Previous Journal Club Schedule

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Speaker Institute Title Host/Sponsor
1/17/2017 Sean Thatcher, PhD "CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury" Cassis Lab
1/24/2017 Hisashi Sawada, PhD "Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events" Daugherty Lab
1/31/2017 Tianfei Hou, PhD "Glucocorticoids Induce Nondipping Blood Pressure by Activating the Thiazide-Sensitive Cotransporter" Gong Lab
2/7/2017 Greg Graf, PhD "Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice" Graf Lab
2/14/2017 Shu Liu "Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome" Zhenheng Guo Lab
2/21/2017 Sangderk Lee "The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation" Sangderk Lee Lab
2/28/2017 Chia-Hua Wu "Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice" Xiangan Li Lab
3/7/2017 Yanzhang Li "Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation" Nancy Webb Lab
3/14/2017 *NO Journal Club-UK Spring Break* *NO Journal Club-UK Spring Break*
3/21/2017 Peter Hecker "The effects of apolipoprotein B depletion on HDL subspecies composition and function" Ryan Temel Lab
3/28/2017 Shayan Mohammad Moradi "Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe−/− Mice" Venkateswaran Subramanian Lab
4/4/2017 *NO Journal Club-Fayette County Spring Break* *NO Journal Club-Fayette County Spring Break*
4/11/2017 Stuart Pope "Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis" Graf Lab
4/18/2017 Tracy Liu "Releasing the Brakes on the Fibrinolytic System in Pulmonary Emboli" Smyth Lab
Speaker Institute Title Host/Sponsor
1/26/2016 Gregory Graf, PhD "A peptide encoded by a transcript annoated as long noncoding RNA enhances SERCA activity in muscle"
2/2/2016 Alan Daugherty, PhD, DSc "Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome"
2/9/2016 Sean Thatcher, PhD "Depletion of fat-resident Treg cells prevents age-associated insulin resistance"
2/16/2016 Florin Despa Lab "Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis"
2/23/2016 Graf Lab "New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk"
3/1/2016 Guo Lab "Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges"
3/8/2016 Lee Lab "Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity"
3/15/2016 UK Spring Break No Journal Club
3/22/2016 Loria Lab "Immune activation caused by vascular oxidation promotes fibrosis and hypertension"
3/29/2016 Satin Lab "Attenuation of the unfolded protein response and endoplasmic reticulum stress after mechanical unloading in dilated cardiomyopathy"
4/5/2016 Temel Lab "Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease"
4/12/2016 Webb Lab "Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains"
4/19/2016 Zhou Lab "FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues"
9/6/2016 Alan Daugherty Lab "FOXE3 mutations predispose to thoracic aortic aneurysms and dissections"
9/13/2016 Ming Gong Lab "Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm"
9/20/2016 Greg Graf Lab "The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria"
9/27/2016 Zhenheng Guo Lab "DC isoketal-modified proteins activate T cells and promote hypertension"
10/4/2016 Sangderk Lee Lab "VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications"
10/11/2016 Xiangan Li Lab "Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis"
10/18/2016 Nancy Webb Lab "TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis"
10/25/2016 Ryan Temel Lab "microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain"
11/1/2016 Shuxia Wang Lab "Farnesoid X Receptor Activation Increases Reverse Cholesterol Transport by Modulating Bile Acid Composition and Cholesterol Absorption in Mice"
11/8/2016 *Election Day! No Journal Club* *Election Day! No Journal Club*
11/15/2016 Venkateswaran Subramanian Lab "Matricellular protein CCN3 mitigates abdominal aortic aneurysm"
11/29/2016 Lisa Cassis Lab "Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm"
 DateSpeakerInstituteTitle
Spring Semester 2015
1/27/2015Sean Thatcher, PhDPharmacology and Nutritional Sciences"Angiotensin II Mobilizes Spleen Monocytes to Promote the Development of Abdominal Aortic Aneurysm in Apoe−/− Mice"
2/3/2015Gregory Graf, PhDPharmaceutical Sciences"The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance"
2/10/2015Joe Layne, PhDSaha Cardiovascular Research Center, Pharmacology and Nutritional Sciences"Alginic acid cell entrapment: a novel method for measuring in vivo macrophage cholesterol homeostasis"
2/17/2015  Cancelled due to weather
2/24/2015Nate HelsleyPharmacology and Nutritional Sciences"MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism"
3/3/2015Sangderk Lee, PhDSaha Cardiovascular Research Center, Pharmacology and Nutritional Sciences"NF-kB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis"
3/17/2015No Journal Club UK Spring Break
3/24/2015Gregory Graf, PhDPharmaceutical Sciences"Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH."
3/31/2015Alan Daugherty, PhD, DScSaha Cardiovascular Research Center, Physiology"Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan Syndrome"
4/7/2015Jianing Li "Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease"
4/14/2015Sonja PijutPharmacology and Nutritional Sciences"Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance"
4/21/2015Yuhuan WangPharmacology and Nutritional Sciences"Interplay between FGF21 and insulin action in the liver regulates metabolism"
4/28/2015Heather NormanPharmacology and Nutritional Sciences"Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice"
Fall Semester 2015
9/8/2015Joe Layne, PhDSaha Cardiovascular Research Center, Pharmacology and Nutritional Sciences"Development and rescue of human familial hypercholesterolaemia in a xenograt mouse model"
9/15/2015Nate HelsleyPharmacology and Nutritional Sciences"The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice"
9/22/2015Heather NormanPharmacology and Nutritional Sciences"The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity"
9/29/2015Jing LiuSaha Cardiovascular Research Center, Pharmacology and Nutritional Sciences"Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production"
10/6/2015Reiya HaydenPharmacology and Nutritional Sciences"New CETP inhibitor K-312 reduces PCSK9 expression: a potentional effect on LDL cholesterol metabolism"
10/13/2015Gregory Graf, PhDPharmaceutical Sciences"Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis"
10/20/2015Leryn ReynoldsPharmacology and Nutritional Sciences"A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis"
10/27/2015Hong Lu, MD, PhDSaha Cardiovascular Research Center, Physiology"Dissecting abdominal aortic aneurysm in Ang II-infused mice- suprarenal branch ruptures and apparent luminal dilatation"
11/3/2015Ryan Temel, PhDPharmacology and Nutritional Sciences"MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels"
11/17/2015Sean Thatcher, PhDPharmacology and Nutritional Sciences"Abnormal mechanosensing and cofilin activation promotes the progression of ascending aoritic aneurysms in mice"
11/24/2015No Journal Club No Cardiovascular Journal Club
12/1/2015Hong Lu, MD, PhDSaha Cardiovascular Research Center, Physiology"A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome"
12/8/2015Yasir Al-SirajPharmacology and Nutritional Sciences"Increased High-Density Lipoprotein Cholesterol Levels in Mice With XX Versus XY Sex Chromosomes"
DATEPRESENTERTITLE
Spring Semester 2014
1/21/2014Robin Shoemaker"Activation of Hypoxia−Inducible Factor−2 in Adipocytes Results in Pathological Cardiac Hypertrophy"
1/28/2014Joseph Layne"Visualization of lipid metabolism in the larval zebrafish intestine reveals a relationship between NPC1L1 mediated cholesterol
2/4/2014Frank Davis"Angiotensin II–dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis" and "Aortic aneurysms in Loeys-Dietz syndrome — a tale of two pathways?"
2/11/2014Ryan TemelGeneration of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
2/18/2014Shu Liu"Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging"
2/25/2014

Xiaoxi Liu

"Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids"
3/4/2014Heather Norman-Burgdolf"Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch"
3/11/2014Nate Helsley"The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion"
3/18/2014UK Spring Break 
3/25/2014Brianna Harfmann 
4/1/2014Jing Liu 
4/8/2014Jianing Li 
4/15/2014Yuhuan Wang 
4/22/2014Yasir Alsiraj 
4/29/2014Sonja Pujit

 

5/6/2014Sean Thatcher 
Fall Semester 2013
9/10/13Hua QingLocal proliferation dominates lesional macrophage accumulation in atherosclerosis
9/17/13Joseph LayneReciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance
9/24/13Alan Daugherty, PhD, DScHow to Review a Paper Improving Bioscience Research reporting:  The ARRIVE Guidelines for Reporting Animal Research A Call for Transparent Reporting to Optimize the Predictive Value of Preclinical Research
10/1/13Robin ShoemakerBetatrophin: A Hormone that Controls Pancreatic β Cell Proliferation 
10/8/13Alan Daugherty, PhD, DScContinuation of 9/24/13 Discussion
10/15/13Sonja PijutCircadian Regulation of Lipid Mobilization in White Adipose Tissue
10/22/13Shaojing YeCholesterol Efflux in Megakaryocyte Progenitors Suppresses Platelet Production and Thromocytosis
10/29/13Catherine KaminskiDiabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation
11/5/13Cancelled 
11/12/13Yu Wang

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

11/19/13Joel ThompsonPlasmin Promotes Foam Cell Formation by Increasing Macrophage Catabolism of Aggregated Low-Density Lipoprotein
11/26/13Frank Davis"Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development"
12/3/13Richard Charnigo, PhD

Power Analysis

12/10/13Greg Wehner"Why Most Published Research Findings Are False"
Spring Semester 2013
1/22/2013Sonja RheeObesity in mice with adipocyte-specific deletion of clock component Arnt1
1/29/2013Yu WangACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
2/5/2013Jing LiuCyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms
2/12/2013Jason MeyerPhilosophy of Science
2/19/2013Xiaoxi LiuDistinct Developmental Signatures of Human Abdominal and Gluteal Subcutaneous Adipose Tissue Depots
2/26/2013Greg GrafJNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
3/5/2013Kyung Sik JungNeutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection
3/12/2013UK Spring Break 
3/19/2013Nate HelsleyCharacterization of the adipocyte cellular lineage in vivo
3/26/2013Sean ThatcherMyocardial infarction accelerates atherosclerosis (Supplement)
4/2/2013Vicky KingTranscriptional Cofactor TBLR1 Controls Lipid Mobilization in White Adipose Tissue
4/9/2013Joseph LayneLymphatic vasculature mediates macrophage reverse cholesterol transport in mice
4/16/2013Catherine KaminskiPhospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy
4/23/2013Matthew ParkerA selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
4/30/2013Robin Shoemaker

Fetal PGC-1 Overexpression Programs Adult Pancreatic Cell Dysfunction

5/7/2013Congqing Wu 
Fall Semester 2012
8/28/12Sonja Rhee"CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action"                          
9/4/12Jason Meyer"Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglyceride"
9/11/12Robin Shoemaker"Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like Peptide 1-dependent mechanism"  Supplement
9/18/12Sean Thatcher"BBS-Induced Ciliary Defect Enhances Adipogenesis, Causing Paradoxical Higher-Insulin Sensitivity, Glucose Usage, and Decreased Inflammatory Response"
9/25/12Alan Daugherty, PhD, DSc"How to Review a Paper"
10/2/12Jianing Li"Trans-Intestinal Cholesterol Efflux is Not Mediated Through High Density Lipoprotein"
10/9/12Cancelled 
10/16/12Yinchuan Xu"Heart repair by reprogramming non-myocytes with cardiac transcription factors"
10/23/12Jenny Lutshumba"Activation of AMP-activated protein kinase Î±2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo"
10/30/12Joseph Layne"Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses"
11/6/12Cancelled - Election Day 
11/13/12Kyung Sik Jung"MMP-2 Regulates Erk1/2 Phosphorylation and Aortic Dilatation in Marfan Syndrome"
11/20/12Nicki Baker

"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats"

11/27/12Paul Mueller"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease."
12/04/12Joel Thompson"Apolipoprotein E mimetic is more effective than apolipoprotein A-I mimetic in reducing lesion formation in older female apo E null mice"
Spring Semester 2012
01/17/12Jon Satin, Ph.D.“Preparation of Competitive Fellowship Applications”                               
01/24/12Jason Meyer"Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth"
01/31/12Nicki Baker"A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis"
02/07/12Kelly Putnam"Inhibitor of Differntiation-3 Mediates High Fat Diet-Induced Visceral Fat Expansion"
02/14/12Kyung Sik Jung"Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice"
02/21/12Robin Shoemaker

"Silence of TRIB3 Supresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE-/- and LDR-/- Mice."

02/28/12Lindsay Carter"Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice"
03/06/12Joseph Layne

"Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue"

03/13/12No Seminar - UK Spring Break 
03/20/12Xiaoxi Liu

"Absence of RIP140 Reveals a Pathway Regulating glut4-Dependent Glucose Uptake in Oxidative Skeletal Muscle through UCP1-Mediated Activation of AMPK"

03/27/12Yuhuan Wang

"The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals" (Supplement)

04/03/12No seminar 
04/10/12Jenny Lutshumba"Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-y, and Proinflammatory Adipokines"
04/17/12No Seminar - ATVB Conference 
04/24/12Sean Thatcher"The CARMA3-Bcl10-MALT1 Signalosome Promotes Angiotensin II-dependent Vascular Inflammation and Atherogenesis”
05/01/12Aruna Poduri"Myeloid-Specific Kruppel-Like Factor 2 Inactivation Increases Macrophage and Neutrophil Adhesion and Promotes Atherosclerosis"
05/08/12Kai Su"Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling"
Fall Semester 2011
9/6/11Greg Graf, Ph.D.High Blood Pressure Research
9/13/11CANCELLED 
9/20/11Sonja RheeClinical Cardiology
9/27/11Nick HatchBasic Cardiovascular Sciences
10/4/11CANCELLED 
10/11/11Kelly Putnam Nutrition, Physical Activity and Metabolism
10/18/11Joel ThompsonPeripheral Vascular Disease
10/25/11Alan Daugherty, Ph.D., D.Sc.Stroke
11/1/11Lindsay CarterHigh Blood Pressure Research
11/8/11Ore AdedoyinArteriosclerosis, Thrombosis and Vascular Biology
11/15/11Xiaofeng ChenClinical Cardiology
11/22/11Aruna PoduriBasic Cardiovascular Sciences
11/29/11Tao TangKidney in Cardiovascular Disease
12/6/11Nicki BakerNutrition, Physical Activity and Metabolism
12/13/11Jenny LutshumbaPeripheral Vascular Disease
Spring Semester 2011
01/25/11Greg GrafHigh Blood Pressure Research
02/01/11Nicki BakerArteriosclerosis, Thrombosis and Vascular Biology
02/08/11Jason MeyerClinical Cardiology
02/15/11CANCELLED 
02/22/11 Kidney in Cardiovascular Disease
03/01/11Kelly PutnamNutrition, Physical Activity and Metabolism
03/08/11Frederique Batifoulier-YiannikourisPeripheral Vascular Disease
03/15/11 No Seminar
03/22/11Congqing WuStroke
03/29/11Nick HatchArteriosclerosis, Thrombosis and Vascular Biology
04/05/11Jingjing LiuBasic Cardiovascular Sciences
04/12/11Aruna PoduriClinical Cardiology
04/19/11Ore AdedoyinArteriosclerosis, Thrombosis and Vascular Biology
04/26/11Yuhuan WangHigh Blood Pressure Research
05/03/11Dan BartosKidney in Cardiovascular Disease
05/10/11Kai SuNutrition, Physical Activity and Metabolism
Fall Semester 2010
09/07Nadia SabevaIntestinal Specific LXR Activation Stimulates Reverse Cholesterol Transport and Protects from Atherosclerosis 
09/14Sean ThatcherATP-Binding Cassette Transporter G1 and High-Density Lipoprotein Promote Endothelial NO Synthesis Through a Decrease in the Interaction of Caveolin-1 and Endothelial NO Synthase
09/21Nicholas HatchCyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes
09/28David PeleshokAn Intracellular Role for ABCG1-Mediated Cholesterol Transport in the Regulated Secretory Pathway of Mouse Pancreatic Beta Cells
10/05Shawn CrumpIncreasing Cardiac Contractility After Myocardial Infarction Exacerbates Cardiac Injury and Pump Dysfunction
10/12Aruna PoduriMiR-33 Contributes to the Regulation of Cholesterol Homeostasis
10/19Jason MeyerNLRP3 Inflammasomes are Required for Atherogenesis and Activated by Cholesterol Crystals
10/26Ling Zou  Adenosine Monophosphate Activated Protein Kinase Induces Cholesterol Efflux from Macrophage-Derived Foam Cells and Alleviates Atherosclerosis in Apolipoprotein E-Deficient Mice
11/02Xiaofeng ChenAngiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice with Myocardial Infarction
11/09Jingjing Liu  SIRT3 Regulates Mitochondrial Fatty-Acid Oxidation by Reversible Enzyme Deacetylation
11/16Tao Tang Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis
11/23Yuhuan WangBiliary Sterol Secretion Is Not Required for Macrophage Reverse Cholesterol Transport
11/30Kai SuAutophagy Regulates Lipid Metabolism
12/07 The Immortal Life of Henrietta Lacks
12/14Dan BartosMutation of an A-Kinase-Anchoring Protein Causes Long-QT Syndrome
12/21 Cancelled
Spring Semester 2010
01/26David PeleshokReducing Endoplasmic Reticulum Stress Through a Macrophage Lipid Chaperone Alleviates Atherosclerosis
02/02Alan Daugherty, Ph.D., D.Sc.What is truth?  Standards of Scientific Integrity in American Heart Association Journals
02/09Nicolas HatchThe impact of Microsomal Prostaglandin E Synthase 1 on Blood Pressure is Determined by Genetic Background Hypertension
02/16Cancelled 
02/23Kelly A. PutnamEffects of Caspase Inhibitor on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E Deficient Mice
03/02Madhura ParulkarTGF-B Activity Protects Against Inflammatory Aortic Aneurysm Progression and Complications in Angiotensin II-Infused Mice
03/09Gregory Graf, Ph.D.Coffee Consumption Enhances High-Density Lipoprotein-Mediated Cholesterol Efflux in Macrophages
03/16Mihail I. Mitov, Ph.D.Glycemic Control Prevents Microvascular Remodeling and Increased Tone in Type 2 Diabetes: Link to Endothelin-1
03/23Xiaofeng ChenThe Rho Exchange Factor Arhgef1 Mediates the Effects of Angiotensin II on Vascular Tone and Blood Pressure.
03/30No Seminar 
04/06Frederique Batifoulier-YiannikourisValsartan Protects Pancreatic Islets and Adipose Tissue from the Inflammatory and Metabolic Consequences of a High-Fat Diet in Mice
04/13VariousDiscussion of ATVB Highlights
04/20Ling ZouNuclear Receptor Liver X Receptor is O-GIcNAc-modified in Response to Glucose
04/27Jingjing LiuDifferential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes 
05/04 *Location changed to Pharmacy, BPC 234BJohn S. Parks, Ph.D.Exploring the Role of Liver ABCA1 in Lipoprotein Metabolism.
05/11Nadezhda S. SabevaSynthetic LXR Agonist Attenuates Plaque Formation in ApoE -/- Mice without Inducing Liver Steatosis and Hypertriglyceridemia
05/18Aruna PoduriVasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E Deficient Mice
Fall Semester 2009
09/08Greg Graf 
09/15David PeleshokLXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor.
09/22Jason MeyerCD36 Deficiency Rescues Lipotoxic Cardiomyopathy.
09/29Chad WilkersonIntrauterine Growth Restriction Increases Fetal Hepatic Gluconeogenic Capacityand Reduces Messenger Ribonucleic Acid Translation Initiation and Nutrient Sensing in Fetal Liver and Skeletal Muscle
10/06No Journal Club 
10/13Nadezhda SabevaFox 01 Mediates Insulin-Dependent Regulation of Hepatic VLDL Production in Mice.
10/20Nicole BrogdenEffect of Rimonabant on the High-Triglyceride/Low HDL-Cholesterol Dyslipidemia, Intraabdominal Adiposity, and Liver Fat: The ADAGIO-Lipids Trial
10/27Jingjing LiuFibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice.
11/03Manisha GupteAngiotensin II Type 1 Receptor-Mediated Reduction of Angiotensin-Converting Enzyme 2 Activity in the Brain Impairs Baroreflex Function in Hypertensive Mice.
11/10Aruna PoduriAcquisition of the Contractile Phenotype by Murine Arterial Smooth Muscle Cells Depends on the Mir143/145 Gene Cluster.
11/17Sean ThatcherPrevention of Pulmonary Hypertension by Angiotensin-Converting Enzyme 2 Gene Transfer.
11/24No Journal Club 
12/01Kelly PutnamAdiponectin Reduces Lipid Accumulation in Macrophage Foam Cells.
12/08Congqing WuThe Protein Kinase IKKε Regulates Energy Balance in Obese Mice.
12/15Xiaofeng ChenVascular Wall ACE is not required for Atherogenesis in ApoE-/- Mice.
Spring Semester 2009
1/13Greg GrafA Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance.
01/20Nicholas HatchProinflammatory Phenotype of Perivascular Adipocytes Influences of High-Fat Feeding.
01/27  
02/03Greg GrafPGC-1a is Coupled to HIF-1 a-Dependent Gene Expression by Increasing Mitochondrial Oxygen Consumption in Skeletal Muscle Cells.
02/10Sean ThatcherSIRTI, a Longevity Gene, Downregulates Angiotensin II Type I Receptor Expression in Vascular Smooth Muscle Cells.
02/17Not Available 
02/24Xia LiMolecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the  AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy.
03/03Frederique YiannikourisDeficiency of Angiotensin Type 2 Receptor Rescues Obesity But Not Hypertension Induced by Overexpression of Angiotensinogen in Adipose Tissue.
03/10Nadezhda SabevaDramatically Increased Intestinal Absorption of Cholesterol Following Hypophysectomy Is Normalized by Thyroid Hormone.
03/17No Journal Club-Spring Break 
03/24Xuan ZhangDiet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia Adiposity, Hypertension, and Insulin Resistance: A Novel Murine Model of Developmental Programming.
03/31No Journal Club-Fayette County School Spring Break 
04/07Preetha ShridasAdPLA Ablation Increases Lipolysis and Prevents Obesity Induced by High-Fat Feeding or Leptin Deficiency.
04/14Lindsay CalderonG12-G13-LARG-Mediated Signaling in Vascular Smooth Muscle is Required for Salt-Induced Hypertension.
04/21Shaoping WangDeletion of Macrophage LDL Receptor-Related Protein Increases Atherogensis in the Mouse.
04/28No Journal Club-ATVB Conference 
05/05Kamalika MukherjeeEpac1 is Upregulated During Neointima Formation and Promotes Vascular Smooth Muscle Cell Migration.
05/12Jingjing LiuFoxO1 Haploinsufficiency Protects Against High Fat Diet-Induced Insulin Resistance with Enhanced PPARy Activation in Adipose Tissue.
05/19Kelly PutnamImplantation of Adipose-Derived Regenerative Cells Enhanced Ischemia-Induced Angiogenesis.
05/26Akinwunmi AkinmusireHigh-Density Lipoprotein Transport Through Aortic Endothelial Cells Involves Scavenger Receptor BI and ATP -Binding Cassette Transporter GI.
Fall Semester 2008
9/2Nick HatchAngiotensin Converting Enzyme-2 (ACE2) Confers Endothelial Protection and Attenuates Atherosclerosis.
9/9Sean ThatcherEndothelium-Specific Interference With Peroxisome Proliferator Activated Receptor Gamma Causes Cerebral Vascular Dysfunction in Response to a High-Fat Diet.
9/16Jasmine LiFSP27 Contributes to Efficient Energy Storage in Murine White Adipocytes by Promoting the Formation of Unilocular Lipid Droplets.
9/23Carmen KiperEvidence from a Genetic Fate-Mapping Study that Stem Cells Refresh Adult Mammalian Cardiomyocytes After Injury.
9/30Zachary FulkersonPlatelet CD36 Links Hyperlipidemia, Oxidant Stress and a Prothrombotic Phenotype.
10/7Phillip OwensApelin Signaling Antagonizes AngII Effects in Mouse of Atherosclerosis.
10/14Zhongwen XieROCK1 Mediates Leukocyte Recruitment and Neointima Formation Following Vascular Injury.
10/21Nadezhda SabevaHepatic Insulin Resistance Directly Promotes Formation of Cholesterol Gallstones.
10/28Venkateswaran SubramanianDifferential Roles of Cardiomyocyctes and macrophage Peroxisome Proliferator-Activated Receptor  in Cardiac Fibrosis.
11/4No Journal Club-Election Day
11/11No Journal Club-AHA Scientific Session
11/18Shaoping WangLocal Activation or Implantation of Cardiac Progenitor Cells Rescues Scarred Infarcted Myocardium Improving Cardiac Function.
11/25Mingming ZhaoDeficiency of Adipose Differentiation-Related Protein Impairs Foam Cell Formation and Protects Against Atherosclerosis.
12/2Xiuling LiIsoprostanes Inhibit Vascular Endothelial Growth Factor-Induced Endothelial Cell Migration, Tube Formation, and Cardiac Vessel Sprouting In Vitro, As Well As Angiogensis In Vivo via Activation of the Thromboxane A Receptor: A Potential Link Between Oxidative Stress and Impaired Angiogenesis.
12/9Manisha GupteAngiotensin (1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart.
12/16Haruhito Adam UchidaAdiponectin Regulates Albuminuria and Podocyte Function in Mice.
Spring Semester 2008
1/15Nick Hatch

Deoxycorticosterone Acetate Salt Hypertension in Apolipoprotein E-/- Mice Results in Accelerated Atherosclerosis.

1/22Boris BoyanovskyPerfusion-Decellularized Matrix: Using Nature's Platform to Engineer a Bioartificial Heart.
1/29  
2/5Jill Cholewa 
2/12Jasmine LiDok1 Mediates High-Fat Diet-Induced Adipocyte Hypertrophy and Obesity through Modulation of PPAR-G Phosphorylation.
2/19Melissa ZackLeptin Induces Macrophage Lipid Body Formation by a Phosphatildylinositol 3-Kinase-and Mammalian Target of Rapamycin-Dependent Mechanism.
2/26No Journal Club 
3/4No Journal Club 
3/11Lindsay CalderonMacrophage ABCA1 and ABCG1, but not SR-BI, Promote Macrophage Reverse Cholesterol Transport in Vivo.
3/18Tao TangFoxO Transcription Factors Activate Akt and Attenuate Insulin Signaling in Heart by Inhibiting Protein Phosphatases.
3/25Hong LuIncreased Energy Expenditure, Dietary Fat Wasting, and Resistance to Diet-Induced Obesity in Mice Lacking Renin.
4/1Fayette Co. Schools Spring Break - No CVJC 
4/8Sara PoliceOverexpression of PAI-1 Prevents the Development of Abdominal Aortic Aneurysms in Mice.
4/15ATVB Conference-No CVJC 
4/22Jingjing LiuFish Oil Increases Cholesterol Storage in White Adipose with Concomitant Decreases in Inflammation, Hepatic Steatosis, and Atherosclerosis in Mice.
4/29Xuan ZhangPrenatal Gender-Related Nicotine Exposure Increases Blood Pressure Response to Angiotensin II in Adult Offspring.
5/6Frederique YiannikourisMineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-{gamma},and Proinflammatory Adipokines.
5/13Anisa JahangiriApolipoprotein All Is a Regulator of Very Low Density Lipoprotein Metabolism and Insulin Resistance.
5/20Phillip OwensNovel Role for Inhibitor of Differentiation 2 in the Genesis of Angiotensin II Induced Hypertension.
5/27Ailing JiFunctional Genomic Screen Reveals Genes Involved in Lipid-Droplet Formation and Utilization.
Fall Semester 2007
09/04Jon SatinYoung Mouse Heart Is Composed of Myocytes Heterogeneous in Age and Function.
09/11William LesterCa2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.
09/18Nick Hatch

Inhibited Aortic Aneurysm Formation in BLT1-Deficient Mice.

09/25Brad BluntCardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factoe-{kappa} B Dependent Pathway.
10/02Lindsay Calderon

Targeted Deletion of Class A Macrophage Scavenger Receptor Increases the Risk of Cardiac Rupture After Experimental Myocardial Infarction.

10/09Venkat Subramanian

Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice

10/16Rebekah WaikelDysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2.
10/23Jasmine LiDisruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.
10/30Jill Cholewa

Delta-Like 4 Induces Notch Signaling in Macrophages: Implications for Inflammation

11/06Miranda Byse

Gene Therapy to Inhibit the Calcium Channel ß Subunit:Physiological Consequences and Pathophysiological Effects in Models of Cardiac Hypertrophy

11/13Sean ThatcherPioplitazone Increases Macrophage Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Nondiabetic Low-Density Lipoprotein Receptor Null Mice." 
11/20Ye Chen-IzuTransgenic CaMKII{delta}C Overexpression Uniquely Alters Cardiac Myocyte Ca2+ Handling: Reduced SR Ca2+ Load and Activated SR Ca2+ Release
11/27Preetha Shridas

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.

12/04Phillip Owens

Cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. 

12/11Manisha Gupte 
Spring Semester 2007
01/16Hsin-Yuan ChengerbB2 is required for G protein-coupled receptor signaling in the heart
01/23Boris BoyanovskyCombinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages
01/30Dejan Nikolic p38 Mitogen-Activated Protein Kinase Inhibition Ameliorates Angiotensin II-Induced Target Organ Damage
02/06  
02/13Kamalika MukherjeeDeletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis
02/20A. Phillip OwensTLR4 links innate immunity and fatty acid-induced insulin resistance
02/27Hong LuAngiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
03/06Vishwesh MokashiDNA Vaccination Against VEGF Receptor 2 Reduces Atherosclerosis in LDL Receptor-Deficient Mice
03/13Miranda ByseThe C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor
03/20Zhenheng GuoRho-kinase as a molecular target for insulin resistance and hypertension
03/27Alan DaughertyElastin Stabilization for Treatment of Abdominal Aortic Aneurysms
04/03Sam BrightDo Statins Reduce Blood Pressure?:  A Meta-Analysis of Randomized, Controlled Trials
04/10Venkat SubramanianAngiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response
04/17Fei HuangDecorin overexpression reduces atherosclerosis development in apolipoprotein E-deficient mice
04/24Leah Allenalpha1-Adrenergic Receptors Activate AKT via a Pyk2/PDK-1 Pathway That Is Tonically Inhibited by Novel Protein Kinase C Isoforms in Cardiomyocytes
05/01Haruhito Adam UchidaMacrophage Scavenger Receptor-A–Deficient Mice Are Resistant Against Diabetic Nephropathy Through Amelioration of Microinflammation
05/08Xiaojie Amy XieLack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E–Deficient Mice
05/15Violeta ArsenescuAn obesity-associated gut microbiome with increased capacity for energy harvest
Fall Semester 2006
09/05Phil OwensDeletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
09/12Miranda ByseInhibition of Nuclear Import of Calcineurin Prevents Myocardial Hypertrophy
09/19Hong LuNatural regulatory T cells control the development of atherosclerosis in mice
09/26Brad BluntGata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure
10/03Emily Helfrich-BradshawHigh-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor
10/10Vishwesh MokashiSmooth Muscle Cells in Atherosclerosis Originate from the Local Vessel Wall and Not Circulating Progenitor Cells in ApoE Knockout Mice
10/17Beth OesterlingLong-term Air Pollution Exposure and Acceleration of Atherosclerosis and Vascular Inflammation in an Animal Model.
10/24Florence GizardVascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress.
10/31Sara PoliceAltered blood pressure responses and normal cardiac phenotype in ACE2-null mice.
11/07Takashi NomiyamaNR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism.
11/14Sean StockerMelanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin.
11/21cancelled 
11/28Kalyani BharadwaiLocal Renin Angiotensin Expression Regulates Human Mesenchymal Stem Cell Differentiation to Adipocytes
12/05Paul AnayaBone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice
12/12Sumitra MiriyalaLysophosphatidic acid induces endothelial cell death by modulating the redox environment
12/19Manikandan PanchatcharamDiabetic Microangiopathy in Ischemic Limb Is a Disease of Disturbance of the Platelet-Derived Growth Factor-BB/Protein Kinase C Axis but Not of Impaired Expression of Angiogenic Factors
Spring Semester 2006
01/31Zhenheng GuoVascular Smooth Muscle Hypertrophy in Transgenic Mice Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice.
02/07Phillip OwensThe Lamina Adventitia Is the Major Site of Immune Cell Accumulation in Standard Chow-Fed Apolipoprotein E–Deficient Mice.
02/14Takashi NomiyamaPPARα inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a.
02/21Vishwesh MokashiRegression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase.
02/28Beth OesterlingPolycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties.
03/07Fjoralba BabamustaCCR2 modulates inflammatory and metabolic effects of high-fat feeding.
03/14Ken CampbellPhosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner.
03/21Anisa JahangiriHigh-Density Lipoprotein Hydrolysis by Endothelial Lipase Activates PPARy:  A Candidate Mechanism for High-Density Lipoprotein-Mediated Repression of Leukocyte Adhesion.
03/28Shoba ShettyElevated Plasma Membrane Cholesterol Content Alters Macrophage Signaling and Function.
04/04Boris BoyanovskyTNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells.
04/11Emily HelfrichInvolvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.
04/18Alan DaughertyLosartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
04/25Julie OestreichEffect of Platelet Antigen Polymorphism on Platelet Inhibition by Aspirin, Clopidogrel, or Their Combination.
05/02Dejan NikolicSelective Rac-1 Inhibition Protects from Diabetes-Induced Vascular Injury.
05/09Leah Allen-KleeExercise Can Prevent the Severity of Hypertrophic Cardiomyopathy
05/16Aaron GayIdentification of Novel PPARy Target Genes in Primary Human Adipocytes
05/23Sam CarmichaelVascular Response to Angiotensin II in Upper Body Obesity
Fall Semester 2005
09/13Steve PostA central role for JNK in obesity and insulin resistance
09/20Qingwei ZhaoBlockade of interleukin-12 function by protein vaccination attenuates atherosclerosis.
09/27Zhenheng GuoRegulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.
10/04Hong LuAliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats.
10/11Meredith BostromMacrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress.
10/18Jill CholewaExpression of Class A Scavenger Receptor Is Enhanced by High Glucose in Vitroand under Diabetic Conditions in Vivo ONE MECHANISM FOR AN INCREASED RATE OF ATHEROSCLEROSIS IN DIABETES*.
10/25Sara PoliceProduction of Chemokines by Perivascular Adipose Tissue: A Role in the Pathogenesis of Atherosclerosis?
11/01Rebecca ScotlandThe transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy.
11/08Fei HuangEndostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis.
11/15No Journal Club - AHA Meetings (Dallas)
11/22Vishwesh MokashiTranscriptional Repression of ATP-Binding Cassette Transporter A1 Gene in Macrophages: A Novel Atherosclerotic Effect of Angiotensin II.
11/29Julie OestreichClopidogrel inhibits platelet-leukocyte adhesion and platelet dependent leukocyte activation.
11/06Phil OwensModulation of atheroslcerosis in mice by Toll-like receptor 2.
Spring Semester 2005
01/25Yanmei WangShort Interfering RNA-Mediated Silencing of Glutaredoxin 2 Increases the Sensitivity of Hela Cells toward Doxorubicin and Phenylarsine Oxide.
02/01Rebecca Scotland 
02/08Vishwesh Mokashi 
02/15Boris BoyanovskyDifferential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ.
02/22Sergey MatveevOverexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment.
03/01Violeta Arsenscu 
03/08Tracy HenriquesInhibitory Effects of AT1 Receptor Blocker, Olmesartan, and Estrogen on Atherosclerosis Via Anti-Oxidative Stress.
03/15Vicky KingCyclooxygenases, Thromboxane, and Atherosclerosis: Plaque Destabilization by Cyclooxygenase-2 Inhibition Combined With Thromboxane Receptor Antagonism
03/22Leah Allen-KleeAkt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes.
03/29Bing SunABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.
04/05Fayette Co. Spring Break - no CVJC 
04/12Zhenheng GuoContractile Properties of the Cultured Vascular Smooth Muscle Cells. The Crucial Role Played by RhoA in the Regulation of Contractility.
04/19Darshini TrivediProstaglandin E2–Mediated Relaxation of the Ductus Arteriosus: Effects of Gestational Age on G Protein-Coupled Receptor Expression, Signaling, and Vasomotor Control.
04/26Jill CholewaHyperhomocysteinemia Activates Nuclear Factor-KB in Endothelial Cells via Oxidative Stress.
05/03Dejan NikolicScavenger receptor A mediates H2O2 production and suppression of IL-12 release in murine macrophages.
05/10Phil OwensFausudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II induced AAA in ApoE -/- mice by inhibiting apoptosis and proteolysis.
05/17Sara PoliceWeight Loss--Associated Induction of Peroxisome Proliferator-Activated Receptor-alpha and Peroxisome Proliferator-Activated Receptor-gamma Correlate With Reduced Atherosclerosis and Improved Cardiovascular Function in Obese Insulin-Resistant Mice.
05/24Kalyani BharadwajAttenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor.
Fall Semester 2004
09/14Richard Lee 
09/21Steve PostRegulation of Muscle Fiber Type and Running Endurance by PPARdelta.
09/28Erik EckhardtThe LDL Receptor Related Protein LRP6 Regulates Proliferation and Survival Through the Wnt Cascade in Vascular Smooth Muscle Cells.
10/05Leah AllenGender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart.
10/12Tracy HenriquesInhibition of Diet-Induced Atherosclerosis and Endothelial Dysfunction in Apolipoprotein E/Angiotensin II Type 1A Receptor Double-Knockout Mice.
10/19Kalyani BharadwajHypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma.
10/26Phil OwensThe 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.
11/02Rebecca Scotland 
11/09AHA Meetings
11/16Darshini TrevediRoles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE-deficient mice.
11/23No CVJC
11/30Deneys van der WesthuyzenGenetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population.
12/07Elzbieta StolarczykInsig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol*.
12/14Meredith BostromMacrophage-specific overexpression of group IIa sPLA2 results in increased atherosclerotic lesion size and enhanced collagen deposition.
Spring Semester 2004
02/02Vicky KingAngiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice.
02/10Kalyani BharadwajMuscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
02/17Dejan NikolicApoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II–induced cardiac hypertrophy and remodeling.
02/24Hong LuObesity is associated with macrophage accumulation in adipose tissue.
03/03Jing HuangArachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.
03/09Tracy HenriquesAndrogen Contributes to Gender-Related Cardiac Hypertrophy and Fibrosis in Mice Lacking the Gene Encoding Guanylyl Cyclase-A.
03/16Zhengheng GuoHypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.
03/23Darshini TrevidiAntimitogenic effects of HDL and APOE mediated by Cox-2–dependent IP activation.
03/30No CVJC - Fayette Schools Spring Break 
04/06Boris BoyanovskyInhibition of NF-KB activation in macrophages increases atherosclerosis in LDL receptor–deficient mice.
04/13Erik EckhardtA Mutant High-Density Lipoprotein Receptor Inhibits Proliferation of Human Breast Cancer Cells.
04/20Ela StolarczykGeneration of Viable Cholesterol-Free Mice.
04/27Alan DaughertyLRP: Role in vascular wall integrity and protection from atherosclerosis.
05/04No CVJC - ATVB meeting 
05/11Bing SunIncreased CD36 protein as a response to defective insulin signaling in macrophages.
05/18Rebecca ScotlandThe α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.
05/25Shoba ShettyOverexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
06/01Lisa TannockExtracellular Matrix Glycoprotein Biglycan Enhances Vascular Smooth Muscle Cell Proliferation and Migration.
06/08Dennis BruemmerImpaired pancreatic growth, β cell mass, and β cell function in E2F1 -/- mice
06/15Lisa CassisSusceptibility to Early Atherosclerosis in Male Mice Is Mediated by Estrogen Receptor.
Fall Semester 2003
09/16Todd PorterEffects of a Dietary Portfolio of Cholesterol-Lowering Foods vs Lovastatin on Serum Lipids and C-Reactive Protein
09/23Dave RandallGlutamate release in midbrain periaqueductal gray by activation of skeletal muscle receptors and arterial baroreceptors
09/30Dejan NikolicMelusin, a muscle-specific integrin â1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload
10/07Nancy WebbLong-term stable expression of human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of FH.
10/14Reto AsmisLeprdb Diabetic Mouse Bone Marrow Cells Inhibit Skin Wound Vascularization but Promote Wound Healing.
10/21Shawn CrumpEnhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2 deficient mice.
10/28Darshini TrevidiCOX-2 induction by Bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous PGE2, EP2 and EP4 receptors.
11/04Carine BoustanyPivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.
11/11AHA mtg. - no journal club
11/18Ming GongInhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
11/25Fjoralba BabamustaNiemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis
12/02Ela StolarczykCholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial.
12/09Rebecca ScotlandCardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy.
12/16Li LiGuggulipid for the treatment of hypercholesterolemia: a randomized controlled trial.
Spring Semester 2003
01/07Dave RandallAbnormal cardiac function associated with sympathetic nervous system hyperactivity in mice.
01/14Zhenheng GuoAngiotensin-converting enzyme 2 is an essential regulator of heart function.
01/21Jon SatinCalmodulin Kinase II and Arrhythmias in a Mouse Model of Cardiac Hypertrophy.
01/28Alan DaughertyIncreased medial degradation with pseudo-aneurysm formation in apolipoprotein E knockout mice deficient in tissue inhibitor of metalloproteinases-1.
02/04Stuart RiceRAGE Blockade Stabilizes Established Atherosclerosis in Diabetic Apolipoprotein E–Null Mice.
02/11Tracy HenriquesGender differences in cardiac ACE expression are normalized in androgen-deprived male mice.
02/18Cancelled - due to weather 
02/25Jing HuangInhibition of Renin-Angiotensin System Ameliorates Endothelial Dysfunction Associated with Aging in Rats.
03/04Sergey MatveevAdipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor ã1 (PPAR ã1) overexpression.
03/11Tracy HenriquesMice Lacking Endothelial ACE: Normal Blood Pressure with Elevated Angiotensin II.
03/18Bing SunThe Recycling of Apolipoprotein E in Primary Cultures of Mouse Hepatocytes.
03/25Deneys van der WesthuyzenEctopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis.
04/01Darshini TrivediProstaglandin E2 Suppresses Chemokine Production in Human Macrophages through the EP4 Receptor.
04/08Spring Break - no CVJC 
04/15Ginell PostAltered PYK2 phosphorylation by ANG II in hypertensive vascular smooth muscle.
04/22Li LiIdentification of Gene-selective Modulators of the Bile Acid Receptor FXR
04/29Catherine MaoSevere Hypercholesterolemia, impaired fat tolerance and advanced atherosclerosis in mice lacking both Low density lipoprotein receptor-related protein 5 and Apolipoprotein E.
05/06  
05/13Mary GarciaThe alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction.
05/20Dejan NikolicSingle Injection of P-Selectin or P-Selectin Glycoprotein Ligand-1 Monoclonal Antibody Blocks Neointima Formation After Arterial Injury in Apolipoprotein E-Deficient Mice.
05/27Fjoralba BabamustaOsteopontin Transgenic Mice Fed a High-Cholesterol Diet Develop Early Fatty-Streak Lesions.

Fall Semester 2002
09/16Todd PorterEffects of a Dietary Portfolio of Cholesterol-Lowering Foods vs Lovastatin on Serum Lipids and C-Reactive Protein
09/23Dave RandallGlutamate release in midbrain periaqueductal gray by activation of skeletal muscle receptors and arterial baroreceptors
09/30Dejan NikolicMelusin, a muscle-specific integrin â1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload
10/07Nancy WebbLong-term stable expression of human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of FH.
10/14Reto AsmisLeprdb Diabetic Mouse Bone Marrow Cells Inhibit Skin Wound Vascularization but Promote Wound Healing.
10/21Shawn CrumpEnhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2 deficient mice.
10/28Darshini TrevidiCOX-2 induction by Bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous PGE2, EP2 and EP4 receptors.
11/04Carine BoustanyPivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.
11/11AHA mtg. - no journal club
11/18Ming GongInhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
11/25Fjoralba BabamustaNiemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis
12/02Ela StolarczykCholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial.
12/09Rebecca ScotlandCardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy.
12/16Li LiGuggulipid for the treatment of hypercholesterolemia: a randomized controlled trial.

No