UK Scientists Feature Prominently at International Cardiovascular Research Conference

University of Kentucky scientists featured prominently at the Vascular Discovery 2019 (formerly ATVB|PVD Scientific Sessions) held in Boston, MA from May 14-16. Researchers from across campus, notably from the Saha Cardiovascular Research Center, were at the forefront of the event, highlighting the continued success of cardiovascular research at the University of Kentucky.

For exclusive video content of Vascular Discovery 2019, including interviews with select University of Kentucky scientists, follow the link below: https://professional.heart.org/professional/EducationMeetings/MeetingsLiveCME/ATVBPVD/UCM_501929_Science-News-for-Vascular-Discovery-2019.jsp

Congratulations to all the UK researchers that participated, listed below. Their heavy involvement in Vascular Discovery 2019 is both a personal achievement and an achievement for the UK Research Community. Their research, along with so many others, is instrumental in continuing the make the University of Kentucky one of the top cardiovascular research universities in the nation.

Committee Chair - Nancy Webb

Program committee - Nancy Webb, Alan Daugherty

Invited Oral Presenters - Lisa Cassis, Jeff Chen, Alan Daugherty,

Invited Moderators - Hong Lu, Nancy Webb,

Abstract reviewers - Alan Daugherty, Ming Gong, Zhenheng Guo, Victoria King, Zhenyu Li, Hong Lu, Lisa Tannock,

Awards - Mentor of Women, Nancy Webb

Poster Presentations Sexual Dimorphism of Experimental Thoracic Aortic Diseases, Jeff Chen, University of Kentucky

AT1a Receptor Deficiency Attenuates Thoracic Aortic Aneurysm Progression in FBN1C1041G/+ Mice, Jeff Chen, Jessica Moorleghen, Mary Sheppard, Alan Daugherty, University of Kentucky

Epigenetic Modifications Influence Macrophage-mediated Inflammation in Abdominal Aortic Aneurysms, Frank M. Davis, Aaron Dendekker, Amrita Joshi, Christopher Audu, Andrea Obi, Steven Kunkel, Jonathan Eliason, University of Michigan, Ann Arbor, MI; Hong Lu, Alan Daugherty, Lexington, KY; Katherin Gallagher, University of Kentucky, University of Michigan

Myeloid Cell-derived Interferon Regulatory Factor 5 Promotes Experimental Abdominal Aortic Aneurysms, Baohui Xu, Yankui Li, Xiaoya Zheng, Stanford University Sch of Med, Stanford, CA; Xiaofeng Chen, Taizhou Hosp Wenzhou Medical University, Linhai, China; Sihai Zhao, Jia Guo, Takahiro Shoji, Stanford University Sch of Med, Stanford, CA; Masaaki Miyata, Kagoshima City Hosp, Kagoshima, Japan; Alan Daugherty, Hong S Lu, SAHA Cardiovascular Res Ctr University of Kentucky, Lexington, KY; Ronald L Dalman, Stanford University School of Medcine, University of Kentucky

Anti-apolipoprotein A-I Antibody Profile Correlates with Cardiovascular Disease Outcomes, David Henson,Ayman Samman Tahhan, Arshed Ali Quyyumi, Vincent Venditto. University of Kentucky, Emory University,

Heparin-Binding EGF-like Growth Factor (HB-EGF) Mediates the Myelopoiesis During the Development of Metabolic Disease. Seonwook Kim, Lihua Yang, Richard G Lee, Mark J Graham, Aldons J Lusis, Judith A Berliner, Ryan E Temel, KY; Himi Tripathi, Ahmed Abdel-Latif, Sangderk Lee. University of Kentucky, UCLA, Ionis Pharmaceuticals

Enhanced Autophagy by Celastrol Supplementation Profoundly Increases Angiotensin II-induced Abdominal Aortic Aneurysm Formation in Male and Female Mice. Aida Javidan, Weihua Jiang, Lihua Yang, Venkateswaran Subramanian. University of Kentucky, Lexington, KY

miR-146a Deficiency Accelerates Abdominal Aortic Aneurysms in Male Mice Co-infused with Lysyl Oxidase Inhibitor and Angiotensin II. Weihua Jiang, Aida Javidan, Michihiro Okuyama, Jessica J Moorleghen, Lihua Yang, Venkateswaran Subramanian. University of Kentucky.

Prolonged Pharmacological Inhibition of Lysyl Oxidase Induces Heterogeneous Aortic Pathologies in Juvenile Male and Female Mice. Michael Franklin. University of Kentucky

Myeloid Cell-specific Deficiency of Hif-1α or Vegf-a Attenuates Experimental Atherosclerosis. Sihai Zhao, Yankui Li, Jia Guo, Stanford University Sch of Med, Stanford, CA; Hong S Lu, SAHA Cardiovascular Res Ctr University of Kentucky, Lexingtong, KY; Xiaoya Zheng, Stanford University Sch of Med, Stanford, CA; Xiaofeng Chen, Taizhou Hosp Wenzhou Medical University, Linhai, China; Alan Daugherty, SAHA Cardiovascular Res Ctr University of Kentucky, Lexingtong, KY; Enqi Liu, Xi’an Jiaotong University Health Science Ctr, Xi’an, China; Baohui Xu, Ronald L Dalman, Stanford University Sch of Med, Stanford, CA

Poly ADP-Ribose Polymerase 1 (PARP-1) in Calf Skeletal Muscle is Associated With Walking Performance in Peripheral Artery Disease Sunil Kumar Saini, University of Florida, Inst on Aging, Dept of Aging and Geriatric Res, Gainesville, FL; Tamar S Polonsky, The University of Chicago Med, Chicago, IL; Tian Lu, Stanford University, Dept of Health Res and Policy Biomedical Data Science, Stanford, CA; Clara B Peek, Northwestern University Feinberg Sch of Med, Chicago, IL; Michael H Criqui, University of California San Diego Dept of Family Med and Public Health, San Diego, CA; Luigi Ferrucci, Natl Inst on Aging, Div of Intramural Res, Baltimore, MD; Jack Guralnik, University of Maryland Sch of Med, Dept of Epidemiology and Public Health, Baltimore, MD; Melina Kibbe, University of North Carolina, Dept of Surgery, Chapel Hill, NC; Charlotte A Peterson, Coll of Health Sciences, University of Kentucky Dept of Epidemiology, Lexington, KY; Robert L Sufit, Northwestern University Feinberg Sch of Med, Dept of Med, Chicago, IL; Christiaan Leeuwenburgh, University of Florida, Inst on Aging, Dept of Aging and Geriatric Res, Gainesville, FL; Mary M McDermott, Northwestern University Feinberg Sch of Med, Dept of Preventive Med, Chicago, IL

High Mobility Group Box 1 is Increased in the Abdominal Aortic Adventitia of Angiotensin II-Infused Hypercholesterolemic Male Mice. Shayan Mohammadmoradi, Deborah A Howatt, Jessica J. Moorleghen, Hisashi Sawada, Hong S Lu, Alan Daugherty, University of Kentucky, Lexington, KY

Endothelial Mineralocorticoid Receptor Mediates Aldosterone and High Salt-Induced Abdominal Aortic Aneurysm in Mice Shu Liu, Yu Zhong, Xufang Mu, Ming Gong, Zhenheng Guo, University of Kentucky, Lexington, KY

Protective Role of LRP1 in Second Heart Field-derived Smooth Muscle Cells Against Angiotensin II-induced Thoracic Aortic Aneurysm Hisashi Sawada, University of Kentucky, Lexington, KY; Hideyuki Higashi, Harvard Medical Sch, Boston, MA; Debra L Rateri, Deborha A Howatt, Jessica J Moorleghen, Bradley C Wright, University of Kentucky, Lexington, KY; Lang H Lee, Sasha A Singh, Masanori Aikawa, Harvard Medical Sch, Boston, MA; Mark W Majesky, University of Washington, Seattle, WA; Alan Daugherty, University of Kentucky, Lexington, KY

Pharmacological Inhibition of Hippo-YAP Signaling Attenuates Angiotensin II-induced Ascending Aortic Aneurysms in Male LDL Receptor Deficient Mice Michihiro Okuyama, Weihua Jiang, Lihua Yang, Aida Javidan, Devi Thiagarajan, Saha Cardiovascular Res Ctr, University of Kentucky, Lexington, KY; Venkateswaran Subramanian, Saha Cardiovascular Res Ctr, University of Kentucky

SAA is not Incorporated into HDL During HDL Biogenesis Ailing Ji, Xuebing Wang, Victoria P Noffsinger, Maria C de Beer, Frederick C de Beer, Lisa R Tannock, Nancy R Webb, University Kentucky, Lexington, KY

High Density Lipoprotein Preserves the Function of Alpha-1-antitrypsin by Shielding the Reactive Center Loop from Oxidation. Alexander A Karakashian, University of Kentucky, Lexington, KY; Denis Sviridov, NHLBI, Bethesda, MD; Toshihiro Sakurai, Hokkaido University, Hokkaido, Japan; Lita A Freeman, NHLBI, Bethesda, MD; Gang Ren, Lawrence Berkeley Natl Lab, Berkeley, CA; Alan T Remaley, NHLBI, Bethesda, MD; Scott M Gordon, University of Kentucky, Lexington, KY

Adipocyte-derived Serum Amyloid A Promotes Angiotensin II-induced Abdominal Aortic Aneurysms in Obese C57BL/6 Mice. Preetha Shridas, Andrea Trumbauer, Ailing Ji, Victoria Noffsinger, Madison Rich, Maria de Beer, Frederick C de Beer, Nancy R Webb, Lisa R Tannock, University of Kentucky, Lexington, KY

Subclass Composition of Anti-Apolipoprotein AI Antibodies in Mice in Response to Inflammatory Stimuli. Michelle Pitts, Michelle Marti, Vincent J Venditto, University of Kentucky, Lexington, KY

Conserved Sequence in the Loop Region of Angiotensinogen Affects Plasma Angiotensinogen Concentrations but Has No Effects on Angiotensin II-mediated Functions. Chia-Hua Wu, Deborah Howatt, Jessica Moorleghen, Craig Vander Kooi, Alan Daugherty, Hong Lu, University of Kentucky, Lexington, KY

Videos https://professional.heart.org/professional/EducationMeetings/MeetingsLiveCME/ATVBPVD/UCM_501929_Science-News-for-Vascular-Discovery-2019.jsp