- 741 S Limestone, BBSRB B249, Lexington, KY 40536-0509
09/1988-07/1993: MD, Zhejiang University College of Medicine, Hangzhou, China
04/2000-03/2003: PhD, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
04/2003-09/2007: Postdoctoral Fellow, University of Kentucky Daugherty Lab, Lexington, KY
Cardiovascular diseases are the leading cause of death in the nation and industrialized nations, accounting for nearly 50% of all deaths. Particularly, atherosclerosis is associated with significantly accelerated rates of cardiovascular complications. With the recognition of this evidence, understanding the mechanisms leading to these vascular diseases has become a focus of my research work. One promising medical therapy of atherosclerosis is the pharmacological inhibition of the renin angiotensin system. I am particularly interested in characterizing the renin angiotensin system by which mechanisms this system initiates and promotes the development of atherosclerosis in a hypercholesterolemic mouse model. While my research work has primarily focused on understanding the renin angiotensin system related mechanisms of atherosclerosis, I am also interested in the effects of the renin angiotensin system on aneurysm, which is the 13th leading cause of death in the United States. Understanding these mechanisms is of considerable interest as many members of the renin angiotensin system can be pharmacologically inhibited by agents already clinically used to treat hypertension in clinical patients. Since these drugs are currently being further investigated in large randomized trials for their efficacy to prevent and treat cardiovascular diseases, my research might point to molecular mechanisms by which these agents prevent the development of atherosclerosis and aneurysms.
1. Lu H, Boustany-Kari CM, Daugherty A, Cassis LA. AngII increases adipose angiotensinogen expression. American Journal of Physiology-Endocrinology and Metabolism 2007; 292: E1280-1287.
2. Lu H, Rateri DL, Feldman DL, Charnigo RJ, Fukamizu A, Ishida J, Oesterling EG, Cassis LA, Daugherty A. Renin inhibition reduces hypercholesterolemia-induced atherosclerosis. Journal of Clinical Investigation 2008; 118: 984-993.
3. Lu H, Cassis LA, Daugherty A. The role of the renin-angiotensin system in vascular aneurysm formation. Current Hypertension Reports 2008; 10: 99 - 106.
4. Wu CQ, Lu H, Cassis LA, Daugherty A. Molecular and pathophysiological features of angiotensinogen: a mini review. North America Journal of Medical Sciences 2011; 4: 196-203.
5. Lu H, Balakrishnan A, Howatt DA, Charnigo RJ, Liau G, Cassis LA, Daugherty A. Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolemia-induced atherosclerosis. British Journal of Pharmacology 2012; 165: 2000-2008.
6. Lu H, Rateri DL, Bruemmer D, Cassis LA, Daugherty A. Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms. Clin Sci 2012; 123: 531-543.
7. Lu H, Rateri DL, Bruemmer D, Cassis LA, Daugherty A. Novel mechanisms of abdominal aortic aneurysms. Curr Atheroscler Rep 2012; 14(5): 402-412.
8. Lu H, Wu CQ, Howatt DA, Balakrishnan A, Charnigo RJ, Cassis LA, Daugherty A. Differential effects of dietary sodium intake on blood pressure and atherosclerosis. Journal of Nutritional Biochemistry 2013; 24: 49-53.
9. Chen X, Lu H, Zhao M, Tashiro K, Cassis LA, Daugherty A. Contributions of leukocyte angiotensin-converting enzyme to development of atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology 2013; 33: 2075-2080.
10. Chen X, Lu H, Rateri DL, Cassis LA, Daugherty A. Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms. Current Opinion in Pharmacology 2013; 13: 180-185.