics in rat using 3D cine DENSE cardiovascular magnetic resonance." NMR in biomedicine 30, 8 (2017): [PubMed Link] | [ Full text ]
Duggal, D.; Requena, S.; Nagwekar, J.; Raut, S.; Rich, R.; Das, H.; Patel, V.; Gryczynski, I.; Fudala, R.; Gryczynski, Z.; Blair, C.; Campbell, KS ; Borejdo, J. "No Difference in Myosin Kinetics and Spatial Distribution of the Lever Arm in the Left and Right Ventricles of Human Hearts." Frontiers in physiology 8, (2017): 732. [PubMed Link] | [ Full text ]
Wang, H.; Zhang, X.; Dorsey, SM ; McGarvey, JR ; Campbell, KS ; Burdick, JA ; Gorman JH, 3rd ; Pilla, JJ ; Gorman, RC ; Wenk, JF "Computational Investigation of Transmural Differences in Left Ventricular Contractility." Journal of biomechanical engineering 138, 11 (2016): [PubMed Link] | [ Full text ]
Campbell, KS "Compliance Accelerates Relaxation in Muscle by Allowing Myosin Heads to Move Relative to Actin." Biophysical journal 110, 3 (2016): 661-668. [PubMed Link] | [ Full text ]
Blair, CA ; Haynes, P.; Campbell, SG ; Chung, C ; Mitov, MI ; Dennis, D.; Bonnell, MR ; Hoopes, CW ; Guglin, M.; Campbell, KS "A Protocol for Collecting Human Cardiac Tissue for Research." The VAD journal : the journal of mechanical assisted circulation and heart failure 2, 1 (2016): [PubMed Link] |
Tang, W.; Blair, CA ; Walton, SD ; Málnási-Csizmadia, A.; Campbell, KS ; Yengo, CM "Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels." Frontiers in physiology 7, (2016): 659. [PubMed Link] | [ Full text ]
Nance, ME ; Whitfield, JT ; Zhu, Y.; Gibson, AK ; Hanft, LM ; Campbell, KS ; Meininger, GA ; McDonald, KS ; Segal, SS ; Domeier, TL "Attenuated sarcomere lengthening of the aged murine left ventricle observed using two-photon fluorescence microscopy." American journal of physiology. Heart and circulatory physiology 309, 5 (2015): H918-25. [PubMed Link] | [ Full text ]
Campbell, KS ; Sorrell, VL "Cell- and molecular-level mechanisms contributing to diastolic dysfunction in HFpEF." Journal of applied physiology (Bethesda, Md. : 1985) 119, 10 (2015): 1228-32. [PubMed Link] | [ Full text ]
Chung, CS ; Mechas, C.; Campbell, KS "Myocyte contractility can be maintained by storing cells with the myosin ATPase inhibitor 2,3 butanedione monoxime." Physiological reports 3, 6 (2015): [PubMed Link] | [ Full text ]
Zhang, X.; Haynes, P.; Campbell, KS ; Wenk, JF "Numerical evaluation of myofiber orientation and transmural contractile strength on left ventricular function." Journal of biomechanical engineering 137, 4 (2015): 044502. [PubMed Link] | [ Full text ]
Campbell, KS "Dynamic coupling of regulated binding sites and cycling myosin heads in striated muscle." The Journal of general physiology 143, 3 (2014): 387-99. [PubMed Link] | [ Full text ]
Chung, CS ; Mitov, MI ; Callahan, LA ; Campbell, KS "Increased myocardial short-range forces in a rodent model of diabetes reflect elevated content of β myosin heavy chain." Archives of biochemistry and biophysics 552-553, (2014): 92-9. [PubMed Link] | [ Full text ]
Haynes, P.; Nava, KE ; Lawson, BA ; Chung, CS ; Mitov, MI ; Campbell, SG ; Stromberg, AJ ; Sadayappan, S.; Bonnell, MR ; Hoopes, CW ; Campbell, KS "Transmural heterogeneity of cellular level power output is reduced in human heart failure." Journal of molecular and cellular cardiology 72, (2014): 1-8. [PubMed Link] | [ Full text ]
Haynes, P.; Campbell, KS "Myocardial hypertrophy reduces transmural variation in mitochondrial function." Frontiers in physiology 5, (2014): 178. [PubMed Link] | [ Full text ]
Campbell, SG ; Haynes, P.; Kelsey Snapp, W.; Nava, KE ; Campbell, KS "Altered ventricular torsion and transmural patterns of myocyte relaxation precede heart failure in aging F344 rats." American journal of physiology. Heart and circulatory physiology 305, 5 (2013): H676-86. [PubMed Link] | [ Full text ]
Chung, CS ; Campbell, KS "Temperature and transmural region influence functional measurements in unloaded left ventricular cardiomyocytes." Physiological reports 1, 6 (2013): e00158. [PubMed Link] | [ Full text ]
Milani-Nejad, N.; Xu, Y.; Davis, JP ; Campbell, KS ; Janssen, PM "Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature." The Journal of general physiology 141, 1 (2013): 133-9. [PubMed Link] | [ Full text ]
Weimer, K.; Theobald, J.; Campbell, KS ; Esser, KA ; Dimario, JX "Genome-wide expression analysis and EMX2 gene expression in embryonic myoblasts committed to diverse skeletal muscle fiber type fates." Developmental dynamics : an official publication of the American Association of Anatomists 242, 8 (2013): 1001-20. [PubMed Link] | [ Full text ]
Jackson, JR ; Mula, J.; Kirby, TJ ; Fry, CS ; Lee, JD ; Ubele, MF ; Campbell, KS ; McCarthy, JJ ; Peterson, CA ; Dupont-Versteegden, EE "Satellite cell depletion does not inhibit adult skeletal muscle regrowth following unloading-induced atrophy." American journal of physiology. Cell physiology 303, 8 (2012): C854-61. [PubMed Link] | [ Full text ]
Burgess, DE ; Bartos, DC ; Reloj, AR ; Campbell, KS ; Johnson, JN ; Tester, DJ ; Ackerman, MJ ; Fressart, V.; Denjoy, I.; Guicheney, P.; Moss, AJ ; Ohno, S.; Horie, M.; Delisle, BP "High-risk long QT syndrome mutations in the Kv7.1 (KCNQ1) pore disrupt the molecular basis for rapid K(+) permeation." Biochemistry 51, 45 (2012): 9076-85. [PubMed Link] | [ Full text ]
Ferreira, LF ; Moylan, JS ; Stasko, S.; Smith, JD ; Campbell, KS ; Reid, MB "Sphingomyelinase depresses force and calcium sensitivity of the contractile apparatus in mouse diaphragm muscle fibers." Journal of applied physiology (Bethesda, Md. : 1985) 112, 9 (2012): 1538-45. [PubMed Link] | [ Full text ]
Lefta, M.; Campbell, KS ; Feng, HZ ; Jin, JP ; Esser, KA "Development of dilated cardiomyopathy in Bmal1-deficient mice." American journal of physiology. Heart and circulatory physiology 303, 4 (2012): H475-85. [PubMed Link] | [ Full text ]
Bossuyt, J.; Chang, CW ; Helmstadter, K.; Kunkel, MT ; Newton, AC ; Campbell, KS ; Martin, JL ; Bossuyt, S.; Robia, SL ; Bers, DM "Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin." The Journal of biological chemistry 286, 38 (2011): 33390-400. [PubMed Link] | [ Full text ]
Campbell, SG ; Hatfield, PC ; Campbell, KS "A mathematical model of muscle containing heterogeneous half-sarcomeres exhibits residual force enhancement." PLoS computational biology 7, 9 (2011): e1002156. [PubMed Link] | [ Full text ]
McCarthy, JJ ; Mula, J.; Miyazaki, M.; Erfani, R.; Garrison, K.; Farooqui, AB ; Srikuea, R.; Lawson, BA ; Grimes, B.; Keller, C.; Van Zant, G.; Campbell, KS ; Esser, KA ; Dupont-Versteegden, EE ; Peterson, CA "Effective fiber hypertrophy in satellite cell-depleted skeletal muscle." Development (Cambridge, England) 138, 17 (2011): 3657-66. [PubMed Link] | [ Full text ]
Ferreira, LF ; Campbell, KS ; Reid, MB "Effectiveness of sulfur-containing antioxidants in delaying skeletal muscle fatigue." Medicine and science in sports and exercise 43, 6 (2011): 1025-31. [PubMed Link] | [ Full text ]
Campbell, KS "Impact of myocyte strain on cardiac myofilament activation." Pflugers Archiv : European journal of physiology 462, 1 (2011): 3-14. [PubMed Link] | [ Full text ]
Campbell, SG ; Campbell, KS "Mechanisms Of Residual Force Enhancement In Skeletal Muscle: Insights From Experiments And Mathematical Models." Biophysical reviews 3, 4 (2011): 199-207. [PubMed Link] | [ Full text ]
Andrews, JL ; Zhang, X.; McCarthy, JJ ; McDearmon, EL ; Hornberger, TA ; Russell, B.; Campbell, KS ; Arbogast, S.; Reid, MB ; Walker, JR ; Hogenesch, JB ; Takahashi, JS ; Esser, KA "CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function." Proceedings of the National Academy of Sciences of the United States of America 107, 44 (2010): 19090-5. [PubMed Link] | [ Full text ]
Mavalli, MD ; DiGirolamo, DJ ; Fan, Y.; Riddle, RC ; Campbell, KS ; Groen, T.; Frank, SJ ; Sperling, MA ; Esser, KA ; Bamman, MM ; Clemens, TL "Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice." The Journal of clinical investigation 120, 11 (2010): 4007-20. [PubMed Link] | [ Full text ]
Campbell, SG ; Lionetti, FV ; Campbell, KS ; McCulloch, AD "Coupling of adjacent tropomyosins enhances cross-bridge-mediated cooperative activation in a markov model of the cardiac thin filament." Biophysical journal 98, 10 (2010): 2254-64. [PubMed Link] | [ Full text ]
Campbell, KS "Distorting the sarcomere." The Journal of general physiology 136, 2 (2010): 155-7. [PubMed Link] | [ Full text ]
Campbell, KS "Short-range mechanical properties of skeletal and cardiac muscles." Advances in experimental medicine and biology 682, (2010): 223-46. [PubMed Link] | [ Full text ]
Campbell, KS "Interactions between connected half-sarcomeres produce emergent mechanical behavior in a mathematical model of muscle." PLoS computational biology 5, 11 (2009): e1000560. [PubMed Link] | [ Full text ]
Mitov, MI ; Holbrook, AM ; Campbell, KS "Myocardial short-range force responses increase with age in F344 rats." Journal of molecular and cellular cardiology 46, 1 (2009): 39-46. [PubMed Link] | [ Full text ]
Hardin, BJ ; Campbell, KS ; Smith, JD ; Arbogast, S.; Smith, J.; Moylan, JS ; Reid, MB "TNF-alpha acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscle." Journal of applied physiology (Bethesda, Md. : 1985) 104, 3 (2008): 694-9. [PubMed Link] | [ Full text ]
Campbell, KS ; Lakie, M. "Response to Bianco et al.: Interaction forces between F-actin and titin PEVK domain measured with optical tweezers." Biophysical journal 94, 1 (2008): 327-8; discussion 329-30. [PubMed Link] | [ Full text ]
McCarthy, JJ ; Andrews, JL ; McDearmon, EL ; Campbell, KS ; Barber, BK ; Miller, BH ; Walker, JR ; Hogenesch, JB ; Takahashi, JS ; Esser, KA "Identification of the circadian transcriptome in adult mouse skeletal muscle." Physiological genomics 31, 1 (2007): 86-95. [PubMed Link] | [ Full text ]
Campbell, KS ; Holbrook, AM "The rate of tension recovery in cardiac muscle correlates with the relative residual tension prevailing after restretch." American journal of physiology. Heart and circulatory physiology 292, 4 (2007): H2020-2. [PubMed Link] | [ Full text ]
Campbell, KS "Tension recovery in permeabilized rat soleus muscle fibers after rapid shortening and restretch." Biophysical journal 90, 4 (2006): 1288-94. [PubMed Link] | [ Full text ]
Campbell, KS "Filament compliance effects can explain tension overshoots during force development." Biophysical journal 91, 11 (2006): 4102-9. [PubMed Link] | [ Full text ]
Greaser, ML ; Krzesinski, PR ; Warren, CM ; Kirkpatrick, B.; Campbell, KS ; Moss, RL "Developmental changes in rat cardiac titin/connectin: transitions in normal animals and in mutants with a delayed pattern of isoform transition." Journal of muscle research and cell motility 26, 6-8 (2005): 325-32. [PubMed Link] | [ Full text ]
Warren, CM ; Krzesinski, PR ; Campbell, KS ; Moss, RL ; Greaser, ML "Titin isoform changes in rat myocardium during development." Mechanisms of development 121, 11 (2004): 1301-12. [PubMed Link] | [ Full text ]
Kloeker, S.; Reed, R.; McConnell, JL ; Chang, D.; Tran, K.; Westphal, RS ; Law, BK ; Colbran, RJ ; Kamoun, M.; Campbell, KS ; Wadzinski, BE "Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein." Protein expression and purification 31, 1 (2003): 19-33. [PubMed Link] | [ Full text ]
Campbell, KS ; Patel, JR ; Moss, RL "Cycling cross-bridges increase myocardial stiffness at submaximal levels of Ca2+ activation." Biophysical journal 84, 6 (2003): 3807-15. [PubMed Link] | [ Full text ]
Campbell, KS ; Moss, RL "SLControl: PC-based data acquisition and analysis for muscle mechanics." American journal of physiology. Heart and circulatory physiology 285, 6 (2003): H2857-64. [PubMed Link] | [ Full text ]
Campbell, KS ; Moss, RL "History-dependent mechanical properties of permeabilized rat soleus muscle fibers." Biophysical journal 82, 2 (2002): 929-43. [PubMed Link] | [ Full text ]
Fitzsimons, DP ; Patel, JR ; Campbell, KS ; Moss, RL "Cooperative mechanisms in the activation dependence of the rate of force development in rabbit skinned skeletal muscle fibers." The Journal of general physiology 117, 2 (2001): 133-48. [PubMed Link] | [ Full text ]
Campbell, KS ; Moss, RL "A thixotropic effect in contracting rabbit psoas muscle: prior movement reduces the initial tension response to stretch." The Journal of physiology 525 Pt 2, (2000): 531-48. [PubMed Link] | [ Full text ]
Campbell, KS ; Lakie, M. "A cross-bridge mechanism can explain the thixotropic short-range elastic component of relaxed frog skeletal muscle." The Journal of physiology 510 ( Pt 3), (1998): 941-62. [PubMed Link] | [ Full text ]
Turowski, P.; Favre, B.; Campbell, KS ; Lamb, NJ ; Hemmings, BA "Modulation of the enzymatic properties of protein phosphatase 2A catalytic subunit by the recombinant 65-kDa regulatory subunit PR65alpha." European journal of biochemistry 248, 1 (1997): 200-8. [PubMed Link] | [ Full text ]