Recent Faculty Publications: "Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation."

Author information

1
Saha Cardiovascular Research Center, University of Kentucky.
2
Department of Physiology, University of Kentucky.

Abstract

BACKGROUND:

Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms.Methods and Results:AngI infusion led to thoracic and abdominal aortic aneurysms in low-density lipoprotein receptor-deficient mice, which were ablated by ACE inhibition. Endothelial or smooth muscle cell-specific ACE deletion resulted in reduction of AngI-induced thoracic, but not abdominal, aortic dilatation.

CONCLUSIONS:

AngI infusion causes thoracic and abdominal aortic aneurysms in mice. ACE in aortic resident cells has differential effects on AngI-induced thoracic and abdominal aortic aneurysms.

KEYWORDS:

Angiotensin; Angiotensin-converting enzyme; Aortic aneurysm; Endothelial cells; Smooth muscle cells

PMID:
 
32238693
 
DOI:
 
10.1253/circj.CJ-19-0955