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Michael T. Piascik, Ph.D.
mtp's picture
  • Connect
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  • Education
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  • mtp@email.uky.edu
  • 859-323-5107
  • MS-320 Medical Ed Bldg, 800 Rose St, Lexington, KY 40536-0298
Position(s): 
Professor
Assistant Dean for Foundational Sciences
Affiliation(s): 
Pharmacology & Nutritional Sciences
Cardiovascular Research Center
Other Affiliation(s): 
CVRC - Affiliated Faculty
Pharmacology and Nutritional Sciences Primary Faculty
Interests / Specialties: 
Cardiovascular & Education
Bio / Education: 

1973 Hiram College,, B.A.
1978 The Ohio State University, College of Pharmacy, Ph.D. Pharmacology
1991 Visiting Scientist,Department of Molecular Cardiology,,The Cleveland Clinic Foundation Cleveland, Ohio.

Selected Publications: 

- Shrout, T.A., Rudy, D.W. and Piascik, M.T. ; Hypertension Update - JNC 8 and Beyond. Current Opinion in Pharmacology , edited by David A Taylor, Abdel A Abdel-Rahman, Robert J Theobald & Ethan J Anderson, 33: 41-46, 2017. Link

- Brody’s Human Pharmacology: Mechanism-Based Therapeutics, L. Wicker, R. Theobald, D. Taylor (Eds) , Chapters on Heart Failure and Antihypertipidemics. Sixth Edition, to be published in 2017

- Pharmacology and Therapeutics for Dentistry, Dowd, F., Johnson, B.S. and Mariotti, A.J. (Eds), Chapters 5, 8 and 9, the Autonomic Nervous System, Adrenergic Drugs and Adrenergic Blocking Drugs, Seventh Edition, 2016

- Swanson, H.I. and Piascik, M.T.: A Pilot Study on the use of Lecture Tools to Enhance the Teaching of Pharmacokinetics and Pharmacodynamics. The Journal of Medical and Education and Curricular Development: 2014:1, p. 23-28.

PubMed Publications: 
  • Shrout, T.;Rudy, D.W.;Piascik, M.T. "Hypertension update, JNC8 and beyond." Current opinion in pharmacology 33, (2017): 41-46. [PubMed Link] | [ Full text ]
  • Papay, R.S.;Shi, T.;Piascik, M.T.;Naga Prasad, S.V.;Perez, D.M. "α₁A-adrenergic receptors regulate cardiac hypertrophy in vivo through interleukin-6 secretion." Molecular pharmacology 83, 5 (2013): 939-48. [PubMed Link] | [ Full text ]
  • García-Cazarín, M.L.;Smith, J.L.;Clair, D.K.;Piascik, M.T. "The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism." Molecular pharmacology 74, 4 (2008): 1000-7. [PubMed Link] | [ Full text ]
  • García-Cazarín, M.L.;Smith, J.L.;Olszewski, K.A.;McCune, D.F.;Simmerman, L.A.;Hadley, R.W.;Kraner, S.D.;Piascik, M.T. "The alpha1D-adrenergic receptor is expressed intracellularly and coupled to increases in intracellular calcium and reactive oxygen species in human aortic smooth muscle cells." Journal of molecular signaling 3, (2008): 6. [PubMed Link] | [ Full text ]
  • Cole, M.P.;Chaiswing, L.;Oberley, T.D.;Edelmann, S.E.;Piascik, M.T.;Lin, S.M.;Kiningham, K.K.;St Clair, D.K. "The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity." Cardiovascular research 69, 1 (2006): 186-97. [PubMed Link] | [ Full text ]
  • Chalothorn, D.;McCune, D.F.;Edelmann, S.E.;Tobita, K.;Keller, B.B.;Lasley, R.D.;Perez, D.M.;Tanoue, A.;Tsujimoto, G.;Post, G.R.;Piascik, M.T. "Differential cardiovascular regulatory activities of the alpha 1B- and alpha 1D-adrenoceptor subtypes." The Journal of pharmacology and experimental therapeutics 305, 3 (2003): 1045-53. [PubMed Link] | [ Full text ]
  • Yun, J.;Zuscik, M.J.;Gonzalez-Cabrera, P.;McCune, D.F.;Ross, S.A.;Gaivin, R.;Piascik, M.T.;Perez, D.M. "Gene expression profiling of alpha(1b)-adrenergic receptor-induced cardiac hypertrophy by oligonucleotide arrays." Cardiovascular research 57, 2 (2003): 443-55. [PubMed Link] |
  • Ross, S.A.;Rorabaugh, B.R.;Chalothorn, D.;Yun, J.;Gonzalez-Cabrera, P.J.;McCune, D.F.;Piascik, M.T.;Perez, D.M. "The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model." Cardiovascular research 60, 3 (2003): 598-607. [PubMed Link] |
  • Chalothorn, D.;McCune, D.F.;Edelmann, S.E.;García-Cazarín, M.L.;Tsujimoto, G.;Piascik, M.T. "Differences in the cellular localization and agonist-mediated internalization properties of the alpha(1)-adrenoceptor subtypes." Molecular pharmacology 61, 5 (2002): 1008-16. [PubMed Link] | [ Full text ]
  • Waldrop, B.A.;Mastalerz, D.;Piascik, M.T.;Post, G.R. "alpha(1B)- and alpha(1D)-Adrenergic receptors exhibit different requirements for agonist and mitogen-activated protein kinase activation to regulate growth responses in rat 1 fibroblasts." The Journal of pharmacology and experimental therapeutics 300, 1 (2002): 83-90. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Perez, D.M. "Alpha1-adrenergic receptors: new insights and directions." The Journal of pharmacology and experimental therapeutics 298, 2 (2001): 403-10. [PubMed Link] | [ Full text ]
  • Zuscik, M.J.;Chalothorn, D.;Hellard, D.;Deighan, C.;McGee, A.;Daly, C.J.;Waugh, D.J.;Ross, S.A.;Gaivin, R.J.;Morehead, A.J.;Thomas, J.D.;Plow, E.F.;McGrath, J.C.;Piascik, M.T.;Perez, D.M. "Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptor." The Journal of biological chemistry 276, 17 (2001): 13738-43. [PubMed Link] | [ Full text ]
  • McCune, D.F.;Edelmann, S.E.;Olges, J.R.;Post, G.R.;Waldrop, B.A.;Waugh, D.J.;Perez, D.M.;Piascik, M.T. "Regulation of the cellular localization and signaling properties of the alpha(1B)- and alpha(1D)-adrenoceptors by agonists and inverse agonists." Molecular pharmacology 57, 4 (2000): 659-66. [PubMed Link] | [ Full text ]
  • Hrometz, S.L.;Edelmann, S.E.;McCune, D.F.;Olges, J.R.;Hadley, R.W.;Perez, D.M.;Piascik, M.T. "Expression of multiple alpha1-adrenoceptors on vascular smooth muscle: correlation with the regulation of contraction." The Journal of pharmacology and experimental therapeutics 290, 1 (1999): 452-63. [PubMed Link] | [ Full text ]
  • Zuscik, M.J.;Piascik, M.T.;Perez, D.M. "Cloning, cell-type specificity, and regulatory function of the mouse alpha(1B)-adrenergic receptor promoter." Molecular pharmacology 56, 6 (1999): 1288-97. [PubMed Link] | [ Full text ]
  • Porter, J.E.;Edelmann, S.E.;Waugh, D.J.;Piascik, M.T.;Perez, D.M. "The agonism and synergistic potentiation of weak partial agonists by triethylamine in alpha 1-adrenergic receptor activation: evidence for a salt bridge as the initiating process." Molecular pharmacology 53, 4 (1998): 766-71. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Hrometz, S.L.;Edelmann, S.E.;Guarino, R.D.;Hadley, R.W.;Brown, R.D. "Immunocytochemical localization of the alpha-1B adrenergic receptor and the contribution of this and the other subtypes to vascular smooth muscle contraction: analysis with selective ligands and antisense oligonucleotides." The Journal of pharmacology and experimental therapeutics 283, 2 (1997): 854-68. [PubMed Link] | [ Full text ]
  • Graham, R.M.;Perez, D.M.;Hwa, J.;Piascik, M.T. "alpha 1-adrenergic receptor subtypes. Molecular structure, function, and signaling." Circulation research 78, 5 (1996): 737-49. [PubMed Link] | [ Full text ]
  • MacMillan, L.B.;Hein, L.;Smith, M.S.;Piascik, M.T.;Limbird, L.E. "Central hypotensive effects of the alpha2a-adrenergic receptor subtype." Science (New York, N.Y.) 273, 5276 (1996): 801-3. [PubMed Link] | [ Full text ]
  • Guarino, R.D.;Perez, D.M.;Piascik, M.T. "Recent advances in the molecular pharmacology of the alpha 1-adrenergic receptors." Cellular signalling 8, 5 (1996): 323-33. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Soltis, E.E.;Piascik, M.M.;MacMillan, L.B. "Alpha-adrenoceptors and vascular regulation: molecular, pharmacologic and clinical correlates." Pharmacology & therapeutics 72, 3 (1996): 215-41. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Guarino, R.D.;Smith, M.S.;Soltis, E.E.;Saussy DL, J.;Perez, D.M. "The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle." The Journal of pharmacology and experimental therapeutics 275, 3 (1995): 1583-9. [PubMed Link] | [ Full text ]
  • Perez, D.M.;Piascik, M.T.;Malik, N.;Gaivin, R.;Graham, R.M. "Cloning, expression, and tissue distribution of the rat homolog of the bovine alpha 1C-adrenergic receptor provide evidence for its classification as the alpha 1A subtype." Molecular pharmacology 46, 5 (1994): 823-31. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Smith, M.S.;Soltis, E.E.;Perez, D.M. "Identification of the mRNA for the novel alpha 1D-adrenoceptor and two other alpha 1-adrenoceptors in vascular smooth muscle." Molecular pharmacology 46, 1 (1994): 30-40. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Smith, M.S.;Barron, K.W.;Soltis, E.E. "The regulation of regional hemodynamics by alpha-1 adrenoceptor subtypes in the conscious rat." The Journal of pharmacology and experimental therapeutics 267, 3 (1993): 1250-5. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Sparks, M.S.;Pruitt, T.A. "Effect of chlorethylclonidine on arterial blood pressure and heart rate in the conscious rat." The Journal of pharmacology and experimental therapeutics 262, 3 (1992): 901-6. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Sparks, M.S.;Pruitt, T.A.;Soltis, E.E. "Evidence for a complex interaction between the subtypes of the alpha 1-adrenoceptor." European journal of pharmacology 199, 3 (1991): 279-89. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Sparks, M.S.;Pruitt, T.A. "Interaction of imidazolines with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes." The Journal of pharmacology and experimental therapeutics 258, 1 (1991): 158-65. [PubMed Link] | [ Full text ]
  • Perez, D.M.;Piascik, M.T.;Graham, R.M. "Solution-phase library screening for the identification of rare clones: isolation of an alpha 1D-adrenergic receptor cDNA." Molecular pharmacology 40, 6 (1991): 876-83. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Kusiak, J.W.;Barron, K.W. "Alpha 1-adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat." European journal of pharmacology 186, 2-3 (1990): 273-8. [PubMed Link] |
  • Piascik, M.T.;Butler, B.T.;Pruitt, T.A.;Kusiak, J.W. "Agonist interaction with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes." The Journal of pharmacology and experimental therapeutics 254, 3 (1990): 982-91. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Butler, B.T.;Pruitt, T.A. "The role of alpha 1-adrenoceptor subtypes in the regulation of arterial blood pressure." European journal of pharmacology 180, 2-3 (1990): 381-6. [PubMed Link] |
  • Piascik, M.T.;Collins, R.;Butler, B.T. "Stereoselective and nonstereoselective inhibition exhibited by the enantiomers of verapamil." Canadian journal of physiology and pharmacology 68, 3 (1990): 439-46. [PubMed Link] |
  • Piascik, M.T.;Butler, B.T.;Kusiak, J.W.;Pitha, J.;Holtman JR, J. "Effect of an alkylating analog of prazosin on alpha-1 adrenoceptor subtypes and arterial blood pressure." The Journal of pharmacology and experimental therapeutics 251, 3 (1989): 878-83. [PubMed Link] | [ Full text ]
  • Kusiak, J.W.;Pitha, J.;Piascik, M.T. "Interaction of a chemically reactive prazosin analog with alpha-1 adrenoceptors of rat tissues." The Journal of pharmacology and experimental therapeutics 249, 1 (1989): 70-7. [PubMed Link] | [ Full text ]
  • Babich, M.;Butler, B.T.;Piascik, M.T. "Effects of calcium channel activators on the response of rabbit aortic rings to alpha 1-receptor agonists: evidence for two modes of action." Pharmacology 39, 3 (1989): 176-84. [PubMed Link] |
  • Piascik, M.T.;Kusiak, J.W.;Pitha, J.;Butler, B.T.;Le, H.T.;Babich, M. "Alkylation of alpha-1 receptors with a chemically reactive analog of prazosin reveals low affinity sites for norepinephrine in rabbit aorta." The Journal of pharmacology and experimental therapeutics 246, 3 (1988): 1001-11. [PubMed Link] | [ Full text ]
  • Babich, M.;Pedigo, N.W.;Butler, B.T.;Piascik, M.T. "Heterogeneity of alpha 1 receptors associated with vascular smooth muscle: evidence from functional and ligand binding studies." Life sciences 41, 6 (1987): 663-73. [PubMed Link] |
  • Hamann, S.R.;Piascik, M.T.;McAllister RG, J. "Aspects of the clinical pharmacology of nifedipine, a dihydropyridine calcium-entry antagonist." Biopharmaceutics & drug disposition 7, 1 (1986): 1-10. [PubMed Link] |
  • Piascik, M.T.;Babich, M. "The facilitative actions of Bay K 8644 on norepinephrine and KCl-induced contractures of rabbit aortic rings." Life sciences 38, 8 (1986): 725-34. [PubMed Link] |
  • Piascik, M.T.;Babich, M.;Jacobson, K.L.;Watson, E.L. "Calmodulin activation and calcium regulation of parotid gland adenylate cyclase." The American journal of physiology 250, 4 Pt 1 (1986): C642-5. [PubMed Link] | [ Full text ]
  • Martin, C.A.;Piascik, M.T. "First degree A-V block in patients on lithium carbonate." Canadian journal of psychiatry. Revue canadienne de psychiatrie 30, 2 (1985): 114-6. [PubMed Link] |
  • Babich, M.;Atkinson, J.;Piascik, M.T. "The effects of trimetoquinol on the intact rabbit heart and myocardial adenylate cyclase activity: evidence for spare myocardial beta receptors." Journal of molecular and cellular cardiology 17, 6 (1985): 565-74. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;McNicholas, L.F. "Effect of pentobarbital dependence on adenylate cyclase activity and calmodulin levels in rat cerebral cortex." Life sciences 37, 1 (1985): 55-62. [PubMed Link] |
  • Piascik, M.T.;Champney, R.B.;Kasarskis, E.J.;Forrester, T. "A method for enriching the cadmium content of cigarette smoke and effect of exposure to this smoke on coronary vascular reactivity in the rat." Toxicology and applied pharmacology 81, 3 Pt 1 (1985): 525-32. [PubMed Link] |
  • Piascik, M.T.;Addison, B.;Babich, M. "Ca2+-dependent inhibition of smooth muscle adenylate cyclase activity." Archives of biochemistry and biophysics 241, 1 (1985): 28-35. [PubMed Link] | [ Full text ]
  • Babich, M.;Hamann, S.R.;McAllister RG, J.;Pratap Reddy, C.;Piascik, M.T. "Effects of verapamil on the arrhythmogenic action of acetylstrophanthidin." Pharmacology 29, 4 (1984): 224-32. [PubMed Link] |
  • Piascik, M.T.;Babich, M.;Rush, M.E. "Calmodulin stimulation and calcium regulation of smooth muscle adenylate cyclase activity." The Journal of biological chemistry 258, 18 (1983): 10913-8. [PubMed Link] | [ Full text ]
  • McAllister RG, J.;Hamann, S.R.;Piascik, M.T. "Aspects of the clinical pharmacology of verapamil, a calcium-entry antagonist." Biopharmaceutics & drug disposition 4, 3 (1983): 203-11. [PubMed Link] |
  • Piascik, M.T.;Piascik, M.F.;Hitzemann, R.J.;Potter, J.D. "Ca2+-dependent regulation of rat caudate nucleus adenylate cyclase and effects on the response to dopamine." Molecular pharmacology 20, 2 (1981): 319-25. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Wisler, P.L.;Johnson, C.L.;Potter, J.D. "Ca2+-dependent regulation of guinea pig brain adenylate cyclase." The Journal of biological chemistry 255, 9 (1980): 4176-81. [PubMed Link] | [ Full text ]
  • Kranias, E.G.;Bilezikjian, L.M.;Potter, J.D.;Piascik, M.T.;Schwartz, A. "The role of calmodulin in regulation of cardiac sarcoplasmic reticulum phosphorylation." Annals of the New York Academy of Sciences 356, (1980): 279-91. [PubMed Link] | [ Full text ]
  • Potter, J.D.;Piascik, M.T.;Wisler, P.L.;Robertson, S.P.;Johnson, C.L. "Calcium dependent regulation of brain and cardiac muscle adenylate cyclase." Annals of the New York Academy of Sciences 356, (1980): 220-31. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Piascik, M.F.;Miller, D.D.;Feller, D.R. "1-substituted tetrahydroisoquinoline analogs: beta adrenoceptor blocking agents in the isolated perfused rabbit heart." Life sciences 24, 26 (1979): 2433-9. [PubMed Link] |
  • Piascik, M.T.;Osei-Gyimah, P.;Miller, D.D.;Feller, D.R. "beta-Adrenoceptor blocking activity of 1-substituted trimetoquinol analogs." Biochemical pharmacology 28, 11 (1979): 1807-10. [PubMed Link] | [ Full text ]
  • Osei-Gyimah, P.;Piascik, M.T.;Fowble, J.W.;Feller, D.R.;Miller, D.D. "Synthesis and beta-adrenoceptor activity of the erythro and threo isomers of substituted alpha-hydroxytrimetoquinol." Journal of medicinal chemistry 21, 11 (1978): 1173-8. [PubMed Link] |
  • Piascik, M.T.;Osei-Gyimah, P.;Miller, D.D.;Feller, D.R. "Stereoselective interaction of tetrahydroisoquinolines in beta-adrenoceptor systems." European journal of pharmacology 48, 4 (1978): 393-401. [PubMed Link] |
  • Piascik, M.T.;Miller, D.D.;Feller, D.R. "Phosphodiesterase inhibition and lipolytic action of the stereoisomers of trimetoquinol." Research communications in chemical pathology and pharmacology 13, 2 (1976): 203-15. [PubMed Link] |
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