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Michael Piascik, PhD
mtp's picture
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mtp@email.uky.edu
(859) 323-5107
MS-320 Medical Ed Bldg, 800 Rose St, Lexington, KY 40536-0298
Position(s): 
Professor
Assistant Dean for Foundational Sciences
Affiliation(s): 
Pharmacology & Nutritional Sciences
Cardiovascular Research Center
Medical Student Education
Lexington Campus
Other Affiliation(s): 
CVRC - Affiliated Faculty
Pharmacology and Nutritional Sciences Primary Faculty
Interests / Specialties: 
Cardiovascular & Education
Bio / Education: 

1973 Hiram College,, B.A.
1978 The Ohio State University, College of Pharmacy, Ph.D. Pharmacology
1991 Visiting Scientist,Department of Molecular Cardiology,,The Cleveland Clinic Foundation Cleveland, Ohio.

Selected Publications: 

- Shrout, T.A., Rudy, D.W. and Piascik, M.T. ; Hypertension Update - JNC 8 and Beyond. Current Opinion in Pharmacology , edited by David A Taylor, Abdel A Abdel-Rahman, Robert J Theobald & Ethan J Anderson, 33: 41-46, 2017. Link

- Brody’s Human Pharmacology: Mechanism-Based Therapeutics, L. Wicker, R. Theobald, D. Taylor (Eds) , Chapters on Heart Failure and Antihypertipidemics. Sixth Edition, to be published in 2017

- Pharmacology and Therapeutics for Dentistry, Dowd, F., Johnson, B.S. and Mariotti, A.J. (Eds), Chapters 5, 8 and 9, the Autonomic Nervous System, Adrenergic Drugs and Adrenergic Blocking Drugs, Seventh Edition, 2016

- Swanson, H.I. and Piascik, M.T.: A Pilot Study on the use of Lecture Tools to Enhance the Teaching of Pharmacokinetics and Pharmacodynamics. The Journal of Medical and Education and Curricular Development: 2014:1, p. 23-28.

PubMed Publications: 
  • Shrout, T.; Rudy, DW ; Piascik, MT "Hypertension update, JNC8 and beyond." Current opinion in pharmacology 33, (2017): 41-46. [PubMed Link] | [ Full text ]
  • Papay, RS ; Shi, T.; Piascik, MT ; Naga Prasad, SV ; Perez, DM "α₁A-adrenergic receptors regulate cardiac hypertrophy in vivo through interleukin-6 secretion." Molecular pharmacology 83, 5 (2013): 939-48. [PubMed Link] | [ Full text ]
  • Garcia-Cazarin, ML ; Smith, JL ; Clair, DK ; Piascik, MT "The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism." Molecular pharmacology 74, 4 (2008): 1000-7. [PubMed Link] | [ Full text ]
  • Garcia-Cazarin, ML ; Smith, JL ; Olszewski, KA ; McCune, DF ; Simmerman, LA ; Hadley, RW ; Kraner, SD ; Piascik, MT "The alpha1D-adrenergic receptor is expressed intracellularly and coupled to increases in intracellular calcium and reactive oxygen species in human aortic smooth muscle cells." Journal of molecular signaling 3, (2008): 6. [PubMed Link] | [ Full text ]
  • Cole, MP ; Chaiswing, L.; Oberley, TD ; Edelmann, SE ; Piascik, MT ; Lin, SM ; Kiningham, KK ; St Clair, DK "The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity." Cardiovascular research 69, 1 (2006): 186-97. [PubMed Link] | [ Full text ]
  • Chalothorn, D.; McCune, DF ; Edelmann, SE ; Tobita, K.; Keller, BB ; Lasley, RD ; Perez, DM ; Tanoue, A.; Tsujimoto, G.; Post, GR ; Piascik, MT "Differential cardiovascular regulatory activities of the alpha 1B- and alpha 1D-adrenoceptor subtypes." The Journal of pharmacology and experimental therapeutics 305, 3 (2003): 1045-53. [PubMed Link] | [ Full text ]
  • Yun, J.; Zuscik, MJ ; Gonzalez-Cabrera, P.; McCune, DF ; Ross, SA ; Gaivin, R.; Piascik, MT ; Perez, DM "Gene expression profiling of alpha(1b)-adrenergic receptor-induced cardiac hypertrophy by oligonucleotide arrays." Cardiovascular research 57, 2 (2003): 443-55. [PubMed Link] | [ Full text ]
  • Ross, SA ; Rorabaugh, BR ; Chalothorn, D.; Yun, J.; Gonzalez-Cabrera, PJ ; McCune, DF ; Piascik, MT ; Perez, DM "The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model." Cardiovascular research 60, 3 (2003): 598-607. [PubMed Link] | [ Full text ]
  • Chalothorn, D.; McCune, DF ; Edelmann, SE ; Garcia-Cazarin, ML ; Tsujimoto, G.; Piascik, MT "Differences in the cellular localization and agonist-mediated internalization properties of the alpha(1)-adrenoceptor subtypes." Molecular pharmacology 61, 5 (2002): 1008-16. [PubMed Link] | [ Full text ]
  • Waldrop, BA ; Mastalerz, D.; Piascik, MT ; Post, GR "alpha(1B)- and alpha(1D)-Adrenergic receptors exhibit different requirements for agonist and mitogen-activated protein kinase activation to regulate growth responses in rat 1 fibroblasts." The Journal of pharmacology and experimental therapeutics 300, 1 (2002): 83-90. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Perez, DM "Alpha1-adrenergic receptors: new insights and directions." The Journal of pharmacology and experimental therapeutics 298, 2 (2001): 403-10. [PubMed Link] | [ Full text ]
  • Zuscik, MJ ; Chalothorn, D.; Hellard, D.; Deighan, C.; McGee, A.; Daly, CJ ; Waugh, DJ ; Ross, SA ; Gaivin, RJ ; Morehead, AJ ; Thomas, JD ; Plow, EF ; McGrath, JC ; Piascik, MT ; Perez, DM "Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptor." The Journal of biological chemistry 276, 17 (2001): 13738-43. [PubMed Link] | [ Full text ]
  • McCune, DF ; Edelmann, SE ; Olges, JR ; Post, GR ; Waldrop, BA ; Waugh, DJ ; Perez, DM ; Piascik, MT "Regulation of the cellular localization and signaling properties of the alpha(1B)- and alpha(1D)-adrenoceptors by agonists and inverse agonists." Molecular pharmacology 57, 4 (2000): 659-66. [PubMed Link] | [ Full text ]
  • Hrometz, SL ; Edelmann, SE ; McCune, DF ; Olges, JR ; Hadley, RW ; Perez, DM ; Piascik, MT "Expression of multiple alpha1-adrenoceptors on vascular smooth muscle: correlation with the regulation of contraction." The Journal of pharmacology and experimental therapeutics 290, 1 (1999): 452-63. [PubMed Link] | [ Full text ]
  • Zuscik, MJ ; Piascik, MT ; Perez, DM "Cloning, cell-type specificity, and regulatory function of the mouse alpha(1B)-adrenergic receptor promoter." Molecular pharmacology 56, 6 (1999): 1288-97. [PubMed Link] | [ Full text ]
  • Porter, JE ; Edelmann, SE ; Waugh, DJ ; Piascik, MT ; Perez, DM "The agonism and synergistic potentiation of weak partial agonists by triethylamine in alpha 1-adrenergic receptor activation: evidence for a salt bridge as the initiating process." Molecular pharmacology 53, 4 (1998): 766-71. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Hrometz, SL ; Edelmann, SE ; Guarino, RD ; Hadley, RW ; Brown, RD "Immunocytochemical localization of the alpha-1B adrenergic receptor and the contribution of this and the other subtypes to vascular smooth muscle contraction: analysis with selective ligands and antisense oligonucleotides." The Journal of pharmacology and experimental therapeutics 283, 2 (1997): 854-68. [PubMed Link] | [ Full text ]
  • Graham, RM ; Perez, DM ; Hwa, J.; Piascik, MT "alpha 1-adrenergic receptor subtypes. Molecular structure, function, and signaling." Circulation research 78, 5 (1996): 737-49. [PubMed Link] | [ Full text ]
  • MacMillan, LB ; Hein, L.; Smith, MS ; Piascik, MT ; Limbird, LE "Central hypotensive effects of the alpha2a-adrenergic receptor subtype." Science (New York, N.Y.) 273, 5276 (1996): 801-3. [PubMed Link] | [ Full text ]
  • Guarino, RD ; Perez, DM ; Piascik, MT "Recent advances in the molecular pharmacology of the alpha 1-adrenergic receptors." Cellular signalling 8, 5 (1996): 323-33. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Soltis, EE ; Piascik, MM ; MacMillan, LB "Alpha-adrenoceptors and vascular regulation: molecular, pharmacologic and clinical correlates." Pharmacology & therapeutics 72, 3 (1996): 215-41. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Guarino, RD ; Smith, MS ; Soltis, EE ; Saussy DL, Jr ; Perez, DM "The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle." The Journal of pharmacology and experimental therapeutics 275, 3 (1995): 1583-9. [PubMed Link] | [ Full text ]
  • Perez, DM ; Piascik, MT ; Malik, N.; Gaivin, R.; Graham, RM "Cloning, expression, and tissue distribution of the rat homolog of the bovine alpha 1C-adrenergic receptor provide evidence for its classification as the alpha 1A subtype." Molecular pharmacology 46, 5 (1994): 823-31. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Smith, MS ; Soltis, EE ; Perez, DM "Identification of the mRNA for the novel alpha 1D-adrenoceptor and two other alpha 1-adrenoceptors in vascular smooth muscle." Molecular pharmacology 46, 1 (1994): 30-40. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Smith, MS ; Barron, KW ; Soltis, EE "The regulation of regional hemodynamics by alpha-1 adrenoceptor subtypes in the conscious rat." The Journal of pharmacology and experimental therapeutics 267, 3 (1993): 1250-5. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Sparks, MS ; Pruitt, TA "Effect of chlorethylclonidine on arterial blood pressure and heart rate in the conscious rat." The Journal of pharmacology and experimental therapeutics 262, 3 (1992): 901-6. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Sparks, MS ; Pruitt, TA ; Soltis, EE "Evidence for a complex interaction between the subtypes of the alpha 1-adrenoceptor." European journal of pharmacology 199, 3 (1991): 279-89. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Sparks, MS ; Pruitt, TA "Interaction of imidazolines with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes." The Journal of pharmacology and experimental therapeutics 258, 1 (1991): 158-65. [PubMed Link] | [ Full text ]
  • Perez, DM ; Piascik, MT ; Graham, RM "Solution-phase library screening for the identification of rare clones: isolation of an alpha 1D-adrenergic receptor cDNA." Molecular pharmacology 40, 6 (1991): 876-83. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Kusiak, JW ; Barron, KW "Alpha 1-adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat." European journal of pharmacology 186, 2-3 (1990): 273-8. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Butler, BT ; Pruitt, TA ; Kusiak, JW "Agonist interaction with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes." The Journal of pharmacology and experimental therapeutics 254, 3 (1990): 982-91. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Butler, BT ; Pruitt, TA "The role of alpha 1-adrenoceptor subtypes in the regulation of arterial blood pressure." European journal of pharmacology 180, 2-3 (1990): 381-6. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Collins, R.; Butler, BT "Stereoselective and nonstereoselective inhibition exhibited by the enantiomers of verapamil." Canadian journal of physiology and pharmacology 68, 3 (1990): 439-46. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Butler, BT ; Kusiak, JW ; Pitha, J.; Holtman JR, Jr "Effect of an alkylating analog of prazosin on alpha-1 adrenoceptor subtypes and arterial blood pressure." The Journal of pharmacology and experimental therapeutics 251, 3 (1989): 878-83. [PubMed Link] | [ Full text ]
  • Kusiak, JW ; Pitha, J.; Piascik, MT "Interaction of a chemically reactive prazosin analog with alpha-1 adrenoceptors of rat tissues." The Journal of pharmacology and experimental therapeutics 249, 1 (1989): 70-7. [PubMed Link] | [ Full text ]
  • Babich, M.; Butler, BT ; Piascik, MT "Effects of calcium channel activators on the response of rabbit aortic rings to alpha 1-receptor agonists: evidence for two modes of action." Pharmacology 39, 3 (1989): 176-84. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Kusiak, JW ; Pitha, J.; Butler, BT ; Le, HT ; Babich, M. "Alkylation of alpha-1 receptors with a chemically reactive analog of prazosin reveals low affinity sites for norepinephrine in rabbit aorta." The Journal of pharmacology and experimental therapeutics 246, 3 (1988): 1001-11. [PubMed Link] | [ Full text ]
  • Babich, M.; Pedigo, NW ; Butler, BT ; Piascik, MT "Heterogeneity of alpha 1 receptors associated with vascular smooth muscle: evidence from functional and ligand binding studies." Life sciences 41, 6 (1987): 663-73. [PubMed Link] | [ Full text ]
  • Hamann, SR ; Piascik, MT ; McAllister RG, Jr "Aspects of the clinical pharmacology of nifedipine, a dihydropyridine calcium-entry antagonist." Biopharmaceutics & drug disposition 7, 1 (1986): 1-10. [PubMed Link] |
  • Piascik, MT ; Babich, M. "The facilitative actions of Bay K 8644 on norepinephrine and KCl-induced contractures of rabbit aortic rings." Life sciences 38, 8 (1986): 725-34. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Babich, M.; Jacobson, KL ; Watson, EL "Calmodulin activation and calcium regulation of parotid gland adenylate cyclase." The American journal of physiology 250, 4 Pt 1 (1986): C642-5. [PubMed Link] | [ Full text ]
  • Martin, CA ; Piascik, MT "First degree A-V block in patients on lithium carbonate." Canadian journal of psychiatry. Revue canadienne de psychiatrie 30, 2 (1985): 114-6. [PubMed Link] | [ Full text ]
  • Babich, M.; Atkinson, J.; Piascik, MT "The effects of trimetoquinol on the intact rabbit heart and myocardial adenylate cyclase activity: evidence for spare myocardial beta receptors." Journal of molecular and cellular cardiology 17, 6 (1985): 565-74. [PubMed Link] | [ Full text ]
  • Piascik, MT ; McNicholas, LF "Effect of pentobarbital dependence on adenylate cyclase activity and calmodulin levels in rat cerebral cortex." Life sciences 37, 1 (1985): 55-62. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Champney, RB ; Kasarskis, EJ ; Forrester, T. "A method for enriching the cadmium content of cigarette smoke and effect of exposure to this smoke on coronary vascular reactivity in the rat." Toxicology and applied pharmacology 81, 3 Pt 1 (1985): 525-32. [PubMed Link] |
  • Piascik, MT ; Addison, B.; Babich, M. "Ca2+-dependent inhibition of smooth muscle adenylate cyclase activity." Archives of biochemistry and biophysics 241, 1 (1985): 28-35. [PubMed Link] | [ Full text ]
  • Babich, M.; Hamann, SR ; McAllister RG, Jr ; Pratap Reddy, C.; Piascik, MT "Effects of verapamil on the arrhythmogenic action of acetylstrophanthidin." Pharmacology 29, 4 (1984): 224-32. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Babich, M.; Rush, ME "Calmodulin stimulation and calcium regulation of smooth muscle adenylate cyclase activity." The Journal of biological chemistry 258, 18 (1983): 10913-8. [PubMed Link] | [ Full text ]
  • McAllister RG, Jr ; Hamann, SR ; Piascik, MT "Aspects of the clinical pharmacology of verapamil, a calcium-entry antagonist." Biopharmaceutics & drug disposition 4, 3 (1983): 203-11. [PubMed Link] |
  • Piascik, MT ; Piascik, MF ; Hitzemann, RJ ; Potter, JD "Ca2+-dependent regulation of rat caudate nucleus adenylate cyclase and effects on the response to dopamine." Molecular pharmacology 20, 2 (1981): 319-25. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Wisler, PL ; Johnson, CL ; Potter, JD "Ca2+-dependent regulation of guinea pig brain adenylate cyclase." The Journal of biological chemistry 255, 9 (1980): 4176-81. [PubMed Link] | [ Full text ]
  • Kranias, EG ; Bilezikjian, LM ; Potter, JD ; Piascik, MT ; Schwartz, A. "The role of calmodulin in regulation of cardiac sarcoplasmic reticulum phosphorylation." Annals of the New York Academy of Sciences 356, (1980): 279-91. [PubMed Link] | [ Full text ]
  • Potter, JD ; Piascik, MT ; Wisler, PL ; Robertson, SP ; Johnson, CL "Calcium dependent regulation of brain and cardiac muscle adenylate cyclase." Annals of the New York Academy of Sciences 356, (1980): 220-31. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Piascik, MF ; Miller, DD ; Feller, DR "1-substituted tetrahydroisoquinoline analogs: beta adrenoceptor blocking agents in the isolated perfused rabbit heart." Life sciences 24, 26 (1979): 2433-9. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Osei-Gyimah, P.; Miller, DD ; Feller, DR "beta-Adrenoceptor blocking activity of 1-substituted trimetoquinol analogs." Biochemical pharmacology 28, 11 (1979): 1807-10. [PubMed Link] | [ Full text ]
  • Osei-Gyimah, P.; Piascik, MT ; Fowble, JW ; Feller, DR ; Miller, DD "Synthesis and beta-adrenoceptor activity of the erythro and threo isomers of substituted alpha-hydroxytrimetoquinol." Journal of medicinal chemistry 21, 11 (1978): 1173-8. [PubMed Link] |
  • Piascik, MT ; Osei-Gyimah, P.; Miller, DD ; Feller, DR "Stereoselective interaction of tetrahydroisoquinolines in beta-adrenoceptor systems." European journal of pharmacology 48, 4 (1978): 393-401. [PubMed Link] | [ Full text ]
  • Piascik, MT ; Miller, DD ; Feller, DR "Phosphodiesterase inhibition and lipolytic action of the stereoisomers of trimetoquinol." Research communications in chemical pathology and pharmacology 13, 2 (1976): 203-15. [PubMed Link] |
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