Robert A. Lodder, Ph.D. | Saha Cardiovascular Research Center

Robert A. Lodder, Ph.D.

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lodder@uky.edu
(859) 257-9232
A123 ASTeCC Bldg, 145 Graham Ave, Lexington, KY 40506-0286
Lodder CV

Position(s):

Pharmaceutical Sciences

Other Affiliation(s):

CVRC - Affiliated Faculty

Nutritional Sciences Graduate Faculty

Bio / Education:

Dr. Lodder received his B.S. degree in Natural Science, along with a M.S. in Chemistry, from Xavier University in 1981 and 1983. He received his Ph.D. in Analytical Chemistry in 1988 after working with Professor Gary M. Hieftje at Indiana University. Dr. Lodder holds joint appointments as a professor in the Department of Electrical and Computer Engineering, and the Division of Analytical Chemistry of the Department of Chemistry at Kentucky. He serves on the board of directors of Spherix (Nasdaq: SPEX), as editor in chief of the astroanalytical chemistry and astrobiology journal Contact in Context, and as a member of the U.S. Food and Drug Administration Advisory Committee on Pharmaceutical Science, Process Analytical Technologies subcommittee.

Dr. Lodder is a first-prize winner in the 1990 international IBM Supercomputing Competition, as well as a winner of a National Science Foundation Young Investigator Award, the American Society of Agricultural Engineers Paper Award, a Buchi NIR Award, the Tomas Hirschfeld Award in Near-IR Spectroscopy (PittCon), a Research and Development 100 Award, and the Orville N. Green Service Award (SETICon).

Grants:

Refer to CV for previously funded grants.

Active Grants:
1. TITLE: Development of food model systems and application of QuEChERS technologies for detection of chemical and biological threats to the food supply
P.I.:, Robert Lodder
AGENCY: Homeland Security
PERIOD: 12/1/2011-11/30/2014
AMOUNT: $2,970,758

News:

“Do it yourself diagnosis” by Darla Carter, Louisville Courier-Journal, Thursday, Aug. 28, 2003

Testing at Home, by Shannon Brownlee and Monika Guttman, Marie Claire, March 2003

“Team from UK tuned in to the stars for answer” by Jim Warren, Lexington Herald-Leader, Oct. 10, 2000, p. 1, vol. 18, no. 281

“The Search for Intelligent Life” by Ashley York, Kentucky Kernel, June 22, 2000, vol. 105, no. 152, p1.

An Arterial View of Atherosclerosis, ACCESS, vol. 12, no. 2, pp. 18-21, 1999.
HMS Beagle Web Pick Award, BiomedNet, 1998

U.S. News and World Report, The Valley of Death: Researchers Probe a Mysterious Plague of Heart Disease, December 21, 1998.

Ch. 27 and Ch. 18 news, Nov. 8, 1998. Coverage of the paper Characterization of the Composition and Vulnerability of Atherosclerotic Plaques by Near-Infrared Spectroscopy, at the American Heart Association National Meeting in Dallas. Also in the Lexington Herald-Leader, Nov. 9, 1998.

Kentucky Kernel, UK Doctors Release New Device, Nov. 10, 1998, page 1.

Kentucky Sunrise morning news, WLEX-TV, Channel 18, 6-7 AM, August 17, 1998.

Blood analysis: Noninvasive methods hover on the horizon, Biophotonics International, May/June 1998, pp. 48-52.

The Test Market, Lexington Herald-Leader, March 17, 1998, p. 8-9

U.K. Researchers surging ahead with high-speed computer networks. Odyssey, Spring 1998, pp. 12-16.

Ch. 27 and Ch. 18 news, Nov. 8, 1998. Coverage of the paper Characterization of the Composition and Vulnerability of Atherosclerotic Plaques by Near-Infrared Spectroscopy@, at the American Heart Association National Meeting in Dallas. Also in the Lexington Herald-Leader, Nov. 9, 1998.

Kentucky Kernel, UK Doctors Release New Device, Nov. 10, 1998, page 1.

Kentucky Sunrise morning news, WLEX-TV, Channel 18, 6-7 AM, August 17, 1998.

Blood analysis: Noninvasive methods hover on the horizon, Biophotonics International, May/June 1998, pp. 48-52.

The Test Market, Lexington Herald-Leader, March 17, 1998, p. 8-9

U.K. Researchers surging ahead with high-speed computer networks. Odyssey, Spring 1998, pp. 12-16.

Chemical and Engineering News, Pittsburgh Conference Instrumentation 1995 issue, March 1995, article on vibrational imaging.

“Analyzing on the Internet”, Analytical Chemistry, 67, Apr. 1, 1995, p. 255A. Our WWW server is listed among analytical resources on the net.

“A Zoom with a View”, NCRR Reporter, NIH, vol. 19, no. 2, pp.12-13. Article on near-IR laser and human carotid plaques.

PubMed Publications:

Ensor, M.;Banfield, A.B.;Smith, R.R.;Williams, J.;Lodder, R.A. "Safety and Efficacy of D-Tagatose in Glycemic Control in Subjects with Type 2 Diabetes." Journal of endocrinology, diabetes & obesity 3, 1 (2015): [PubMed Link] |
Williams, J.;Ensor, C.;Gardner, S.;Smith, R.;Lodder, R. "BSN723T Prevents Atherosclerosis and Weight Gain in ApoE Knockout Mice Fed a Western Diet." WebmedCentral 6, 12 (2015): [PubMed Link] |
Ensor, M.;Williams, J.;Smith, R.;Banfield, A.;Lodder, R.A. "Effects of Three Low-Doses of D-Tagatose on Glycemic Control Over Six Months in Subjects with Mild Type 2 Diabetes Mellitus Under Control with Diet and Exercise." Journal of endocrinology, diabetes & obesity 2, 4 (2014): 1057. [PubMed Link] |
Metts, B.;Thatcher, S.;Lewis, E.;Karounos, M.;Cassis, L.;Smith, R.;Lodder, R.A. "DDDAS Design of Drug Interventions for the Treatment of Dyslipidemia in ApoE<sup>-/-</sup> Mice." Journal of developing drugs 2, 2 (2013): [PubMed Link] |
Williams, J.;Spitnale, M.;Lodder, R. "The Effect of D-Tagatose on Fructose Absorption in a Rat Model." Journal of developing drugs 2, (2013): [PubMed Link] |
Wetzel, D.L.;Wetzel, L.H.;Wetzel, M.D.;Lodder, R.A. "Imminent cardiac risk assessment via optical intravascular biochemical analysis." The Analyst 134, 6 (2009): 1099-106. [PubMed Link] | [ Full text ]
Police, S.B.;Harris, J.C.;Lodder, R.A.;Cassis, L.A. "Effect of diets containing sucrose vs. D-tagatose in hypercholesterolemic mice." Obesity (Silver Spring, Md.) 17, 2 (2009): 269-75. [PubMed Link] | [ Full text ]
Medendorp, J.P.;Paudel, K.S.;Lodder, R.A.;Stinchcomb, A.L. "Near infrared spectrometry for the quantification of human dermal absorption of econazole nitrate and estradiol." Pharmaceutical research 24, 1 (2007): 186-93. [PubMed Link] | [ Full text ]
Dai, B.;Urbas, A.;Douglas, C.C.;Lodder, R.A. "Molecular factor computing for predictive spectroscopy." Pharmaceutical research 24, 8 (2007): 1441-9. [PubMed Link] | [ Full text ]
Medendorp, J.;Buice, R.G.;Lodder, R.A. "Acoustic-resonance spectrometry as a process analytical technology for the quantification of active pharmaceutical ingredient in semi-solids." AAPS PharmSciTech 7, 3 (2006): E22-E29. [PubMed Link] |
Medendorp, J.;Lodder, R.A. "Acoustic-resonance spectrometry as a process analytical technology for rapid and accurate tablet identification." AAPS PharmSciTech 7, 1 (2006): E25. [PubMed Link] |
Medendorp, J.;Lodder, R.A. "Acoustic-resonance spectrometry as a process analytical technology for rapid and accurate tablet identification." AAPS PharmSciTech 7, 1 (2006): E175-E183. [PubMed Link] |
Medendorp, J.;Buice RG, J.;Lodder, R.A. "Acoustic-resonance spectrometry as a process analytical technology for the quantification of active pharmaceutical ingredient in semi-solids." AAPS PharmSciTech 7, 3 (2006): 59. [PubMed Link] |
Medendorp, J.;Yedluri, J.;Hammell, D.C.;Ji, T.;Lodder, R.A.;Stinchcomb, A.L. "Near-infrared spectrometry for the quantification of dermal absorption of econazole nitrate and 4-cyanophenol." Pharmaceutical research 23, 4 (2006): 835-43. [PubMed Link] | [ Full text ]
Cassis, L.A.;Urbas, A.;Lodder, R.A. "Hyperspectral integrated computational imaging." Analytical and bioanalytical chemistry 382, 4 (2005): 868-72. [PubMed Link] | [ Full text ]
Fountain, W.;Dumstorf, K.;Lowell, A.E.;Lodder, R.A.;Mumper, R.J. "Near-infrared spectroscopy for the determination of testosterone in thin-film composites." Journal of pharmaceutical and biomedical analysis 33, 2 (2003): 181-9. [PubMed Link] | [ Full text ]
Naghavi, M.;Libby, P.;Falk, E.;Casscells, S.W.;Litovsky, S.;Rumberger, J.;Badimon, J.J.;Stefanadis, C.;Moreno, P.;Pasterkamp, G.;Fayad, Z.;Stone, P.H.;Waxman, S.;Raggi, P.;Madjid, M.;Zarrabi, A.;Burke, A.;Yuan, C.;Fitzgerald, P.J.;Siscovick, D.S.;Korte, C.L.;Aikawa, M.;Juhani Airaksinen, K.E.;Assmann, G.;Becker, C.R.;Chesebro, J.H.;Farb, A.;Galis, Z.S.;Jackson, C.;Jang, I.K.;Koenig, W.;Lodder, R.A.;March, K.;Demirovic, J.;Navab, M.;Priori, S.G.;Rekhter, M.D.;Bahr, R.;Grundy, S.M.;Mehran, R.;Colombo, A.;Boerwinkle, E.;Ballantyne, C.;Insull W, J.;Schwartz, R.S.;Vogel, R.;Serruys, P.W.;Hansson, G.K.;Faxon, D.P.;Kaul, S.;Drexler, H.;Greenland, P.;Muller, J.E.;Virmani, R.;Ridker, P.M.;Zipes, D.P.;Shah, P.K.;Willerson, J.T. "From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I." Circulation 108, 14 (2003): 1664-72. [PubMed Link] | [ Full text ]
Naghavi, M.;Libby, P.;Falk, E.;Casscells, S.W.;Litovsky, S.;Rumberger, J.;Badimon, J.J.;Stefanadis, C.;Moreno, P.;Pasterkamp, G.;Fayad, Z.;Stone, P.H.;Waxman, S.;Raggi, P.;Madjid, M.;Zarrabi, A.;Burke, A.;Yuan, C.;Fitzgerald, P.J.;Siscovick, D.S.;Korte, C.L.;Aikawa, M.;Airaksinen, K.E.;Assmann, G.;Becker, C.R.;Chesebro, J.H.;Farb, A.;Galis, Z.S.;Jackson, C.;Jang, I.K.;Koenig, W.;Lodder, R.A.;March, K.;Demirovic, J.;Navab, M.;Priori, S.G.;Rekhter, M.D.;Bahr, R.;Grundy, S.M.;Mehran, R.;Colombo, A.;Boerwinkle, E.;Ballantyne, C.;Insull W, J.;Schwartz, R.S.;Vogel, R.;Serruys, P.W.;Hansson, G.K.;Faxon, D.P.;Kaul, S.;Drexler, H.;Greenland, P.;Muller, J.E.;Virmani, R.;Ridker, P.M.;Zipes, D.P.;Shah, P.K.;Willerson, J.T. "From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II." Circulation 108, 15 (2003): 1772-8. [PubMed Link] | [ Full text ]
Urbas, A.;Manning, M.W.;Daugherty, A.;Cassis, L.A.;Lodder, R.A. "Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse." Analytical chemistry 75, 14 (2003): 3650-5. [PubMed Link] |
Hamilton, S.J.;Lowell, A.E.;Lodder, R.A. "Hyperspectral techniques in analysis of oral dosage forms." Journal of biomedical optics 7, 4 (2002): 561-70. [PubMed Link] |
Moreno, P.R.;Lodder, R.A.;Purushothaman, K.R.;Charash, W.E.;O'Connor, W.N.;Muller, J.E. "Detection of lipid pool, thin fibrous cap, and inflammatory cells in human aortic atherosclerotic plaques by near-infrared spectroscopy." Circulation 105, 8 (2002): 923-7. [PubMed Link] | [ Full text ]
El-Hagrasy, A.S.;Morris, H.R.;D'Amico, F.;Lodder, R.A.;Drennen JK, 3rd "Near-infrared spectroscopy and imaging for the monitoring of powder blend homogeneity." Journal of pharmaceutical sciences 90, 9 (2001): 1298-307. [PubMed Link] | [ Full text ]
Malik, I.;Poonacha, M.;Moses, J.;Lodder, R.A. "Multispectral imaging of tablets in blister packaging." AAPS PharmSciTech 2, 2 (2001): E9. [PubMed Link] |
Gold, T.B.;Buice RG, J.;Lodder, R.A.;Digenis, G.A. "Detection of formaldehyde-induced crosslinking in soft elastic gelatin capsules using near-infrared spectrophotometry." Pharmaceutical development and technology 3, 2 (1998): 209-14. [PubMed Link] | [ Full text ]
Cassis, L.A.;Marshall, D.E.;Fettinger, M.J.;Rosenbluth, B.;Lodder, R.A. "Mechanisms contributing to angiotensin II regulation of body weight." The American journal of physiology 274, 5 Pt 1 (1998): E867-76. [PubMed Link] |
Buice RG, J.;Cassis, L.A.;Lodder, R.A. "Near-IR and IR imaging in lipid metabolism and obesity." Cellular and molecular biology (Noisy-le-Grand, France) 44, 1 (1998): 53-64. [PubMed Link] |
Dempsey, R.J.;Cassis, L.A.;Davis, D.G.;Lodder, R.A. "Near-infrared imaging and spectroscopy in stroke research: lipoprotein distribution and disease." Annals of the New York Academy of Sciences 820, (1997): 149-69. [PubMed Link] | [ Full text ]
Gold, T.B.;Buice RG, J.;Lodder, R.A.;Digenis, G.A. "Determination of extent of formaldehyde-induced crosslinking in hard gelatin capsules by near-infrared spectrophotometry." Pharmaceutical research 14, 8 (1997): 1046-50. [PubMed Link] |
Buice RG, J.;Gold, T.B.;Lodder, R.A.;Digenis, G.A. "Determination of moisture in intact gelatin capsules by near-infrared spectrophotometry." Pharmaceutical research 12, 1 (1995): 161-3. [PubMed Link] |
Carney, J.M.;Landrum, W.;Mayes, L.;Zou, Y.;Lodder, R.A. "Near-infrared spectrophotometric monitoring of stroke-related changes in the protein and lipid composition of whole gerbil brains." Analytical chemistry 65, 10 (1993): 1305-13. [PubMed Link] |
Cassis, L.A.;Lodder, R.A. "Near-IR imaging of atheromas in living arterial tissue." Analytical chemistry 65, 9 (1993): 1247-56. [PubMed Link] |
Galante, L.J.;Brinkley, M.A.;Lodder, R.A. "Bacterial monitoring in vials using a spectrophotometric assimilation method." Pharmaceutical research 9, 3 (1992): 357-64. [PubMed Link] |
Zannikos, P.N.;Li, W.I.;Drennen, J.K.;Lodder, R.A. "Spectrophotometric prediction of the dissolution rate of carbamazepine tablets." Pharmaceutical research 8, 8 (1991): 974-8. [PubMed Link] |
Drennen, J.K.;Lodder, R.A. "Nondestructive near-infrared analysis of intact tablets for determination of degradation products." Journal of pharmaceutical sciences 79, 7 (1990): 622-7. [PubMed Link] | [ Full text ]
Galante, L.J.;Brinkley, M.A.;Drennen, J.K.;Lodder, R.A. "Near-infrared spectrometry of microorganisms in liquid pharmaceuticals." Analytical chemistry 62, 23 (1990): 2514-21. [PubMed Link] |
Kamat, M.S.;Lodder, R.A.;DeLuca, P.P. "Near-infrared spectroscopic determination of residual moisture in lyophilized sucrose through intact glass vials." Pharmaceutical research 6, 11 (1989): 961-5. [PubMed Link] |
Lodder, R.A.;Hieftje, G.M.;Moorehead, W.;Robertson, S.P.;Rand, P. "Assessment of the feasibility of determination of cholesterol and other blood constituents by near-infrared reflectance analysis." Talanta 36, 1-2 (1989): 193-8. [PubMed Link] | [ Full text ]