Recent Faculty Publication: "Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases."

Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases.
Kim S1, Subramanian V1,2, Abdel-Latif A1,3, Lee S1,4.
Author information
1 Saha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington, Kentucky.
2 Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky.
3 Department of Medicine-Cardiology, and University of Kentucky College of Medicine, Lexington, Kentucky.
4 Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky.

Abstract

Heparin-binding EGF-like growth factor (HB-EGF) is an EGF family member that interacts with epidermal growth factor receptor (EGFR) and ERBB4. Since HB-EGF was first identified as a novel growth factor secreted from a human macrophage cell line, numerous pathological and physiological functions related to cell proliferation, migration, and inflammation have been reported. Notably, the expression of HB-EGF is sensitively upregulated by oxidative stress in the endothelial cells and functions for auto- and paracrine-EGFR signaling. Overnutrition and obesity cause elevation of HB-EGF expression and EGFR signaling in the hepatic and vascular systems. Modulations of HB-EGF signaling showed a series of protections against phenotypes related to metabolic syndrome and advanced metabolic diseases, suggesting HB-EGF as a potential target against metabolic diseases.

KEYWORDS:
HB-EGF; NAFLD; atherosclerosis; endothelial cells; metabolic syndrome

PMID: 32077785 DOI: 10.1089/met.2019.0120