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Christopher Mark Waters, Ph.D.
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chris.waters41@uky.edu
(859) 218-1707
741 South Limestone Street, Biomedical/Biological Sciences Research Building, Rm: B257, Lexington, KY 40536-0509
PDF icon Waters CV Aug2020.pdf
Position(s): 
Professor
Dr. Donald T. Frazier Professor of Physiology
Affiliation(s): 
Physiology
Cardiovascular Research Center
Other Affiliation(s): 
CVRC - Core Faculty
CVRC - Affiliated Faculty
Bio / Education: 

University of Tennessee at Chattanooga, B.S.E. (Chemical Engineering), 1985 (Summa Cum Laude)
University of Miami, M.S. (Biomedical Engineering), 1987
Vanderbilt University, Ph.D. (Biomedical Engineering, 1991
Vanderbilt University, Postdoc, 1992

Research Description: 

The Waters lab focuses on mechanobiology and acute lung injury. Patients with acute respiratory distress syndrome (ARDS) are placed on mechanical ventilators to improve oxygenation, but the ventilator may cause additional injury to the lungs due to either overdistention or airway collapse and reopening. Clinical trials have demonstrated a substantial reduction in mortality in ARDS patients when ventilation strategies are used that reduce overdistention (lower tidal volumes) and minimize airway collapse and reopening (positive end expiratory pressure). The lung is a mechanically dynamic organ, and cells in the lung are subjected to shear stress due to fluid flow, tensile and compressive forces due to respiratory motion, and normal forces due to vascular or airway pressure. High tidal volume mechanical ventilation in injured lungs induces mechanical stresses that increase injury to the lung epithelium, stimulate inflammatory responses, and decrease repair mechanisms. We are focusing on the mechanisms by which mechanical forces contribute to lung injury, inhibit wound healing of lung epithelial cells, and stimulate inflammation. We are examining signaling pathways related to injury and repair (CXCL12/CXCR4, ASK1, FAK, Rho GTPases), cell migration and wound healing, inflammasome activation, cytoskeletal remodeling, stimulation of reactive oxygen species, cytokine secretion, and regional variations in cellular tension. In addition we are examining lung injury in vivo and the effects of exposure to high levels of oxygen (hyperoxia). My research seeks to identify the levels of mechanical forces and the types of lung injury that cells experience in vivo, to develop in vitro models to evaluate cellular responses, to identify mechanisms by which mechanical forces are transduced into biological signals, and to develop approaches to reduce lung injury.

Current techniques:
• Lung injury models in mice and rats.
• Targeted gene deletion models.
• Mechanically ventilated mice and rats; measurement of lung mechanics (resistance and compliance).
• Hyperoxia exposure (mice, cells).
• Isolation and culture of airway and alveolar epithelial cells, lung vascular endothelial cells, and brain microvascular endothelial cells.
• Application of cyclic mechanical strain to cells.
• Atomic force microscopy to determine distribution of mechanical properties in migrating cells.
• Wound healing assays.
• Spectrophotometry and fluorescence microscopy to measure reactive oxygen species production.
• Application of fluid shear stress to cells - flow chambers, cell columns.
• Evaluation of barrier function/permeability of cell monolayers - cell column (on line), transwell culture.
• Transepithelial electrical resistance measurements (including the ECIS system).
• Western analysis to evaluate signaling pathways and cytoskeletal and focal adhesion levels.
• Confocal fluorescence microscopy to visualize cell cytoskeleton (f-actin, microtubules), focal adhesions, integrins, junctional assembly.

Grants: 

R01 HL151419 Waters (PI)
Title: Biophysical mechanisms of hyperoxia-induced lung injury
PI: Christopher M. Waters, PhD
Role in Project: PI
Funding Agency: NIH

R01 HL131526 (Waters, PI)
NIH/NHLBI
Title: ASK1 and Ventilator-Induced Lung Injury

R01 AI090059 Cormier (PI)
Title: Regulation and Function of IL33 During Neonatal RSV Infection
Role in Project: co-Investigator

Principal Investigator (Multi-PI; Morris): “Kentucky Research Alliance for Lung Disease (K-RALD),” Academic Research Alliance, College of Medicine, University of Kentucky.

Co-investigator: “Exposure to E-cigarette vapor alters gene expression and induces inflammatory responses,” National Institute of Environmental Health Sciences (P30 ES026529); UK-CARES Innovation and High Impact Award; Dr. David Orren (P.I.); 05/01/20-03/31/21.

Co-investigator: “Development of Non-Invasive Cage-Based Breathing Tracking for Mouse Models of COVID-19,” UK-CURE COVID-19 Pilot Grant; Dr. O’Hara (P.I.).

PubMed Publications: 
  • Kamatham, S ; Waters, CM ; Schwingshackl, A.; Mancarella, S "TREK-1 protects the heart against ischemia-reperfusion-induced injury and from adverse remodeling after myocardial infarction." Pflugers Archiv : European journal of physiology 471, 10 (2019): 1263-1272. [PubMed Link] | [ Full text ]
  • Immanuel, CN ; Teng, B.; Dong, B.; Gordon, EM ; Kennedy, JA ; Luellen, C.; Schwingshackl, A.; Cormier, SA ; Fitzpatrick, EA ; Waters, CM "Apoptosis signal-regulating kinase-1 promotes inflammasome priming in macrophages." American journal of physiology. Lung cellular and molecular physiology 316, 3 (2019): L418-L427. [PubMed Link] | [ Full text ]
  • Phung, TN ; Sinclair, SE ; Makena, P.; Molthen, RC ; Waters, CM "Dynamic airway constriction in rats: heterogeneity and response to deep inspiration." American journal of physiology. Lung cellular and molecular physiology 317, 1 (2019): L39-L48. [PubMed Link] | [ Full text ]
  • Xiao, Z.; Baudry, J.; Cao, L.; Huang, J.; Chen, H.; Yates, CR ; Li, W.; Dong, B.; Waters, CM ; Smith, JC ; Quarles, LD "Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis." The Journal of clinical investigation 128, 1 (2018): 157-174. [PubMed Link] | [ Full text ]
  • Ghosh, MC ; Makena, PS ; Kennedy, J.; Teng, B.; Luellen, C.; Sinclair, SE ; Waters, CM "A heteromeric molecular complex regulates the migration of lung alveolar epithelial cells during wound healing." Scientific reports 7, 1 (2017): 2155. [PubMed Link] | [ Full text ]
  • Gangwar, R.; Meena, AS ; Shukla, PK ; Nagaraja, AS ; Dorniak, PL ; Pallikuth, S.; Waters, CM ; Sood, A.; Rao, R. "Calcium-mediated oxidative stress: a common mechanism in tight junction disruption by different types of cellular stress." The Biochemical journal 474, 5 (2017): 731-749. [PubMed Link] | [ Full text ]
  • Schwingshackl, A.; Lopez, B.; Teng, B.; Luellen, C.; Lesage, F.; Belperio, J.; Olcese, R.; Waters, CM "Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins." American journal of physiology. Lung cellular and molecular physiology 313, 6 (2017): L1030-L1046. [PubMed Link] | [ Full text ]
  • Michael, CF ; Waters, CM ; LeMessurier, KS ; Samarasinghe, AE ; Song, CY ; Malik, KU ; Lew, DB "Airway Epithelial Repair by a Prebiotic Mannan Derived from <i>Saccharomyces cerevisiae</i>." Journal of immunology research 2017, (2017): 8903982. [PubMed Link] | [ Full text ]
  • Andrews, K.; Ghosh, MC ; Schwingshackl, A.; Rapalo, G.; Luellen, C.; Waters, CM ; Fitzpatrick, EA "Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response." American journal of physiology. Lung cellular and molecular physiology 310, 5 (2016): L393-402. [PubMed Link] | [ Full text ]
  • Roan, E.; Wilhelm, KR ; Waters, CM "Kymographic Imaging of the Elastic Modulus of Epithelial Cells during the Onset of Migration." Biophysical journal 109, 10 (2015): 2051-7. [PubMed Link] | [ Full text ]
  • Lee, SC ; Fujiwara, Y.; Liu, J.; Yue, J.; Shimizu, Y.; Norman, DD ; Wang, Y.; Tsukahara, R.; Szabo, E.; Patil, R.; Banerjee, S.; Miller, DD ; Balazs, L.; Ghosh, MC ; Waters, CM ; Oravecz, T.; Tigyi, GJ "Autotaxin and LPA1 and LPA5 receptors exert disparate functions in tumor cells versus the host tissue microenvironment in melanoma invasion and metastasis." Molecular cancer research : MCR 13, 1 (2015): 174-85. [PubMed Link] | [ Full text ]
  • Rapalo, G.; Herwig, JD ; Hewitt, R.; Wilhelm, KR ; Waters, CM ; Roan, E. "Live Cell Imaging during Mechanical Stretch." Journal of visualized experiments : JoVE 102 (2015): e52737. [PubMed Link] | [ Full text ]
  • Schwingshackl, A.; Roan, E.; Teng, B.; Waters, CM "TREK-1 Regulates Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements." PloS one 10, 5 (2015): e0126781. [PubMed Link] | [ Full text ]
  • Schwingshackl, A.; Teng, B.; Makena, P.; Ghosh, M.; Sinclair, SE ; Luellen, C.; Balasz, L.; Rovnaghi, C.; Bryan, RM ; Lloyd, EE ; Fitzpatrick, E.; Saravia, JS ; Cormier, SA ; Waters, CM "Deficiency of the two-pore-domain potassium channel TREK-1 promotes hyperoxia-induced lung injury." Critical care medicine 42, 11 (2014): e692-701. [PubMed Link] | [ Full text ]
  • Samak, G.; Gangwar, R.; Crosby, LM ; Desai, LP ; Wilhelm, K.; Waters, CM ; Rao, R. "Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism." American journal of physiology. Gastrointestinal and liver physiology 306, 11 (2014): G947-58. [PubMed Link] | [ Full text ]
  • Wilhelm, KR ; Roan, E.; Ghosh, MC ; Parthasarathi, K.; Waters, CM "Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase." The FEBS journal 281, 3 (2014): 957-69. [PubMed Link] | [ Full text ]
  • Toutounchian, JJ ; Steinle, JJ ; Makena, PS ; Waters, CM ; Wilson, MW ; Haik, BG ; Miller, DD ; Yates, CR "Modulation of radiation injury response in retinal endothelial cells by quinic acid derivative KZ-41 involves p38 MAPK." PloS one 9, 6 (2014): e100210. [PubMed Link] | [ Full text ]
  • Roan, E.; Waters, CM ; Teng, B.; Ghosh, M.; Schwingshackl, A. "The 2-pore domain potassium channel TREK-1 regulates stretch-induced detachment of alveolar epithelial cells." PloS one 9, 2 (2014): e89429. [PubMed Link] | [ Full text ]
  • Schwingshackl, A.; Teng, B.; Ghosh, M.; Lim, KG ; Tigyi, G.; Narayanan, D.; Jaggar, JH ; Waters, CM "Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells." American journal of physiology. Lung cellular and molecular physiology 304, 4 (2013): L276-86. [PubMed Link] | [ Full text ]
  • Ghosh, MC ; Gorantla, V.; Makena, PS ; Luellen, C.; Sinclair, SE ; Schwingshackl, A.; Waters, CM "Insulin-like growth factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5a." American journal of physiology. Lung cellular and molecular physiology 305, 3 (2013): L222-8. [PubMed Link] | [ Full text ]
  • Schwingshackl, A.; Teng, B.; Ghosh, M.; Waters, CM "Regulation of Monocyte Chemotactic Protein-1 secretion by the Two-Pore-Domain Potassium (K2P) channel TREK-1 in human alveolar epithelial cells." American journal of translational research 5, 5 (2013): 530-42. [PubMed Link] |
  • Bellows, LE ; Koestler, BJ ; Karaba, SM ; Waters, CM ; Lathem, WW "Hfq-dependent, co-ordinate control of cyclic diguanylate synthesis and catabolism in the plague pathogen Yersinia pestis." Molecular microbiology 86, 3 (2012): 661-74. [PubMed Link] | [ Full text ]
  • Schwingshackl, A.; Teng, B.; Ghosh, M.; West, AN ; Makena, P.; Gorantla, V.; Sinclair, SE ; Waters, CM "Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells." American journal of physiology. Lung cellular and molecular physiology 302, 1 (2012): L93-L102. [PubMed Link] | [ Full text ]
  • Waters, CM ; Roan, E.; Navajas, D. "Mechanobiology in lung epithelial cells: measurements, perturbations, and responses." Comprehensive Physiology 2, 1 (2012): 1-29. [PubMed Link] | [ Full text ]
  • Makena, PS ; Gorantla, VK ; Ghosh, MC ; Bezawada, L.; Kandasamy, K.; Balazs, L.; Luellen, CL ; Thompson, KE ; Parthasarathi, K.; Ichijo, H.; Waters, CM ; Sinclair, SE "Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice." American journal of respiratory cell and molecular biology 46, 4 (2012): 461-9. [PubMed Link] | [ Full text ]
  • Crosby, LM ; Luellen, C.; Zhang, Z.; Tague, LL ; Sinclair, SE ; Waters, CM "Balance of life and death in alveolar epithelial type II cells: proliferation, apoptosis, and the effects of cyclic stretch on wound healing." American journal of physiology. Lung cellular and molecular physiology 301, 4 (2011): L536-46. [PubMed Link] | [ Full text ]
  • Makena, PS ; Luellen, CL ; Balazs, L.; Ghosh, MC ; Parthasarathi, K.; Waters, CM ; Sinclair, SE "Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes." American journal of physiology. Lung cellular and molecular physiology 299, 5 (2010): L711-9. [PubMed Link] | [ Full text ]
  • Crosby, LM ; Waters, CM "Epithelial repair mechanisms in the lung." American journal of physiology. Lung cellular and molecular physiology 298, 6 (2010): L715-31. [PubMed Link] | [ Full text ]
  • Mugabe, BE ; Yaghini, FA ; Song, CY ; Buharalioglu, CK ; Waters, CM ; Malik, KU "Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation." The Journal of pharmacology and experimental therapeutics 332, 1 (2010): 116-24. [PubMed Link] | [ Full text ]
  • Desai, LP ; White, SR ; Waters, CM "Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation." The Journal of biological chemistry 285, 7 (2010): 4511-9. [PubMed Link] | [ Full text ]
  • Desai, LP ; Chapman, KE ; Waters, CM "Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1." American journal of physiology. Lung cellular and molecular physiology 295, 5 (2008): L958-65. [PubMed Link] | [ Full text ]
  • Xi, Q.; Adebiyi, A.; Zhao, G.; Chapman, KE ; Waters, CM ; Hassid, A.; Jaggar, JH "IP3 constricts cerebral arteries via IP3 receptor-mediated TRPC3 channel activation and independently of sarcoplasmic reticulum Ca2+ release." Circulation research 102, 9 (2008): 1118-26. [PubMed Link] | [ Full text ]
  • Wagh, AA ; Roan, E.; Chapman, KE ; Desai, LP ; Rendon, DA ; Eckstein, EC ; Waters, CM "Localized elasticity measured in epithelial cells migrating at a wound edge using atomic force microscopy." American journal of physiology. Lung cellular and molecular physiology 295, 1 (2008): L54-60. [PubMed Link] | [ Full text ]
  • Desai, LP ; Sinclair, SE ; Chapman, KE ; Hassid, A.; Waters, CM "High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion." American journal of physiology. Lung cellular and molecular physiology 293, 3 (2007): L769-78. [PubMed Link] | [ Full text ]
  • Kumar, N.; Mishra, J.; Narang, VS ; Waters, CM "Janus kinase 3 regulates interleukin 2-induced mucosal wound repair through tyrosine phosphorylation of villin." The Journal of biological chemistry 282, 42 (2007): 30341-5. [PubMed Link] | [ Full text ]
  • Sinclair, SE ; Molthen, RC ; Haworth, ST ; Dawson, CA ; Waters, CM "Airway strain during mechanical ventilation in an intact animal model." American journal of respiratory and critical care medicine 176, 8 (2007): 786-94. [PubMed Link] | [ Full text ]
  • Zhuang, Y.; Fraga, CH ; Hubbard, KE ; Hagedorn, N.; Panetta, JC ; Waters, CM ; Stewart, CF "Topotecan central nervous system penetration is altered by a tyrosine kinase inhibitor." Cancer research 66, 23 (2006): 11305-13. [PubMed Link] | [ Full text ]
  • Ceacareanu, AC ; Ceacareanu, B.; Zhuang, D.; Chang, Y.; Ray, RM ; Desai, L.; Chapman, KE ; Waters, CM ; Hassid, A. "Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas." American journal of physiology. Cell physiology 290, 4 (2006): C1263-70. [PubMed Link] | [ Full text ]
  • Motl, S.; Zhuang, Y.; Waters, CM ; Stewart, CF "Pharmacokinetic considerations in the treatment of CNS tumours." Clinical pharmacokinetics 45, 9 (2006): 871-903. [PubMed Link] | [ Full text ]
  • Geiger, RC ; Waters, CM ; Kamp, DW ; Glucksberg, MR "KGF prevents oxygen-mediated damage in ARPE-19 cells." Investigative ophthalmology & visual science 46, 9 (2005): 3435-42. [PubMed Link] | [ Full text ]
  • Chapman, KE ; Sinclair, SE ; Zhuang, D.; Hassid, A.; Desai, LP ; Waters, CM "Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells." American journal of physiology. Lung cellular and molecular physiology 289, 5 (2005): L834-41. [PubMed Link] | [ Full text ]
  • Tomar, A.; Wang, Y.; Kumar, N.; George, S.; Ceacareanu, B.; Hassid, A.; Chapman, KE ; Aryal, AM ; Waters, CM ; Khurana, S. "Regulation of cell motility by tyrosine phosphorylated villin." Molecular biology of the cell 15, 11 (2004): 4807-17. [PubMed Link] | [ Full text ]
  • Zhuang, D.; Ceacareanu, AC ; Lin, Y.; Ceacareanu, B.; Dixit, M.; Chapman, KE ; Waters, CM ; Rao, GN ; Hassid, A. "Nitric oxide attenuates insulin- or IGF-I-stimulated aortic smooth muscle cell motility by decreasing H2O2 levels: essential role of cGMP." American journal of physiology. Heart and circulatory physiology 286, 6 (2004): H2103-12. [PubMed Link] | [ Full text ]
  • Savla, U.; Olson, LE ; Waters, CM "Mathematical modeling of airway epithelial wound closure during cyclic mechanical strain." Journal of applied physiology (Bethesda, Md. : 1985) 96, 2 (2004): 566-74. [PubMed Link] | [ Full text ]
  • Desai, LP ; Aryal, AM ; Ceacareanu, B.; Hassid, A.; Waters, CM "RhoA and Rac1 are both required for efficient wound closure of airway epithelial cells." American journal of physiology. Lung cellular and molecular physiology 287, 6 (2004): L1134-44. [PubMed Link] | [ Full text ]
  • Boardman, KC ; Aryal, AM ; Miller, WM ; Waters, CM "Actin re-distribution in response to hydrogen peroxide in airway epithelial cells." Journal of cellular physiology 199, 1 (2004): 57-66. [PubMed Link] | [ Full text ]
  • Leffler, CW ; Balabanova, L.; Fedinec, AL ; Waters, CM ; Parfenova, H. "Mechanism of glutamate stimulation of CO production in cerebral microvessels." American journal of physiology. Heart and circulatory physiology 285, 1 (2003): H74-80. [PubMed Link] | [ Full text ]
  • Waters, CM ; Sporn, PH ; Liu, M.; Fredberg, JJ "Cellular biomechanics in the lung." American journal of physiology. Lung cellular and molecular physiology 283, 3 (2002): L503-9. [PubMed Link] | [ Full text ]
  • Chapman, KE ; Waters, CM ; Miller, WM "Continuous exposure of airway epithelial cells to hydrogen peroxide: protection by KGF." Journal of cellular physiology 192, 1 (2002): 71-80. [PubMed Link] | [ Full text ]
  • Waters, CM ; Glucksberg, MR ; Lautenschlager, EP ; Lee, CW ; Van Matre, RM ; Warp, RJ ; Savla, U.; Healy, KE ; Moran, B.; Castner, DG ; Bearinger, JP "A system to impose prescribed homogenous strains on cultured cells." Journal of applied physiology (Bethesda, Md. : 1985) 91, 4 (2001): 1600-10. [PubMed Link] | [ Full text ]
  • Waters, CM ; Krejcie, TC ; Avram, MJ "Facilitated uptake of fentanyl, but not alfentanil, by human pulmonary endothelial cells." Anesthesiology 93, 3 (2000): 825-31. [PubMed Link] | [ Full text ]
  • Albuquerque, ML ; Waters, CM ; Savla, U.; Schnaper, HW ; Flozak, AS "Shear stress enhances human endothelial cell wound closure in vitro." American journal of physiology. Heart and circulatory physiology 279, 1 (2000): H293-302. [PubMed Link] | [ Full text ]
  • Gillis, P.; Savla, U.; Volpert, OV ; Jimenez, B.; Waters, CM ; Panos, RJ ; Bouck, NP "Keratinocyte growth factor induces angiogenesis and protects endothelial barrier function." Journal of cell science 112 ( Pt 12), (1999): 2049-57. [PubMed Link] | [ Full text ]
  • Waters, CM ; Avram, MJ ; Krejcie, TC ; Henthorn, TK "Uptake of fentanyl in pulmonary endothelium." The Journal of pharmacology and experimental therapeutics 288, 1 (1999): 157-63. [PubMed Link] | [ Full text ]
  • Waters, CM ; Savla, U. "Keratinocyte growth factor accelerates wound closure in airway epithelium during cyclic mechanical strain." Journal of cellular physiology 181, 3 (1999): 424-32. [PubMed Link] | [ Full text ]
  • Waters, CM ; Ridge, KM ; Sunio, G.; Venetsanou, K.; Sznajder, JI "Mechanical stretching of alveolar epithelial cells increases Na(+)-K(+)-ATPase activity." Journal of applied physiology (Bethesda, Md. : 1985) 87, 2 (1999): 715-21. [PubMed Link] | [ Full text ]
  • Savla, U.; Waters, CM "Mechanical strain inhibits repair of airway epithelium in vitro." American journal of physiology. Lung cellular and molecular physiology 274, 6 (1998): L883-L892. [PubMed Link] | [ Full text ]
  • Savla, U.; Waters, CM "Mechanical strain inhibits repair of airway epithelium in vitro." The American journal of physiology 274, 6 (1998): L883-92. [PubMed Link] | [ Full text ]
  • Savla, U.; Waters, CM "Barrier function of airway epithelium: effects of radiation and protection by keratinocyte growth factor." Radiation research 150, 2 (1998): 195-203. [PubMed Link] |
  • Rezania, A.; Thomas, CH ; Branger, AB ; Waters, CM ; Healy, KE "The detachment strength and morphology of bone cells contacting materials modified with a peptide sequence found within bone sialoprotein." Journal of biomedical materials research 37, 1 (1997): 9-19. [PubMed Link] |
  • Savla, U.; Sporn, PHS ; Waters, CM "Cyclic stretch of airway epithelium inhibits prostanoid synthesis." American journal of physiology. Lung cellular and molecular physiology 273, 5 (1997): L1013-L1019. [PubMed Link] | [ Full text ]
  • Savla, U.; Sporn, PH ; Waters, CM "Cyclic stretch of airway epithelium inhibits prostanoid synthesis." The American journal of physiology 273, 5 (1997): L1013-9. [PubMed Link] | [ Full text ]
  • Waters, CM ; Chang, JY ; Glucksberg, MR ; DePaola, N.; Grotberg, JB "Mechanical forces alter growth factor release by pleural mesothelial cells." The American journal of physiology 272, 3 Pt 1 (1997): L552-7. [PubMed Link] | [ Full text ]
  • Waters, CM ; Savla, U.; Panos, RJ "KGF prevents hydrogen peroxide-induced increases in airway epithelial cell permeability." The American journal of physiology 272, 4 Pt 1 (1997): L681-9. [PubMed Link] | [ Full text ]
  • Behnia, R.; Molteni, A.; Waters, CM ; Panos, RJ ; Ward, WF ; Schnaper, HW ; TS'Ao, CH "Early markers of ventilator-induced lung injury in rats." Annals of clinical and laboratory science 26, 5 (1996): 437-50. [PubMed Link] |
  • Waters, CM ; Taylor, JM ; Molteni, A.; Ward, WF "Dose-response effects of radiation on the permeability of endothelial cells in culture." Radiation research 146, 3 (1996): 321-8. [PubMed Link] |
  • Waters, CM ; Glucksberg, MR ; DePaola, N.; Chang, J.; Grotberg, JB "Shear stress alters pleural mesothelial cell permeability in culture." Journal of applied physiology (Bethesda, Md. : 1985) 81, 1 (1996): 448-58. [PubMed Link] | [ Full text ]
  • Waters, CM "Flow-induced modulation of the permeability of endothelial cells cultured on microcarrier beads." Journal of cellular physiology 168, 2 (1996): 403-11. [PubMed Link] | [ Full text ]
Dr. Waters interview

https://med.uky.edu/news/uk-physiologist-uses-biomechanics-understand-lu...

Lab Information

Lab Members: 

Brittany Dong, M.S.
Elizabeth Gordon, Ph.D.
Samuel Valenca, Ph.D.
Juan Uriarte, Ph.D.

Lab Positions Available: 

Postdoc position available

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