Preetha Shridas, Ph.D. | Saha Cardiovascular Research Center

Preetha Shridas, Ph.D.

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preetha.shridas@uky.edu

C.T. Wethington Bldg, Room 537, 900 S Limestone St, Lexington, KY 40536-0200

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Inflammation and Lipoprotein Metabolism Research Group

Position(s):

Associate Professor

Affiliation(s):

Internal Medicine

Cardiovascular Research Center

Other Affiliation(s):

Internal Medicine - Endocrinology

CVRC - Affiliated Faculty

Bio / Education:

• PhD (1999) Bharathiar University, India 641046
  Emphasis: Biochemistry
• Masters in Biochemistry (1985-1987), Bharathiar University, India
• Bachelors (1983-1985) Bharathiar University, India
  Emphasis: Biochemistry, Chemistry, Nutrition & Dietitics.

PubMed Publications:

Fourie, C ; Shridas, P.; Davis, T.; de Villiers, WJS ; Engelbrecht, AM "Serum amyloid A and inflammasome activation: A link to breast cancer progression?" Cytokine & growth factor reviews 59, (2021): 62-70. [PubMed Link] | [ Full text ]
Davis, TA ; Conradie, D ; Shridas, P.; Beer, FC ; Engelbrecht, AM ; de Villiers, WJS "Serum Amyloid A Promotes Inflammation-Associated Damage and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer." Cellular and molecular gastroenterology and hepatology (2021): [PubMed Link] | [ Full text ]
Thompson, JC ; Wilson, PG ; Shridas, P.; Ji, A.; Beer, M.; Beer, FC ; Webb, NR ; Tannock, LR "Serum amyloid A3 is pro-atherogenic." Atherosclerosis 268, (2018): 32-35. [PubMed Link] | [ Full text ]
Tannock, LR ; De Beer, MC ; Ji, A.; Shridas, P.; Noffsinger, VP ; Hartigh, L.; Chait, A.; Beer, FC ; Webb, NR "Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein." Journal of lipid research 59, 2 (2018): 339-347. [PubMed Link] | [ Full text ]
Shridas, P.; De Beer, MC ; Webb, NR "High-density lipoprotein inhibits serum amyloid A-mediated reactive oxygen species generation and NLRP3 inflammasome activation." The Journal of biological chemistry 293, 34 (2018): 13257-13269. [PubMed Link] | [ Full text ]
Wilson, PG ; Thompson, JC ; Shridas, P.; McNamara, PJ ; De Beer, MC ; Beer, FC ; Webb, NR ; Tannock, LR "Serum Amyloid A Is an Exchangeable Apolipoprotein." Arteriosclerosis, thrombosis, and vascular biology 38, 8 (2018): 1890-1900. [PubMed Link] | [ Full text ]
Shridas, P.; Noffsinger, VP ; Trumbauer, AC ; Webb, NR "The dual role of group V secretory phospholipase A<sub>2</sub> in pancreatic β-cells." Endocrine 58, 1 (2017): 47-58. [PubMed Link] | [ Full text ]
Webb, NR ; De Beer, MC ; Wroblewski, JM ; Ji, A.; Bailey, W.; Shridas, P.; Charnigo, RJ ; Noffsinger, VP ; Witta, J.; Howatt, DA ; Balakrishnan, A.; Rateri, DL ; Daugherty, A.; Beer, FC "Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation." Arteriosclerosis, thrombosis, and vascular biology 35, 5 (2015): 1156-65. [PubMed Link] | [ Full text ]
Layne, JD ; Shridas, P.; Webb, NR "Ectopically expressed pro-group X secretory phospholipase A2 is proteolytically activated in mouse adrenal cells by furin-like proprotein convertases: implications for the regulation of adrenal steroidogenesis." The Journal of biological chemistry 290, 12 (2015): 7851-60. [PubMed Link] | [ Full text ]
Shridas, P.; Zahoor, L.; Forrest, KJ ; Layne, JD ; Webb, NR "Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism." The Journal of biological chemistry 289, 40 (2014): 27410-7. [PubMed Link] | [ Full text ]
De Beer, MC ; Wroblewski, JM ; Noffsinger, VP ; Rateri, DL ; Howatt, DA ; Balakrishnan, A.; Ji, A.; Shridas, P.; Thompson, JC ; Westhuyzen, DR ; Tannock, LR ; Daugherty, A.; Webb, NR ; Beer, FC "Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice." Arteriosclerosis, thrombosis, and vascular biology 34, 2 (2014): 255-61. [PubMed Link] | [ Full text ]
Boyanovsky, BB ; Bailey, W.; Dixon, L.; Shridas, P.; Webb, NR "Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice." The American journal of pathology 181, 3 (2012): 1088-98. [PubMed Link] | [ Full text ]
Carter, LG ; Lewis, KN ; Wilkerson, DC ; Tobia, CM ; Ngo Tenlep, SY ; Shridas, P.; Garcia-Cazarin, ML ; Wolff, G.; Andrade, FH ; Charnigo, RJ ; Esser, KA ; Egan, JM ; Cabo, R.; Pearson, KJ "Perinatal exercise improves glucose homeostasis in adult offspring." American journal of physiology. Endocrinology and metabolism 303, 8 (2012): E1061-8. [PubMed Link] | [ Full text ]
Shridas, P.; Bailey, WM ; Talbott, KR ; Oslund, RC ; Gelb, MH ; Webb, NR "Group X secretory phospholipase A2 enhances TLR4 signaling in macrophages." Journal of immunology (Baltimore, Md. : 1950) 187, 1 (2011): 482-9. [PubMed Link] | [ Full text ]
Zack, M.; Boyanovsky, BB ; Shridas, P.; Bailey, W.; Forrest, K.; Howatt, DA ; Gelb, MH ; Beer, FC ; Daugherty, A.; Webb, NR "Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice." Atherosclerosis 214, 1 (2011): 58-64. [PubMed Link] | [ Full text ]
Shridas, P.; Bailey, WM ; Gizard, F.; Oslund, RC ; Gelb, MH ; Bruemmer, D.; Webb, NR "Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages." Arteriosclerosis, thrombosis, and vascular biology 30, 10 (2010): 2014-21. [PubMed Link] | [ Full text ]
Li, X.; Shridas, P.; Forrest, K.; Bailey, W.; Webb, NR "Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 11 (2010): 4313-24. [PubMed Link] | [ Full text ]
Shridas, P.; Bailey, WM ; Boyanovsky, BB ; Oslund, RC ; Gelb, MH ; Webb, NR "Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands." The Journal of biological chemistry 285, 26 (2010): 20031-9. [PubMed Link] | [ Full text ]
Boyanovsky, BB ; Li, X.; Shridas, P.; Sunkara, M.; Morris, AJ ; Webb, NR "Bioactive products generated by group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines." Cytokine 50, 1 (2010): 50-7. [PubMed Link] | [ Full text ]
Boyanovsky, BB ; Shridas, P.; Simons, M.; Westhuyzen, DR ; Webb, NR "Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL." Journal of lipid research 50, 4 (2009): 641-50. [PubMed Link] | [ Full text ]
Sun, B.; Boyanovsky, BB ; Connelly, MA ; Shridas, P.; Westhuyzen, DR ; Webb, NR "Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI." Journal of lipid research 48, 12 (2007): 2560-70. [PubMed Link] | [ Full text ]
Shridas, P.; Waechter, CJ "Human dolichol kinase, a polytopic endoplasmic reticulum membrane protein with a cytoplasmically oriented CTP-binding site." The Journal of biological chemistry 281, 42 (2006): 31696-704. [PubMed Link] | [ Full text ]
Shridas, P.; Rush, JS ; Waechter, CJ "Identification and characterization of a cDNA encoding a long-chain cis-isoprenyltranferase involved in dolichyl monophosphate biosynthesis in the ER of brain cells." Biochemical and biophysical research communications 312, 4 (2003): 1349-56. [PubMed Link] | [ Full text ]