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Thad E. Wilson, Ph.D.
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Thad.Wilson@uky.edu
(859) 562-3290
800 Rose Street, UK Chandler Medical Center, Medical Sciences Building, Rm: MS-601, Lexington, KY 40536-0298
Position(s): 
Professor, Department of Physiology, UK College of Medicine
Professor, Department of Preventative Medicine & Environmental Health, UK College of Public Health
Affiliation(s): 
Physiology
Cardiovascular Research Center
UK Center for Appalachian Research in Environmental Sciences
Other Affiliation(s): 
CVRC - Affiliated Faculty
Center for Clinical and Translational Sciences
Bio / Education: 

B.S. University of Wyoming, Laramie, WY
M.S. University of Wyoming, Laramie, WY
Ph.D. University of Utah, Salt Lake City, UT
Postdoctoral Fellow, Presbyterian Hospital of Dallas & University of Texas Southwestern Medical Center, Dallas, TX

Research Description: 

The goals of our laboratory/clinical-focused research are to: 1) identify the mechanisms of eccrine sweat gland and skin blood flow disorders to develop meaningful treatments; 2) quantify and model regional skin barriers and transdermal molecule movement during environmental exposures; and 3) determine the interactions of the thermal environment on medical conditions and worker health/safety.

The goals of our physiological education-focused research are to: 1) determine if function diagrams increase physiology knowledge recall; 2) identify the role of prediction in knowledge acquisition during physiology simulations; and 3) determine if incorporating lifespan and sex-specific differences impacts physiology knowledge retention in medical education.

Selected Publications: 

Wilson, T. E. & Barrett, K. E. Gastrointestinal jabberwocky to bioengineering design: Using function diagrams to teach physiology. Advances in Physiological Education, in press.

Wilson, T. E., Narra, S., Metzler-Wilson, K., Schneider, A., Bullens, K., & Holt, I. S. Role of bradykinin type 2 receptors in human sweat secretion: translational evidence does not support a functional relationship. Skin Pharmacology & Physiology, in press.

Luetkemeier, M. J., Allen, D. R., Huang, M., Pizzey, F. K., Parupia, I. M., Wilson, T. E., & Davis, S. L. Skin tattooing impairs sweating during passive whole-body heating. Journal of Applied Physiology, 129: 1033-1038, 2020.

Wilson, T. E., Mulye, M. & Akbar, S. Opportunistic physiology: Inserting physiology and pathophysiology content into virtually delivered clinical rotations. Advances in Physiological Education, 44: 545–549, 2020.

Gelfman, D.M., & Wilson, T. E. The importance of the “The David Sign”. Hektoen International Journal (Cardiology), 2020; hekint.org/2020/08/25/the-importance-of-the-the-david-sign/.

Metzler-Wilson, K., Vrable, A., Schaub, A., Schmale, T., Rodimel, B., Krause, B. A., & Wilson, T. E. Effect of suboccipital release on pain perception and autonomic reflex responses to ischemic and cold pain. Pain Medicine, 21:3024-3033, 2020.

Preston, R. R. & Wilson, T.E., Lippincott Illustrated Reviews: Physiology (2E), Lippincott Williams & Wilkins (Wolters Kluwer Co.), Baltimore, MD., 2019; ISBN: 978-1496385826.

Davis, S. L., Jay, O., & Wilson, T. E. Thermoregulation in multiple sclerosis. Handbook of Clinical Neurology, 157:701-714, 2018.

Kenny G. P., Wilson, T. E., Fujii, N., & Flouris, A. Heat exhaustion. Handbook of Clinical Neurology, 157:505-529, 2018.

Wilson, T. E. Cardiovascular and metabolic responses to thermal insults. Theory and Applications of Heat Transfer in Cells and Organs (edited by D. Shrivastava), John Wiley & Sons, Inc., New York, NY, 2018; ISBN: 978-1119127307.

Wilson, T. E. & Metzler-Wilson, K. Autonomic thermoregulation. Oxford Research Encyclopedia of Neuroscience - Neuroendocrine and Autonomic Systems. Oxford University Press, 2018; DOI: 10.1093/acrefore/9780190264086.013.15.

Wilson, T. E. Renal sympathetic nerve, blood flow, and epithelial transport responses to thermal stress. Autonomic Neuroscience: Basic and Clinical, 204: 25-34, 2017.

Metzler-Wilson, K. & Wilson, T. E. Calcium regulation's impact on eccrine sweating and sweating disorders: the view from cells to glands to intact human skin. Experimental Physiology, 101: 345–346, 2016.

Schlader, Z. J., Wilson, T. E., Crandall, C. G. Mechanisms of orthostatic intolerance during heat stress. Autonomic Neuroscience: Basic and Clinical, 196:37-46, 2016.

Metzler-Wilson, K., Toma, K., Sammons, D.L., Mann, S., Jurovcik, A. J., Demidova, O., & Wilson, T. E. Augmented supraorbital skin sympathetic nerve activity responses to symptom trigger events in rosacea patients. Journal of Neurophysiology, 114: 1530-1537, 2015.

Gray, B. D., Metzler-Wilson, K., Dawes, K. W., & Wilson, T. E. A neural link to understanding rosacea: Focusing on flushing triggers. Journal of the American Osteopathic College of Dermatology, 33: 11-16, 2015.

Wilson, T. E. & Metzler-Wilson, K. Sweating chloride bullets: Understanding the role of calcium in eccrine sweat glands and possible implications for hyperhidrosis. Experimental Dermatology, 24: 177-178, 2015.

Crandall, C. G. & Wilson, T. E. Human cardiovascular responses to passive heat stress. Comprehensive Physiology, 5: 17-43, 2015.

Brothers, R. B., Pecini, R., Dalsgaard, M., Bundgaard-Nielsen, M., Wilson, T. E., Secher, N. H., & Crandall, C. G. Effect of elevating cardiac pre-load on left-ventricular diastolic function and volume during heat stress: implication toward tolerance during hemorrhage. American Journal of Physiology (Regulatory, Integrative, and Comparative Physiology), 307: R1036-R1041, 2014.

Henley, C. & Wilson, T. E. Using beat-to-beat cardiovascular variability to determine the validity of sham controls in osteopathic manipulation research. Journal of the American Osteopathic Association, 114: 860-866, 2014.

Wilson, T. E., Klabunde, R. E. & Monahan, K. D. Using thermal stress to model aspects of disease states. Journal of Thermal Biology, 43: 24-32, 2014.

Metzler-Wilson, K., Sammons, D. L., Ossim, M. A., Metzger, N. R., Jurovcik, A. J., Krause, B. A. & Wilson, T. E. Extracellular calcium chelation and attenuation of calcium entry inhibit human in vivo cholinergic-induced eccrine sweating. Experimental Physiology, 99:393-402, 2013.

Klabunde, R. E., LePorte, A. D., & Wilson, T. E. Effect of temperature on isoproterenol-induced increases in left ventricular developed pressure. Journal of Thermal Biology, 38: 369-373, 2013.

Schlader, Z. J., Seifert, T., Wilson, T. E., Bundgaard-Nielsen, M., Secher, N. H., & Crandall, C. G. Acute volume expansion attenuates hyperthermia-induced reductions in cerebral perfusion during simulated hemorrhage. Journal of Applied Physiology, 114: 1730-1735, 2013.

Wilson, T. E. Sweating the details: What really drives eccrine output during exercise-heat stress. Journal of Physiology (London), 591: 2777, 2013.

Metzler-Wilson, K., & Wilson, T. E. Topical anesthesia does not affect cutaneous vasomotor or sudomotor responses in humans. Autonomic and Autacoid Pharmacology, 33: 25-33, 2013.

Clark, B. C., LePorte, A., Clark, S., Hoffman, R. L., Quick, A., Wilson, T. E., & Thomas, J. S. Characterization of Persistent Mal de Debarquement Syndrome: Effects on balance, psychological traits, and motor cortical excitability. Journal of Clinical Neuroscience, 20: 446-450, 2013.

Preston, R. R. & Wilson, T.E., Lippincott Illustrated Reviews: Physiology (1E). Lippincott Williams & Wilkins (Wolters Kluwer Co.), Baltimore, MD., 2013; ISBN: 978-1609132415.

Blackburn, S., Sammons, D. & Wilson, T. E. Palmar-plantar and axillary hyperhidrosis: Physiology, pathophysiology and treatment options. Journal of the American Osteopathic College of Dermatology, 22: 64-68, 2012.

Metzler-Wilson, K., Kellie, L. A., Tomc, C., Simpson, C., Sammons, D, & Wilson, T. E. Differential vasodilatory responses to local heating in facial, glabrous and hairy skin. Clinical Physiology and Functional Imaging, 32: 361-366, 2012.

Snyder, K. A. M., Shamimi-Noori, S., Wilson, T. E., and Monahan, K. D. Age- and limb-related differences in the vasoconstrictor response to limb dependency are not mediated by a sympathetic mechanism in humans. Acta Physiologica, 205(3): 372-380, 2012.

Crandall, C. G., Wilson, T. E., Marving, J., Bundgaard-Nielsen, M., Seifert, T., Klausen, T. L., Andersen, F., Secher, N. H., & Hesse, B. Colloid volume loading does not mitigate decreases in central blood volume during simulated hemorrhage while heat stressed. Journal of Physiology (London), 590, 1287-97, 2012.

Vogelsang, T. W., Marving, J., Crandall, C. G., Wilson, T. E., Yoshiga, C. C., Secher, N. H., Hesse, B. & Kjær, A. Atrial natriuretic peptide and acute changes in central blood volume by hyperthermia in healthy humans. The Open Neuroendocrinology Journal, 5, 1-4, 2012.

Gao, Z., Wilson, T. E., Drew, R., Ettinger, J., & Monahan, K. D. Altered coronary vascular control during cold stress in healthy older adults. American Journal of Physiology (Heart & Circulatory Physiology), 302: H312-318, 2012.

Wenner, M., Wilson, T. E., Davis, S. L., & Stachenfeld, N. Pharmacological curve fitting to analyze cutaneous adrenergic responses. Journal of Applied Physiology, 111: 1703-1709, 2011.

Toma, K., Walkowski, S., Metzler-Wilson, K., & Wilson, T. E. Acupuncture attenuates exercise-induced increases in skin sympathetic nerve activity. Autonomic Neuroscience: Basic and Clinical, 162: 84-88, 2011.

Wilson, T. E., & Crandall, C. G. Effect of thermal stress on cardiac function. Exercise and Sport Sciences Reviews, 39:12-17, 2011.

Bender, R., Wilson, T. E., Hoffman, R. F., & Clark, B. C. Passive-heat stress does not induce muscle fatigue, central activation failure, or changes in intracortical properties in wrist flexors. Ergonomics, 54: 565-575, 2011.

Shibasaki, M., Wilson, T. E., Bundgaard-Nielsen, M., Larsen, T. S., Secher, N. H., & Crandall, C. G. Modelflow underestimates cardiac output in heat stressed individuals. American Journal of Physiology (Regulatory, Integrative, and Comparative Physiology), 300: R486-491, 2011.

Crandall, C. G., Shibasaki, M., Wilson, T. E. Insufficient cutaneous vasoconstriction leading up to and at the onset of syncopal symptoms in the heat stressed human. American Journal of Physiology (Heart & Circulatory Physiology), 299: H1168-1173, 2010.

Davis, S. L., Wilson, T. E., White, A. T., & Frohman, E. M. Thermoregulation in multiple sclerosis. Journal of Applied Physiology, 109:1531-1537, 2010.

Crandall, C. G., Wilson, T. E., & Kregel, K. C. Highlighted Topic: Mechanisms and modulators of temperature regulation. Journal of Applied Physiology, 109: 1219-1220, 2010.

Bundgaard-Nielsen, M., Wilson, T. E., Seifert, T., Secher, N. H. & Crandall, C. G. Effect of volume loading on the Frank-Starling relation during simulated orthostatic stress in heated humans. Journal of Physiology (London), 588: 3333–3339, 2010.

Wilson, T. E., Gao, Z., Hess, K. L., & Monahan, K. D. Effect of aging on cardiac function during cold stress in humans. American Journal of Physiology (Regulatory, Integrative, and Comparative Physiology), 298: R1627-R1633, 2010.

Wilson, T. E., Monahan, K. D., Fogelman, A., Kearney, M. L., Sauder, C. L. & Ray, C. A. Aerobic exercise training improves maximal in vivo cholinergic responsiveness but not sensitivity of eccrine sweat glands. Journal of Investigative Dermatology, 130: 2328-2330, 2010.

Dearth, D. J., Umbel, J., Hoffman, R. L., Russ, D. W., Wilson, T. E., and Clark, B. C. Men and women exhibit a similar time to task failure for a sustained, submaximal elbow extensor contraction. European Journal of Applied Physiology, 108: 1089-1098, 2010.

Hess, K. L., Wilson, T. E., Gao, Z., Ray, C. A., and Monahan, K. D. Aging affects the acute cardiovascular responses to cooling in humans. Journal of Applied Physiology, 107:1076-1082, 2009.

Wilson, T. E., Brothers, R. M., Tollund, C., Dawson, E. A., Nissen, P., Yoshiga, C. C., Jons, C., Secher, N. H., Crandall, C. G. Effect of thermal stress on Frank-Starling relations in humans. Journal of Physiology (London), 587:3383-3392, 2009.

Crandall, C. G., Wilson, T. E., Marving, J., Vogelsang, T. W., Kjaer, A., Hesse, B., & Secher, N. H. Effects of heat stress on regional blood volume distribution in humans. Journal of Physiology (London), 586: 293-301, 2008.

Timson, B. F., Falls, H. B., Wilson, T. E., & Zimmerman, S. D. Effect of muscle strength of VO2 plateau occurrence rate. Isokinetics and Exercise Science, Volume 16: 231-237, 2008.

Wilson, T. E., Tollund, C., Yoshiga, C. C., Dawson, E. A., Nissen, P. , Secher, N. H. & Crandall, C. G. Effects of heat and cold stress on central vascular pressures during orthostasis in humans. Journal of Physiology (London), 585: 297-285, 2007.

Wilson, T. E., Sauder, C. L., Kerney, M. L., Kuipers, N. T., Leuenberger, U. A., Monahan, K. D., & Ray, C. A. Whole-body cold stress elicits peripheral and visceral vasoconstriction in humans. Journal of Applied Physiology, 103: 1257-1262, 2007.

Wilson, T. E., Cui, J., Zhang, R., & Crandall, C. G. Heat stress reduces cerebral blood velocity and markedly impairs orthostatic tolerance in humans. American Journal of Physiology (Regulatory, Integrative, and Comparative Physiology), 291: R1443-R1448, 2006.

Shibasaki, M, Wilson, T. E., & Crandall, C. G., Neural control and mechanisms of eccrine sweating during exercise and heat stress. Journal of Applied Physiology, 100: 1692-1701, 2006.

Cui, J., M. Sathishkumar, Wilson, T. E., & Crandall, C. G. Spectral characteristics of skin sympathetic nerve activity in heat stressed humans. American Journal of Physiology (Heart & Circulatory Physiology), 290: H1601-1609, 2006.

Wilson, T. E., Dyckman, D. J., & Ray, C. A. Determinants of skin sympathetic nerve responses to isometric exercise. Journal of Applied Physiology, 100: 1043-1048, 2006.

Wilson, T. E., Zhang, R., Levine, B. D., & Crandall, C. G. Dynamic autoregulation of the cutaneous circulation: differential control in glabrous vs nonglabrous skin. American Journal of Physiology (Heart & Circulatory Physiology), 289: H385–H391, 2005.

Davis, S. L., Wilson, T. E., Vener, J. M., Crandall, C. G., Petajan, J. H., & White, A. T. Pilocarpine-induced sweat function in individuals with multiple sclerosis. Journal of Applied Physiology, 98: 1740-1744, 2005.

Wilson, T. E., Cui, J., & Crandall, C. G. Mean body temperature does not modulate eccrine sweat rate during upright tilt. Journal of Applied Physiology, 98: 1207-1212, 2005.

Davison, J. L., Short, D. S., & Wilson, T. E. Effect of local heating and vasodilation on the cutaneous venoarteriolar response. Clinical Autonomic Research, 14: 385-390, 2004.

Cui, J., Wilson, T. E., & Crandall, C. G. Orthostatic challenge does not alter skin sympathetic nerve activity in heat stressed humans. Autonomic Neuroscience: Basic and Clinical, 116: 54-61, 2004.

Wilson, T. E., Monahan, K. D., Short, D. S., & Ray, C. A. Effect of age on cutaneous vasoconstrictor responses to norepinephrine in humans. American Journal of Physiology (Regulatory, Integrative, and Comparative Physiology), 287: R1230-1234, 2004.

Monahan, K. D., Wilson, T. E., & Ray C. A. Omega-3 fatty acid supplementation on muscle sympathetic nerve activity at rest and during physiological stress in humans. Hypertension, 44: 732-738, 2004.

Wilson, T. E. & Ray, C. A. Effect of thermal stress on the vestibulosympathetic reflexes in humans. Journal of Applied Physiology, 97: 1367-1370, 2004.

Wilson, T. E., Kuipers, N. T., McHugh, E. A., & Ray, C. A. Vestibular activation does not influence skin sympathetic nerve responses during whole-body heating. Journal of Applied Physiology, 97: 540-544, 2004.

Durand, S., Zhang, R., Cui, J., Wilson, T. E., & Crandall, C. G. Evidence for vascular autoregulation of glabrous and non-glabrous skin. Journal of Applied Physiology, 97: 535-539, 2004.

Ray, C. A. & Wilson, T. E., Comparison of skin sympathetic nerve responses to isometric arm and leg exercise. Journal of Applied Physiology, 97: 160-164, 2004.

Cui, J., Wilson, T. E., & Crandall, C. G. Muscle sympathetic nerve activity during lower-body negative pressure is accentuated in heat stressed humans. Journal of Applied Physiology, 96: 2103-2108, 2004.

Cui, J., Zhang, R., Wilson, T. E., and Craig G. Crandall. Spectral analysis of muscle sympathetic nerve activity in heat stressed humans. American Journal of Physiology (Heart & Circulatory Physiology), 286: H863-869, 2004.

Zhang, R., Wilson, T. E., Witkowski, S., Cui, J., Zuckerman, J. H., Crandall, C. G., & Levine, B. D. Inhibition of nitric oxide synthase does not alter dynamic cerebral autoregulation in humans. American Journal of Physiology (Heart & Circulatory Physiology), 286: H1101-1106, 2004.

Wilson, T. E., Carter, R., Cutler, M. J., Cui, J., Smith, M. L., & Crandall, C. G. Active recovery attenuates the fall in sweat rate but not cutaneous vascular conductance after supine exercise. Journal of Applied Physiology, 96: 668-673, 2004.

Shibasaki, M., Wilson, T. E., Cui, J., Levine, B. D, & Crandall, C. G. Exercise during simulated microgravity exposure preserves thermoregulatory responses. Journal of Applied Physiology, 95: 1817-1823, 2003.

Cui, J., Zhang, R., Wilson, T. E., Witkowski, S., Crandall, C. G., & Levine, B. D. Nitric oxide synthase inhibition does not affect regulation of muscle sympathetic nerve activity during head-up tilt. American Journal of Physiology (Heart & Circulatory Physiology), 285: H2105-2110, 2003.

Wilson, T. E., Shibasaki, M., Cui, J., Levine, B. D., & Crandall, C. G. Effects of 14 days head-down tilt bed rest on cutaneous vasoconstrictor responses in humans. Journal of Applied Physiology. 94: 2133-2118, 2003.

Crandall, C. G., Shibasaki, M., Wilson, T. E., Cui, J., & Levine, B. D. Prolonged head-down tilt exposure reduces maximal cutaneous vasodilator and sweat rate capacity in humans. Journal of Applied Physiology, 94: 2330-2336, 2003.

Crandall, C. G., Cui, J., & Wilson, T. E. Effects of heat stress of baroreflex regulation of blood pressure in man. Acta Physiologia Scandinavia, 177: 321-328, 2003.

White, A. T., Davis, S. L., & Wilson, T. E., Physiologic and thermoregulatory responses during submaximal exercise following lower body and whole body precooling. Journal of Applied Physiology, 94: 1039-1044, 2003.

Carter, R., Wilson, T. E., Watenpaugh, D. E., Smith, M. L. & Crandall, C. G. Effects of mode of exercise recovery on thermoregulatory and cardiovascular responses. Journal of Applied Physiology, 93: 1918-1924, 2002.

Shibasaki, M., Wilson, T. E., Cui, J., & Crandall, C. G. Acetylcholine released from cholinergic nerves contributes to cutaneous vasodilation during heat stress. Journal of Applied Physiology, 93: 1947-1951, 2002.

Wilson, T. E., Johnson, S. C., Petajan, J. H., Davis, S. L., Gappmaier, E., Luetkemeier, M. J., & White, A. T. Thermal regulatory responses to submaximal cycling following partial body precooling. European Journal of Applied Physiology, 88: 67-75, 2002.

Cui, J., Wilson, T. E., & Crandall, C. G. Phenylephrine-induced elevation in arterial blood pressure is attenuated in heat stressed humans. American Journal of Physiology (Regulatory, Integrative, and Comparative Physiology), 283: R1221-1226, 2002.

Zhang, R., Zuckerman, J. H., Iwasaki, K., Wilson, T. E., Crandall, C. G., & Levine, B. D. Autonomic control of cerebral autoregulation in humans. Circulation, 106: 1814-1820, 2002.

Cooke, W. H., Zhang, R., Zuckerman, J. H., Cui, J., Wilson, T. E., Crandall, C. G., & Levine, B. D. Does nitric oxide buffer arterial pressure variability in humans? Journal of Applied Physiology, 93: 1466-1470, 2002.

Wilson, T. E., Cui, J., & Crandall, C. G. Effect of local and whole-body heating on human cutaneous alpha-adrenergic vasoconstrictor responsiveness. Autonomic Neuroscience: Basic and Clinical, 97: 122-128, 2002.

Wilson, T. E., Cui, J., Zhang, R., Witkowski, S., & Crandall, C. G. Rapid skin-surface cooling maintains cerebral blood velocity and improves orthostatic tolerance during tilting in the heated human. Journal of Applied Physiology, 93: 85-91, 2002.

Cui, J., Wilson, T. E. & Crandall, C. G. Baroreflex modulation of muscle sympathetic nerve activity and heart rate during cold pressor test in humans. American Journal of Physiology (Heart & Circulatory Physiology), 282: H1717-1723, 2002.

Cui, J., Wilson, T. E. & Crandall, C. G. Baroreflex modulation of sympathetic nerve activity to muscle in heat-stressed humans. American Journal of Physiology (Regulatory, Integrative, and Comparative Physiology). 282: R252-258, 2002.

Wilson, T. E., Cui, J., & Crandall, C.G. Absence of baroreflex modulation of skin sympathetic nerve activity and sweat rate during whole-body heating in humans. Journal of Physiology (London), 536: 615-623, 2001.

Cui, J., Wilson, T. E., Shibasaki, M., Hodges, N. A., & Crandall, C. G. Baroreflex modulation of muscle sympathetic nerve activity during post handgrip muscle ischemia in humans. Journal of Applied Physiology, 91: 1679-1686, 2001.

White, A. T., Wilson, T. E., Davis, S. L., & Petajan, J. H. Effect of precooling on physical performance in multiple sclerosis. Multiple Sclerosis, 6: 176-180, 2000.

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