Andrew J. Morris, Ph.D. | Saha Cardiovascular Research Center

Andrew J. Morris, Ph.D.

Connect
About
Education
Research
Publications

a.j.morris@uky.edu
859-323-3749
741 S Limestone, BBSRB B347, Lexington, KY 40536-0509
Biosketch
Small Molecule Mass Spectrometry Core Laboratory

Position(s):

Director, Small Molecule Mass Spectrometry Core Laboratory

Ashwini Anand Professor of Cardiology

Affiliation(s):

Internal Medicine

Cardiovascular Research Center

Other Affiliation(s):

MD/PhD Program Internal Advisory Committee

MD/PhD Program Mentor

CVRC - Core Faculty

Lexington VAMC

Internal Medicine - Cardiology

pharmns-Joint Faculty

Bio / Education:

University of Bristol, B.Sc.,1981-84, Biochemistry
University of Birmingham, Ph.D., 1984-88, Biochemistry
University of North Carolina, Chapel Hill, NC, Post Doctoral, 1988-9, Pharmacology

Research Description:

Our laboratory studies the role of lipid metabolism and lipid signaling in mechanisms that determine environmental and heritable cardiovascular disease risk. Current areas of interest include studies of integral membrane lipid phosphatases and bioactive lysophospholipid meditators and investigations into mechanisms linking diet induced obesity and exposure to environmental pollutants to human disease. We are also invested in the development and application of mass spectrometry-based methods for structural analysis and quantitation of lipids and other biologically important molecules.

Selected Publications:

Dr. Morris has published more than 220 peer reviewed research articles with a total of 12400 citations. Selected recent publications include:

1: Panchatcharam M, Salous AK, Brandon J, Miriyala S, Wheeler J, Patil P, Sunkara M, Morris AJ, Escalante-Alcalde D, Smyth SS. Mice with targeted inactivation of ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability. Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):837-45. doi: 10.1161/ATVBAHA.113.302335. Epub 2014 Feb 6. PubMed PMID: 24504738; PubMed Central PMCID: PMC4001868.

2: Wu T, Kooi CV, Shah P, Charnigo R, Huang C, Smyth SS, Morris AJ. Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration. FASEB J. 2014 Feb;28(2):861-70. doi: 10.1096/fj.13-232868. Epub 2013 Nov 25. PubMed PMID: 24277575; PubMed Central PMCID: PMC3898650.

3: Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 3;502(7469):105-9. doi: 10.1038/nature12501. Epub 2013 Sep 1. PubMed PMID: 23995678; PubMed Central PMCID: PMC3791160.

4: Salous AK, Panchatcharam M, Sunkara M, Mueller P, Dong A, Wang Y, Graf GA, Smyth SS, Morris AJ. Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice. J Lipid Res. 2013 Oct;54(10):2775-84. doi: 10.1194/jlr.M039685. Epub 2013 Aug 15. PubMed PMID: 23948545; PubMed Central PMCID: PMC3770090.

5: Onono F, Subramanian T, Sunkara M, Subramanian KL, Spielmann HP, Morris AJ. Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. J Biol Chem. 2013 Sep 20;288(38):27444-55. doi: 10.1074/jbc.M113.482307. Epub 2013 Aug 1. PubMed PMID: 23908355; PubMed Central PMCID: PMC3779739.

6: Mitra MS, Chen Z, Ren H, Harris TE, Chambers KT, Hall AM, Nadra K, Klein S, Chrast R, Su X, Morris AJ, Finck BN. Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):642-7. doi: 10.1073/pnas.1213493110. Epub 2012 Dec 24. PubMed PMID: 23267081; PubMed Central PMCID: PMC3545773.

7: Bréart B, Ramos-Perez WD, Mendoza A, Salous AK, Gobert M, Huang Y, Adams RH, Lafaille JJ, Escalante-Alcalde D, Morris AJ, Schwab SR. Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med. 2011 Jun 6;208(6):1267-78. doi: 10.1084/jem.20102551. Epub 2011 May 16. PubMed PMID: 21576386; PubMed Central PMCID: PMC3173249.

8: Huang H, Gao Q, Peng X, Choi SY, Sarma K, Ren H, Morris AJ, Frohman MA. piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. Dev Cell. 2011 Mar 15;20(3):376-87. doi: 10.1016/j.devcel.2011.01.004. PubMed PMID: 21397848; PubMed Central PMCID: PMC3061402.

9: Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A. Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol. 2011 Feb;18(2):198-204. doi: 10.1038/nsmb.1980. Epub 2011 Jan 16. PubMed PMID: 21240271; PubMed Central PMCID: PMC3064516.

PubMed Publications:

D'Souza, K ; Nzirorera, C ; Cowie, AM ; Varghese, GP ; Trivedi, P.; Eichmann, TO ; Biswas, D.; Touaibia, M ; Morris, AJ ; Aidinis, V.; Kane, DA ; Pulinilkunnil, T.; Kienesberger, PC "Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism." Journal of lipid research 59, 10 (2018): 1805-1817. [PubMed Link] | [ Full text ]
Zaytseva, YY ; Rychahou, PG ; Le, AT ; Scott, TL ; Flight, RM ; Kim, JT ; Harris, J.; Liu, J.; Wang, C.; Morris, AJ ; Sivakumaran, TA ; Fan, T.; Moseley, H.; Gao, T.; Lee, EY ; Weiss, HL ; Heuer, TS ; Kemble, G.; Evers, M. "Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer." Oncotarget 9, 37 (2018): 24787-24800. [PubMed Link] | [ Full text ]
Sung, YJ ; Winkler, TW ; Las Fuentes, L.; Bentley, AR ; Brown, MR ; Kraja, AT ; Schwander, K.; Ntalla, I.; Guo, X.; Franceschini, N.; Lu, Y.; Cheng, CY ; Sim, X.; Vojinovic, D.; Marten, J.; Musani, SK ; Li, C.; Feitosa, MF ; Kilpeläinen, TO ; Richard, MA ; Noordam, R.; Aslibekyan, S.; Aschard, H.; Bartz, TM ; Dorajoo, R.; Liu, Y.; Manning, AK ; Rankinen, T.; Smith, AV ; Tajuddin, SM ; Tayo, BO ; Warren, HR ; Zhao, W.; Zhou, Y.; Matoba, N.; Sofer, T.; Alver, M.; Amini, M.; Boissel, M.; Chai, JF ; Chen, X.; Divers, J.; Gandin, I.; Gao, C.; Giulianini, F.; Goel, A.; Harris, SE ; Hartwig, FP ; Horimoto, ARVR ; Hsu, FC ; Jackson, AU ; Kähönen, M.; Kasturiratne, A.; Kühnel, B.; Leander, K.; Lee, WJ ; Lin, KH ; 'an Luan, J.; McKenzie, CA ; Meian, H.; Nelson, CP ; Rauramaa, R.; Schupf, N.; Scott, RA ; Sheu, WHH ; Stančáková, A.; Takeuchi, F.; Most, PJ ; Varga, TV ; Wang, H.; Wang, Y.; Ware, EB ; Weiss, S.; Wen, W.; Yanek, LR ; Zhang, W.; Zhao, JH ; Afaq, S.; Alfred, T.; Amin, N.; Arking, D.; Aung, T.; Barr, RG ; Bielak, LF ; Boerwinkle, E.; Bottinger, EP ; Braund, PS ; Brody, JA ; Broeckel, U.; Cabrera, CP ; Cade, B.; Caizheng, Y.; Campbell, A.; Canouil, M.; Chakravarti, A.; CHARGE Neurology Working, Group. ; Chauhan, G.; Christensen, K.; Cocca, M.; COGENT-Kidney, Consortium. ; Collins, FS ; Connell, JM ; Mutsert, R.; Silva, HJ ; Debette, S.; Dörr, M.; Duan, Q.; Eaton, CB ; Ehret, G.; Evangelou, E.; Faul, JD ; Fisher, VA ; Forouhi, NG ; Franco, OH ; Friedlander, Y.; Gao, H.; GIANT, Consortium. ; Gigante, B.; Graff, M.; Gu, CC ; Gu, D.; Gupta, P.; Hagenaars, SP ; Harris, TB ; He, J.; Heikkinen, S.; Heng, CK ; Hirata, M.; Hofman, A.; Howard, BV ; Hunt, S.; Irvin, MR ; Jia, Y.; Joehanes, R.; Justice, AE ; Katsuya, T.; Kaufman, J.; Kerrison, ND ; Khor, CC ; Koh, WP ; Koistinen, HA ; Komulainen, P.; Kooperberg, C.; Krieger, JE ; Kubo, M.; Kuusisto, J.; Langefeld, CD ; Langenberg, C.; Launer, LJ ; Lehne, B.; Lewis, CE ; Li, Y.; Lifelines Cohort, Study. ; Lim, SH ; Lin, S.; Liu, CT ; Liu, J.; Liu, J.; Liu, K.; Liu, Y.; Loh, M.; Lohman, KK ; Long, J.; Louie, T.; Mägi, R.; Mahajan, A.; Meitinger, T.; Metspalu, A.; Milani, L.; Momozawa, Y.; Morris, AP ; Mosley TH, Jr ; Munson, P.; Murray, AD ; Nalls, MA ; Nasri, U.; Norris, JM ; North, K.; Ogunniyi, A.; Padmanabhan, S.; Palmas, WR ; Palmer, ND ; Pankow, JS ; Pedersen, NL ; Peters, A.; Peyser, PA ; Polasek, O.; Raitakari, OT ; Renström, F.; Rice, TK ; Ridker, PM ; Robino, A.; Robinson, JG ; Rose, LM ; Rudan, I.; Sabanayagam, C.; Salako, BL ; Sandow, K.; Schmidt, CO ; Schreiner, PJ ; Scott, WR ; Seshadri, S.; Sever, P.; Sitlani, CM ; Smith, JA ; Snieder, H.; Starr, JM ; Strauch, K.; Tang, H.; Taylor, KD ; Teo, YY ; Tham, YC ; Uitterlinden, AG ; Waldenberger, M.; Wang, L.; Wang, YX ; Wei, WB ; Williams, C.; Wilson, G.; Wojczynski, MK ; Yao, J.; Yuan, JM ; Zonderman, AB ; Becker, DM ; Boehnke, M.; Bowden, DW ; Chambers, JC ; Chen, YI ; Faire, U.; Deary, IJ ; Esko, T.; Farrall, M.; Forrester, T.; Franks, PW ; Freedman, BI ; Froguel, P.; Gasparini, P.; Gieger, C.; Horta, BL ; Hung, YJ ; Jonas, JB ; Kato, N.; Kooner, JS ; Laakso, M.; Lehtimäki, T.; Liang, KW ; Magnusson, PKE ; Newman, AB ; Oldehinkel, AJ ; Pereira, AC ; Redline, S.; Rettig, R.; Samani, NJ ; Scott, J.; Shu, XO ; Harst, P.; Wagenknecht, LE ; Wareham, NJ ; Watkins, H.; Weir, DR ; Wickremasinghe, AR ; Wu, T.; Zheng, W.; Kamatani, Y.; Laurie, CC ; Bouchard, C.; Cooper, RS ; Evans, MK ; Gudnason, V.; Kardia, SLR ; Kritchevsky, SB ; Levy, D.; O'Connell, JR ; Psaty, BM ; Dam, RM ; Sims, M.; Arnett, DK ; Mook-Kanamori, DO ; Kelly, TN ; Fox, ER ; Hayward, C.; Fornage, M.; Rotimi, CN ; Province, MA ; Duijn, CM ; Tai, ES ; Wong, TY ; Loos, RJF ; Reiner, AP ; Rotter, JI ; Zhu, X.; Bierut, LJ ; Gauderman, WJ ; Caulfield, MJ ; Elliott, P.; Rice, K.; Munroe, PB ; Morrison, AC ; Cupples, LA ; Rao, DC ; Chasman, DI "A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure." American journal of human genetics 102, 3 (2018): 375-400. [PubMed Link] | [ Full text ]
Lidgerwood, GE ; Morris, AJ ; Conquest, A.; Daniszewski, M.; Rooney, LA ; Lim, SY ; Hernandez, D.; Liang, HH ; Allen, P.; Connell, PP ; Guymer, RH ; Hewitt, AW ; Pébay, A. "Role of lysophosphatidic acid in the retinal pigment epithelium and photoreceptors." Biochimica et biophysica acta. Molecular and cell biology of lipids 1863, 7 (2018): 750-761. [PubMed Link] |
Jafari, N.; Drury, J ; Morris, AJ ; Onono, FO ; Stevens, PD ; Gao, T.; Liu, J.; Wang, C.; Lee, EY ; Weiss, HL ; Evers, BM ; Zaytseva, YY "De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer." Molecular cancer research : MCR (2018): [PubMed Link] | [ Full text ]
Thalman, C.; Horta, G.; Qiao, L.; Endle, H.; Tegeder, I.; Cheng, H.; Laube, G.; Sigrudsson, T.; Hauser, MJ ; Tenzer, S.; Distler, U.; Aoki, J.; Morris, AJ ; Geisslinger, G.; Röper, J.; Kirischuk, S.; Luhmann, HJ ; Radyushkin, K.; Nitsch, R.; Vogt, J. "Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders." Molecular psychiatry 23, 8 (2018): 1699-1710. [PubMed Link] | [ Full text ]
Thalman, C.; Horta, G.; Qiao, L.; Endle, H.; Tegeder, I.; Cheng, H.; Laube, G.; Sigrudsson, T.; Hauser, MJ ; Tenzer, S.; Distler, U.; Aoki, J.; Morris, AJ ; Geisslinger, G.; Röper, J.; Kirischuk, S.; Luhmann, HJ ; Radyushkin, K.; Nitsch, R.; Vogt, J. "Astrocytic ATX fuels synaptic phospholipid signaling involved in psychiatric disorders." Molecular psychiatry 23, 8 (2018): 1685-1686. [PubMed Link] | [ Full text ]
Petriello, MC ; Brandon, JA ; Hoffman, J.; Wang, C.; Tripathi, H.; Abdel-Latif, A.; Ye, X.; Li, X.; Yang, L.; Lee, E.; Soman, S.; Barney, J.; Wahlang, B.; Hennig, B.; Morris, AJ "Dioxin-like PCB 126 Increases Systemic Inflammation and Accelerates Atherosclerosis in Lean LDL Receptor-Deficient Mice." Toxicological sciences : an official journal of the Society of Toxicology 162, 2 (2018): 548-558. [PubMed Link] | [ Full text ]
Chandra, M.; Escalante-Alcalde, D.; Bhuiyan, MS ; Orr, AW ; Kevil, C.; Morris, AJ ; Nam, H.; Dominic, P.; McCarthy, KJ ; Miriyala, S.; Panchatcharam, M. "Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure." Redox biology 14, (2018): 261-271. [PubMed Link] | [ Full text ]
Petriello, MC ; Charnigo, R.; Sunkara, M.; Soman, S.; Pavuk, M.; Birnbaum, L.; Morris, AJ ; Hennig, B. "Relationship between serum trimethylamine N-oxide and exposure to dioxin-like pollutants." Environmental research 162, (2018): 211-218. [PubMed Link] | [ Full text ]
Malik, R.; Chauhan, G.; Traylor, M.; Sargurupremraj, M.; Okada, Y.; Mishra, A.; Rutten-Jacobs, L.; Giese, AK ; Laan, SW ; Gretarsdottir, S.; Anderson, CD ; Chong, M.; Adams, HHH ; Ago, T.; Almgren, P.; Amouyel, P.; Ay, H.; Bartz, TM ; Benavente, OR ; Bevan, S.; Boncoraglio, GB ; Brown RD, Jr ; Butterworth, AS ; Carrera, C.; Carty, CL ; Chasman, DI ; Chen, WM ; Cole, JW ; Correa, A.; Cotlarciuc, I.; Cruchaga, C.; Danesh, J.; Bakker, PIW ; DeStefano, AL ; Hoed, M.; Duan, Q.; Engelter, ST ; Falcone, GJ ; Gottesman, RF ; Grewal, RP ; Gudnason, V.; Gustafsson, S.; Haessler, J.; Harris, TB ; Hassan, A.; Havulinna, AS ; Heckbert, SR ; Holliday, EG ; Howard, G.; Hsu, FC ; Hyacinth, HI ; Ikram, MA ; Ingelsson, E.; Irvin, MR ; Jian, X.; Jiménez-Conde, J.; Johnson, JA ; Jukema, JW ; Kanai, M.; Keene, KL ; Kissela, BM ; Kleindorfer, DO ; Kooperberg, C.; Kubo, M.; Lange, LA ; Langefeld, CD ; Langenberg, C.; Launer, LJ ; Lee, JM ; Lemmens, R.; Leys, D.; Lewis, CM ; Lin, WY ; Lindgren, AG ; Lorentzen, E.; Magnusson, PK ; Maguire, J.; Manichaikul, A.; McArdle, PF ; Meschia, JF ; Mitchell, BD ; Mosley, TH ; Nalls, MA ; Ninomiya, T.; O'Donnell, MJ ; Psaty, BM ; Pulit, SL ; Rannikmäe, K.; Reiner, AP ; Rexrode, KM ; Rice, K.; Rich, SS ; Ridker, PM ; Rost, NS ; Rothwell, PM ; Rotter, JI ; Rundek, T.; Sacco, RL ; Sakaue, S.; Sale, MM ; Salomaa, V.; Sapkota, BR ; Schmidt, R.; Schmidt, CO ; Schminke, U.; Sharma, P.; Slowik, A.; Sudlow, CLM ; Tanislav, C.; Tatlisumak, T.; Taylor, KD ; Thijs, VNS ; Thorleifsson, G.; Thorsteinsdottir, U.; Tiedt, S.; Trompet, S.; Tzourio, C.; Duijn, CM ; Walters, M.; Wareham, NJ ; Wassertheil-Smoller, S.; Wilson, JG ; Wiggins, KL ; Yang, Q.; Yusuf, S.; Bis, JC ; Pastinen, T.; Ruusalepp, A.; Schadt, EE ; Koplev, S.; Björkegren, JLM ; Codoni, V.; Civelek, M.; Smith, NL ; Trégouët, DA ; Christophersen, IE ; Roselli, C.; Lubitz, SA ; Ellinor, PT ; Tai, ES ; Kooner, JS ; Kato, N.; He, J.; Harst, P.; Elliott, P.; Chambers, JC ; Takeuchi, F.; Johnson, AD ; Sanghera, DK ; Melander, O.; Jern, C.; Strbian, D.; Fernandez-Cadenas, I.; Longstreth WT, Jr ; Rolfs, A.; Hata, J.; Woo, D.; Rosand, J.; Pare, G.; Hopewell, JC ; Saleheen, D.; Stefansson, K.; Worrall, BB ; Kittner, SJ ; Seshadri, S.; Fornage, M.; Markus, HS ; Howson, JMM ; Kamatani, Y.; Debette, S.; Dichgans, M.; Malik, R.; Chauhan, G.; Traylor, M.; Sargurupremraj, M.; Okada, Y.; Mishra, A.; Rutten-Jacobs, L.; Giese, AK ; Laan, SW ; Gretarsdottir, S.; Anderson, CD ; Chong, M.; Adams, HHH ; Ago, T.; Almgren, P.; Amouyel, P.; Ay, H.; Bartz, TM ; Benavente, OR ; Bevan, S.; Boncoraglio, GB ; Brown RD, Jr ; Butterworth, AS ; Carrera, C.; Carty, CL ; Chasman, DI ; Chen, WM ; Cole, JW ; Correa, A.; Cotlarciuc, I.; Cruchaga, C.; Danesh, J.; Bakker, PIW ; DeStefano, AL ; Hoed, MD ; Duan, Q.; Engelter, ST ; Falcone, GJ ; Gottesman, RF ; Grewal, RP ; Gudnason, V.; Gustafsson, S.; Haessler, J.; Harris, TB ; Hassan, A.; Havulinna, AS ; Heckbert, SR ; Holliday, EG ; Howard, G.; Hsu, FC ; Hyacinth, HI ; Ikram, MA ; Ingelsson, E.; Irvin, MR ; Jian, X.; Jiménez-Conde, J.; Johnson, JA ; Jukema, JW ; Kanai, M.; Keene, KL ; Kissela, BM ; Kleindorfer, DO ; Kooperberg, C.; Kubo, M.; Lange, LA ; Langefeld, CD ; Langenberg, C.; Launer, LJ ; Lee, JM ; Lemmens, R.; Leys, D.; Lewis, CM ; Lin, WY ; Lindgren, AG ; Lorentzen, E.; Magnusson, PK ; Maguire, J.; Manichaikul, A.; McArdle, PF ; Meschia, JF ; Mitchell, BD ; Mosley, TH ; Nalls, MA ; Ninomiya, T.; O'Donnell, MJ ; Psaty, BM ; Pulit, SL ; Rannikmäe, K.; Reiner, AP ; Rexrode, KM ; Rice, K.; Rich, SS ; Ridker, PM ; Rost, NS ; Rothwell, PM ; Rotter, JI ; Rundek, T.; Sacco, RL ; Sakaue, S.; Sale, MM ; Salomaa, V.; Sapkota, BR ; Schmidt, R.; Schmidt, CO ; Schminke, U.; Sharma, P.; Slowik, A.; Sudlow, CLM ; Tanislav, C.; Tatlisumak, T.; Taylor, KD ; Thijs, VNS ; Thorleifsson, G.; Thorsteinsdottir, U.; Tiedt, S.; Trompet, S.; Tzourio, C.; Duijn, CM ; Walters, M.; Wareham, NJ ; Wassertheil-Smoller, S.; Wilson, JG ; Wiggins, KL ; Yang, Q.; Yusuf, S.; Amin, N.; Aparicio, HS ; Arnett, DK ; Attia, J.; Beiser, AS ; Berr, C.; Buring, JE ; Bustamante, M.; Caso, V.; Cheng, YC ; Choi, SH ; Chowhan, A.; Cullell, N.; Dartigues, JF ; Delavaran, H.; Delgado, P.; Dörr, M.; Engström, G.; Ford, I.; Gurpreet, WS ; Hamsten, A.; Heitsch, L.; Hozawa, A.; Ibáñez, L.; Ilinca, A.; Ingelsson, M.; Iwasaki, M.; Jackson, RD ; Jood, K.; Jousilahti, P.; Kaffashian, S.; Kalra, L.; Kamouchi, M.; Kitazono, T.; Kjartansson, O.; Kloss, M.; Koudstaal, PJ ; Krupinski, J.; Labovitz, DL ; Laurie, CC ; Levi, CR ; Li, L.; Lind, L.; Lindgren, CM ; Lioutas, V.; Liu, YM ; Lopez, OL ; Makoto, H.; Martinez-Majander, N.; Matsuda, K.; Minegishi, N.; Montaner, J.; Morris, AP ; Muiño, E.; Müller-Nurasyid, M.; Norrving, B.; Ogishima, S.; Parati, EA ; Peddareddygari, LR ; Pedersen, NL ; Pera, J.; Perola, M.; Pezzini, A.; Pileggi, S.; Rabionet, R.; Riba-Llena, I.; Ribasés, M.; Romero, JR ; Roquer, J.; Rudd, AG ; Sarin, AP ; Sarju, R.; Sarnowski, C.; Sasaki, M.; Satizabal, CL ; Satoh, M.; Sattar, N.; Sawada, N.; Sibolt, G.; Sigurdsson, Á.; Smith, A.; Sobue, K.; Soriano-Tárraga, C.; Stanne, T.; Stine, OC ; Stott, DJ ; Strauch, K.; Takai, T.; Tanaka, H.; Tanno, K.; Teumer, A.; Tomppo, L.; Torres-Aguila, NP ; Touzé, E.; Tsugane, S.; Uitterlinden, AG ; Valdimarsson, EM ; Lee, SJ ; Völzke, H.; Wakai, K.; Weir, D.; Williams, SR ; Wolfe, CDA ; Wong, Q.; Xu, H.; Yamaji, T.; Sanghera, DK ; Melander, O.; Jern, C.; Strbian, D.; Fernandez-Cadenas, I.; Longstreth WT, Jr ; Rolfs, A.; Hata, J.; Woo, D.; Rosand, J.; Pare, G.; Hopewell, JC ; Saleheen, D.; Stefansson, K.; Worrall, BB ; Kittner, SJ ; Seshadri, S.; Fornage, M.; Markus, HS ; Howson, JMM ; Kamatani, Y.; Debette, S.; Dichgans, M.; AFGen, Consortium. ; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), Consortium. ; International Genomics of Blood Pressure (iGEN-BP), Consortium. ; INVENT, Consortium. ; , STARNET. ; BioBank Japan Cooperative Hospital, Group. ; COMPASS, Consortium. ; EPIC-CVD, Consortium. ; EPIC-InterAct, Consortium. ; International Stroke Genetics Consortium, (ISGC). ; METASTROKE, Consortium. ; Neurology Working Group of the CHARGE, Consortium. ; NINDS Stroke Genetics Network, (SiGN). ; UK Young Lacunar DNA, Study. ; MEGASTROKE, Consortium. ; MEGASTROKE, Consortium:. "Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes." Nature genetics 50, 4 (2018): 524-537. [PubMed Link] | [ Full text ]
Federico, L.; Yang, L.; Brandon, J.; Panchatcharam, M.; Ren, H.; Mueller, P.; Sunkara, M.; Escalante-Alcalde, D.; Morris, AJ ; Smyth, SS "Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice." PloS one 13, 6 (2018): e0198063. [PubMed Link] | [ Full text ]
Rush, JS ; Edgar, RJ ; Deng, P.; Chen, J.; Zhu, H.; Sorge, NM ; Morris, AJ ; Korotkov, KV ; Korotkova, N. "The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A carbohydrate in Streptococcus pyogenes." The Journal of biological chemistry 292, 47 (2017): 19441-19457. [PubMed Link] | [ Full text ]
Dong, A.; Mueller, P.; Yang, F.; Yang, L.; Morris, A.; Smyth, SS "Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice." Thrombosis research 159, (2017): 58-64. [PubMed Link] | [ Full text ]
Keune, WJ ; Potjewyd, F.; Heidebrecht, T.; Salgado-Polo, F.; Macdonald, SJ ; Chelvarajan, L.; Abdel Latif, A.; Soman, S.; Morris, AJ ; Watson, AJ ; Jamieson, C.; Perrakis, A. "Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators." Journal of medicinal chemistry 60, 5 (2017): 2006-2017. [PubMed Link] | [ Full text ]
Patil, VS ; Gutierrez, AM ; Sunkara, M.; Morris, AJ ; Hilt, JZ ; Kalika, DS ; Dziubla, TD "Curcumin Acrylation for Biological and Environmental Applications." Journal of natural products 80, 7 (2017): 1964-1971. [PubMed Link] | [ Full text ]
Zhang, J.; Hughes, RR ; Saunders, MA ; Elshahawi, SI ; Ponomareva, LV ; Zhang, Y.; Winchester, SR ; Scott, SA ; Sunkara, M.; Morris, AJ ; Prendergast, MA ; Shaaban, KA ; Thorson, JS "Identification of Neuroprotective Spoxazomicin and Oxachelin Glycosides via Chemoenzymatic Glycosyl-Scanning." Journal of natural products 80, 1 (2017): 12-18. [PubMed Link] | [ Full text ]
Tang, S.; Floy, M.; Bhandari, R.; Sunkara, M.; Morris, AJ ; Dziubla, TD ; Hilt, JZ "Synthesis and Characterization of Thermoresponsive Hydrogels Based on N-Isopropylacrylamide Crosslinked with 4,4'-Dihydroxybiphenyl Diacrylate." ACS omega 2, 12 (2017): 8723-8729. [PubMed Link] | [ Full text ]
Wahlang, B.; Barney, J.; Thompson, B.; Wang, C.; Hamad, OM ; Hoffman, JB ; Petriello, MC ; Morris, AJ ; Hennig, B. "Editor's Highlight: PCB126 Exposure Increases Risk for Peripheral Vascular Diseases in a Liver Injury Mouse Model." Toxicological sciences : an official journal of the Society of Toxicology 160, 2 (2017): 256-267. [PubMed Link] | [ Full text ]
Liu, DJ ; Peloso, GM ; Yu, H.; Butterworth, AS ; Wang, X.; Mahajan, A.; Saleheen, D.; Emdin, C.; Alam, D.; Alves, AC ; Amouyel, P.; Di Angelantonio, E.; Arveiler, D.; Assimes, TL ; Auer, PL ; Baber, U.; Ballantyne, CM ; Bang, LE ; Benn, M.; Bis, JC ; Boehnke, M.; Boerwinkle, E.; Bork-Jensen, J.; Bottinger, EP ; Brandslund, I.; Brown, M.; Busonero, F.; Caulfield, MJ ; Chambers, JC ; Chasman, DI ; Chen, YE ; Chen, YI ; Chowdhury, R.; Christensen, C.; Chu, AY ; Connell, JM ; Cucca, F.; Cupples, LA ; Damrauer, SM ; Davies, G.; Deary, IJ ; Dedoussis, G.; Denny, JC ; Dominiczak, A.; Dubé, MP ; Ebeling, T.; Eiriksdottir, G.; Esko, T.; Farmaki, AE ; Feitosa, MF ; Ferrario, M.; Ferrières, J.; Ford, I.; Fornage, M.; Franks, PW ; Frayling, TM ; Frikke-Schmidt, R.; Fritsche, LG ; Frossard, P.; Fuster, V.; Ganesh, SK ; Gao, W.; Garcia, ME ; Gieger, C.; Giulianini, F.; Goodarzi, MO ; Grallert, H.; Grarup, N.; Groop, L.; Grove, ML ; Gudnason, V.; Hansen, T.; Harris, TB ; Hayward, C.; Hirschhorn, JN ; Holmen, OL ; Huffman, J.; Huo, Y.; Hveem, K.; Jabeen, S.; Jackson, AU ; Jakobsdottir, J.; Jarvelin, MR ; Jensen, GB ; Jørgensen, ME ; Jukema, JW ; Justesen, JM ; Kamstrup, PR ; Kanoni, S.; Karpe, F.; Kee, F.; Khera, AV ; Klarin, D.; Koistinen, HA ; Kooner, JS ; Kooperberg, C.; Kuulasmaa, K.; Kuusisto, J.; Laakso, M.; Lakka, T.; Langenberg, C.; Langsted, A.; Launer, LJ ; Lauritzen, T.; Liewald, DCM ; Lin, LA ; Linneberg, A.; Loos, RJF ; Lu, Y.; Lu, X.; Mägi, R.; Malarstig, A.; Manichaikul, A.; Manning, AK ; Mäntyselkä, P.; Marouli, E.; Masca, NGD ; Maschio, A.; Meigs, JB ; Melander, O.; Metspalu, A.; Morris, AP ; Morrison, AC ; Mulas, A.; Müller-Nurasyid, M.; Munroe, PB ; Neville, MJ ; Nielsen, JB ; Nielsen, SF ; Nordestgaard, BG ; Ordovas, JM ; Mehran, R.; O'Donnell, CJ ; Orho-Melander, M.; Molony, CM ; Muntendam, P.; Padmanabhan, S.; Palmer, CNA ; Pasko, D.; Patel, AP ; Pedersen, O.; Perola, M.; Peters, A.; Pisinger, C.; Pistis, G.; Polasek, O.; Poulter, N.; Psaty, BM ; Rader, DJ ; Rasheed, A.; Rauramaa, R.; Reilly, DF ; Reiner, AP ; Renström, F.; Rich, SS ; Ridker, PM ; Rioux, JD ; Robertson, NR ; Roden, DM ; Rotter, JI ; Rudan, I.; Salomaa, V.; Samani, NJ ; Sanna, S.; Sattar, N.; Schmidt, EM ; Scott, RA ; Sever, P.; Sevilla, RS ; Shaffer, CM ; Sim, X.; Sivapalaratnam, S.; Small, KS ; Smith, AV ; Smith, BH ; Somayajula, S.; Southam, L.; Spector, TD ; Speliotes, EK ; Starr, JM ; Stirrups, KE ; Stitziel, N.; Strauch, K.; Stringham, HM ; Surendran, P.; Tada, H.; Tall, AR ; Tang, H.; Tardif, JC ; Taylor, KD ; Trompet, S.; Tsao, PS ; Tuomilehto, J.; Tybjaerg-Hansen, A.; Zuydam, NR ; Varbo, A.; Varga, TV ; Virtamo, J.; Waldenberger, M.; Wang, N.; Wareham, NJ ; Warren, HR ; Weeke, PE ; Weinstock, J.; Wessel, J.; Wilson, JG ; Wilson, PWF ; Xu, M.; Yaghootkar, H.; Young, R.; Zeggini, E.; Zhang, H.; Zheng, NS ; Zhang, W.; Zhang, Y.; Zhou, W.; Zhou, Y.; Zoledziewska, M.; Charge Diabetes Working, Group. ; EPIC-InterAct, Consortium. ; EPIC-CVD, Consortium. ; GOLD, Consortium. ; VA Million Veteran, Program. ; Howson, JMM ; Danesh, J.; McCarthy, MI ; Cowan, CA ; Abecasis, G.; Deloukas, P.; Musunuru, K.; Willer, CJ ; Kathiresan, S. "Exome-wide association study of plasma lipids in >300,000 individuals." Nature genetics 49, 12 (2017): 1758-1766. [PubMed Link] | [ Full text ]
Song, ES ; Jang, H.; Guo, HF ; Juliano, MA ; Juliano, L.; Morris, AJ ; Galperin, E.; Rodgers, DW ; Hersh, LB "Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes." Proceedings of the National Academy of Sciences of the United States of America 114, 14 (2017): E2826-E2835. [PubMed Link] | [ Full text ]
Jafari, N.; Kim, H.; Park, R.; Li, L.; Jang, M.; Morris, AJ ; Park, J.; Huang, C. "CRISPR-Cas9 Mediated NOX4 Knockout Inhibits Cell Proliferation and Invasion in HeLa Cells." PloS one 12, 1 (2017): e0170327. [PubMed Link] | [ Full text ]
Dobierzewska, A.; Soman, S.; Illanes, SE ; Morris, AJ "Plasma cross-gestational sphingolipidomic analyses reveal potential first trimester biomarkers of preeclampsia." PloS one 12, 4 (2017): e0175118. [PubMed Link] | [ Full text ]
Huber, TD ; Wang, F.; Singh, S.; Johnson, BR ; Zhang, J.; Sunkara, M.; Van Lanen, SG ; Morris, AJ ; Phillips GN, Jr ; Thorson, JS "Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways." ACS chemical biology 11, 9 (2016): 2484-91. [PubMed Link] | [ Full text ]
Liu, M.; Verma, N.; Peng, X.; Srodulski, S.; Morris, A.; Chow, M.; Hersh, LB ; Chen, J.; Zhu, H.; Netea, MG ; Margulies, KB ; Despa, S.; Despa, F. "Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury." Diabetes 65, 9 (2016): 2772-83. [PubMed Link] | [ Full text ]
Wang, X.; Maruvada, R.; Morris, AJ ; Liu, JO ; Wolfgang, MJ ; Baek, DJ ; Bittman, R.; Kim, KS "Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier." PLoS pathogens 12, 10 (2016): e1005926. [PubMed Link] | [ Full text ]
Morris, AJ ; Smyth, SS "Regulation of Lysophosphatidic Acid Metabolism and Signaling by Lipoproteins." Arteriosclerosis, thrombosis, and vascular biology 36, 10 (2016): 2029-30. [PubMed Link] | [ Full text ]
Li, J.; Song, J.; Zaytseva, YY ; Liu, Y.; Rychahou, P.; Jiang, K.; Starr, ME ; Kim, JT ; Harris, JW ; Yiannikouris, FB ; Katz, WS ; Nilsson, PM ; Orho-Melander, M.; Chen, J.; Zhu, H.; Fahrenholz, T.; Higashi, RM ; Gao, T.; Morris, AJ ; Cassis, LA ; Fan, TW ; Weiss, HL ; Dobner, PR ; Melander, O.; Jia, J.; Evers, BM "An obligatory role for neurotensin in high-fat-diet-induced obesity." Nature 533, 7603 (2016): 411-5. [PubMed Link] | [ Full text ]
Liu, CT ; Raghavan, S.; Maruthur, N.; Kabagambe, EK ; Hong, J.; Ng, MC ; Hivert, MF ; Lu, Y.; An, P.; Bentley, AR ; Drolet, AM ; Gaulton, KJ ; Guo, X.; Armstrong, LL ; Irvin, MR ; Li, M.; Lipovich, L.; Rybin, DV ; Taylor, KD ; Agyemang, C.; Palmer, ND ; Cade, BE ; Chen, WM ; Dauriz, M.; Delaney, JA ; Edwards, TL ; Evans, DS ; Evans, MK ; Lange, LA ; Leong, A.; Liu, J.; Liu, Y.; Nayak, U.; Patel, SR ; Porneala, BC ; Rasmussen-Torvik, LJ ; Snijder, MB ; Stallings, SC ; Tanaka, T.; Yanek, LR ; Zhao, W.; Becker, DM ; Bielak, LF ; Biggs, ML ; Bottinger, EP ; Bowden, DW ; Chen, G.; Correa, A.; Couper, DJ ; Crawford, DC ; Cushman, M.; Eicher, JD ; Fornage, M.; Franceschini, N.; Fu, YP ; Goodarzi, MO ; Gottesman, O.; Hara, K.; Harris, TB ; Jensen, RA ; Johnson, AD ; Jhun, MA ; Karter, AJ ; Keller, MF ; Kho, AN ; Kizer, JR ; Krauss, RM ; Langefeld, CD ; Li, X.; Liang, J.; Liu, S.; Lowe WL, Jr ; Mosley, TH ; North, KE ; Pacheco, JA ; Peyser, PA ; Patrick, AL ; Rice, KM ; Selvin, E.; Sims, M.; Smith, JA ; Tajuddin, SM ; Vaidya, D.; Wren, MP ; Yao, J.; Zhu, X.; Ziegler, JT ; Zmuda, JM ; Zonderman, AB ; Zwinderman, AH ; AAAG, Consortium. ; CARe, Consortium. ; COGENT-BP, Consortium. ; , Consortium. ; MEDIA, Consortium. ; Adeyemo, A.; Boerwinkle, E.; Ferrucci, L.; Hayes, MG ; Kardia, SL ; Miljkovic, I.; Pankow, JS ; Rotimi, CN ; Sale, MM ; Wagenknecht, LE ; Arnett, DK ; Chen, YD ; Nalls, MA ; MAGIC, Consortium. ; Province, MA ; Kao, WH ; Siscovick, DS ; Psaty, BM ; Wilson, JG ; Loos, RJ ; Dupuis, J.; Rich, SS ; Florez, JC ; Rotter, JI ; Morris, AP ; Meigs, JB "Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin." American journal of human genetics 99, 1 (2016): 56-75. [PubMed Link] | [ Full text ]
Petriello, MC ; Hoffman, JB ; Sunkara, M.; Wahlang, B.; Perkins, JT ; Morris, AJ ; Hennig, B. "Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker trimethylamine N-oxide from dietary precursors." The Journal of nutritional biochemistry 33, (2016): 145-53. [PubMed Link] | [ Full text ]
Vogt, J.; Yang, JW ; Mobascher, A.; Cheng, J.; Li, Y.; Liu, X.; Baumgart, J.; Thalman, C.; Kirischuk, S.; Unichenko, P.; Horta, G.; Radyushkin, K.; Stroh, A.; Richers, S.; Sahragard, N.; Distler, U.; Tenzer, S.; Qiao, L.; Lieb, K.; Tüscher, O.; Binder, H.; Ferreiros, N.; Tegeder, I.; Morris, AJ ; Gropa, S.; Nürnberg, P.; Toliat, MR ; Winterer, G.; Luhmann, HJ ; Huai, J.; Nitsch, R. "Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP." EMBO molecular medicine 8, 1 (2016): 25-38. [PubMed Link] | [ Full text ]
Murphy, MO ; Petriello, MC ; Han, SG ; Sunkara, M.; Morris, AJ ; Esser, K.; Hennig, B. "Exercise protects against PCB-induced inflammation and associated cardiovascular risk factors." Environmental science and pollution research international 23, 3 (2016): 2201-11. [PubMed Link] | [ Full text ]
Keune, WJ ; Hausmann, J.; Bolier, R.; Tolenaars, D.; Kremer, A.; Heidebrecht, T.; Joosten, RP ; Sunkara, M.; Morris, AJ ; Matas-Rico, E.; Moolenaar, WH ; Oude Elferink, RP ; Perrakis, A. "Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling." Nature communications 7, (2016): 11248. [PubMed Link] | [ Full text ]