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741 South Limestone Street, BBSRB, B348B, Lexington, KY 40536-0298
Position(s):
Scientist III
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Other Affiliation(s):
Physiology - Staff
PubMed Publications:
- Peng, H.; Shindo, K ; Donahue, RR ; Abdel-Latif, A. "Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair." International journal of molecular sciences 22, 3 (2021): [PubMed Link] | [ Full text ]
- DeMaria, PJ ; Bilusic, M.; Park, DM ; Heery, CR ; Donahue, RN ; Madan, RA ; Bagheri, MH ; Strauss, J.; Shen, V ; Marté, JL ; Steinberg, SM ; Schlom, J.; Gilbert, MR ; Gulley, JL "Randomized, Double-Blind, Placebo-Controlled Phase II Study of Yeast-Brachyury Vaccine (GI-6301) in Combination with Standard-of-Care Radiotherapy in Locally Advanced, Unresectable Chordoma." The oncologist (2021): [PubMed Link] | [ Full text ]
- McFarlane, K ; Otto, TE ; Bailey, WM ; Veldhorst, AK ; Donahue, RR ; Taylor, BK ; Gensel, JC "Effect of Sex on Motor Function, Lesion Size, and Neuropathic Pain after Contusion Spinal Cord Injury in Mice." Journal of neurotrauma 37, 18 (2020): 1983-1990. [PubMed Link] | [ Full text ]
- Al-Darraji, A.; Donahue, RR ; Tripathi, H.; Peng, H.; Levitan, BM ; Chelvarajan, L.; Haydar, D.; Gao, E.; Henson, D.; Gensel, JC ; Feola, DJ ; Venditto, VJ ; Abdel-Latif, A. "Liposomal delivery of azithromycin enhances its immunotherapeutic efficacy and reduces toxicity in myocardial infarction." Scientific reports 10, 1 (2020): 16596. [PubMed Link] | [ Full text ]
- Tripathi, H.; Al-Darraji, A.; Abo-Aly, M ; Peng, H.; Shokri, E ; Chelvarajan, L.; Donahue, R.; Levitan, BM ; Gao, E.; Hernández, G.; Morris, AJ ; Smyth, SS ; Abdel-Latif, A. "Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction." Journal of molecular and cellular cardiology (2020): [PubMed Link] | [ Full text ]
- Schlom, J.; Donahue, RN "The Importance of Cellular Immunity in the Development of Vaccines and Therapeutics for COVID-19." The Journal of infectious diseases 222, 9 (2020): 1435-1438. [PubMed Link] | [ Full text ]
- Marté, JL ; Toney, NJ ; Cordes, L ; Schlom, J.; Donahue, RN ; Gulley, JL "Early changes in immune cell subsets with corticosteroids in patients with solid tumors: implications for COVID-19 management." Journal for immunotherapy of cancer 8, 2 (2020): [PubMed Link] | [ Full text ]
- Fabian, KP ; Padget, MR ; Donahue, RN ; Solocinski, K ; Robbins, Y ; Allen, CT ; Lee, JH ; Rabizadeh, S ; Soon-Shiong, P ; Schlom, J.; Hodge, JW "PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations." Journal for immunotherapy of cancer 8, 1 (2020): [PubMed Link] | [ Full text ]
- Sater, Abdul ; Marté, JL ; Donahue, RN ; Walter-Rodriguez, B ; Heery, CR ; Steinberg, SM ; Cordes, LM ; Chun, G ; Karzai, F ; Bilusic, M.; Harmon, SA ; Turkbey, IB ; Choyke, PL ; Schlom, J.; Dahut, WL ; Madan, RA ; Pinto, PA ; Gulley, JL "Neoadjuvant PROSTVAC prior to radical prostatectomy enhances T-cell infiltration into the tumor immune microenvironment in men with prostate cancer." Journal for immunotherapy of cancer 8, 1 (2020): [PubMed Link] | [ Full text ]
- Gatti-Mays, ME ; Redman, JM ; Donahue, RN ; Palena, C ; Madan, RA ; Karzai, F ; Bilusic, M.; Sater, HA ; Marté, JL ; Cordes, LM ; McMahon, S ; Steinberg, SM ; Orpia, A ; Burmeister, A ; Schlom, J.; Gulley, JL ; Strauss, J. "A Phase I Trial Using a Multitargeted Recombinant Adenovirus 5 (CEA/MUC1/Brachyury)-Based Immunotherapy Vaccine Regimen in Patients with Advanced Cancer." The oncologist 25, 6 (2020): 479-e899. [PubMed Link] | [ Full text ]
- Collins, JM ; Donahue, RN ; Tsai, YT ; Manu, M ; Palena, C ; Gatti-Mays, ME ; Marté, JL ; Madan, RA ; Karzai, F ; Heery, CR ; Strauss, J.; Abdul-Sater, H ; Cordes, L ; Schlom, J.; Gulley, JL ; Bilusic, M. "Phase I Trial of a Modified Vaccinia Ankara Priming Vaccine Followed by a Fowlpox Virus Boosting Vaccine Modified to Express Brachyury and Costimulatory Molecules in Advanced Solid Tumors." The oncologist 25, 7 (2020): 560-e1006. [PubMed Link] | [ Full text ]
- Lind, H ; , ; Jochems, C.; Donahue, RN ; Strauss, J.; JL, MD Gulley; Palena, C ; Schlom, J. "Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances." Journal for immunotherapy of cancer 8, 1 (2020): [PubMed Link] | [ Full text ]
- Custodio-Patsey, L ; Donahue, RR ; Fu, W.; Lambert, J.; Smith, BN ; Taylor, BK "Sex differences in kappa opioid receptor inhibition of latent postoperative pain sensitization in dorsal horn." Neuropharmacology 163, (2020): 107726. [PubMed Link] | [ Full text ]
- Strauss, J.; Gatti-Mays, ME ; Cho, BC ; Hill, A.; Salas, S ; McClay, E ; Redman, JM ; Sater, HA ; Donahue, RN ; Jochems, C.; Lamping, E ; Burmeister, A ; Marté, JL ; Cordes, LM ; Bilusic, M.; Karzai, F ; Ojalvo, LS ; Jehl, G ; Rolfe, PA ; Hinrichs, CS ; Madan, RA ; Schlom, J.; Gulley, JL "Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies." Journal for immunotherapy of cancer 8, 2 (2020): [PubMed Link] | [ Full text ]
- Tripathi, H.; Peng, H.; Donahue, R.; Chelvarajan, L.; Gottipati, A ; Levitan, B.; Al-Darraji, A.; Gao, E.; Abdel-Latif, A.; Berron, BJ "Isolation Methods for Human CD34 Subsets Using Fluorescent and Magnetic Activated Cell Sorting: an In Vivo Comparative Study." Stem cell reviews and reports 16, 2 (2020): 413-423. [PubMed Link] | [ Full text ]
- Del Rivero, J ; Donahue, RN ; Marté, JL ; Gramza, AW ; Bilusic, M.; Rauckhorst, M.; Cordes, L ; Merino, MJ ; Dahut, WL ; Schlom, J.; Gulley, JL ; Madan, RA "A Case Report of Sequential Use of a Yeast-CEA Therapeutic Cancer Vaccine and Anti-PD-L1 Inhibitor in Metastatic Medullary Thyroid Cancer." Frontiers in endocrinology 11, (2020): 490. [PubMed Link] | [ Full text ]
- Bilusic, M.; Heery, CR ; Collins, JM ; Donahue, RN ; Palena, C ; Madan, RA ; Karzai, F ; Marté, JL ; Strauss, J.; Gatti-Mays, ME ; Schlom, J.; Gulley, JL "Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors." Journal for immunotherapy of cancer 7, 1 (2019): 240. [PubMed Link] | [ Full text ]
- Rajan, A ; Heery, CR ; Thomas, A.; Mammen, AL ; Perry, S.; Coyne, G O.'Sullivan; Guha, U ; Berman, A ; Szabo, E.; Madan, RA ; Ballester, LY ; Pittaluga, S ; Donahue, RN ; Tsai, YT ; Lepone, LM ; Chin, K ; Ginty, F ; Sood, A.; Hewitt, SM ; Schlom, J.; Hassan, R ; Gulley, JL "Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (Avelumab) treatment in advanced thymoma." Journal for immunotherapy of cancer 7, 1 (2019): 269. [PubMed Link] | [ Full text ]
- Nelson, TS ; Fu, W.; Donahue, RR ; Corder, GF ; Hökfelt, T.; Wiley, RG ; Taylor, BK "Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn." Scientific reports 9, 1 (2019): 7248. [PubMed Link] | [ Full text ]
- Cho, J.; Bell, N ; Botzet, G ; Vora, P ; Fowler, BJ ; Donahue, R.; Bush, H.; Taylor, BK ; Albuquerque, RJC "Latent Sensitization in a Mouse Model of Ocular Neuropathic Pain." Translational vision science & technology 8, 2 (2019): 6. [PubMed Link] |
- Griggs, RB ; Santos, DF ; Laird, DE ; Doolen, S.; Donahue, RR ; Wessel, CR ; Fu, W.; Sinha, GP ; Wang, P.; Zhou, J.; Brings, S ; Fleming, T.; Nawroth, PP ; Susuki, K.; Taylor, BK "Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes." Neurobiology of disease 127, (2019): 76-86. [PubMed Link] | [ Full text ]
- Strauss, J.; Heery, CR ; Kim, JW ; Jochems, C.; Donahue, RN ; Montgomery, AS ; McMahon, S ; Lamping, E ; Marté, JL ; Madan, RA ; Bilusic, M.; Silver, MR ; Bertotti, E ; Schlom, J.; Gulley, JL "First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors." Clinical cancer research : an official journal of the American Association for Cancer Research 25, 1 (2019): 99-109. [PubMed Link] | [ Full text ]
- Mammen, AL ; Rajan, A ; Pak, K ; Lehky, T ; Casciola-Rosen, L ; Donahue, RN ; Lepone, LM ; Zekeridou, A ; Pittock, SJ ; Hassan, R ; Schlom, J.; Gulley, JL "Pre-existing antiacetylcholine receptor autoantibodies and B cell lymphopaenia are associated with the development of myositis in patients with thymoma treated with avelumab, an immune checkpoint inhibitor targeting programmed death-ligand 1." Annals of the rheumatic diseases 78, 1 (2019): 150-152. [PubMed Link] | [ Full text ]
- Gatti-Mays, ME ; Strauss, J.; Donahue, RN ; Palena, C ; Del Rivero, J ; Redman, JM ; Madan, RA ; Marté, JL ; Cordes, LM ; Lamping, E ; Orpia, A ; Burmeister, A ; Wagner, E.; Navarro, Pico ; Heery, CR ; Schlom, J.; Gulley, JL "A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules." Clinical cancer research : an official journal of the American Association for Cancer Research 25, 16 (2019): 4933-4944. [PubMed Link] | [ Full text ]
- Gensel, JC ; Donahue, RR ; Bailey, WM ; Taylor, BK "Sexual Dimorphism of Pain Control: Analgesic Effects of Pioglitazone and Azithromycin in Chronic Spinal Cord Injury." Journal of neurotrauma 36, 15 (2019): 2372-2376. [PubMed Link] | [ Full text ]
- Taylor, BK ; Sinha, GP ; Donahue, RR ; Grachen, CM ; Morón, JA ; Doolen, S. "Opioid receptors inhibit the spinal AMPA receptor Ca<sup>2+</sup> permeability that mediates latent pain sensitization." Experimental neurology 314, (2019): 58-66. [PubMed Link] | [ Full text ]
- Parsons, JK ; Pinto, PA ; Pavlovich, CP ; Uchio, E.; Kim, HL ; Nguyen, MN ; Gulley, JL ; Jamieson, C.; Hsu, P ; Wojtowicz, M.; Parnes, H ; Schlom, J.; Dahut, WL ; Madan, RA ; Donahue, RN ; Chow, HS "A Randomized, Double-blind, Phase II Trial of PSA-TRICOM (PROSTVAC) in Patients with Localized Prostate Cancer: The Immunotherapy to Prevent Progression on Active Surveillance Study." European urology focus 4, 5 (2018): 636-638. [PubMed Link] | [ Full text ]
- Strauss, J.; Heery, CR ; Schlom, J.; Madan, RA ; Cao, L.; Kang, Z.; Lamping, E ; Marté, JL ; Donahue, RN ; Grenga, I.; Cordes, L ; Christensen, O ; Mahnke, L ; Helwig, C ; Gulley, JL "Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors." Clinical cancer research : an official journal of the American Association for Cancer Research 24, 6 (2018): 1287-1295. [PubMed Link] | [ Full text ]
- Grenga, I.; Donahue, RN ; Gargulak, ML ; Lepone, LM ; Roselli, M ; Bilusic, M.; Schlom, J. "Anti-PD-L1/TGFβR2 (M7824) fusion protein induces immunogenic modulation of human urothelial carcinoma cell lines, rendering them more susceptible to immune-mediated recognition and lysis." Urologic oncology 36, 3 (2018): 93.e1-93.e11. [PubMed Link] | [ Full text ]
- Onifer, SM ; Sozio, RS ; DiCarlo, DM ; Li, Q.; Donahue, RR ; Taylor, BK ; Long, CR "Spinal manipulative therapy reduces peripheral neuropathic pain in the rat." Neuroreport 29, 3 (2018): 191-196. [PubMed Link] | [ Full text ]
- Doolen, S.; Iannitti, T.; Donahue, RR ; Shaw, BC ; Grachen, CM ; Taylor, BK "Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn." Pain 159, 2 (2018): 224-238. [PubMed Link] | [ Full text ]
- Karzai, F ; VanderWeele, D ; Madan, RA ; Owens, H ; Cordes, LM ; Hankin, A ; Couvillon, A ; Nichols, E ; Bilusic, M.; Beshiri, ML ; Kelly, K ; Krishnasamy, V ; Lee, S.; Lee, MJ ; Yuno, A ; Trepel, JB ; Merino, MJ ; Dittamore, R ; Marté, J ; Donahue, RN ; Schlom, J.; Killian, KJ ; Meltzer, PS ; Steinberg, SM ; Gulley, JL ; Lee, JM ; Dahut, WL "Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations." Journal for immunotherapy of cancer 6, 1 (2018): 141. [PubMed Link] | [ Full text ]
- McGee, HM ; Daly, ME ; Azghadi, S ; Stewart, SL ; Oesterich, L ; Schlom, J.; Donahue, R.; Schoenfeld, JD ; Chen, Q.; Rao, S.; Fragoso, RC ; Valicenti, RK ; Canter, RJ ; Maverakis, EM ; Murphy, WJ ; Kelly, K ; Monjazeb, AM "Stereotactic Ablative Radiation Therapy Induces Systemic Differences in Peripheral Blood Immunophenotype Dependent on Irradiated Site." International journal of radiation oncology, biology, physics 101, 5 (2018): 1259-1270. [PubMed Link] | [ Full text ]
- Gollihue, JL ; Patel, SP ; Eldahan, KC ; Cox, DH ; Donahue, RR ; Taylor, BK ; Sullivan, PG ; Rabchevsky, AG "Effects of Mitochondrial Transplantation on Bioenergetics, Cellular Incorporation, and Functional Recovery after Spinal Cord Injury." Journal of neurotrauma 35, 15 (2018): 1800-1818. [PubMed Link] | [ Full text ]
- Hicks, KC ; Fantini, M ; Donahue, RN ; Schwab, A.; Knudson, KM ; , ; Jochems, C.; Clavijo, PE ; Allen, CT ; Hodge, JW ; Tsang, KY ; Schlom, J.; , "Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types." Oncoimmunology 7, 11 (2018): e1466018. [PubMed Link] | [ Full text ]
- Heery, CR ; Palena, C ; McMahon, S ; Donahue, RN ; Lepone, LM ; Grenga, I.; Dirmeier, U ; Cordes, L ; Marté, J ; Dahut, W ; Singh, H.; Madan, RA ; Fernando, RI ; Hamilton, DH ; Schlom, J.; Gulley, JL "Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury." Clinical cancer research : an official journal of the American Association for Cancer Research 23, 22 (2017): 6833-6845. [PubMed Link] | [ Full text ]
- Heery, CR ; O'Sullivan-Coyne, G ; Madan, RA ; Cordes, L ; Rajan, A ; Rauckhorst, M.; Lamping, E ; Oyelakin, I ; Marté, JL ; Lepone, LM ; Donahue, RN ; Grenga, I.; Cuillerot, JM ; Neuteboom, B ; Heydebreck, AV ; Chin, K ; Schlom, J.; Gulley, JL "Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial." The Lancet. Oncology 18, 5 (2017): 587-598. [PubMed Link] | [ Full text ]
- Mamet, J.; Klukinov, M.; Harris, S.; Manning, DC ; Xie, S.; Pascual, C.; Taylor, BK ; Donahue, RR ; Yeomans, DC "Intrathecal administration of AYX2 DNA-decoy produces a long-term pain treatment in rat models of chronic pain by inhibiting the KLF6, KLF9 and KLF15 transcription factors." Molecular pain 13, (2017): 1744806917727917. [PubMed Link] | [ Full text ]
- Mamet, J.; Harris, S.; Klukinov, M.; Yeomans, DC ; Donahue, RR ; Taylor, BK ; Eddinger, K.; Yaksh, T.; Manning, DC "Pharmacology, pharmacokinetics, and metabolism of the DNA-decoy AYX1 for the prevention of acute and chronic post-surgical pain." Molecular pain 13, (2017): 1744806917703112. [PubMed Link] | [ Full text ]
- Griggs, RB ; Laird, DE ; Donahue, RR ; Fu, W.; Taylor, BK "Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation." Frontiers in neuroscience 11, (2017): 679. [PubMed Link] | [ Full text ]
- Donahue, RN ; Lepone, LM ; Grenga, I.; Jochems, C.; Fantini, M ; Madan, RA ; Heery, CR ; Gulley, JL ; Schlom, J. "Analyses of the peripheral immunome following multiple administrations of avelumab, a human IgG1 anti-PD-L1 monoclonal antibody." Journal for immunotherapy of cancer 5, (2017): 20. [PubMed Link] | [ Full text ]
- Farsaci, B ; Donahue, RN ; Grenga, I.; Lepone, LM ; Kim, PS ; Dempsey, B ; Siebert, JC ; Ibrahim, NK ; Madan, RA ; Heery, CR ; Gulley, JL ; Schlom, J. "Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy." Cancer immunology research 4, 9 (2016): 755-65. [PubMed Link] | [ Full text ]
- Heery, CR ; Madan, RA ; Stein, MN ; Stadler, WM ; Di Paola, RS ; Rauckhorst, M.; Steinberg, SM ; Marté, JL ; Chen, CC ; Grenga, I.; Donahue, RN ; Jochems, C.; Dahut, WL ; Schlom, J.; Gulley, JL "Samarium-153-EDTMP (Quadramet®) with or without vaccine in metastatic castration-resistant prostate cancer: A randomized Phase 2 trial." Oncotarget 7, 42 (2016): 69014-69023. [PubMed Link] | [ Full text ]
- Duggan, MC ; Jochems, C.; Donahue, RN ; Richards, J.; Karpa, V ; Foust, E ; Paul, B.; Brooks, T.; Tridandapani, S.; Olencki, T ; Pan, X.; Lesinski, GB ; Schlom, J.; Iii, WE Carson "A phase I study of recombinant (r) vaccinia-CEA(6D)-TRICOM and rFowlpox-CEA(6D)-TRICOM vaccines with GM-CSF and IFN-α-2b in patients with CEA-expressing carcinomas." Cancer immunology, immunotherapy : CII 65, 11 (2016): 1353-1364. [PubMed Link] | [ Full text ]
- Grenga, I.; Donahue, RN ; Lepone, LM ; Richards, J.; Schlom, J. "A fully human IgG1 anti-PD-L1 MAb in an in vitro assay enhances antigen-specific T-cell responses." Clinical & translational immunology 5, 5 (2016): e83. [PubMed Link] |
- Griggs, RB ; Donahue, RR ; Adkins, BG ; Anderson, KL ; Thibault, O.; Taylor, BK "Pioglitazone Inhibits the Development of Hyperalgesia and Sensitization of Spinal Nociresponsive Neurons in Type 2 Diabetes." The journal of pain 17, 3 (2016): 359-73. [PubMed Link] | [ Full text ]
- Jochems, C.; Fantini, M ; Fernando, RI ; Kwilas, AR ; Donahue, RN ; Lepone, LM ; Grenga, I.; Kim, YS ; Brechbiel, MW ; Gulley, JL ; Madan, RA ; Heery, CR ; Hodge, JW ; Newton, R ; Schlom, J.; Tsang, KY "The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells." Oncotarget 7, 25 (2016): 37762-37772. [PubMed Link] | [ Full text ]
- Lepone, LM ; Donahue, RN ; Grenga, I.; Metenou, S ; Richards, J.; Heery, CR ; Madan, RA ; Gulley, JL ; Schlom, J. "Analyses of 123 Peripheral Human Immune Cell Subsets: Defining Differences with Age and between Healthy Donors and Cancer Patients Not Detected in Analysis of Standard Immune Cell Types." Journal of circulating biomarkers 5, (2016): 5. [PubMed Link] | [ Full text ]
- Harte, SE ; Meyers, JB ; Donahue, RR ; Taylor, BK ; Morrow, TJ "Mechanical Conflict System: A Novel Operant Method for the Assessment of Nociceptive Behavior." PloS one 11, 2 (2016): e0150164. [PubMed Link] | [ Full text ]
- Heery, CR ; Ibrahim, NK ; Arlen, PM ; Mohebtash, M ; Murray, JL ; Koenig, K.; Madan, RA ; McMahon, S ; Marté, JL ; Steinberg, SM ; Donahue, RN ; Grenga, I.; Jochems, C.; Farsaci, B ; Folio, LR ; Schlom, J.; Gulley, JL "Docetaxel Alone or in Combination With a Therapeutic Cancer Vaccine (PANVAC) in Patients With Metastatic Breast Cancer: A Randomized Clinical Trial." JAMA oncology 1, 8 (2015): 1087-95. [PubMed Link] | [ Full text ]
- Heery, CR ; Singh, BH ; Rauckhorst, M.; Marté, JL ; Donahue, RN ; Grenga, I.; Rodell, TC ; Dahut, W ; Arlen, PM ; Madan, RA ; Schlom, J.; Gulley, JL "Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury." Cancer immunology research 3, 11 (2015): 1248-56. [PubMed Link] | [ Full text ]
- Griggs, RB ; Donahue, RR ; Morgenweck, J.; Grace, PM ; Sutton, A.; Watkins, LR ; Taylor, BK "Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms." Pain 156, 3 (2015): 469-482. [PubMed Link] | [ Full text ]
- Grenga, I.; Kwilas, AR ; Donahue, RN ; Farsaci, B ; Hodge, JW "Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack." Journal for immunotherapy of cancer 3, (2015): 52. [PubMed Link] | [ Full text ]
- Pereira, MP ; Donahue, RR ; Dahl, JB ; Werner, M.; Taylor, BK ; Werner, MU "Endogenous Opioid-Masked Latent Pain Sensitization: Studies from Mouse to Human." PloS one 10, 8 (2015): e0134441. [PubMed Link] | [ Full text ]
- Kwilas, AR ; Donahue, RN ; Tsang, KY ; Hodge, JW "Immune consequences of tyrosine kinase inhibitors that synergize with cancer immunotherapy." Cancer cell & microenvironment 2, 1 (2015): [PubMed Link] |
- Ardiani, A ; , ; Kwilas, AR ; Donahue, RN ; Hodge, JW "Androgen deprivation therapy sensitizes prostate cancer cells to T-cell killing through androgen receptor dependent modulation of the apoptotic pathway." Oncotarget 5, 19 (2014): 9335-48. [PubMed Link] | [ Full text ]
- Kwilas, AR ; Ardiani, A ; Donahue, RN ; Aftab, DT ; Hodge, JW "Dual effects of a targeted small-molecule inhibitor (cabozantinib) on immune-mediated killing of tumor cells and immune tumor microenvironment permissiveness when combined with a cancer vaccine." Journal of translational medicine 12, (2014): 294. [PubMed Link] | [ Full text ]
- Farsaci, B ; Donahue, RN ; Coplin, MA ; Grenga, I.; Lepone, LM ; Molinolo, AA ; Hodge, JW "Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines." Cancer immunology research 2, 11 (2014): 1090-102. [PubMed Link] | [ Full text ]
- Donahue, RN ; Duncan, BB ; Fry, TJ ; Jones, B.; Bachovchin, WW ; Kiritsy, CP ; Lai, JH ; Wu, W.; Zhao, P.; Liu, Y.; Tsang, KY ; Hodge, JW "A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines." Vaccine 32, 26 (2014): 3223-31. [PubMed Link] | [ Full text ]
- Kim, PS ; Jochems, C.; Grenga, I.; Donahue, RN ; Tsang, KY ; Gulley, JL ; Schlom, J.; Farsaci, B "Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy." Journal of immunology (Baltimore, Md. : 1950) 192, 6 (2014): 2622-33. [PubMed Link] | [ Full text ]
- Rahn, EJ ; Iannitti, T.; Donahue, RR ; Taylor, BK "Sex differences in a mouse model of multiple sclerosis: neuropathic pain behavior in females but not males and protection from neurological deficits during proestrus." Biology of sex differences 5, 1 (2014): 4. [PubMed Link] | [ Full text ]
- Mamet, J.; Klukinov, M.; Yaksh, TL ; Malkmus, SA ; Williams, S.; Harris, S.; Manning, DC ; Taylor, BK ; Donahue, RR ; Porreca, F ; Xie, JY ; Oyarzo, J ; Brennan, TJ ; Subieta, A ; Schmidt, WK ; Yeomans, DC "Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury." Pain 155, 2 (2014): 322-333. [PubMed Link] | [ Full text ]
- Farsaci, B ; Jochems, C.; Grenga, I.; Donahue, RN ; Tucker, JA ; Pinto, PA ; Merino, MJ ; Heery, CR ; Madan, RA ; Gulley, JL ; Schlom, J. "Identification by digital immunohistochemistry of intratumoral changes of immune infiltrates after vaccine in the absence of modifications of PBMC immune cell subsets." International journal of cancer 135, 4 (2014): 862-70. [PubMed Link] | [ Full text ]
- Roselli, M ; Cereda, V ; di Bari, MG ; Formica, V ; Spila, A ; Jochems, C.; Farsaci, B ; Donahue, R.; Gulley, JL ; Schlom, J.; Guadagni, F "Effects of conventional therapeutic interventions on the number and function of regulatory T cells." Oncoimmunology 2, 10 (2013): e27025. [PubMed Link] | [ Full text ]
- Zagon, IS ; Donahue, R.; McLaughlin, PJ "Targeting the opioid growth factor: opioid growth factor receptor axis for treatment of human ovarian cancer." Experimental biology and medicine (Maywood, N.J.) 238, 5 (2013): 579-87. [PubMed Link] | [ Full text ]
- Donahue, RN ; McLaughlin, PJ ; Zagon, IS "Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer." Experimental biology and medicine (Maywood, N.J.) 237, 2 (2012): 167-77. [PubMed Link] | [ Full text ]
- Fanning, J ; Hossler, CA ; Kesterson, JP ; Donahue, RN ; McLaughlin, PJ ; Zagon, IS "Expression of the opioid growth factor-opioid growth factor receptor axis in human ovarian cancer." Gynecologic oncology 124, 2 (2012): 319-24. [PubMed Link] | [ Full text ]
- Kwilas, AR ; Donahue, RN ; Bernstein, MB ; Hodge, JW "In the field: exploiting the untapped potential of immunogenic modulation by radiation in combination with immunotherapy for the treatment of cancer." Frontiers in oncology 2, (2012): 104. [PubMed Link] | [ Full text ]
- Donahue, RN ; McLaughlin, PJ ; Zagon, IS "Low-dose naltrexone targets the opioid growth factor-opioid growth factor receptor pathway to inhibit cell proliferation: mechanistic evidence from a tissue culture model." Experimental biology and medicine (Maywood, N.J.) 236, 9 (2011): 1036-50. [PubMed Link] | [ Full text ]
- Zagon, IS ; Donahue, RN ; Bonneau, RH ; McLaughlin, PJ "T lymphocyte proliferation is suppressed by the opioid growth factor ( Met(5) -enkephalin)-opioid growth factor receptor axis: implication for the treatment of autoimmune diseases." Immunobiology 216, 5 (2011): 579-90. [PubMed Link] | [ Full text ]
- Donahue, RN ; McLaughlin, PJ ; Zagon, IS "Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin." Experimental biology and medicine (Maywood, N.J.) 236, 7 (2011): 883-95. [PubMed Link] | [ Full text ]
- Zagon, IS ; Donahue, RN ; Bonneau, RH ; McLaughlin, PJ "B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: Implication for the treatment of autoimmune diseases." Immunobiology 216, 1-2 (2011): 173-83. [PubMed Link] | [ Full text ]
- Donahue, RN ; McLaughlin, PJ ; Zagon, IS "The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice." Gynecologic oncology 122, 2 (2011): 382-8. [PubMed Link] | [ Full text ]
- Solway, B ; Bose, SC ; Corder, G.; Donahue, RR ; Taylor, BK "Tonic inhibition of chronic pain by neuropeptide Y." Proceedings of the National Academy of Sciences of the United States of America 108, 17 (2011): 7224-9. [PubMed Link] | [ Full text ]
- Klocek, MS ; Sassani, JW ; Donahue, RN ; McLaughlin, PJ ; Zagon, IS "Regulation of Tenon's capsule fibroblast cell proliferation by the opioid growth factor and the opioid growth factor receptor axis." Investigative ophthalmology & visual science 51, 10 (2010): 5054-61. [PubMed Link] | [ Full text ]
- Avella, DM ; Kimchi, ET ; Donahue, RN ; Tagaram, HR ; McLaughlin, PJ ; Zagon, IS ; Staveley-O'Carroll, KF "The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer." American journal of physiology. Regulatory, integrative and comparative physiology 298, 2 (2010): R459-66. [PubMed Link] | [ Full text ]
- McLaughlin, PJ ; Zagon, IS ; Park, SS ; Conway, A ; Donahue, RN ; Goldenberg, D "Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis." BMC cancer 9, (2009): 369. [PubMed Link] | [ Full text ]
- Zagon, IS ; Donahue, RN ; McLaughlin, PJ "Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers." American journal of physiology. Regulatory, integrative and comparative physiology 297, 4 (2009): R1154-61. [PubMed Link] | [ Full text ]
- Donahue, RN ; McLaughlin, PJ ; Zagon, IS "Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis." American journal of physiology. Regulatory, integrative and comparative physiology 296, 6 (2009): R1716-25. [PubMed Link] | [ Full text ]
- HJ, 3rd Gould; Garrett, C ; Donahue, RR ; Paul, D.; Diamond, I ; Taylor, BK "Ranolazine attenuates behavioral signs of neuropathic pain." Behavioural pharmacology 20, 8 (2009): 755-8. [PubMed Link] | [ Full text ]
- Zagon, IS ; Donahue, RN ; Rogosnitzky, M ; McLaughlin, PJ "Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function." Experimental biology and medicine (Maywood, N.J.) 233, 8 (2008): 968-79. [PubMed Link] | [ Full text ]
- LaBuda, CJ ; Donahue, R.; Fuchs, PN "Enhanced formalin nociceptive responses following L5 nerve ligation in the rat reveals neuropathy-induced inflammatory hyperalgesia." Pain 94, 1 (2001): 59-63. [PubMed Link] | [ Full text ]