| 9/4/12 | Jason Meyer | "Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglyceride" |
| 9/11/12 | Robin Shoemaker | "Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like Peptide 1-dependent mechanism" Supplement |
| 9/18/12 | Sean Thatcher | "BBS-Induced Ciliary Defect Enhances Adipogenesis, Causing Paradoxical Higher-Insulin Sensitivity, Glucose Usage, and Decreased Inflammatory Response" |
| 9/25/12 | Alan Daugherty, PhD, DSc | "How to Review a Paper" |
| 10/2/12 | Jianing Li | "Trans-Intestinal Cholesterol Efflux is Not Mediated Through High Density Lipoprotein" |
| 10/9/12 | Cancelled | |
| 10/16/12 | Yinchuan Xu | "Heart repair by reprogramming non-myocytes with cardiac transcription factors" |
| 10/23/12 | Jenny Lutshumba | "Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo" |
| 10/30/12 | Joseph Layne | "Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses" |
| 11/6/12 | Cancelled - Election Day | |
| 11/13/12 | Kyung Sik Jung | "MMP-2 Regulates Erk1/2 Phosphorylation and Aortic Dilatation in Marfan Syndrome" |
| 11/20/12 | Nicki Baker | "Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats" |
| 11/27/12 | Paul Mueller | "Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease." |
| 12/04/12 | Joel Thompson | "Apolipoprotein E mimetic is more effective than apolipoprotein A-I mimetic in reducing lesion formation in older female apo E null mice" |
| Spring Semester 2012 |
| 01/17/12 | Jon Satin, Ph.D. | “Preparation of Competitive Fellowship Applications” |
| 01/24/12 | Jason Meyer | "Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth" |
| 01/31/12 | Nicki Baker | "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" |
| 02/07/12 | Kelly Putnam | "Inhibitor of Differntiation-3 Mediates High Fat Diet-Induced Visceral Fat Expansion" |
| 02/14/12 | Kyung Sik Jung | "Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice" |
| 02/21/12 | Robin Shoemaker | "Silence of TRIB3 Supresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE-/- and LDR-/- Mice." |
| 02/28/12 | Lindsay Carter | "Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice" |
| 03/06/12 | Joseph Layne | "Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue" |
| 03/13/12 | No Seminar - UK Spring Break | |
| 03/20/12 | Xiaoxi Liu | "Absence of RIP140 Reveals a Pathway Regulating glut4-Dependent Glucose Uptake in Oxidative Skeletal Muscle through UCP1-Mediated Activation of AMPK" |
| 03/27/12 | Yuhuan Wang | "The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals" (Supplement) |
| 04/03/12 | No seminar | |
| 04/10/12 | Jenny Lutshumba | "Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-y, and Proinflammatory Adipokines" |
| 04/17/12 | No Seminar - ATVB Conference | |
| 04/24/12 | Sean Thatcher | "The CARMA3-Bcl10-MALT1 Signalosome Promotes Angiotensin II-dependent Vascular Inflammation and Atherogenesis” |
| 05/01/12 | Aruna Poduri | "Myeloid-Specific Kruppel-Like Factor 2 Inactivation Increases Macrophage and Neutrophil Adhesion and Promotes Atherosclerosis" |
| 05/08/12 | Kai Su | "Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling" |
| Fall Semester 2011 |
| 9/6/11 | Greg Graf, Ph.D. | High Blood Pressure Research |
| 9/13/11 | CANCELLED | |
| 9/20/11 | Sonja Rhee | Clinical Cardiology |
| 9/27/11 | Nick Hatch | Basic Cardiovascular Sciences |
| 10/4/11 | CANCELLED | |
| 10/11/11 | Kelly Putnam | Nutrition, Physical Activity and Metabolism |
| 10/18/11 | Joel Thompson | Peripheral Vascular Disease |
| 10/25/11 | Alan Daugherty, Ph.D., D.Sc. | Stroke |
| 11/1/11 | Lindsay Carter | High Blood Pressure Research |
| 11/8/11 | Ore Adedoyin | Arteriosclerosis, Thrombosis and Vascular Biology |
| 11/15/11 | Xiaofeng Chen | Clinical Cardiology |
| 11/22/11 | Aruna Poduri | Basic Cardiovascular Sciences |
| 11/29/11 | Tao Tang | Kidney in Cardiovascular Disease |
| 12/6/11 | Nicki Baker | Nutrition, Physical Activity and Metabolism |
| 12/13/11 | Jenny Lutshumba | Peripheral Vascular Disease |
| Spring Semester 2011 |
| 01/25/11 | Greg Graf | High Blood Pressure Research |
| 02/01/11 | Nicki Baker | Arteriosclerosis, Thrombosis and Vascular Biology |
| 02/08/11 | Jason Meyer | Clinical Cardiology |
| 02/15/11 | CANCELLED | |
| 02/22/11 | | Kidney in Cardiovascular Disease |
| 03/01/11 | Kelly Putnam | Nutrition, Physical Activity and Metabolism |
| 03/08/11 | Frederique Batifoulier-Yiannikouris | Peripheral Vascular Disease |
| 03/15/11 | | No Seminar |
| 03/22/11 | Congqing Wu | Stroke |
| 03/29/11 | Nick Hatch | Arteriosclerosis, Thrombosis and Vascular Biology |
| 04/05/11 | Jingjing Liu | Basic Cardiovascular Sciences |
| 04/12/11 | Aruna Poduri | Clinical Cardiology |
| 04/19/11 | Ore Adedoyin | Arteriosclerosis, Thrombosis and Vascular Biology |
| 04/26/11 | Yuhuan Wang | High Blood Pressure Research |
| 05/03/11 | Dan Bartos | Kidney in Cardiovascular Disease |
| 05/10/11 | Kai Su | Nutrition, Physical Activity and Metabolism |
| Fall Semester 2010 |
| 09/07 | Nadia Sabeva | Intestinal Specific LXR Activation Stimulates Reverse Cholesterol Transport and Protects from Atherosclerosis |
| 09/14 | Sean Thatcher | ATP-Binding Cassette Transporter G1 and High-Density Lipoprotein Promote Endothelial NO Synthesis Through a Decrease in the Interaction of Caveolin-1 and Endothelial NO Synthase |
| 09/21 | Nicholas Hatch | Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes |
| 09/28 | David Peleshok | An Intracellular Role for ABCG1-Mediated Cholesterol Transport in the Regulated Secretory Pathway of Mouse Pancreatic Beta Cells |
| 10/05 | Shawn Crump | Increasing Cardiac Contractility After Myocardial Infarction Exacerbates Cardiac Injury and Pump Dysfunction |
| 10/12 | Aruna Poduri | MiR-33 Contributes to the Regulation of Cholesterol Homeostasis |
| 10/19 | Jason Meyer | NLRP3 Inflammasomes are Required for Atherogenesis and Activated by Cholesterol Crystals |
| 10/26 | Ling Zou | Adenosine Monophosphate Activated Protein Kinase Induces Cholesterol Efflux from Macrophage-Derived Foam Cells and Alleviates Atherosclerosis in Apolipoprotein E-Deficient Mice |
| 11/02 | Xiaofeng Chen | Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice with Myocardial Infarction |
| 11/09 | Jingjing Liu | SIRT3 Regulates Mitochondrial Fatty-Acid Oxidation by Reversible Enzyme Deacetylation |
| 11/16 | Tao Tang | Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis |
| 11/23 | Yuhuan Wang | Biliary Sterol Secretion Is Not Required for Macrophage Reverse Cholesterol Transport |
| 11/30 | Kai Su | Autophagy Regulates Lipid Metabolism |
| 12/07 | | The Immortal Life of Henrietta Lacks |
| 12/14 | Dan Bartos | Mutation of an A-Kinase-Anchoring Protein Causes Long-QT Syndrome |
| 12/21 | | Cancelled |
| Spring Semester 2010 |
| 01/26 | David Peleshok | Reducing Endoplasmic Reticulum Stress Through a Macrophage Lipid Chaperone Alleviates Atherosclerosis |
| 02/02 | Alan Daugherty, Ph.D., D.Sc. | What is truth? Standards of Scientific Integrity in American Heart Association Journals |
| 02/09 | Nicolas Hatch | The impact of Microsomal Prostaglandin E Synthase 1 on Blood Pressure is Determined by Genetic Background Hypertension |
| 02/16 | Cancelled | |
| 02/23 | Kelly A. Putnam | Effects of Caspase Inhibitor on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E Deficient Mice |
| 03/02 | Madhura Parulkar | TGF-B Activity Protects Against Inflammatory Aortic Aneurysm Progression and Complications in Angiotensin II-Infused Mice |
| 03/09 | Gregory Graf, Ph.D. | Coffee Consumption Enhances High-Density Lipoprotein-Mediated Cholesterol Efflux in Macrophages |
| 03/16 | Mihail I. Mitov, Ph.D. | Glycemic Control Prevents Microvascular Remodeling and Increased Tone in Type 2 Diabetes: Link to Endothelin-1 |
| 03/23 | Xiaofeng Chen | The Rho Exchange Factor Arhgef1 Mediates the Effects of Angiotensin II on Vascular Tone and Blood Pressure. |
| 03/30 | No Seminar | |
| 04/06 | Frederique Batifoulier-Yiannikouris | Valsartan Protects Pancreatic Islets and Adipose Tissue from the Inflammatory and Metabolic Consequences of a High-Fat Diet in Mice |
| 04/13 | Various | Discussion of ATVB Highlights |
| 04/20 | Ling Zou | Nuclear Receptor Liver X Receptor is O-GIcNAc-modified in Response to Glucose |
| 04/27 | Jingjing Liu | Differential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes |
| 05/04 *Location changed to Pharmacy, BPC 234B | John S. Parks, Ph.D. | Exploring the Role of Liver ABCA1 in Lipoprotein Metabolism. |
| 05/11 | Nadezhda S. Sabeva | Synthetic LXR Agonist Attenuates Plaque Formation in ApoE -/- Mice without Inducing Liver Steatosis and Hypertriglyceridemia |
| 05/18 | Aruna Poduri | Vasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E Deficient Mice |
| Fall Semester 2009 |
| 09/08 | Greg Graf | |
| 09/15 | David Peleshok | LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor. |
| 09/22 | Jason Meyer | CD36 Deficiency Rescues Lipotoxic Cardiomyopathy. |
| 09/29 | Chad Wilkerson | Intrauterine Growth Restriction Increases Fetal Hepatic Gluconeogenic Capacityand Reduces Messenger Ribonucleic Acid Translation Initiation and Nutrient Sensing in Fetal Liver and Skeletal Muscle |
| 10/06 | No Journal Club | |
| 10/13 | Nadezhda Sabeva | Fox 01 Mediates Insulin-Dependent Regulation of Hepatic VLDL Production in Mice. |
| 10/20 | Nicole Brogden | Effect of Rimonabant on the High-Triglyceride/Low HDL-Cholesterol Dyslipidemia, Intraabdominal Adiposity, and Liver Fat: The ADAGIO-Lipids Trial |
| 10/27 | Jingjing Liu | Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice. |
| 11/03 | Manisha Gupte | Angiotensin II Type 1 Receptor-Mediated Reduction of Angiotensin-Converting Enzyme 2 Activity in the Brain Impairs Baroreflex Function in Hypertensive Mice. |
| 11/10 | Aruna Poduri | Acquisition of the Contractile Phenotype by Murine Arterial Smooth Muscle Cells Depends on the Mir143/145 Gene Cluster. |
| 11/17 | Sean Thatcher | Prevention of Pulmonary Hypertension by Angiotensin-Converting Enzyme 2 Gene Transfer. |
| 11/24 | No Journal Club | |
| 12/01 | Kelly Putnam | Adiponectin Reduces Lipid Accumulation in Macrophage Foam Cells. |
| 12/08 | Congqing Wu | The Protein Kinase IKKε Regulates Energy Balance in Obese Mice. |
| 12/15 | Xiaofeng Chen | Vascular Wall ACE is not required for Atherogenesis in ApoE-/- Mice. |
| Spring Semester 2009 |
| 1/13 | Greg Graf | A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance. |
| 01/20 | Nicholas Hatch | Proinflammatory Phenotype of Perivascular Adipocytes Influences of High-Fat Feeding. |
| 01/27 | | |
| 02/03 | Greg Graf | PGC-1a is Coupled to HIF-1 a-Dependent Gene Expression by Increasing Mitochondrial Oxygen Consumption in Skeletal Muscle Cells. |
| 02/10 | Sean Thatcher | SIRTI, a Longevity Gene, Downregulates Angiotensin II Type I Receptor Expression in Vascular Smooth Muscle Cells. |
| 02/17 | Not Available | |
| 02/24 | Xia Li | Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy. |
| 03/03 | Frederique Yiannikouris | Deficiency of Angiotensin Type 2 Receptor Rescues Obesity But Not Hypertension Induced by Overexpression of Angiotensinogen in Adipose Tissue. |
| 03/10 | Nadezhda Sabeva | Dramatically Increased Intestinal Absorption of Cholesterol Following Hypophysectomy Is Normalized by Thyroid Hormone. |
| 03/17 | No Journal Club-Spring Break | |
| 03/24 | Xuan Zhang | Diet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia Adiposity, Hypertension, and Insulin Resistance: A Novel Murine Model of Developmental Programming. |
| 03/31 | No Journal Club-Fayette County School Spring Break | |
| 04/07 | Preetha Shridas | AdPLA Ablation Increases Lipolysis and Prevents Obesity Induced by High-Fat Feeding or Leptin Deficiency. |
| 04/14 | Lindsay Calderon | G12-G13-LARG-Mediated Signaling in Vascular Smooth Muscle is Required for Salt-Induced Hypertension. |
| 04/21 | Shaoping Wang | Deletion of Macrophage LDL Receptor-Related Protein Increases Atherogensis in the Mouse. |
| 04/28 | No Journal Club-ATVB Conference | |
| 05/05 | Kamalika Mukherjee | Epac1 is Upregulated During Neointima Formation and Promotes Vascular Smooth Muscle Cell Migration. |
| 05/12 | Jingjing Liu | FoxO1 Haploinsufficiency Protects Against High Fat Diet-Induced Insulin Resistance with Enhanced PPARy Activation in Adipose Tissue. |
| 05/19 | Kelly Putnam | Implantation of Adipose-Derived Regenerative Cells Enhanced Ischemia-Induced Angiogenesis. |
| 05/26 | Akinwunmi Akinmusire | High-Density Lipoprotein Transport Through Aortic Endothelial Cells Involves Scavenger Receptor BI and ATP -Binding Cassette Transporter GI. |
| Fall Semester 2008 |
| 9/2 | Nick Hatch | Angiotensin Converting Enzyme-2 (ACE2) Confers Endothelial Protection and Attenuates Atherosclerosis. |
| 9/9 | Sean Thatcher | Endothelium-Specific Interference With Peroxisome Proliferator Activated Receptor Gamma Causes Cerebral Vascular Dysfunction in Response to a High-Fat Diet. |
| 9/16 | Jasmine Li | FSP27 Contributes to Efficient Energy Storage in Murine White Adipocytes by Promoting the Formation of Unilocular Lipid Droplets. |
| 9/23 | Carmen Kiper | Evidence from a Genetic Fate-Mapping Study that Stem Cells Refresh Adult Mammalian Cardiomyocytes After Injury. |
| 9/30 | Zachary Fulkerson | Platelet CD36 Links Hyperlipidemia, Oxidant Stress and a Prothrombotic Phenotype. |
| 10/7 | Phillip Owens | Apelin Signaling Antagonizes AngII Effects in Mouse of Atherosclerosis. |
| 10/14 | Zhongwen Xie | ROCK1 Mediates Leukocyte Recruitment and Neointima Formation Following Vascular Injury. |
| 10/21 | Nadezhda Sabeva | Hepatic Insulin Resistance Directly Promotes Formation of Cholesterol Gallstones. |
| 10/28 | Venkateswaran Subramanian | Differential Roles of Cardiomyocyctes and macrophage Peroxisome Proliferator-Activated Receptor in Cardiac Fibrosis. |
| 11/4 | No Journal Club-Election Day |
| 11/11 | No Journal Club-AHA Scientific Session |
| 11/18 | Shaoping Wang | Local Activation or Implantation of Cardiac Progenitor Cells Rescues Scarred Infarcted Myocardium Improving Cardiac Function. |
| 11/25 | Mingming Zhao | Deficiency of Adipose Differentiation-Related Protein Impairs Foam Cell Formation and Protects Against Atherosclerosis. |
| 12/2 | Xiuling Li | Isoprostanes Inhibit Vascular Endothelial Growth Factor-Induced Endothelial Cell Migration, Tube Formation, and Cardiac Vessel Sprouting In Vitro, As Well As Angiogensis In Vivo via Activation of the Thromboxane A Receptor: A Potential Link Between Oxidative Stress and Impaired Angiogenesis. |
| 12/9 | Manisha Gupte | Angiotensin (1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart. |
| 12/16 | Haruhito Adam Uchida | Adiponectin Regulates Albuminuria and Podocyte Function in Mice. |
| Spring Semester 2008 |
| 1/15 | Nick Hatch | Deoxycorticosterone Acetate Salt Hypertension in Apolipoprotein E-/- Mice Results in Accelerated Atherosclerosis. |
| 1/22 | Boris Boyanovsky | Perfusion-Decellularized Matrix: Using Nature's Platform to Engineer a Bioartificial Heart. |
| 1/29 | | |
| 2/5 | Jill Cholewa | |
| 2/12 | Jasmine Li | Dok1 Mediates High-Fat Diet-Induced Adipocyte Hypertrophy and Obesity through Modulation of PPAR-G Phosphorylation. |
| 2/19 | Melissa Zack | Leptin Induces Macrophage Lipid Body Formation by a Phosphatildylinositol 3-Kinase-and Mammalian Target of Rapamycin-Dependent Mechanism. |
| 2/26 | No Journal Club | |
| 3/4 | No Journal Club | |
| 3/11 | Lindsay Calderon | Macrophage ABCA1 and ABCG1, but not SR-BI, Promote Macrophage Reverse Cholesterol Transport in Vivo. |
| 3/18 | Tao Tang | FoxO Transcription Factors Activate Akt and Attenuate Insulin Signaling in Heart by Inhibiting Protein Phosphatases. |
| 3/25 | Hong Lu | Increased Energy Expenditure, Dietary Fat Wasting, and Resistance to Diet-Induced Obesity in Mice Lacking Renin. |
| 4/1 | Fayette Co. Schools Spring Break - No CVJC | |
| 4/8 | Sara Police | Overexpression of PAI-1 Prevents the Development of Abdominal Aortic Aneurysms in Mice. |
| 4/15 | ATVB Conference-No CVJC | |
| 4/22 | Jingjing Liu | Fish Oil Increases Cholesterol Storage in White Adipose with Concomitant Decreases in Inflammation, Hepatic Steatosis, and Atherosclerosis in Mice. |
| 4/29 | Xuan Zhang | Prenatal Gender-Related Nicotine Exposure Increases Blood Pressure Response to Angiotensin II in Adult Offspring. |
| 5/6 | Frederique Yiannikouris | Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-{gamma},and Proinflammatory Adipokines. |
| 5/13 | Anisa Jahangiri | Apolipoprotein All Is a Regulator of Very Low Density Lipoprotein Metabolism and Insulin Resistance. |
| 5/20 | Phillip Owens | Novel Role for Inhibitor of Differentiation 2 in the Genesis of Angiotensin II Induced Hypertension. |
| 5/27 | Ailing Ji | Functional Genomic Screen Reveals Genes Involved in Lipid-Droplet Formation and Utilization. |
| Fall Semester 2007 |
| 09/04 | Jon Satin | Young Mouse Heart Is Composed of Myocytes Heterogeneous in Age and Function. |
| 09/11 | William Lester | Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. |
| 09/18 | Nick Hatch | Inhibited Aortic Aneurysm Formation in BLT1-Deficient Mice. |
| 09/25 | Brad Blunt | Cardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factoe-{kappa} B Dependent Pathway. |
| 10/02 | Lindsay Calderon | Targeted Deletion of Class A Macrophage Scavenger Receptor Increases the Risk of Cardiac Rupture After Experimental Myocardial Infarction. |
| 10/09 | Venkat Subramanian | Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice |
| 10/16 | Rebekah Waikel | Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2. |
| 10/23 | Jasmine Li | Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. |
| 10/30 | Jill Cholewa | Delta-Like 4 Induces Notch Signaling in Macrophages: Implications for Inflammation |
| 11/06 | Miranda Byse | Gene Therapy to Inhibit the Calcium Channel ß Subunit:Physiological Consequences and Pathophysiological Effects in Models of Cardiac Hypertrophy |
| 11/13 | Sean Thatcher | Pioplitazone Increases Macrophage Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Nondiabetic Low-Density Lipoprotein Receptor Null Mice." |
| 11/20 | Ye Chen-Izu | Transgenic CaMKII{delta}C Overexpression Uniquely Alters Cardiac Myocyte Ca2+ Handling: Reduced SR Ca2+ Load and Activated SR Ca2+ Release |
| 11/27 | Preetha Shridas | Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. |
| 12/04 | Phillip Owens | Cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. |
| 12/11 | Manisha Gupte | |
| Spring Semester 2007 |
| 01/16 | Hsin-Yuan Cheng | erbB2 is required for G protein-coupled receptor signaling in the heart |
| 01/23 | Boris Boyanovsky | Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages |
| 01/30 | Dejan Nikolic | p38 Mitogen-Activated Protein Kinase Inhibition Ameliorates Angiotensin II-Induced Target Organ Damage |
| 02/06 | | |
| 02/13 | Kamalika Mukherjee | Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis |
| 02/20 | A. Phillip Owens | TLR4 links innate immunity and fatty acid-induced insulin resistance |
| 02/27 | Hong Lu | Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney |
| 03/06 | Vishwesh Mokashi | DNA Vaccination Against VEGF Receptor 2 Reduces Atherosclerosis in LDL Receptor-Deficient Mice |
| 03/13 | Miranda Byse | The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor |
| 03/20 | Zhenheng Guo | Rho-kinase as a molecular target for insulin resistance and hypertension |
| 03/27 | Alan Daugherty | Elastin Stabilization for Treatment of Abdominal Aortic Aneurysms |
| 04/03 | Sam Bright | Do Statins Reduce Blood Pressure?: A Meta-Analysis of Randomized, Controlled Trials |
| 04/10 | Venkat Subramanian | Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response |
| 04/17 | Fei Huang | Decorin overexpression reduces atherosclerosis development in apolipoprotein E-deficient mice |
| 04/24 | Leah Allen | alpha1-Adrenergic Receptors Activate AKT via a Pyk2/PDK-1 Pathway That Is Tonically Inhibited by Novel Protein Kinase C Isoforms in Cardiomyocytes |
| 05/01 | Haruhito Adam Uchida | Macrophage Scavenger Receptor-A–Deficient Mice Are Resistant Against Diabetic Nephropathy Through Amelioration of Microinflammation |
| 05/08 | Xiaojie Amy Xie | Lack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E–Deficient Mice |
| 05/15 | Violeta Arsenescu | An obesity-associated gut microbiome with increased capacity for energy harvest |
| Fall Semester 2006 |
| 09/05 | Phil Owens | Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. |
| 09/12 | Miranda Byse | Inhibition of Nuclear Import of Calcineurin Prevents Myocardial Hypertrophy |
| 09/19 | Hong Lu | Natural regulatory T cells control the development of atherosclerosis in mice |
| 09/26 | Brad Blunt | Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure |
| 10/03 | Emily Helfrich-Bradshaw | High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor |
| 10/10 | Vishwesh Mokashi | Smooth Muscle Cells in Atherosclerosis Originate from the Local Vessel Wall and Not Circulating Progenitor Cells in ApoE Knockout Mice |
| 10/17 | Beth Oesterling | Long-term Air Pollution Exposure and Acceleration of Atherosclerosis and Vascular Inflammation in an Animal Model. |
| 10/24 | Florence Gizard | Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress. |
| 10/31 | Sara Police | Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. |
| 11/07 | Takashi Nomiyama | NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. |
| 11/14 | Sean Stocker | Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. |
| 11/21 | cancelled | |
| 11/28 | Kalyani Bharadwai | Local Renin Angiotensin Expression Regulates Human Mesenchymal Stem Cell Differentiation to Adipocytes |
| 12/05 | Paul Anaya | Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice |
| 12/12 | Sumitra Miriyala | Lysophosphatidic acid induces endothelial cell death by modulating the redox environment |
| 12/19 | Manikandan Panchatcharam | Diabetic Microangiopathy in Ischemic Limb Is a Disease of Disturbance of the Platelet-Derived Growth Factor-BB/Protein Kinase C Axis but Not of Impaired Expression of Angiogenic Factors |
| Spring Semester 2006 |
| 01/31 | Zhenheng Guo | Vascular Smooth Muscle Hypertrophy in Transgenic Mice Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice. |
| 02/07 | Phillip Owens | The Lamina Adventitia Is the Major Site of Immune Cell Accumulation in Standard Chow-Fed Apolipoprotein E–Deficient Mice. |
| 02/14 | Takashi Nomiyama | PPARα inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a. |
| 02/21 | Vishwesh Mokashi | Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. |
| 02/28 | Beth Oesterling | Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties. |
| 03/07 | Fjoralba Babamusta | CCR2 modulates inflammatory and metabolic effects of high-fat feeding. |
| 03/14 | Ken Campbell | Phosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner. |
| 03/21 | Anisa Jahangiri | High-Density Lipoprotein Hydrolysis by Endothelial Lipase Activates PPARy: A Candidate Mechanism for High-Density Lipoprotein-Mediated Repression of Leukocyte Adhesion. |
| 03/28 | Shoba Shetty | Elevated Plasma Membrane Cholesterol Content Alters Macrophage Signaling and Function. |
| 04/04 | Boris Boyanovsky | TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells. |
| 04/11 | Emily Helfrich | Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. |
| 04/18 | Alan Daugherty | Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. |
| 04/25 | Julie Oestreich | Effect of Platelet Antigen Polymorphism on Platelet Inhibition by Aspirin, Clopidogrel, or Their Combination. |
| 05/02 | Dejan Nikolic | Selective Rac-1 Inhibition Protects from Diabetes-Induced Vascular Injury. |
| 05/09 | Leah Allen-Klee | Exercise Can Prevent the Severity of Hypertrophic Cardiomyopathy |
| 05/16 | Aaron Gay | Identification of Novel PPARy Target Genes in Primary Human Adipocytes |
| 05/23 | Sam Carmichael | Vascular Response to Angiotensin II in Upper Body Obesity |
| Fall Semester 2005 |
| 09/13 | Steve Post | A central role for JNK in obesity and insulin resistance |
| 09/20 | Qingwei Zhao | Blockade of interleukin-12 function by protein vaccination attenuates atherosclerosis. |
| 09/27 | Zhenheng Guo | Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. |
| 10/04 | Hong Lu | Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats. |
| 10/11 | Meredith Bostrom | Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress. |
| 10/18 | Jill Cholewa | Expression of Class A Scavenger Receptor Is Enhanced by High Glucose in Vitroand under Diabetic Conditions in Vivo ONE MECHANISM FOR AN INCREASED RATE OF ATHEROSCLEROSIS IN DIABETES*. |
| 10/25 | Sara Police | Production of Chemokines by Perivascular Adipose Tissue: A Role in the Pathogenesis of Atherosclerosis? |
| 11/01 | Rebecca Scotland | The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. |
| 11/08 | Fei Huang | Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis. |
| 11/15 | No Journal Club - AHA Meetings (Dallas) |
| 11/22 | Vishwesh Mokashi | Transcriptional Repression of ATP-Binding Cassette Transporter A1 Gene in Macrophages: A Novel Atherosclerotic Effect of Angiotensin II. |
| 11/29 | Julie Oestreich | Clopidogrel inhibits platelet-leukocyte adhesion and platelet dependent leukocyte activation. |
| 11/06 | Phil Owens | Modulation of atheroslcerosis in mice by Toll-like receptor 2. |
| Spring Semester 2005 |
| 01/25 | Yanmei Wang | Short Interfering RNA-Mediated Silencing of Glutaredoxin 2 Increases the Sensitivity of Hela Cells toward Doxorubicin and Phenylarsine Oxide. |
| 02/01 | Rebecca Scotland | |
| 02/08 | Vishwesh Mokashi | |
| 02/15 | Boris Boyanovsky | Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ. |
| 02/22 | Sergey Matveev | Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. |
| 03/01 | Violeta Arsenscu | |
| 03/08 | Tracy Henriques | Inhibitory Effects of AT1 Receptor Blocker, Olmesartan, and Estrogen on Atherosclerosis Via Anti-Oxidative Stress. |
| 03/15 | Vicky King | Cyclooxygenases, Thromboxane, and Atherosclerosis: Plaque Destabilization by Cyclooxygenase-2 Inhibition Combined With Thromboxane Receptor Antagonism |
| 03/22 | Leah Allen-Klee | Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. |
| 03/29 | Bing Sun | ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. |
| 04/05 | Fayette Co. Spring Break - no CVJC | |
| 04/12 | Zhenheng Guo | Contractile Properties of the Cultured Vascular Smooth Muscle Cells. The Crucial Role Played by RhoA in the Regulation of Contractility. |
| 04/19 | Darshini Trivedi | Prostaglandin E2–Mediated Relaxation of the Ductus Arteriosus: Effects of Gestational Age on G Protein-Coupled Receptor Expression, Signaling, and Vasomotor Control. |
| 04/26 | Jill Cholewa | Hyperhomocysteinemia Activates Nuclear Factor-KB in Endothelial Cells via Oxidative Stress. |
| 05/03 | Dejan Nikolic | Scavenger receptor A mediates H2O2 production and suppression of IL-12 release in murine macrophages. |
| 05/10 | Phil Owens | Fausudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II induced AAA in ApoE -/- mice by inhibiting apoptosis and proteolysis. |
| 05/17 | Sara Police | Weight Loss--Associated Induction of Peroxisome Proliferator-Activated Receptor-alpha and Peroxisome Proliferator-Activated Receptor-gamma Correlate With Reduced Atherosclerosis and Improved Cardiovascular Function in Obese Insulin-Resistant Mice. |
| 05/24 | Kalyani Bharadwaj | Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor. |
| Fall Semester 2004 |
| 09/14 | Richard Lee | |
| 09/21 | Steve Post | Regulation of Muscle Fiber Type and Running Endurance by PPARdelta. |
| 09/28 | Erik Eckhardt | The LDL Receptor Related Protein LRP6 Regulates Proliferation and Survival Through the Wnt Cascade in Vascular Smooth Muscle Cells. |
| 10/05 | Leah Allen | Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart. |
| 10/12 | Tracy Henriques | Inhibition of Diet-Induced Atherosclerosis and Endothelial Dysfunction in Apolipoprotein E/Angiotensin II Type 1A Receptor Double-Knockout Mice. |
| 10/19 | Kalyani Bharadwaj | Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. |
| 10/26 | Phil Owens | The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. |
| 11/02 | Rebecca Scotland | |
| 11/09 | AHA Meetings |
| 11/16 | Darshini Trevedi | Roles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE-deficient mice. |
| 11/23 | No CVJC |
| 11/30 | Deneys van der Westhuyzen | Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population. |
| 12/07 | Elzbieta Stolarczyk | Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol*. |
| 12/14 | Meredith Bostrom | Macrophage-specific overexpression of group IIa sPLA2 results in increased atherosclerotic lesion size and enhanced collagen deposition. |
| Spring Semester 2004 |
| 02/02 | Vicky King | Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. |
| 02/10 | Kalyani Bharadwaj | Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. |
| 02/17 | Dejan Nikolic | Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II–induced cardiac hypertrophy and remodeling. |
| 02/24 | Hong Lu | Obesity is associated with macrophage accumulation in adipose tissue. |
| 03/03 | Jing Huang | Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. |
| 03/09 | Tracy Henriques | Androgen Contributes to Gender-Related Cardiac Hypertrophy and Fibrosis in Mice Lacking the Gene Encoding Guanylyl Cyclase-A. |
| 03/16 | Zhengheng Guo | Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. |
| 03/23 | Darshini Trevidi | Antimitogenic effects of HDL and APOE mediated by Cox-2–dependent IP activation. |
| 03/30 | No CVJC - Fayette Schools Spring Break | |
| 04/06 | Boris Boyanovsky | Inhibition of NF-KB activation in macrophages increases atherosclerosis in LDL receptor–deficient mice. |
| 04/13 | Erik Eckhardt | A Mutant High-Density Lipoprotein Receptor Inhibits Proliferation of Human Breast Cancer Cells. |
| 04/20 | Ela Stolarczyk | Generation of Viable Cholesterol-Free Mice. |
| 04/27 | Alan Daugherty | LRP: Role in vascular wall integrity and protection from atherosclerosis. |
| 05/04 | No CVJC - ATVB meeting | |
| 05/11 | Bing Sun | Increased CD36 protein as a response to defective insulin signaling in macrophages. |
| 05/18 | Rebecca Scotland | The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. |
| 05/25 | Shoba Shetty | Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. |
| 06/01 | Lisa Tannock | Extracellular Matrix Glycoprotein Biglycan Enhances Vascular Smooth Muscle Cell Proliferation and Migration. |
| 06/08 | Dennis Bruemmer | Impaired pancreatic growth, β cell mass, and β cell function in E2F1 -/- mice |
| 06/15 | Lisa Cassis | Susceptibility to Early Atherosclerosis in Male Mice Is Mediated by Estrogen Receptor. |
| Fall Semester 2003 |
| 09/16 | Todd Porter | Effects of a Dietary Portfolio of Cholesterol-Lowering Foods vs Lovastatin on Serum Lipids and C-Reactive Protein |
| 09/23 | Dave Randall | Glutamate release in midbrain periaqueductal gray by activation of skeletal muscle receptors and arterial baroreceptors |
| 09/30 | Dejan Nikolic | Melusin, a muscle-specific integrin â1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload |
| 10/07 | Nancy Webb | Long-term stable expression of human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of FH. |
| 10/14 | Reto Asmis | Leprdb Diabetic Mouse Bone Marrow Cells Inhibit Skin Wound Vascularization but Promote Wound Healing. |
| 10/21 | Shawn Crump | Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2 deficient mice. |
| 10/28 | Darshini Trevidi | COX-2 induction by Bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous PGE2, EP2 and EP4 receptors. |
| 11/04 | Carine Boustany | Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. |
| 11/11 | AHA mtg. - no journal club |
| 11/18 | Ming Gong | Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells |
| 11/25 | Fjoralba Babamusta | Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis |
| 12/02 | Ela Stolarczyk | Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. |
| 12/09 | Rebecca Scotland | Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy. |
| 12/16 | Li Li | Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial. |
| Spring Semester 2003 |
| 01/07 | Dave Randall | Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice. |
| 01/14 | Zhenheng Guo | Angiotensin-converting enzyme 2 is an essential regulator of heart function. |
| 01/21 | Jon Satin | Calmodulin Kinase II and Arrhythmias in a Mouse Model of Cardiac Hypertrophy. |
| 01/28 | Alan Daugherty | Increased medial degradation with pseudo-aneurysm formation in apolipoprotein E knockout mice deficient in tissue inhibitor of metalloproteinases-1. |
| 02/04 | Stuart Rice | RAGE Blockade Stabilizes Established Atherosclerosis in Diabetic Apolipoprotein E–Null Mice. |
| 02/11 | Tracy Henriques | Gender differences in cardiac ACE expression are normalized in androgen-deprived male mice. |
| 02/18 | Cancelled - due to weather | |
| 02/25 | Jing Huang | Inhibition of Renin-Angiotensin System Ameliorates Endothelial Dysfunction Associated with Aging in Rats. |
| 03/04 | Sergey Matveev | Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor ã1 (PPAR ã1) overexpression. |
| 03/11 | Tracy Henriques | Mice Lacking Endothelial ACE: Normal Blood Pressure with Elevated Angiotensin II. |
| 03/18 | Bing Sun | The Recycling of Apolipoprotein E in Primary Cultures of Mouse Hepatocytes. |
| 03/25 | Deneys van der Westhuyzen | Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. |
| 04/01 | Darshini Trivedi | Prostaglandin E2 Suppresses Chemokine Production in Human Macrophages through the EP4 Receptor. |
| 04/08 | Spring Break - no CVJC | |
| 04/15 | Ginell Post | Altered PYK2 phosphorylation by ANG II in hypertensive vascular smooth muscle. |
| 04/22 | Li Li | Identification of Gene-selective Modulators of the Bile Acid Receptor FXR |
| 04/29 | Catherine Mao | Severe Hypercholesterolemia, impaired fat tolerance and advanced atherosclerosis in mice lacking both Low density lipoprotein receptor-related protein 5 and Apolipoprotein E. |
| 05/06 | | |
| 05/13 | Mary Garcia | The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction. |
| 05/20 | Dejan Nikolic | Single Injection of P-Selectin or P-Selectin Glycoprotein Ligand-1 Monoclonal Antibody Blocks Neointima Formation After Arterial Injury in Apolipoprotein E-Deficient Mice. |
| 05/27 | Fjoralba Babamusta | Osteopontin Transgenic Mice Fed a High-Cholesterol Diet Develop Early Fatty-Streak Lesions.
|
| Fall Semester 2002 |
| 09/16 | Todd Porter | Effects of a Dietary Portfolio of Cholesterol-Lowering Foods vs Lovastatin on Serum Lipids and C-Reactive Protein |
| 09/23 | Dave Randall | Glutamate release in midbrain periaqueductal gray by activation of skeletal muscle receptors and arterial baroreceptors |
| 09/30 | Dejan Nikolic | Melusin, a muscle-specific integrin â1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload |
| 10/07 | Nancy Webb | Long-term stable expression of human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of FH. |
| 10/14 | Reto Asmis | Leprdb Diabetic Mouse Bone Marrow Cells Inhibit Skin Wound Vascularization but Promote Wound Healing. |
| 10/21 | Shawn Crump | Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2 deficient mice. |
| 10/28 | Darshini Trevidi | COX-2 induction by Bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous PGE2, EP2 and EP4 receptors. |
| 11/04 | Carine Boustany | Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. |
| 11/11 | AHA mtg. - no journal club |
| 11/18 | Ming Gong | Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells |
| 11/25 | Fjoralba Babamusta | Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis |
| 12/02 | Ela Stolarczyk | Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. |
| 12/09 | Rebecca Scotland | Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy. |
| 12/16 | Li Li | Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial.
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