Ahmed Abdel-Latif, M.D., Ph.D.

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abdel-latif@uky.edu
859-323-6036
741 S Limestone, BBSRB B349, Lexington, KY 40536-0509
Biosketch

Position(s):

Associate Professor

Affiliation(s):

Internal Medicine

Cardiovascular Research Center

Other Affiliation(s):

Lexington VAMC

CVRC - Core Faculty

Internal Medicine - Cardiology

Nutritional Sciences Graduate Faculty

Interests / Specialties:

Cardiovascular Medicine

Bio / Education:

Ain Shams University, Cairo, Egypt, M.D. 1990-1997 Medicine
Cleveland Clinic Foundation, Cleveland, OH, 2001-2004 Medicine
University of Louisville, Louisville, KY, 2004-2007 Cardiology
University of Louisville, Louisville, KY, M.S. 2005-2007 Public Health
University of Kentucky, Lexington, KY, 2007-2009 Interventional Cardiology
University of Kentucky, Lexington, KY, Ph.D. 2008-2012 Immunology and Molecular Biology

Selected Publications:

1. Bolli R, Abdel-Latif A. “No pain, no gain. The useful function of angina”. Circulation. 2005; 112: 3541-3543. PMID: 16330693

2. Dawn B, Zuba-Surma EK, Abdel-Latif A, Tiwari S, Bolli R. “Cardiac stem cell therapy for myocardial regeneration. A clinical perspective”. Minerva Cardioangiol. 2005; 53 (6): 549-564. PMID: 16333238

3. Zuba-Surma EK, Abdel-Latif A, Case J, Tiwari S, Hunt G, Vincent RJ, Ranjan S, Srour EF, Bolli R, Dawn B. Sca-1 expression is associated with decreased cardiomyogenic differentiation potential of adult primitive cells. J Mol Cell Cardiol. 2006; 41 (4): 650-660. PMID: 16938308

4. Abdel-Latif A, Bolli R, Tleyjeh IM, Montori VM, Perin EC, Hornung CA, Zuba-Surma EK, Al-Mallah M, Dawn B. “Adult Bone Marrow-Derived Cells for Cardiac Repair: A Systematic Review and Meta-Analysis”. Arch Intern Med. 2007; 167 (10): 989-997. PMID: 17533201

5. Zuba-Surma E, Kucia M, Abdel-Latif A, Lillard JW, Jr., Ratajczak MZ. "The ImageStream System: A Key Step to a New Era in Imaging". Folia Histochem Cytobiol. 2007; 45 (4): 279-290. PMID: 18165167

6. Zuba-Surma E, Kucia M, Abdel-Latif A, Dawn B, Brian Hall, Singh R, Lillard JW, Jr., Ratajczak MZ. “Morphological characterization of very small embryonic- like stem cells (VSELs) by image stream system analysis”. J Cell Mol Med. 2008; 12 (1): 292-303. PMID: 18031297

7. Flaherty MP, Abdel-Latif A, Li Q, Hunt G, Ranjan S, Ou Q, Tang X, Johnson RK, Bolli R, Dawn B. “Noncanonical wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells”. Circulation, 2008; 117 (17); 2241-2252. PMID: 18427129

8. Dawn B, Tiwari S, Kucia M, Zuba-Surma EK, Guo Y, SanganalMath SK, Abdel-Latif A, Hunt G, Vincent RJ, Taher H, Reed NJ, Ratajczak MZ, Bolli R. “Transplantation of bone marrow-derived very small embryonic-like stem cells (VSELs) attenuates left ventricular dysfunction and remodeling after myocardial infarction”. Stem Cells, 2008; 26 (6):1646-1655. PMID: 18420834

9. Abdel-Latif A, Bolli R, Zuba-Surma EK, Tleyjeh IM, Hornung CA, Dawn B. “G-CSF therapy in acute myocardial infarction: a systematic review and meta-analysis of the randomized controlled studies”. Am Heart J. 2008; 156 (2): 216-226. PMID: 18657649

10. Abdel-Latif A, Zuba-Surma E, Case J, Tiwari S, Hunt G, Ranjan S, Vincent R, Srour E, Bolli R, Dawn B. “TGF-β1 enhances cardiomyogenic differentiation potential of skeletal muscle derived adult primitive cells”. Basic Res Cardiol, 2008: 103 (6): 514-524. PMID: 103 (6): 514-524. PMID: 18500484

PubMed Publications:

Keune, W.J.;Potjewyd, F.;Heidebrecht, T.;Salgado-Polo, F.;Macdonald, S.J.;Chelvarajan, L.;Abdel Latif, A.;Soman, S.;Morris, A.J.;Watson, A.J.;Jamieson, C.;Perrakis, A. "Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators." Journal of medicinal chemistry 60, 5 (2017): 2006-2017. [PubMed Link] | [ Full text ]
Hayek, S.S.;Klyachkin, Y.;Asfour, A.;Ghasemzadeh, N.;Awad, M.;Hesaroieh, I.;Ahmed, H.;Gray, B.;Kim, J.;Waller, E.K.;Quyyumi, A.A.;Abdel-Latif, A.K. "Bioactive Lipids and Circulating Progenitor Cells in Patients with Cardiovascular Disease." Stem cells translational medicine 6, 3 (2017): 731-735. [PubMed Link] | [ Full text ]
Misumida, N.;Kobayashi, A.;Kim, S.M.;Abdel-Latif, A.;Ziada, K.M. "Role of Routine Follow-up Coronary Angiography After Percutaneous Coronary Intervention　- Systematic Review and Meta-Analysis." Circulation journal : official journal of the Japanese Circulation Society (2017): [PubMed Link] | [ Full text ]
Adamiak, M.;Chelvarajan, L.;Lynch, K.R.;Santos, W.L.;Abdel-Latif, A.;Ratajczak, M.Z. "Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells." Oncotarget (2017): [PubMed Link] | [ Full text ]
Quyyumi, A.A.;Vasquez, A.;Kereiakes, D.J.;Klapholz, M.;Schaer, G.L.;Abdel-Latif, A.;Frohwein, S.;Henry, T.D.;Schatz, R.A.;Dib, N.;Toma, C.;Davidson, C.J.;Barsness, G.W.;Shavelle, D.M.;Cohen, M.;Poole, J.;Moss, T.;Hyde, P.;Kanakaraj, A.M.;Druker, V.;Chung, A.;Junge, C.;Preti, R.A.;Smith, R.L.;Mazzo, D.J.;Pecora, A.;Losordo, D.W. "PreSERVE-AMI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intracoronary Administration of Autologous CD34+ Cells in Patients With Left Ventricular Dysfunction Post STEMI." Circulation research 120, 2 (2017): 324-331. [PubMed Link] | [ Full text ]
Cavalcanti, R.;Aboul-Hosn, N.;Morales, G.;Abdel-Latif, A. "Implantable Cardioverter Defibrillator for the Primary Prevention of Sudden Cardiac Death in Patients With Nonischemic Cardiomyopathy." Angiology (2017): 3319717710851. [PubMed Link] | [ Full text ]
Adamiak, M.;Abdelbaset-Ismail, A.;Suszynska, M.;Abdel-Latif, A.;Ratajczak, J.;Ratajczak, M.Z. "Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades." Leukemia 31, 1 (2017): 262-265. [PubMed Link] | [ Full text ]
Pumphrey, A.L.;Ye, S.;Yang, Z.;Simkin, J.;Gensel, J.C.;Abdel-Latif, A.;Vandsburger, M.H. "Cardiac Chemical Exchange Saturation Transfer MR Imaging Tracking of Cell Survival or Rejection in Mouse Models of Cell Therapy." Radiology 282, 1 (2017): 131-138. [PubMed Link] | [ Full text ]
Adamiak, M.;Abdelbaset-Ismail, A.;Moore JB, 4th;Zhao, J.;Abdel-Latif, A.;Wysoczynski, M.;Ratajczak, M.Z. "Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking." Stem cell reviews 13, 1 (2017): 92-103. [PubMed Link] | [ Full text ]
Hayek, S.S.;Klyachkin, Y.;Asfour, A.;Ghasemzadeh, N.;Awad, M.;Hesaroieh, I.;Ahmed, H.;Gray, B.;Kim, J.;Waller, E.K.;Quyyumi, A.A.;Abdel-Latif, A.K. "Bioactive Lipids and Circulating Progenitor Cells in Patients With Cardiovascular Disease." Stem cells translational medicine (2016): [PubMed Link] | [ Full text ]
Ziada, K.M.;Abdel-Latif, A.K.;Charnigo, R.;Moliterno, D.J. "Safety of an abbreviated duration of dual antiplatelet therapy (≤6 months) following second-generation drug-eluting stents for coronary artery disease: A systematic review and meta-analysis of randomized trials." Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 87, 4 (2016): 722-732. [PubMed Link] | [ Full text ]
Lolay, G.A.;Abdel-Latif, A.K. "Trauma induced myocardial infarction." International journal of cardiology 203, (2016): 19-21. [PubMed Link] | [ Full text ]
Ruiz-Rodriguez, E.;Asfour, A.;Lolay, G.;Ziada, K.M.;Abdel-Latif, A.K. "Systematic Review and Meta-Analysis of Major Cardiovascular Outcomes for Radial Versus Femoral Access in Patients With Acute Coronary Syndrome." Southern medical journal 109, 1 (2016): 61-76. [PubMed Link] | [ Full text ]
Pumphrey, A.;Yang, Z.;Ye, S.;Powell, D.K.;Thalman, S.;Watt, D.S.;Abdel-Latif, A.;Unrine, J.;Thompson, K.;Fornwalt, B.;Ferrauto, G.;Vandsburger, M. "Advanced cardiac chemical exchange saturation transfer (cardioCEST) MRI for in vivo cell tracking and metabolic imaging." NMR in biomedicine 29, 1 (2016): 74-83. [PubMed Link] | [ Full text ]
Abdel Hamid, M.;Bakhoum, S.W.;Sharaf, Y.;Sabry, D.;El-Gengehe, A.T.;Abdel-Latif, A. "Circulating Endothelial Cells and Endothelial Function Predict Major Adverse Cardiac Events and Early Adverse Left Ventricular Remodeling in Patients With ST-Segment Elevation Myocardial Infarction." Journal of interventional cardiology 29, 1 (2016): 89-98. [PubMed Link] | [ Full text ]
Adamiak, M.;Suszynska, M.;Abdel-Latif, A.;Abdelbaset-Ismail, A.;Ratajczak, J.;Ratajczak, M.Z. "The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells." Stem cell reviews 12, 6 (2016): 613-620. [PubMed Link] | [ Full text ]
Darrat, Y.H.;Agarwal, A.;Morales, G.X.;Thompson, J.;Abdel-Latif, A.;Waespe, K.;Di Biase, L.;Natale, A.;Patwardan, A.;Elayi, C.S. "Radiofrequency and Cryo-Ablation Effect on Transvenous Pacing and Defibrillatory Lead Integrity: An In Vitro Study." Journal of cardiovascular electrophysiology 27, 8 (2016): 976-80. [PubMed Link] | [ Full text ]
Wallace, E.L.;Tasan, E.;Cook, B.S.;Charnigo, R.;Abdel-Latif, A.K.;Ziada, K.M. "Long-Term Outcomes and Causes of Death in Patients With Renovascular Disease Undergoing Renal Artery Stenting." Angiology 67, 7 (2016): 657-63. [PubMed Link] | [ Full text ]
Adamiak, M.;Poniewierska-Baran, A.;Borkowska, S.;Schneider, G.;Abdelbaset-Ismail, A.;Suszynska, M.;Abdel-Latif, A.;Kucia, M.;Ratajczak, J.;Ratajczak, M.Z. "Evidence that a lipolytic enzyme--hematopoietic-specific phospholipase C-β2--promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes." Leukemia 30, 4 (2016): 919-28. [PubMed Link] | [ Full text ]