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Postdoc: UT-Southwestern Med. Ctr. Dallas 1993 with Drs. Michael Brown and Joseph Goldstein
Ph.D. Biochemsitry, Purdue University, 1990 with Dr. Jack E. Dixon
B.S., Chemsitry, University of Wisconsin, Madison, 1985
Cells are highly responsive to signals from their environment. These signals include growth factors, hormones, or even neuronal firing. The sensing and processing of these signals are carried out by molecular circuits within the cell which detect, amplify and integrate these environmental cues into a specific response. Ras-related GTP-binding proteins function as GTP/GDP- regulated “switches” and are widely utilized in cellular response pathways. Ras G- proteins respond to extracellular stimuli by exchanging GTP for bound GDP, thereby triggering intracellular signaling cascades through their GTP-dependent interaction with a variety of target molecule(s) to produce a characteristic cellular effect. My laboratory is interested in deciphering the role of Ras GTPases in various cellular paradigms, as Ras family G-proteins play key roles in the ontogency of cancer, diabetes, and heart disease as well as the processes of neuronal survival and axonal growth. Because we have studied the function of several GTPases in some detail, I will review some of our findings in this area and briefly outline our current research interests.
- Levitan, BM ; Ahern, BM ; Aloysius, A ; Brown, L.; Wen, Y.; Andres, DA ; Satin, J. "Rad-GTPase contributes to heart rate via L-type calcium channel regulation." Journal of molecular and cellular cardiology 154, (2021): 60-69. [PubMed Link] | [ Full text ]
- Andres, DA ; Young, LEA ; Veeranki, S.; Hawkinson, TR ; Levitan, BM ; He, D.; Wang, C.; Satin, J.; Sun, RC "Improved workflow for mass spectrometry-based metabolomics analysis of the heart." The Journal of biological chemistry 295, 9 (2020): 2676-2686. [PubMed Link] | [ Full text ]
- Andres, DA ; Young, LEA ; Gentry, MS ; Sun, RC "Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging." Journal of lipid research 61, 12 (2020): 1537. [PubMed Link] | [ Full text ]
- Andres, DA ; Young, LEA ; Gentry, MS ; Sun, RC "Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging." Journal of lipid research 61, 12 (2020): 1537. [PubMed Link] | [ Full text ]
- Andres, DA ; Young, LEA ; Gentry, MS ; Sun, RC "Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging." Journal of lipid research 61, 12 (2020): 1537. [PubMed Link] | [ Full text ]
- Ahern, BM ; Levitan, BM ; Veeranki, S.; Shah, M.; Ali, N.; Sebastian, A.; Su, W.; Gong, MC ; Li, J.; Stelzer, JE ; Andres, DA ; Satin, J. "Myocardial-restricted ablation of the GTPase RAD results in a pro-adaptive heart response in mice." The Journal of biological chemistry 294, 28 (2019): 10913-10927. [PubMed Link] | [ Full text ]
- Mir, S.; Andres, DA "Small GTPase RIT1 in Mouse Retina; Cellular and Functional Analysis." Current eye research 43, 9 (2018): 1160-1168. [PubMed Link] | [ Full text ]
- Manning, JR ; Chelvarajan, L.; Levitan, BM ; Withers, CN ; Nagareddy, PR ; Haggerty, CM ; Fornwalt, BK ; Gao, E.; Tripathi, H.; Abdel-Latif, A.; Andres, DA ; Satin, J. "Rad GTPase deletion attenuates post-ischemic cardiac dysfunction and remodeling." JACC. Basic to translational science 3, 1 (2018): 83-96. [PubMed Link] | [ Full text ]
- Withers, CN ; Brown, DM ; Byiringiro, I.; Allen, MR ; Condon, KW ; Satin, J.; Andres, DA "Rad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice." Bone 103, (2017): 270-280. [PubMed Link] | [ Full text ]
- Mir, S.; Cai, W.; Carlson, SW ; Saatman, KE ; Andres, DA "IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade." Scientific reports 7, 1 (2017): 3283. [PubMed Link] | [ Full text ]
- Mir, S.; Cai, W.; Andres, DA "RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis." The Journal of biological chemistry 292, 6 (2017): 2054-2064. [PubMed Link] | [ Full text ]
- Koenighofer, M.; Hung, CY ; McCauley, JL ; Dallman, J.; Back, EJ ; Mihalek, I.; Gripp, KW ; Sol-Church, K.; Rusconi, P.; Zhang, Z.; Shi, GX ; Andres, DA ; Bodamer, OA "Mutations in RIT1 cause Noonan syndrome - additional functional evidence and expanding the clinical phenotype." Clinical genetics 89, 3 (2016): 359-66. [PubMed Link] | [ Full text ]
- Levitan, BM ; Manning, JR ; Withers, CN ; Smith, JD ; Shaw, RM ; Andres, DA ; Sorrell, VL ; Satin, J. "Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart." Journal of cardiovascular translational research 9, 5-6 (2016): 432-444. [PubMed Link] | [ Full text ]
- Manning, JR ; Withers, CN ; Levitan, B.; Smith, JD ; Andres, DA ; Satin, J. "Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging." American journal of physiology. Heart and circulatory physiology 309, 8 (2015): H1336-45. [PubMed Link] | [ Full text ]
- Holland, AJ ; Reis, RM ; Niessen, S.; Pereira, C.; Andres, DA ; Spielmann, HP ; Cleveland, DW ; Desai, A.; Gassmann, R. "Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors." Molecular biology of the cell 26, 10 (2015): 1845-56. [PubMed Link] | [ Full text ]
- Rising, KA ; Crenshaw, CM ; Koo, HJ ; Subramanian, T.; Chehade, KA ; Starks, C.; Allen, KD ; Andres, DA ; Spielmann, HP ; Noel, JP ; Chappell, J. "Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase." ACS chemical biology 10, 7 (2015): 1729-36. [PubMed Link] | [ Full text ]
- Berger, AH ; Imielinski, M.; Duke, F.; Wala, J.; Kaplan, N.; Shi, GX ; Andres, DA ; Meyerson, M. "Oncogenic RIT1 mutations in lung adenocarcinoma." Oncogene 33, 35 (2014): 4418-23. [PubMed Link] | [ Full text ]
- Cai, W.; Andres, DA "mTORC2 is required for rit-mediated oxidative stress resistance." PloS one 9, 12 (2014): e115602. [PubMed Link] | [ Full text ]
- Shi, GX ; Cai, W.; Andres, DA "Rit subfamily small GTPases: regulators in neuronal differentiation and survival." Cellular signalling 25, 10 (2013): 2060-8. [PubMed Link] | [ Full text ]
- Cai, W.; Shi, GX ; Andres, DA "Putting the Rit in cellular resistance: Rit, p38 MAPK and oxidative stress." Communicative & integrative biology 6, 1 (2013): e22297. [PubMed Link] | [ Full text ]
- Crump, SM ; Andres, DA ; Sievert, G.; Satin, J. "The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium." American journal of physiology. Heart and circulatory physiology 304, 3 (2013): H455-64. [PubMed Link] | [ Full text ]
- Manning, JR ; Yin, G.; Kaminski, CN ; Magyar, J.; Feng, HZ ; Penn, J.; Sievert, G.; Thompson, K.; Jin, JP ; Andres, DA ; Satin, J. "Rad GTPase deletion increases L-type calcium channel current leading to increased cardiac contraction." Journal of the American Heart Association 2, 6 (2013): e000459. [PubMed Link] | [ Full text ]
- Zhang, Z.; Convertini, P.; Shen, M.; Xu, X.; Lemoine, F.; Grange, P.; Andres, DA ; Stamm, S. "Valproic acid causes proteasomal degradation of DICER and influences miRNA expression." PloS one 8, 12 (2013): e82895. [PubMed Link] | [ Full text ]
- Subramanian, T.; Pais, JE ; Liu, S.; Troutman, JM ; Suzuki, Y.; Leela Subramanian, K.; Fierke, CA ; Andres, DA ; Spielmann, HP "Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase." Biochemistry 51, 41 (2012): 8307-19. [PubMed Link] | [ Full text ]
- Shi, GX ; Cai, W.; Andres, DA "Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade." The Journal of biological chemistry 287, 47 (2012): 39859-68. [PubMed Link] | [ Full text ]
- Magyar, J.; Kiper, CE ; Sievert, G.; Cai, W.; Shi, GX ; Crump, SM ; Li, L.; Niederer, S.; Smith, N.; Andres, DA ; Satin, J. "Rem-GTPase regulates cardiac myocyte L-type calcium current." Channels (Austin, Tex.) 6, 3 (2012): 166-73. [PubMed Link] | [ Full text ]
- Chang, SY ; Hudon-Miller, SE ; Yang, SH ; Jung, HJ ; Lee, JM ; Farber, E.; Subramanian, T.; Andres, DA ; Spielmann, HP ; Hrycyna, CA ; Young, SG ; Fong, LG "Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24." Journal of lipid research 53, 6 (2012): 1176-82. [PubMed Link] | [ Full text ]
- Cai, W.; Carlson, SW ; Brelsfoard, JM ; Mannon, CE ; Moncman, CL ; Saatman, KE ; Andres, DA "Rit GTPase signaling promotes immature hippocampal neuronal survival." The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 29 (2012): 9887-97. [PubMed Link] | [ Full text ]
- Cai, W.; Rudolph, JL ; Sengoku, T.; Andres, DA "Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway." Neuroscience letters 531, 2 (2012): 125-30. [PubMed Link] | [ Full text ]
- Gunton, JE ; Sisavanh, M.; Stokes, RA ; Satin, J.; Satin, LS ; Zhang, M.; Liu, SM ; Cai, W.; Cheng, K.; Cooney, GJ ; Laybutt, DR ; So, T.; Molero, JC ; Grey, ST ; Andres, DA ; Rolph, MS ; Mackay, CR "Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling." PloS one 7, 6 (2012): e39462. [PubMed Link] | [ Full text ]
- Cai, W.; Rudolph, JL ; Harrison, SM ; Jin, L.; Frantz, AL ; Harrison, DA ; Andres, DA "An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance." Molecular biology of the cell 22, 17 (2011): 3231-41. [PubMed Link] | [ Full text ]
- Shi, GX ; Jin, L.; Andres, DA "A rit GTPase-p38 mitogen-activated protein kinase survival pathway confers resistance to cellular stress." Molecular and cellular biology 31, 10 (2011): 1938-48. [PubMed Link] | [ Full text ]
- Shi, GX ; Andres, DA ; Cai, W. "Ras family small GTPase-mediated neuroprotective signaling in stroke." Central nervous system agents in medicinal chemistry 11, 2 (2011): 114-37. [PubMed Link] |
- Yang, SH ; Chang, SY ; Ren, S.; Wang, Y.; Andres, DA ; Spielmann, HP ; Fong, LG ; Young, SG "Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin." Human molecular genetics 20, 3 (2011): 436-44. [PubMed Link] | [ Full text ]
- Yang, D.; Bruun, D.; Andres, DA ; Lein, PJ "Method for Shipping Live Cultures of Dissociated Rat Hippocampal Neurons." Current neurobiology 1, 2 (2010): 95-98. [PubMed Link] |
- Pang, C.; Crump, SM ; Jin, L.; Correll, RN ; Finlin, BS ; Satin, J.; Andres, DA "Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation." Channels (Austin, Tex.) 4, 3 (2010): 192-202. [PubMed Link] | [ Full text ]
- Shi, GX ; Jin, L.; Andres, DA "Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation." Molecular biology of the cell 21, 9 (2010): 1597-608. [PubMed Link] | [ Full text ]
- Davies, BS ; Barnes RH, 2nd ; Tu, Y.; Ren, S.; Andres, DA ; Spielmann, HP ; Lammerding, J.; Wang, Y.; Young, SG ; Fong, LG "An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria." Human molecular genetics 19, 13 (2010): 2682-94. [PubMed Link] | [ Full text ]
- Gurden, MD ; Holland, AJ ; Zon, W.; Tighe, A.; Vergnolle, MA ; Andres, DA ; Spielmann, HP ; Malumbres, M.; Wolthuis, RM ; Cleveland, DW ; Taylor, SS "Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F." Journal of cell science 123, Pt 3 (2010): 321-30. [PubMed Link] | [ Full text ]
- Yang, SH ; Chang, SY ; Andres, DA ; Spielmann, HP ; Young, SG ; Fong, LG "Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria." Journal of lipid research 51, 2 (2010): 400-5. [PubMed Link] | [ Full text ]
- Onono, FO ; Morgan, MA ; Spielmann, HP ; Andres, DA ; Subramanian, T.; Ganser, A.; Reuter, CW "A tagging-via-substrate approach to detect the farnesylated proteome using two-dimensional electrophoresis coupled with Western blotting." Molecular & cellular proteomics : MCP 9, 4 (2010): 742-51. [PubMed Link] |
- Fong, LG ; Vickers, TA ; Farber, EA ; Choi, C.; Yun, UJ ; Hu, Y.; Yang, SH ; Coffinier, C.; Lee, R.; Yin, L.; Davies, BS ; Andres, DA ; Spielmann, HP ; Bennett, CF ; Young, SG "Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides." Human molecular genetics 18, 13 (2009): 2462-71. [PubMed Link] | [ Full text ]
- Davies, BS ; Yang, SH ; Farber, E.; Lee, R.; Buck, SB ; Andres, DA ; Spielmann, HP ; Agnew, BJ ; Tamanoi, F.; Fong, LG ; Young, SG "Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome." Journal of lipid research 50, 1 (2009): 126-34. [PubMed Link] | [ Full text ]
- Lester, WC ; Schroder, EA ; Burgess, DE ; Yozwiak, D.; Andres, DA ; Satin, J. "Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block." Cell calcium 44, 4 (2008): 353-62. [PubMed Link] | [ Full text ]
- Yang, SH ; Andres, DA ; Spielmann, HP ; Young, SG ; Fong, LG "Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated." The Journal of clinical investigation 118, 10 (2008): 3291-300. [PubMed Link] | [ Full text ]
- Subramanian, T.; Liu, S.; Troutman, JM ; Andres, DA ; Spielmann, HP "Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity." Chembiochem : a European journal of chemical biology 9, 17 (2008): 2872-82. [PubMed Link] | [ Full text ]
- Correll, RN ; Pang, C.; Niedowicz, DM ; Satin, J.; Andres, DA "Calmodulin binding is dispensable for Rem-mediated Ca2+ channel inhibition." Molecular and cellular biochemistry 310, 1-2 (2008): 103-10. [PubMed Link] | [ Full text ]
- Correll, RN ; Botzet, GJ ; Satin, J.; Andres, DA ; Finlin, BS "Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids." Cellular signalling 20, 2 (2008): 400-8. [PubMed Link] | [ Full text ]
- Correll, RN ; Pang, C.; Niedowicz, DM ; Finlin, BS ; Andres, DA "The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling." Cellular signalling 20, 2 (2008): 292-300. [PubMed Link] | [ Full text ]
- Andres, DA ; Shi, GX ; Bruun, D.; Barnhart, C.; Lein, PJ "Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation." Journal of neurochemistry 107, 5 (2008): 1436-47. [PubMed Link] | [ Full text ]
- Shi, GX ; Jin, L.; Andres, DA "Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation." Molecular and cellular biology 28, 16 (2008): 4940-51. [PubMed Link] | [ Full text ]
- Coffinier, C.; Hudon, SE ; Lee, R.; Farber, EA ; Nobumori, C.; Miner, JH ; Andres, DA ; Spielmann, HP ; Hrycyna, CA ; Fong, LG ; Young, SG "A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells." The Journal of biological chemistry 283, 15 (2008): 9797-804. [PubMed Link] | [ Full text ]
- Correll, RN ; Pang, C.; Finlin, BS ; Dailey, AM ; Satin, J.; Andres, DA "Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition." The Journal of biological chemistry 282, 39 (2007): 28431-40. [PubMed Link] | [ Full text ]
- Troutman, JM ; Andres, DA ; Spielmann, HP "Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release." Biochemistry 46, 40 (2007): 11299-309. [PubMed Link] | [ Full text ]
- Troutman, JM ; Subramanian, T.; Andres, DA ; Spielmann, HP "Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues." Biochemistry 46, 40 (2007): 11310-21. [PubMed Link] | [ Full text ]
- Dechat, T.; Shimi, T.; Adam, SA ; Rusinol, AE ; Andres, DA ; Spielmann, HP ; Sinensky, MS ; Goldman, RD "Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging." Proceedings of the National Academy of Sciences of the United States of America 104, 12 (2007): 4955-60. [PubMed Link] | [ Full text ]
- Rudolph, JL ; Shi, GX ; Erdogan, E.; Fields, AP ; Andres, DA "Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction." Biochimica et biophysica acta 1773, 12 (2007): 1793-800. [PubMed Link] | [ Full text ]
- Lein, PJ ; Guo, X.; Shi, GX ; Moholt-Siebert, M.; Bruun, D.; Andres, DA "The novel GTPase Rit differentially regulates axonal and dendritic growth." The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 17 (2007): 4725-36. [PubMed Link] | [ Full text ]
- Crump, SM ; Correll, RN ; Schroder, EA ; Lester, WC ; Finlin, BS ; Andres, DA ; Satin, J. "L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current." American journal of physiology. Heart and circulatory physiology 291, 4 (2006): H1959-71. [PubMed Link] | [ Full text ]
- Roberts, MJ ; Troutman, JM ; Chehade, KA ; Cha, HC ; Kao, JP ; Huang, X.; Zhan, CG ; Peterson, YK ; Subramanian, T.; Kamalakkannan, S.; Andres, DA ; Spielmann, HP "Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors." Biochemistry 45, 51 (2006): 15862-72. [PubMed Link] | [ Full text ]
- Shi, GX ; Rehmann, H.; Andres, DA "A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation." Molecular and cellular biology 26, 23 (2006): 9136-47. [PubMed Link] | [ Full text ]
- Finlin, BS ; Correll, RN ; Pang, C.; Crump, SM ; Satin, J.; Andres, DA "Analysis of the complex between Ca2+ channel beta-subunit and the Rem GTPase." The Journal of biological chemistry 281, 33 (2006): 23557-66. [PubMed Link] | [ Full text ]
- Key, MD ; Andres, DA ; Der, CJ ; Repasky, GA "Characterization of RERG: an estrogen-regulated tumor suppressor gene." Methods in enzymology 407, (2006): 513-27. [PubMed Link] | [ Full text ]
- Andres, DA ; Rudolph, JL ; Sengoku, T.; Shi, GX "Analysis of Rit signaling and biological activity." Methods in enzymology 407, (2006): 499-512. [PubMed Link] | [ Full text ]
- Andres, DA ; Crump, SM ; Correll, RN ; Satin, J.; Finlin, BS "Analyses of Rem/RGK signaling and biological activity." Methods in enzymology 407, (2006): 484-98. [PubMed Link] | [ Full text ]
- Troutman, JM ; Roberts, MJ ; Andres, DA ; Spielmann, HP "Tools to analyze protein farnesylation in cells." Bioconjugate chemistry 16, 5 (2005): 1209-17. [PubMed Link] | [ Full text ]
- Shi, GX ; Han, J.; Andres, DA "Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation." The Journal of biological chemistry 280, 45 (2005): 37599-609. [PubMed Link] | [ Full text ]
- Subramanian, T.; Wang, Z.; Troutman, JM ; Andres, DA ; Spielmann, HP "Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis." Organic letters 7, 11 (2005): 2109-12. [PubMed Link] | [ Full text ]
- Harrison, SM ; Rudolph, JL ; Spencer, ML ; Wes, PD ; Montell, C.; Andres, DA ; Harrison, DA "Activated RIC, a small GTPase, genetically interacts with the Ras pathway and calmodulin during Drosophila development." Developmental dynamics : an official publication of the American Association of Anatomists 232, 3 (2005): 817-26. [PubMed Link] | [ Full text ]
- Shi, GX ; Andres, DA "Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades." Molecular and cellular biology 25, 2 (2005): 830-46. [PubMed Link] | [ Full text ]
- Finlin, BS ; Mosley, AL ; Crump, SM ; Correll, RN ; Ozcan, S.; Satin, J.; Andres, DA "Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase." The Journal of biological chemistry 280, 51 (2005): 41864-71. [PubMed Link] | [ Full text ]
- Troutman, JM ; Chehade, KA ; Kiegiel, K.; Andres, DA ; Spielmann, HP "Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate." Bioorganic & medicinal chemistry letters 14, 19 (2004): 4979-82. [PubMed Link] | [ Full text ]
- Kim, IJ ; Drahushuk, KM ; Kim, WY ; Gonsiorek, EA ; Lein, P.; Andres, DA ; Higgins, D. "Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 13 (2004): 3304-12. [PubMed Link] | [ Full text ]
- Andres, DA "Nonradioactive methods for detecting activation of Ras-related small G proteins." Methods in molecular biology (Clifton, N.J.) 284, (2004): 163-73. [PubMed Link] | [ Full text ]
- Finlin, BS ; Crump, SM ; Satin, J.; Andres, DA "Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases." Proceedings of the National Academy of Sciences of the United States of America 100, 24 (2003): 14469-74. [PubMed Link] | [ Full text ]
- Hynds, DL ; Spencer, ML ; Andres, DA ; Snow, DM "Rit promotes MEK-independent neurite branching in human neuroblastoma cells." Journal of cell science 116, Pt 10 (2003): 1925-35. [PubMed Link] | [ Full text ]
- Spencer, ML ; Shao, H.; Tucker, HM ; Andres, DA "Nerve growth factor-dependent activation of the small GTPase Rin." The Journal of biological chemistry 277, 20 (2002): 17605-15. [PubMed Link] | [ Full text ]
- Spencer, ML ; Shao, H.; Andres, DA "Induction of neurite extension and survival in pheochromocytoma cells by the Rit GTPase." The Journal of biological chemistry 277, 23 (2002): 20160-8. [PubMed Link] | [ Full text ]
- Chehade, KA ; Kiegiel, K.; Isaacs, RJ ; Pickett, JS ; Bowers, KE ; Fierke, CA ; Andres, DA ; Spielmann, HP "Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase." Journal of the American Chemical Society 124, 28 (2002): 8206-19. [PubMed Link] | [ Full text ]
- Micali, E.; Chehade, KA ; Isaacs, RJ ; Andres, DA ; Spielmann, HP "Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups." Biochemistry 40, 41 (2001): 12254-65. [PubMed Link] | [ Full text ]
- Finlin, BS ; Gau, CL ; Murphy, GA ; Shao, H.; Kimel, T.; Seitz, RS ; Chiu, YF ; Botstein, D.; Brown, PO ; Der, CJ ; Tamanoi, F.; Andres, DA ; Perou, CM "RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer." The Journal of biological chemistry 276, 45 (2001): 42259-67. [PubMed Link] | [ Full text ]
- Than, C.; Morimoto, H.; Williams, PG ; Chehade, KA ; Andres, DA ; Spielmann, HP "Preparation, NMR characterization, and labeling reactions of tritiated triacetoxy sodium borohydride." The Journal of organic chemistry 66, 10 (2001): 3602-5. [PubMed Link] |
- Andres, DA "Expression cloning to identify monomeric GTP-binding proteins by GTP overlay." Methods in enzymology 332, (2001): 203-10. [PubMed Link] | [ Full text ]
- Andres, DA "Expression cloning of farnesylated proteins." Methods in enzymology 332, (2001): 195-202. [PubMed Link] | [ Full text ]
- Rusyn, EV ; Reynolds, ER ; Shao, H.; Grana, TM ; Chan, TO ; Andres, DA ; Cox, AD "Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways." Oncogene 19, 41 (2000): 4685-94. [PubMed Link] | [ Full text ]
- Shao, H.; Andres, DA "A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras." The Journal of biological chemistry 275, 35 (2000): 26914-24. [PubMed Link] | [ Full text ]
- Chehade, KA ; Andres, DA ; Morimoto, H.; Spielmann, HP "Design and synthesis of a transferable farnesyl pyrophosphate analogue to Ras by protein farnesyltransferase." The Journal of organic chemistry 65, 10 (2000): 3027-33. [PubMed Link] | [ Full text ]
- Finlin, BS ; Shao, H.; Kadono-Okuda, K.; Guo, N.; Andres, DA "Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases." The Biochemical journal 347 Pt 1, (2000): 223-31. [PubMed Link] |
- Shao, H.; Kadono-Okuda, K.; Finlin, BS ; Andres, DA "Biochemical characterization of the Ras-related GTPases Rit and Rin." Archives of biochemistry and biophysics 371, 2 (1999): 207-19. [PubMed Link] | [ Full text ]
- Finlin, BS ; Andres, DA "Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins." Archives of biochemistry and biophysics 368, 2 (1999): 401-12. [PubMed Link] | [ Full text ]
- Andres, DA ; Crick, DC ; Finlin, BS ; Waechter, CJ "Rapid identification of cysteine-linked isoprenyl groups by metabolic labeling with 3H farnesol and 3H geranylgeraniol." Methods in molecular biology (Clifton, N.J.) 116, (1999): 107-23. [PubMed Link] | [ Full text ]
- Crick, DC ; Andres, DA ; Danesi, R.; Macchia, M.; Waechter, CJ "Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells." Journal of neurochemistry 70, 6 (1998): 2397-405. [PubMed Link] | [ Full text ]
- Andres, DA ; Shao, H.; Crick, DC ; Finlin, BS "Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue." Archives of biochemistry and biophysics 346, 1 (1997): 113-24. [PubMed Link] | [ Full text ]
- Crick, DC ; Andres, DA ; Waechter, CJ "Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate." Experimental cell research 231, 2 (1997): 302-7. [PubMed Link] | [ Full text ]
- Kadono-Okuda, K.; Andres, DA "An expression cloning method to identify monomeric GTP-binding proteins by GTP overlay." Analytical biochemistry 254, 2 (1997): 187-91. [PubMed Link] | [ Full text ]
- Finlin, BS ; Andres, DA "Rem is a new member of the Rad- and Gem/Kir Ras-related GTP-binding protein family repressed by lipopolysaccharide stimulation." The Journal of biological chemistry 272, 35 (1997): 21982-8. [PubMed Link] | [ Full text ]
- Crick, DC ; Andres, DA ; Waechter, CJ "Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation." Biochemical and biophysical research communications 237, 3 (1997): 483-7. [PubMed Link] | [ Full text ]
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